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Amniotic membran

Gilles Faron, Lisa Balepa, José Parra, Jean-François Fils, Leonardo Gucciardo
BACKGROUND: The identification of women at risk for preterm birth should allow interventions which could improve neonatal outcome. Fetal fibronectin, a glycoprotein which acts normally as glue between decidua and amniotic membranes could be a good marker of impending labour when its concentration in cervicovaginal secretions between 22 and 36 weeks of gestation is ≥ 50 ng/mL. Many authors worldwide have tested this marker with many different methodologies and clinical settings, but conclusions about its clinical use are mixed...
June 18, 2018: Journal of Maternal-fetal & Neonatal Medicine
Hyo Kyozuka, Syun Yasuda, Tsuyoshi Hiraiwa, Yasuhisa Nomura, Keiya Fujimori
OBJECTIVE: Histological chorioamnionitis (CAM) is related to neonatal mortality and morbidity. However, identifying intrauterine inflammation before delivery is challenging. The aim of this study was to investigate the changes in fetal heart rate (FHR) short-term variability (STV) during the course of histological CAM. STUDY DESIGN: Changes in STV were measured in 7 chronically instrumented fetal sheep at 111-120 days of gestation. Lipopolysaccharide (LPS) was infused into the amniotic cavity for 2 days following the 4th postoperative day to develop histological CAM...
June 11, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Claudia Patricia Cataño Sabogal, Javier Fonseca, Herney Andrés García-Perdomo
INTRODUCTION: The aim of this study was to determine the diagnostic performance of different diagnostic tests for histologic chorioamnionitis in patients at more than 20 weeks of gestation. METHODS: A systematic search was carried out through MEDLINE, EMBASE, LILACS, CENTRAL and unpublished literature. Observational studies included with pregnant women (>20 weeks) with chorioamnionitis. The reference standard was the histopathological study of the placenta, umbilical cord and fetal membranes...
June 9, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Y F Huang, L L Wang
Ocular chemical burns are common and serious ocular emergencies which require immediate and intensive evaluation and treatment. Loss of vision and disfigurement affect the victims, bringing great sufferings to themselves and their families. China is the biggest developing country in the world with a large number of such cases. The prevention of ocular chemical burns is emphasized in different aspects. After emergency treatment, proper care of chemical burns is started by control of inflammation with corticosteroids...
June 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Leila Etemad, Mohammad Moshiri, Mahdi Balali-Mood
The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive...
May 2018: Iranian Journal of Medical Sciences
Ivana Musilova, Ctirad Andrys, Helena Hornychova, Lenka Pliskova, Marcela Drahosova, Barbora Zednikova, Radka Bolehovska, Tomas Faist, Bo Jacobsson, Marian Kacerovsky
OBJECTIVE: To determine changes in the intraamniotic environment during the latency period using paired amniotic and gastric fluid samples in pregnancies complicated by preterm prelabor rupture of membranes (PPROM). METHODS: A total of 34 women with singleton pregnancies complicated by PPROM prior to 34 weeks were included in the study. Amniotic fluid was obtained by transabdominal amniocentesis at the time of admission. Immediately after delivery, umbilical cord blood and gastric fluid were obtained...
May 31, 2018: Pediatric Research
Mariya P Dobreva, Vanesa Abon Escalona, Kirstie A Lawson, Marina N Sanchez, Ljuba C Ponomarev, Paulo N G Pereira, Agata Stryjewska, Nathan Criem, Danny Huylebroeck, Susana M Chuva de Sousa Lopes, Stein Aerts, An Zwijsen
Upon gastrulation, the mammalian conceptus transforms rapidly from a simple bilayer into a multi-layered embryo enveloped by its extraembryonic membranes. Impaired development of the amnion, the innermost membrane, causes major malformations. To clarify the origin of the mouse amnion, we used single cell-labelling and clonal analysis. We identified four clone types with distinct clonal growth patterns in amniotic ectoderm (AmEc). Two main types have progenitors in extreme proximal-anterior epiblast. Early descendants initiate and expand AmEc posteriorly, while descendants of cells remaining anteriorly later expand AmEc from its anterior side...
June 8, 2018: Development
Ramyar Farzan, Mahsa Moeinian, Alireza Abdollahi, Zahra Jahangard-Rafsanjani, Abbas Alipour, Marzieh Ebrahimi, Ghasemali Khorasani
OBJECTIVE: Angiogenesis, formation of new vessels from pre-existing vessels, is an essential part of wound healing. We aimed to compare amniotic membrane extract with deferoxamine in angiogenesis and to assess any synergistic effect. METHOD: We examined four groups of rats (five per group): control, deferoxamine, amniotic membrane extract, and deferocxamine and amniotic membrane extract in combination. A distal-based skin flap was created. Deferoxamine (100mg/kg), amniotic membrane extract (0...
June 1, 2018: Journal of Wound Care
Young-Joo Lee, Seung-Chul Kim, Jong-Kil Joo, Dong-Hyung Lee, Ki-Hyung Kim, Kyu-Sup Lee
OBJECTIVE: Prediction of delivery latency complicated with preterm premature rupture of membrane (PPROM) is crucial for reducing maternal and neonatal complications. Therefore, we investigated the correlations between latency period and cut-off values of ultrasonographic parameters, ultimately predicting delivery latency. MATERIALS AND METHODS: The retrospective study was performed on 121 PPROM patients enrolled between March 2010 and July 2015. Parameters including amniotic fluid index (AFI), single deepest pocket (SDP) and transvaginal cervical length (TVCL) were measured in 99 singleton pregnancies with PPROM...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
Song Yi Kook, Kyo Hoon Park, Ji Ae Jang, Yu Mi Kim, Hyunsoo Park, Se Jeong Jeon
OBJECTIVE: To determine whether vitamin D-binding protein (VDBP) in cervicovaginal fluid (CVF) is independently predictive of intra-amniotic infection and imminent spontaneous preterm delivery (SPTD, delivery within 48 hours) in women with preterm labor with intact membranes (PTL) or preterm premature rupture of membranes (PPROM). METHOD: This was a single-center retrospective cohort study. CVF samples for VDBP assays were obtained along with serum C-reactive protein (CRP) levels immediately after amniocentesis in consecutive women with PTL (n = 148) or PPROM (n = 103) between 23...
2018: PloS One
Mohd Rehan, Manish Khatri, Mansi Bansal, Komal Puri, Ashish Kumar
Background: An amnion membrane is a placenta-derived tissue that consists of numerous growth factors, proteins, and stem cell reserves which help in accelerated wound healing and regeneration. Platelet-rich fibrin (PRF) also releases growth factors after activation from the platelets and gets trapped within fibrin matrix which has been shown to stimulate the mitogenic response in the periosteum for bone repair and regeneration during normal wound healing. This preliminary, controlled, randomized clinical trial with an 18-month follow-up was aimed to evaluate the effectiveness of coronally advanced flap (CAF) with either PRF membrane or bioresorbable amniotic membrane (AM) in treatment of localized gingival recession defects...
April 2018: Contemporary Clinical Dentistry
Brittany M Woodall, Nicholas Elena, Joseph T Gamboa, Edward C Shin, Neil Pathare, Patrick J McGahan, James L Chen
Anterior cruciate ligament (ACL) ruptures are common and unfortunate injuries for many athletes. The standard therapy for ACL rupture is ACL reconstruction with either autograft, harvested from hamstring or patellar tendon, or allograft tendon from a tissue donor. Advances in tissue engineering have produced interventions to augment the healing process and may have applications when it comes to ACL reconstruction. In this Technical Note and accompanying video, we describe a simple technique to implant an amnion matrix graft with a tendon graft during ACL reconstruction...
April 2018: Arthroscopy Techniques
Nadia Nawaz, Ahmed Raheem Buksh
Amniotic fluid embolism is a rare and severe problem in obstetric patients. We experienced a 21-year primigravida who underwent emergency cesarean section due to sudden collapse and fetal distress after rupture of membranes in labour. Subsequently, she developed intraoperative coagulopathy, hemorrhage, hypotension, and respiratory collapse requiring ventilation. Both maternal and neonatal lives were saved with full recovery and discharged in stable condition. The clinical diagnosis of amniotic fluid embolism (AFE) was made, which is a very rare complication of pregnancy/puerperium with varying presentation, ranging from cardiac arrest, circulatory collapse and death through mild degrees of organ system dysfunction with or without coagulopathy...
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Mélissa Julien, Laury N'guema, Amina Bouzerara, Benoit Toro, Edouard Lecarpentier, Jean Guibourdenche
Premature rupture of the membranes (PROM) is a frequent event affecting 3% of pregnancies. PROM causes 30% of premature deliveries and 20% of perinatal mortality. The diagnosis relies mainly on the clinical visualization of the amniotic fluid flow in the vagina. If not, clinicians can use bedside tests detecting either the change of the vaginal pH or the presence of amniotic components mainly IGFBP-1 or AFP in the vaginal fluid. We aimed to study the technical and analytical characteristics of 5 immunochromatographic tests (easyProm®, ActimProm®, Toda Amniodiag 5 strip®, Amnioquick® Duo, Amnisure®) that mainly detect IGFBP-1 in order to compare our results with the data from the manufacturer...
June 1, 2018: Annales de Biologie Clinique
Louise J Lu, Laura Hall, Ji Liu
Conventional glaucoma surgeries, such as trabeculectomy and glaucoma drainage device (GDD) surgery, have been enhanced by surgeons to improve outcome and decrease complications. Over the last two decades, adjuncts, such as collagen matrix implants, fibrin adhesives, and amniotic membrane transplantation (AMT) have been found to be effective in modulating fibrosis and scarring during the wound-healing process, reducing postoperative inflammation, and repairing bleb leakage or conjunctival erosion. The use of these tools provides several advantages when used in trabeculectomy, GDD surgery, and surface reconstruction associated with glaucoma surgery complications...
January 2018: Journal of Current Glaucoma Practice
Elisabetta Marton, Enrico Giordan, Giorgio Gioffrè, Giuseppe Canova, Adolfo Paolin, Marina Grazia Mazzucco, Pierluigi Longatti
OBJECTIVE: Surgical management of spinal dysraphism often requires the use of dural substitutes. Amniotic membrane (AM) has drawn the interest of clinicians for its valuable concentration of cytokines and factors capable of promoting wound healing, re-epithelialization, inhibiting fibrosis and regulating angiogenesis. These beneficial qualities could make AM an interesting dural substitute for spina bifida repair. In this study, we describe the use of banked homologous AM as a dural substitute for the repair of spinal dysraphism in newborns...
June 1, 2018: Acta Neurochirurgica
Mathilde Fénelon, Olivier Chassande, Jérome Kalisky, Florelle Gindraux, Stéphanie Brun, Reine Bareille, Zoran Ivanovic, Jean-Christophe Fricain, Claudine Boiziau
Due to its biological properties, human amniotic membrane (hAM) is widely studied in the field of tissue engineering and regenerative medicine. hAM is already very attractive for wound healing and it may be helpful as a support for bone regeneration. However, few studies assessed its potential for guided bone regeneration (GBR). The purpose of the present study was to assess the potential of the hAM as a membrane for GBR. In vitro, cell viability in fresh and cryopreserved hAM was assessed. In vivo, we evaluated the impact of fresh versus cryopreserved hAM, using both the epithelial or the mesenchymal layer facing the defect, on bone regeneration in a critical calvarial bone defect in mice...
June 1, 2018: Journal of Materials Science. Materials in Medicine
Eva Maria Rehbinder, Karin C Lødrup Carlsen, Anne Cathrine Staff, Inga Leena Angell, Linn Landrø, Katarina Hilde, Peter Gaustad, Knut Rudi
BACKGROUND: The "sterile womb" paradigm is debated. Recent evidence suggests that the offspring's first microbial encounter is before birth in term uncomplicated pregnancies. The establishment of a healthy microbiota early in life might be crucial for reducing the burden of diseases later in life. OBJECTIVE: We aimed to investigate the presence of a microbiota in sterilely collected amniotic fluid in uncomplicated pregnancies at term in the Preventing Atopic Dermatitis and Allergies in children (PreventADALL) study cohort...
May 28, 2018: American Journal of Obstetrics and Gynecology
Rachelle N Palchesko, Santiago D Carrasquilla, Adam W Feinberg
Corneal blindness is a major cause of vision loss, estimated to affect over 10 million people worldwide. Once impaired through clouding or shape change, the best treatment option for restoring vision is corneal transplantation using full or partial thickness cadaveric grafts. However, donor corneas are globally limited and face rejection and graft failure, similar to other transplanted organs. Thus, there is a need for viable alternatives to donor corneas in order to increase supply, reduce rejection, and to minimize variability in tissue quality...
May 29, 2018: Advanced Healthcare Materials
Li-Jing Ran, Yun Zeng, Shao-Chun Wang, Di-Si Zhang, Min Hong, Shao-You Li, Jian Dong, Ming-Xia Shi
The aim of the present study was to investigate the effect of co‑culture with amniotic epithelial cells (AECs) on the biological characteristics of amniotic mesenchymal stem cells (AMSCs), to compare the expression of C‑X‑C motif chemokine receptor 4 (CXCR4) in co‑cultured AMSCs and to investigate the roles of the stromal cell‑derived factor‑1 (SDF‑1)/CXCR4 axis in the homing and migration of AMSCs. AMSCs were isolated from human amniotic membranes, purified and then differentiated into osteoblasts and adipocytes in vitro, which was verified by von Kossa Staining and Oil Red O staining...
May 23, 2018: Molecular Medicine Reports
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