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https://www.readbyqxmd.com/read/29623466/is-tumor-volume-reduction-during-radiotherapy-prognostic-relevant-in-patients-with-stage-iii-non-small-cell-lung-cancer
#1
Khaled Elsayad, Laith Samhouri, Sergiu Scobioala, Uwe Haverkamp, Hans Theodor Eich
PURPOSE/OBJECTIVE(S): Lung cancer tumor volume reduction is common during radiation treatment (RT). The purpose of this study was to investigate tumor volume reduction ratio (VRR) and its correlation with outcomes in a cohort of patients with stage III non-small cell lung cancer (NSCLC) who underwent image-guided radiochemotherapy (RCTx). MATERIALS/METHODS: Fifty patients with NSCLC treated with fractionated RT at our institution between 2013 and 2017 were included...
April 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29614508/diagnosis-and-management-of-asthma-the-swiss-guidelines
#2
Thomas Rothe, Paolo Spagnolo, Pierre-Olivier Bridevaux, Christian Clarenbach, Christine Eich-Wanger, Franca Meyer, David Miedinger, Alexander Möller, Laurent P Nicod, Geneviève Nicolet-Chatelain, Alain Sauty, Claudia Steurer-Stey, Joerg D Leuppi
The Global Initiative for Asthma (GINA) is a network of individuals, organizations, and public health officials that was established to disseminate information about the care of patients with asthma and to improve asthma care. The GINA ("Global Strategy for Asthma Management and Prevention") report has been updated annually since 2002. Due to new knowledge and therapeutic development in the field, the Swiss Respiratory Society felt the need to provide a new document that is based on both the available literature and the recommendations of the 2016 GINA report...
April 3, 2018: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29604794/design-and-performance-of-an-ultra-high-vacuum-spin-polarized-scanning-tunneling-microscope-operating-at-30-mk-and-in-a-vector-magnetic-field
#3
Henning von Allwörden, Andreas Eich, Elze J Knol, Jan Hermenau, Andreas Sonntag, Jan W Gerritsen, Daniel Wegner, Alexander A Khajetoorians
We describe the design and performance of a scanning tunneling microscope (STM) that operates at a base temperature of 30 mK in a vector magnetic field. The cryogenics is based on an ultra-high vacuum (UHV) top-loading wet dilution refrigerator that contains a vector magnet allowing for fields up to 9 T perpendicular and 4 T parallel to the sample. The STM is placed in a multi-chamber UHV system, which allows in situ preparation and exchange of samples and tips. The entire system rests on a 150-ton concrete block suspended by pneumatic isolators, which is housed in an acoustically isolated and electromagnetically shielded laboratory optimized for extremely low noise scanning probe measurements...
March 2018: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29579537/use-of-high-metal-containing-biogas-digestates-in-cereal-production-mobility-of-chromium-and-aluminium
#4
Ivan Dragicevic, Susanne Eich-Greatorex, Trine A Sogn, Svein J Horn, Tore Krogstad
Biogas digestate use as organic fertilizer has been widely promoted in recent years as a part of the global agenda on recycling waste and new sustainable energy production. Although many studies have confirmed positive effects of digestates on soil fertility, there is still lack of information on the potential adverse effects of digestates on natural soil heavy metal content, metal leaching and leaching of other pollutants. We have investigated the release of aluminium (Al) and chromium (Cr) from different soils treated with commercial digestates high in mentioned potentially problematic metals in a field experiment, while a greenhouse and a laboratory column experiment were used to address mobility of these metals in two other scenarios...
March 23, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29561066/safety-immunogenicity-pharmacokinetics-and-efficacy-of-degradation-of-anti-hla-antibodies-by-ides-imlifidase-in-chronic-kidney-disease-patients
#5
Tomas Lorant, Mats Bengtsson, Torsten Eich, Britt-Marie Eriksson, Lena Winstedt, Sofia Järnum, Yvonne Stenberg, Anna-Karin Robertson, Kristina Mosén, Lars Björck, Lars Bäckman, Erik Larsson, Kathryn Wood, Gunnar Tufveson, Christian Kjellman
Safety, immunogenicity, pharmacokinetics and efficacy of the immunoglobulin G-degrading enzyme of Streptococcus pyogenes (IdeS, Imlifidase) was assessed in a single centre, open label ascending dose study in highly sensitised chronic kidney disease patients. Eight patients with cytotoxic panel-reactive antibodies (median cytotoxic PRA of 64%) at enrolment received 1 or 2 intravenous infusions of IdeS on consecutive days (0.12 mg/kg body weight x2 (n=3); 0.25 mg/kg x1 (n=3) or 0.25 mg/kg x2 (n=2)). IgG degradation was observed in all subjects after IdeS treatment, with <1% plasma IgG remaining within 48 hours and remaining low up to 7 days...
March 21, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29554368/eye-pain-and-dry-eye-in-patients-with-fibromyalgia
#6
Alexander Karl-Georg Schuster, Markus Wettstein, Andreas Gerhardt, Wolfgang Eich, Christiane Bieber, Jonas Tesarz
Objectives: The aim of this study was to examine visual function and eye symptoms in fibromyalgia patients, with a particular focus on dry eye syndrome and eye pain. Methods: A tertiary care center-based cross-sectional study was carried out in chronic musculoskeletal pain patients diagnosed with fibromyalgia. Chronic musculoskeletal pain patients without fibromyalgia were enrolled as a comparison group. Self-reported eye pain was investigated with the McGill pain questionnaire and the numeric rating scale...
March 15, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29550384/long-term-efficacy-of-reduced-intensity-versus-myeloablative-conditioning-before-allogeneic-haemopoietic-cell-transplantation-in-patients-with-acute-myeloid-leukaemia-in-first-complete-remission-retrospective-follow-up-of-an-open-label-randomised-phase-3-trial
#7
Frederick Fasslrinner, Johannes Schetelig, Andreas Burchert, Michael Kramer, Rudolf Trenschel, Ute Hegenbart, Michael Stadler, Kerstin Schäfer-Eckart, Michael Bätzel, Hans Eich, Martin Stuschke, Rita Engenhart-Cabillic, Mechthild Krause, Peter Dreger, Andreas Neubauer, Gerhard Ehninger, Dietrich Beelen, Wolfgang E Berdel, Timo Siepmann, Matthias Stelljes, Martin Bornhäuser
BACKGROUND: The impact of the intensity of conditioning before allogeneic haemopoietic cell transplantation (HCT) has been studied in a randomised phase 3 trial comparing reduced-intensity conditioning with myeloablative conditioning in patients with acute myeloid leukaemia in first complete remission. Because of the short follow-up of the original trial, whether reduced-intensity conditioning increases the risk of late relapse compared with myeloablative conditioning remained unclear...
March 14, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29510865/stereotactic-body-radiotherapy-sbrt-for-multiple-pulmonary-oligometastases-analysis-of-number-and-timing-of-repeat-sbrt-as-impact-factors-on-treatment-safety-and-efficacy
#8
R J Klement, J Hoerner-Rieber, S Adebahr, N Andratschke, O Blanck, J Boda-Heggemann, M Duma, M J Eble, H C Eich, M Flentje, S Gerum, P Hass, C Henkenberens, G Hildebrandt, D Imhoff, K H Kahl, N D Klass, R Krempien, F Lohaus, C Petersen, E Schrade, T G Wendt, A Wittig, M Guckenberger
BACKGROUND: Stereotactic body radiotherapy (SBRT) for oligometastatic disease is characterized by an excellent safety profile; however, experiences are mostly based on treatment of one single metastasis. It was the aim of this study to evaluate safety and efficacy of SBRT for multiple pulmonary metastases. PATIENTS AND METHODS: This study is based on a retrospective database of the DEGRO stereotactic working group, consisting of 637 patients with 858 treatments...
March 3, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29360921/recommendations-for-the-clinical-management-of-the-elderly-patient-with-malignant-lymphoma
#9
L Specht, B Aleman, H Eich, T M Illidge, Y Kirova, N G Mikhaeel, U Ricardi, J Yahalom
No abstract text is available yet for this article.
January 19, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29355766/reference-ability-neural-networks-and-behavioral-performance-across-the-adult-life-span
#10
Christian Habeck, Teal Eich, Ray Razlighi, Yunglin Gazes, Yaakov Stern
To better understand the impact of aging, along with other demographic and brain health variables, on the neural networks that support different aspects of cognitive performance, we applied a brute-force search technique based on Principal Components Analysis to derive 4 corresponding spatial covariance patterns (termed Reference Ability Neural Networks -RANNs) from a large sample of participants across the age range. Two hundred and fifty-five clinically healthy, community-dwelling adults, aged 20-77, underwent fMRI while performing 12 tasks, 3 tasks for each of the following cognitive reference abilities: Episodic Memory, Reasoning, Perceptual Speed, and Vocabulary...
January 17, 2018: NeuroImage
https://www.readbyqxmd.com/read/29314698/s2k-leitlinie-kutane-lymphome-update-2016-teil-2-therapie-und-nachsorge-icd10-c82-c86
#11
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
January 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29286668/electrostatically-induced-quantum-point-contacts-in-bilayer-graphene
#12
Hiske Overweg, Hannah Eggimann, Xi Chen, Sergey Slizovskiy, Marius Eich, Riccardo Pisoni, Yongjin Lee, Peter Rickhaus, Kenji Watanabe, Takashi Taniguchi, Vladimir Fal'ko, Thomas Ihn, Klaus Ensslin
We report the fabrication of electrostatically defined nanostructures in encapsulated bilayer graphene, with leakage resistances below depletion gates as high as R ∼ 10 GΩ. This exceeds previously reported values of R = 10-100 kΩ.1-3 We attribute this improvement to the use of a graphite back gate. We realize two split gate devices which define an electronic channel on the scale of the Fermi-wavelength. A channel gate covering the gap between the split gates varies the charge carrier density in the channel...
January 10, 2018: Nano Letters
https://www.readbyqxmd.com/read/29280595/s2k-guidelines-cutaneous-lymphomas-update-2016-part-2-treatment-and-follow-up-icd10-c82-c86
#13
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
January 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29228489/s2k-leitlinie-kutane-lymphome-update-2016-teil-1-klassifikation-und-diagnostik-icd10-c82-c86
#14
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29226696/to-change-or-not-to-change-that-is-the-question-a-qualitative-study-of-lifestyle-changes-following-acute-myocardial-infarction
#15
Jennifer Nicolai, Nicole Müller, Stefan Noest, Stefanie Wilke, Jobst-Hendrik Schultz, Christian A Gleißner, Wolfgang Eich, Christiane Bieber
Objective The purpose of this study was to investigate key factors related to lifestyle changes following acute myocardial infarction (AMI) by eliciting survivors' subjective needs for, attitudes towards and experiences with behaviour changes in their everyday life to improve future interventions promoting lifestyle changes. Methods Semi-structured interviews were conducted with 21 individuals who had recently experienced an AMI. The interviews were audio-recorded and transcribed verbatim. The data were analysed using qualitative content analysis...
March 2018: Chronic Illness
https://www.readbyqxmd.com/read/29217535/in-vivo-single-cell-analysis-reveals-gata2-dynamics-in-cells-transitioning-to-hematopoietic-fate
#16
Christina Eich, Jochen Arlt, Chris S Vink, Parham Solaimani Kartalaei, Polynikis Kaimakis, Samanta A Mariani, Reinier van der Linden, Wiggert A van Cappellen, Elaine Dzierzak
Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play central roles in hematopoietic fate establishment. Although Gata2 is essential to the embryonic development and function of hematopoietic stem cells that form the adult hierarchy, little is known about the in vivo expression dynamics of Gata2 in single cells. Here, we examine Gata2 expression in single aortic cells as they establish hematopoietic fate in Gata2Venus mouse embryos...
January 2, 2018: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29199756/a-ferroelectric-liquid-crystal-confined-in-cylindrical-nanopores-reversible-smectic-layer-buckling-enhanced-light-rotation-and-extremely-fast-electro-optically-active-goldstone-excitations
#17
Mark Busch, Andriy V Kityk, Wiktor Piecek, Tommy Hofmann, Dirk Wallacher, Sylwia Całus, Przemysław Kula, Martin Steinhart, Manfred Eich, Patrick Huber
The orientational and translational order of a thermotropic ferroelectric liquid crystal (2MBOCBC) imbibed in self-organized, parallel, cylindrical pores with radii of 10, 15, or 20 nm in anodic aluminium oxide monoliths (AAO) are explored by high-resolution linear and circular optical birefringence as well as neutron diffraction texture analysis. The results are compared to experiments on the bulk system. The native oxidic pore walls do not provide a stable smectogen wall anchoring. By contrast, a polymeric wall grafting enforcing planar molecular anchoring results in a thermal-history independent formation of smectic C* helices and a reversible chevron-like layer buckling...
December 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29193659/s2k-guidelines-cutaneous-lymphomas-update-2016-part-1-classification-and-diagnosis-icd10-c82-c86
#18
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29147841/radiotherapy-for-extramedullary-leukaemic-manifestation-chloroma
#19
Michael Oertel, Khaled Elsayad, Uwe Haverkamp, Matthias Stelljes, Hans Theodor Eich
PURPOSE: Extramedullary leukaemic disease (EMD, synonym chloroma) is a rare solid manifestation of myeloid leukaemia for which the value of radiotherapy (RT) as a treatment strategy remains controversial. The aim of this study is to analyse the effectiveness of various RT doses for EMD in the modern treatment era. MATERIALS AND METHODS: Between January 2000 and June 2016, 20 patients with total of 45 lesions underwent RT for EMD at our institution. RESULTS: With a median radiation dose of 26 Gy (range 4-42 Gy), local remission could be achieved in 91% of patients (complete remission rate: 71%)...
November 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29092653/prostate-cancer-incidence-mortality-and-survival-trends-in-estonia-1995-2014
#20
Kaire Innos, Aleksei Baburin, Andres Kotsar, Ivar-Endrik Eiche, Katrin Lang
OBJECTIVE: The aim of this study was to analyze long-term trends in prostate cancer (PCa) incidence, mortality and survival in Estonia, with specific focus on age and stage. MATERIALS AND METHODS: Data on PCa incident cases and deaths in 1995-2014 were obtained from the Estonian Cancer Registry and the Causes of Death Registry, respectively. Joinpoint regression was used to estimate the annual percentage change for incidence and mortality trends. Relative survival ratios (RSRs) were calculated for four 5 year periods...
December 2017: Scandinavian Journal of Urology
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