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https://www.readbyqxmd.com/read/29228489/s2k-leitlinie-kutane-lymphome-update-2016-teil-1-klassifikation-und-diagnostik-icd10-c82-c86
#1
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29226696/to-change-or-not-to-change-that-is-the-question-a-qualitative-study-of-lifestyle-changes-following-acute-myocardial-infarction
#2
Jennifer Nicolai, Nicole Müller, Stefan Noest, Stefanie Wilke, Jobst-Hendrik Schultz, Christian A Gleißner, Wolfgang Eich, Christiane Bieber
Objective The purpose of this study was to investigate key factors related to lifestyle changes following acute myocardial infarction (AMI) by eliciting survivors' subjective needs for, attitudes towards and experiences with behaviour changes in their everyday life to improve future interventions promoting lifestyle changes. Methods Semi-structured interviews were conducted with 21 individuals who had recently experienced an AMI. The interviews were audio-recorded and transcribed verbatim. The data were analysed using qualitative content analysis...
January 1, 2017: Chronic Illness
https://www.readbyqxmd.com/read/29217535/in-vivo-single-cell-analysis-reveals-gata2-dynamics-in-cells-transitioning-to-hematopoietic-fate
#3
Christina Eich, Jochen Arlt, Chris S Vink, Parham Solaimani Kartalaei, Polynikis Kaimakis, Samanta A Mariani, Reinier van der Linden, Wiggert A van Cappellen, Elaine Dzierzak
Cell fate is established through coordinated gene expression programs in individual cells. Regulatory networks that include the Gata2 transcription factor play central roles in hematopoietic fate establishment. Although Gata2 is essential to the embryonic development and function of hematopoietic stem cells that form the adult hierarchy, little is known about the in vivo expression dynamics of Gata2 in single cells. Here, we examine Gata2 expression in single aortic cells as they establish hematopoietic fate in Gata2Venus mouse embryos...
December 7, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29199756/a-ferroelectric-liquid-crystal-confined-in-cylindrical-nanopores-reversible-smectic-layer-buckling-enhanced-light-rotation-and-extremely-fast-electro-optically-active-goldstone-excitations
#4
Mark Busch, Andriy V Kityk, Wiktor Piecek, Tommy Hofmann, Dirk Wallacher, Sylwia Całus, Przemysław Kula, Martin Steinhart, Manfred Eich, Patrick Huber
The orientational and translational order of a thermotropic ferroelectric liquid crystal (2MBOCBC) imbibed in self-organized, parallel, cylindrical pores with radii of 10, 15, or 20 nm in anodic aluminium oxide monoliths (AAO) are explored by high-resolution linear and circular optical birefringence as well as neutron diffraction texture analysis. The results are compared to experiments on the bulk system. The native oxidic pore walls do not provide a stable smectogen wall anchoring. By contrast, a polymeric wall grafting enforcing planar molecular anchoring results in a thermal-history independent formation of smectic C* helices and a reversible chevron-like layer buckling...
December 4, 2017: Nanoscale
https://www.readbyqxmd.com/read/29193659/s2k-guidelines-cutaneous-lymphomas-update-2016-part-1-classification-and-diagnosis-icd10-c82-c86
#5
Edgar Dippel, Chalid Assaf, Jürgen C Becker, Michael von Bergwelt-Baildon, Marc Beyer, Antonio Cozzio, Hans Theodor Eich, Markus Follmann, Stephan Grabbe, Uwe Hillen, Wolfram Klapper, Claus-Detlev Klemke, Cristina Lamos, Carmen Loquai, Frank Meiß, Dominik Mestel, Dorothee Nashan, Jan P Nicolay, Ilske Oschlies, Max Schlaak, Christoph Stoll, Tibor Vag, Michael Weichenthal, Marion Wobser, Rudolf Stadler
No abstract text is available yet for this article.
December 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29147841/radiotherapy-for-extramedullary-leukaemic-manifestation-chloroma
#6
Michael Oertel, Khaled Elsayad, Uwe Haverkamp, Matthias Stelljes, Hans Theodor Eich
PURPOSE: Extramedullary leukaemic disease (EMD, synonym chloroma) is a rare solid manifestation of myeloid leukaemia for which the value of radiotherapy (RT) as a treatment strategy remains controversial. The aim of this study is to analyse the effectiveness of various RT doses for EMD in the modern treatment era. MATERIALS AND METHODS: Between January 2000 and June 2016, 20 patients with total of 45 lesions underwent RT for EMD at our institution. RESULTS: With a median radiation dose of 26 Gy (range 4-42 Gy), local remission could be achieved in 91% of patients (complete remission rate: 71%)...
November 16, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29092653/prostate-cancer-incidence-mortality-and-survival-trends-in-estonia-1995-2014
#7
Kaire Innos, Aleksei Baburin, Andres Kotsar, Ivar-Endrik Eiche, Katrin Lang
OBJECTIVE: The aim of this study was to analyze long-term trends in prostate cancer (PCa) incidence, mortality and survival in Estonia, with specific focus on age and stage. MATERIALS AND METHODS: Data on PCa incident cases and deaths in 1995-2014 were obtained from the Estonian Cancer Registry and the Causes of Death Registry, respectively. Joinpoint regression was used to estimate the annual percentage change for incidence and mortality trends. Relative survival ratios (RSRs) were calculated for four 5 year periods...
November 2, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/29078793/prediction-of-clinical-response-to-drugs-in-ovarian-cancer-using-the-chemotherapy-resistance-test-ctr-test
#8
Frank Christian Kischkel, Carina Meyer, Julia Eich, Mani Nassir, Monika Mentze, Ioana Braicu, Annette Kopp-Schneider, Jalid Sehouli
BACKGROUND: In order to validate if the test result of the Chemotherapy Resistance Test (CTR-Test) is able to predict the resistances or sensitivities of tumors in ovarian cancer patients to drugs, the CTR-Test result and the corresponding clinical response of individual patients were correlated retrospectively. Results were compared to previous recorded correlations. METHODS: The CTR-Test was performed on tumor samples from 52 ovarian cancer patients for specific chemotherapeutic drugs...
October 27, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29066840/dynamic-measurement-of-near-field-radiative-heat-transfer
#9
S Lang, G Sharma, S Molesky, P U Kränzien, T Jalas, Z Jacob, A Yu Petrov, M Eich
Super-Planckian near-field radiative heat transfer allows effective heat transfer between a hot and a cold body to increase beyond the limits long known for black bodies. Until present, experimental techniques to measure the radiative heat flow relied on steady-state systems. Here, we present a dynamic measurement approach based on the transient plane source technique, which extracts thermal properties from a temperature transient caused by a step input power function. Using this versatile method, that requires only single sided contact, we measure enhanced radiative conduction up to 16 times higher than the blackbody limit on centimeter sized glass samples without any specialized sample preparation or nanofabrication...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29061295/pet-guided-treatment-in-patients-with-advanced-stage-hodgkin-s-lymphoma-hd18-final-results-of-an-open-label-international-randomised-phase-3-trial-by-the-german-hodgkin-study-group
#10
Peter Borchmann, Helen Goergen, Carsten Kobe, Andreas Lohri, Richard Greil, Dennis A Eichenauer, Josée M Zijlstra, Jana Markova, Julia Meissner, Michaela Feuring-Buske, Andreas Hüttmann, Judith Dierlamm, Martin Soekler, Hans-Joachim Beck, Wolfgang Willenbacher, Wolf-Dieter Ludwig, Thomas Pabst, Max S Topp, Felicitas Hitz, Martin Bentz, Ulrich Bernd Keller, Dagmar Kühnhardt, Helmut Ostermann, Norbert Schmitz, Bernd Hertenstein, Walter Aulitzky, Georg Maschmeyer, Tom Vieler, Hans Eich, Christian Baues, Harald Stein, Michael Fuchs, Georg Kuhnert, Volker Diehl, Markus Dietlein, Andreas Engert
BACKGROUND: The intensive polychemotherapy regimen eBEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone in escalated doses) is very active in patients with advanced-stage Hodgkin's lymphoma, albeit at the expense of severe toxicities. Individual patients might be cured with less burdensome therapy. We investigated whether metabolic response determined by PET after two cycles of standard regimen eBEACOPP (PET-2) would allow adaption of treatment intensity, increasing it for PET-2-positive patients and reducing it for PET-2-negative patients...
October 20, 2017: Lancet
https://www.readbyqxmd.com/read/29050956/lung-toxicity-after-radiation-in-childhood-results-of-the-international-project-on-prospective-analysis-of-radiotoxicity-in-childhood-and-adolescence
#11
Gerhild Stoppel, Hans-Theodor Eich, Christiane Matuschek, Rolf-Dieter Kortmann, Frank Meyer, Ulla Martinsson, Kristina Nilsson, Ingrid Kristensen, Dirk Vordermark, Normann Willich, Hans Christiansen, Raphael Koch, Diana Steinmann
BACKGROUND AND PURPOSE: This study presents the evaluation of acute and late toxicities of the lung in children and adolescents after irradiation in terms of dose-volume effects. MATERIALS AND METHODS: Irradiated children and adolescents in Germany have prospectively been documented since 2001 in the "Registry for the Evaluation of Side-Effects after Radiotherapy in Childhood and Adolescence (RiSK)"; in Sweden since 2008 in the RADTOX registry. RESULTS: Up to April 2012, 1,392 children were recruited from RiSK, and up to June 2013, 485 from the RADTOX-registry...
October 16, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29024644/m-%C3%A2-tuberculosis-induced-necrosis-of-infected-neutrophils-promotes-bacterial-growth-following-phagocytosis-by-macrophages
#12
Tobias Dallenga, Urska Repnik, Björn Corleis, Jacqueline Eich, Rudolph Reimer, Gareth W Griffiths, Ulrich E Schaible
Neutrophils represent the main infected cell population in the lungs of active tuberculosis patients. Efficient removal of infected and dying neutrophils is required to protect the surrounding tissue from bioactive neutrophil molecules and subsequent pathological sequelae. While the removal of apoptotic M. tuberculosis (Mtb)-infected cells, or efferocytosis, is considered beneficial for host defense, little is known about Mtb-infected necrotic neutrophils. We found that Mtb induces necrosis of human neutrophils in an ESX-1-dependent manner, and neutrophil-produced reactive oxygen species (ROS) drive this necrosis...
October 11, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28959121/inhaled-steroids-and-active-smoking-drive-chronic-obstructive-pulmonary-disease-symptoms-and-biomarkers-to-a-greater-degree-than-airflow-limitation
#13
Philip E Silkoff, Dave Singh, J Mark FitzGerald, Andreas Eich, Andrea Ludwig-Sengpiel, Geoffrey C Chupp, Vibeke Backer, Celeste Porsbjerg, Pierre-Olivier Girodet, Mark T Dransfield, Frederic Baribaud, Vedrana S Susulic, Matthew J Loza
RATIONALE: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of pathophysiologic phenotypes. OBJECTIVES: The purpose of the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study was to correlate clinical features and biomarkers with molecular characteristics in a well-profiled COPD cohort. METHODS: A total of 67 COPD subjects (forced expiratory volume in the first second of expiration [FEV1]: 45%-80% predicted) and 63 healthy smoking and nonsmoking controls underwent multiple assessments including patient questionnaires, lung function, and clinical biomarkers including fractional exhaled nitric oxide (FENO), induced sputum, and blood...
2017: Biomarker Insights
https://www.readbyqxmd.com/read/28953946/skills-and-compensation-strategies-in-adult-adhd-a-qualitative-study
#14
Carlos Canela, Anna Buadze, Anish Dube, Dominique Eich, Michael Liebrenz
OBJECTIVE: The primary objectives of this study were to investigate how adult patients with ADHD coped with their symptoms prior to diagnosis and treatment, what skills and compensation strategies they had developed and what their self-perceptions of these strategies were. METHODS: We used a qualitative approach to analyze interviews with 32 outpatients of a specialty care unit at a university hospital. RESULTS: Patients reported frequent use of diverse compensatory strategies with varying degrees of effectiveness...
2017: PloS One
https://www.readbyqxmd.com/read/28911068/early-stage-mantle-cell-lymphoma-a-retrospective-analysis-from-the-international-lymphoma-radiation-oncology-group-ilrog
#15
B S Dabaja, A D Zelenetz, A K Ng, R W Tsang, S Qi, P K Allen, D Hodgson, U Ricardi, R T Hoppe, R Advani, P M Mauch, L S Constine, L Specht, Y Li, S A Terezakis, A Wirth, G Reinartz, H T Eich, B M P Aleman, P Barr, J Yahalom
Background: Mantle cell lymphoma (MCL) rarely presents as early-stage disease, but clinical observations suggest that patients who present with early-stage disease may have better outcomes than those with advanced-stage disease. Patients and methods: In this 13-institution study, we examined outcomes among 179 patients with early-stage (stage I or II) MCL in an attempt to identify prognostic factors that influence treatment selection and outcome. Variables examined included clinical characteristics, treatment modality, response to therapy, sites of failure, and survival...
September 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28887665/impact-of-radiation-technique-radiation-fraction-dose-and-total-cisplatin-dose-on-hearing-retrospective-analysis-of-29%C3%A2-medulloblastoma-patients
#16
Sergiu Scobioala, Ross Parfitt, Peter Matulat, Christopher Kittel, Fatemeh Ebrahimi, Heidi Wolters, Antoinette Am Zehnhoff-Dinnesen, Hans Theodor Eich
PURPOSE: To analyze the incidence and degree of sensorineural hearing loss (SNHL) resulting from different radiation techniques, fractionation dose, mean cochlear radiation dose (Dmean), and total cisplatin dose. MATERIAL AND METHODS: In all, 29 children with medulloblastoma (58 ears) with subclinical pretreatment hearing thresholds participated. Radiotherapy (RT) and cisplatin had been applied sequentially according to the HIT MED Guidance. Audiological outcomes up to the latest follow-up (median 2...
November 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28884194/-erratum-to-definition-classification-clinical-diagnosis-and-prognosis-of-fibromyalgia-syndrome-updated-guidelines-2017-and-overview-of-systematic-review-articles
#17
W Eich, K-J Bär, M Bernateck, M Burgmer, C Dexl, F Petzke, C Sommer, A Winkelmann, W Häuser
No abstract text is available yet for this article.
September 7, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28790889/the-calcineurin-binding-activity-dependent-splice-variant-dynamin1xb-is-highly-enriched-in-synapses-in-various-regions-of-the-central-nervous-system
#18
Marie-Lisa Eich, Ekta Dembla, Silke Wahl, Mayur Dembla, Karin Schwarz, Frank Schmitz
In the present study, we generated and characterized a splice site-specific monoclonal antibody that selectively detects the calcineurin-binding dynamin1 splice variant dynamin1xb. Calcineurin is a Ca(2+)-regulated phosphatase that enhances dynamin1 activity and is an important Ca(2+)-sensing mediator of homeostatic synaptic plasticity in neurons. Using this dynamin1xb-specific antibody, we found dynamin1xb highly enriched in synapses of all analyzed brain regions. In photoreceptor ribbon synapses, dynamin1xb was enriched in close vicinity to the synaptic ribbon in a manner indicative of a peri-active zone immunolabeling...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28767349/igg-endopeptidase-in-highly-sensitized-patients-undergoing-transplantation
#19
MULTICENTER STUDY
Stanley C Jordan, Tomas Lorant, Jua Choi, Christian Kjellman, Lena Winstedt, Mats Bengtsson, Xiaohai Zhang, Torsten Eich, Mieko Toyoda, Britt-Marie Eriksson, Shili Ge, Alice Peng, Sofia Järnum, Kathryn J Wood, Torbjorn Lundgren, Lars Wennberg, Lars Bäckman, Erik Larsson, Rafael Villicana, Joe Kahwaji, Sabrina Louie, Alexis Kang, Mark Haas, Cynthia Nast, Ashley Vo, Gunnar Tufveson
BACKGROUND: Donor-specific antibodies create an immunologic barrier to transplantation. Current therapies to modify donor-specific antibodies are limited and ineffective in the most highly HLA-sensitized patients. The IgG-degrading enzyme derived from Streptococcus pyogenes (IdeS), an endopeptidase, cleaves human IgG into F(ab')2 and Fc fragments inhibiting complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity, which suggests that IdeS might be useful for desensitization...
August 3, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28753067/a-randomized-placebo-controlled-phase-2-trial-of-cnto-6785-in-chronic-obstructive-pulmonary-disease
#20
Andreas Eich, Veronika Urban, Marek Jutel, Jiri Vlcek, Jae Jeong Shim, Vasiliy I Trofimov, Chong-Kin Liam, Ping-Hung Kuo, Yanyan Hou, Jun Xiao, Patrick Branigan, Christopher D O'Brien
Interleukin (IL)-17A may be an underlying factor in the pathophysiology of chronic obstructive pulmonary disease (COPD). Anti-IL-17 monoclonal antibodies have been used successfully in treating several immune-mediated inflammatory diseases. This phase 2, randomized, placebo-controlled, double-blind, parallel-group, proof-of-concept study is the first clinical study evaluating the efficacy and safety of the anti-IL-17A monoclonal antibody CNTO 6785 in patients with symptomatic moderate-to-severe COPD. Patients were treated with CNTO 6785 (n = 93) or placebo (n = 94) intravenously at Weeks 0, 2, and 4 (induction), then Weeks 8 and 12, and followed till Week 24...
July 28, 2017: COPD
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