Matt S Zinter, Christopher C Dvorak, Madeline Y Mayday, Gustavo Reyes, Miriam R Simon, Emma M Pearce, Hanna Kim, Peter J Shaw, Courtney M Rowan, Jeffrey J Auletta, Paul L Martin, Kamar Godder, Christine N Duncan, Nahal R Lalefar, Erin M Kreml, Janet R Hume, Hisham Abdel-Azim, Caitlin Hurley, Geoffrey D E Cuvelier, Amy K Keating, Muna Qayed, James S Killinger, Julie C Fitzgerald, Rabi Hanna, Kris M Mahadeo, Troy C Quigg, Prakash Satwani, Paul Castillo, Shira J Gertz, Theodore B Moore, Benjamin Hanisch, Aly Abdel-Mageed, Rachel Phelan, Dereck B Davis, Michelle P Hudspeth, Greg A Yanik, Michael A Pulsipher, Imran Sulaiman, Leopoldo N Segal, Birgitta A Versluys, Caroline A Lindemans, Jaap J Boelens, Joseph L DeRisi
Lung injury is a major determinant of survival after pediatric hematopoietic cell transplantation (HCT). A deeper understanding of the relationship between pulmonary microbes, immunity, and the lung epithelium is needed to improve outcomes. In this multicenter study, we collected 278 bronchoalveolar lavage (BAL) samples from 229 patients treated at 32 children's hospitals between 2014-2022. Using paired metatranscriptomes and human gene expression data, we identified 4 patient clusters with varying BAL composition...
November 29, 2023: medRxiv