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https://www.readbyqxmd.com/read/28102815/assessment-of-the-characteristics-and-quality-of-life-of-patients-with-uremic-peripheral-neuropathy%C3%A2
#1
Xiu-Zhi Yu, Shi Lu, Wei Gou, Wei Wang, Shui-Hong Zou, Yin-Xia Han, Wei-Wei Wang, Jin-Yuan Zhang
OBJECTIVES: This study seeks to examine the characteristics and health-related quality of life (HRQL) of patients with uremic peripheral neuropathy. METHODS: Uremic patients undergoing maintenance hemodialysis (MHD) at our hospital were enrolled in this study. Data collection began in January 2011 and ended in June 2011. The patients were divided into two groups, the lesion group (110 cases) and the non-lesion group (168 cases), based on the presence or absence of peripheral neuropathy...
January 19, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28102813/intramedullary-amputation-neuroma-a-case-report-and-review-of-the-literature
#2
Laura Stone McGuire, Mandana Behbahini, Sumit Das, David Loeffler, Peter Burger, Herbert Engelhard, Tibor Valyi-Nagy, Ankit Mehta
BACKGROUND AND IMPORTANCE: Amputation neuromas consist of non-neoplastic collections of myelinated axons and Schwann cells and typically arise in injured peripheral nerves. Rarely, however, neuromas occur within the spinal cord. Intramedullary amputation neuromas have been described both with and without a history of trauma within the peripheral nervous system. We report a rare case of an isolated intramedullary spinal cord amputation neuroma. CLINICAL PRESENTATION: This 43-year-old man presented with progressive and severe gait deterioration for ~ 7 years...
January 19, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28102455/soluble-form-of-lr11-is-highly-increased-in-the-vitreous-fluids-of-patients-with-idiopathic-epiretinal-membrane
#3
Ryuya Hashimoto, Meizi Jiang, Tomoaki Shiba, Nobuyuki Hiruta, Mao Takahashi, Morihiro Higashi, Yuichi Hori, Hideaki Bujo, Takatoshi Maeno
PURPOSE: LR11 (also called SorLA or SORL1) is a migration regulator of adherent cells with the immature proliferative phenotype. The present study investigated the clinical and pathological involvement of the soluble form of LR11 (sLR11) in the idiopathic epiretinal membrane (iERM). METHODS: The subjects were 51 patients with iERM (24 cellophane macular reflex (CMR) and 27 preretinal macular fibrosis (PMF)) and 45 patients with macular holes as age and sex-matched controls...
January 19, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28102095/significance-of-the-ionized-calcium-measurement-to-assess-calcium-status-in-osteopenic-osteoporosis-postmenopausal-outpatients
#4
Letizia Guiducci, Silvia Maffei, Laura Sabatino, Luc Zyw, Debora Battaglia, Alessandro Vannucci, Pietro Di Cecco, Cristina Vassalle
INTRODUCTION: Evaluation of calcium status is important in the osteoporotic risk assessment. Although guidelines indicate total calcium (tCa) as first-line measurement, directly measured ionized calcium (m-iCa), considered as the gold standard, is more and more often required. Aim of this study is to evaluate the agreement between m-iCa, tCa and iCa calculated from a formula based on total calcium and albumin (c-iCa) in osteopenic/osteoporotic postmenopausal outpatients. METHODS: A total of 140 postmenopausal outpatients, 41 osteopenic (OPN) and 99 osteoporotic (OP) were enrolled...
January 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28100202/a-novel-reflex-cough-testing-device
#5
Kazunori Fujiwara, Katsuyuki Kawamoto, Yoko Shimizu, Takahiro Fukuhara, Satoshi Koyama, Hideyuki Kataoka, Hiroya Kitano, Hiromi Takeuchi
BACKGROUND: The reflex cough test is useful for detecting silent aspiration, a risk factor for aspiration pneumonia. However, assessing the risk of aspiration pneumonia requires measuring not only the cough reflex but also cough strength. Currently, no reflex cough testing device is available that can directly measure reflex cough strength. We therefore developed a new testing device that can easily and simultaneously measure cough strength and the time until the cough reflex, and verified whether screening with this new instrument is feasible for evaluating the risk of aspiration pneumonia...
January 18, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28099586/serotoninergic-modulation-of-basal-cardiovascular-responses-and-responses-induced-by-isotonic-extracellular-volume-expansion-in-rats
#6
Isadora Ferraz Semionatto, Adrieli Oliveira Raminelli, Angelica Cristina Alves, Caroline Santos Capitelli, Rosangela Soares Chriguer
Background: Isotonic blood volume expansion (BVE) induced alterations of sympathetic and parasympathetic activity in the heart and blood vessels, which can be modulated by serotonergic pathways. Objective: To evaluate the effect of saline or serotonergic agonist (DOI) administration in the hypothalamic paraventricular nucleus (PVN) on cardiovascular responses after BVE. Methods: We recorded pulsatile blood pressure through the femoral artery to obtain the mean arterial pressure (MAP), systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR) and the sympathetic-vagal ratio (LF/HF) of Wistar rats before and after they received bilateral microinjections of saline or DOI into the PVN, followed by BVE...
January 16, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28097654/melanopsin-expressing-ganglion-cells-in-human-retina-morphology-distribution-and-synaptic-connections
#7
Subha Nasir-Ahmad, Sammy C S Lee, Paul R Martin, Ulrike Grünert
Melanopsin-expressing retinal ganglion cells are intrinsically photosensitive cells that are involved in non-image forming visual processes such as the pupillary light reflex and circadian entrainment but also contribute to visual perception. Here we used immunohistochemistry to study the morphology, density, distribution and synaptic connectivity of melanopsin-expressing ganglion cells in four post mortem human donor retinas. Two types of melanopsin-expressing ganglion cells were distinguished based on their dendritic stratification near either the outer or the inner border of the inner plexiform layer...
January 18, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28097516/are-event-related-potentials-to-dynamic-facial-expressions-of-emotion-related-to-individual-differences-in-the-accuracy-of-processing-facial-expressions-and-identity
#8
Guillermo Recio, Oliver Wilhelm, Werner Sommer, Andrea Hildebrandt
Despite a wealth of knowledge about the neural mechanisms behind emotional facial expression processing, little is known about how they relate to individual differences in social cognition abilities. We studied individual differences in the event-related potentials (ERPs) elicited by dynamic facial expressions. First, we assessed the latent structure of the ERPs, reflecting structural face processing in the N170, and the allocation of processing resources and reflexive attention to emotionally salient stimuli, in the early posterior negativity (EPN) and the late positive complex (LPC)...
January 17, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28095174/medical-oncologists-experiences-in-using-genomic-testing-for-lung-and-colorectal-cancer-care
#9
Stacy W Gray, Benjamin Kim, Lynette Sholl, Angel Cronin, Aparna R Parikh, Carrie N Klabunde, Katherine L Kahn, David A Haggstrom, Nancy L Keating
PURPOSE: Genomic testing improves outcomes for many at-risk individuals and patients with cancer; however, little is known about how genomic testing for non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC) is used in clinical practice. PATIENTS AND METHODS: In 2012 to 2013, we surveyed medical oncologists who care for patients in diverse practice and health care settings across the United States about their use of guideline- and non-guideline-endorsed genetic tests...
January 17, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28094764/neuromorphic-meets-neuromechanics-part-ii-the-role-of-fusimotor-drive
#10
Kian Jalaleddini, Chuanxin Niu, Suraj Chakravarthi Raja, Won Joon Sohn, Gerald Loeb, Terence Sanger, Francisco Valero-Cuevas
OBJECTIVE: We studied the fundamentals of muscle afferentation by building a neuro-mechano-morphic system actuating a cadaveric finger. This system is a faithful implementation of the stretch reflex circuitry. It allowed the systematic exploration of the effects of different fusimotor drives to the muscle spindle on the closed-loop stretch reflex response. APPROACH: As in Part I of this work, sensory neurons conveyed proprioceptive information from muscle spindles (with static and dynamic fusimotor drive) to populations of ��-motor neurons (with recruitment and rate coding properties)...
January 17, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28093778/brainstem-reflex-excitability-changes-in-patients-with-als
#11
Bülent Cengiz, Merve Bahar Ercan, Mustafa İskender, Hidayet Reha Kuruoğlu
Objective We explored brainstem reflex excitability changes, blink reflex recovery cycles (BRRC), and masseter inhibitory reflexes (MIR) in patients with ALS. Methods Fourteen ALS patients and 14 healthy control subjects were recruited. The BRRC was examined at interstimulus intervals (ISI) of 100, 200, 300, 400, 500, and 600 ms. The latencies and durations of silent period 1 (SP1) and silent period 2 (SP2) of the MIR were measured. Results Decreased R2 area suppression was prominent in the ALS group at ISIs of 200, 300, and 400 ms (P<0...
January 17, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28093646/mechanisms-of-inhibitory-action-of-trk-130-naltalimide-a-%C3%AE-opioid-receptor-partial-agonist-on-the-micturition-reflex
#12
Morihiro Fujimura, Naoki Izumimoto, Sayoko Kanie, Ryosuke Kobayashi, Satoru Yoshikawa, Shinobu Momen, Mikito Hirakata, Toshikazu Komagata, Satoshi Okanishi, Masashi Iwata, Tadatoshi Hashimoto, Takayuki Doi, Naoki Yoshimura, Koji Kawai
PURPOSE: To clarify the mechanism of inhibitory action of TRK-130 (Naltalimide), a unique µ-opioid receptor partial agonist, on the micturition reflex. METHODS: The effect of TRK-130 on isovolumetric rhythmic bladder contractions (RBCs) was examined in guinea pigs, the effect of which was clarified by co-treatment with naloxone or in spinal cord transection. The effect of TRK-130 on urodynamic parameters was also observed in guinea pigs. In addition, the effect of TRK-130 on bladder contraction induced by peripheral stimulation of the pelvic nerve was investigated in rats...
January 16, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28093315/using-acoustic-reflex-threshold-auditory-brainstem-response-and-loudness-judgments-to-investigate-changes-in-neural-gain-following-acute-unilateral-deprivation-in-normal-hearing-adults
#13
Hannah Brotherton, Christopher J Plack, Roland Schaette, Kevin J Munro
Unilateral auditory deprivation induces a reduction in the acoustic reflex threshold (ART) and an increase in loudness. These findings have been interpreted as a compensatory change in neural gain, governed by changes in excitatory and inhibitory neural inputs. There is also evidence to suggest that changes in neural gain can be measured using the auditory brainstem response (ABR). The present study extended Munro et al. (2014) [J. Acoust. Soc. Am. 135, 315-322] by investigating changes after 4 days of unilateral earplug use to: (i) ART, (ii) auditory brainstem response (ABR) and (iii) loudness...
January 13, 2017: Hearing Research
https://www.readbyqxmd.com/read/28093306/establishing-between-session-reliability-of-tms-conditioned-soleus-h-reflexes
#14
W A Gray, M J Sabatier, T M Kesar, M R Borich
Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can be used to evaluate descending corticomotor influences on spinal reflex excitability through modulation of the Hoffman reflex (H-reflex). The purpose of this study was to characterize between-session reliability of cortical, spinal, and cortical-conditioned spinal excitability measures collected from the soleus muscle. Thirteen able-bodied young adult participants were tested over four sessions. Intraclass correlation coefficients were calculated to quantify between-session reliability of active motor threshold (AMT), unconditioned H-reflexes (expressed as a percentage of Mmax), and conditioned H-reflexes using short-latency facilitation (SLF) and long-latency facilitation (LLF)...
January 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28093112/clinical-indicators-of-blood-gas-disturbances-elevated-l-lactate-concentration-and-other-abnormal-blood-parameters-in-newborn-beef-calves
#15
E R Homerosky, N A Caulkett, E Timsit, E A Pajor, J P Kastelic, M C Windeyer
Blood gas disturbances, commonly resulting from dystocia, are associated with failed transfer of passive immunity, morbidity and mortality in newborn calves. Modified APGAR scores intended to identify compromised calves are not widely adopted due to lack of practicality and inconsistent associations with blood parameters. The objective of this study was to determine clinical indicators of acidemia in newborn beef calves. Blood parameters at 10 min and 24 h after birth were compared to at-birth clinical examination parameters and calving characteristics in 77 commercial beef calves...
January 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28091857/lack-of-heart-rate-variability-during-sleep-related-apnea-in-patients-with-temporal-lobe-epilepsy-tle-an-indirect-marker-of-sudep
#16
C S Nayak, S Sinha, M Nagappa, K Thennarasu, A B Taly
PURPOSE: Apneas occurring during sleep may precipitate autonomic instability in epilepsy patients making them susceptible to sudden death (SUDEP). Literature on heart rate variability (HRV) during apnea among patients with temporal lobe epilepsy (TLE) is sparse. The aim of this study was to characterize the HRV during the peri-apneic period in patients with TLE and compare with HRV of matched healthy individuals during the overnight polysomnographic (PSG) recording. Further, the role of carbamazepine (CBZ) in modulating peri-apneic HRV in the above cohort was also assessed...
January 14, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28091707/gastric-distension-causes-changes-in-heart-rate-and-arterial-blood-pressure-by-affecting-the-crosstalk-between-vagal-and-splanchnic-systems-in-anesthetised-rats
#17
Maurizio Sabbatini, Elena Grossini, Claudio Molinari, David A S G Mary, Giovanni Vacca, Mario Cannas
Various hindbrain nuclei have been demonstrated to be involved in the control of the cardiovascular reflexes elicited by both non-noxious and noxious gastric distension, through parasympathetic and sympathetic activation. The different role played by the branches of autonomic nervous system in exerting these effects and their crosstalk in relation to low-/high-pressure distension rate has not been examined yet. Therefore, in the present work, monolateral and bilateral vagotomy and splanchnicotomy were performed in anesthetised rats to analyse the involvement of hindbrain nuclei in haemodynamic changes caused by gastric distension at high (80 mmHg) and low (15 mmHg) pressure...
January 13, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28089558/startle-suppression-after-mild-traumatic-brain-injury-is-associated-with-an-increase-in-pro-inflammatory-cytokines-reactive-gliosis-and-neuronal-loss-in-the-caudal-pontine-reticular-nucleus
#18
Swamini P Sinha, Pelin Avcu, Kevin M Spiegler, Sreeya Komaravolu, Kevin Kim, Tara Cominski, Richard J Servatius, Kevin C H Pang
Mild traumatic brain injury (mTBI) can produce somatic symptoms such as headache, dizziness, fatigue, sleep disturbances and sensorimotor dysfunction. Sensorimotor function can be measured by tests such as the acoustic startle reflex (ASR), an evolutionarily conserved defensive response to a brief yet sharp acoustic stimulus. mTBI produces a long-lasting suppression of ASR in rodents and humans; however, the mechanism of this suppression is unknown. The present study examined whether inflammatory processes in the brainstem (particularly the caudal pontine reticular nucleus, PnC) could account for the suppression of ASR after mTBI, because the PnC is an essential nucleus of the ASR circuit...
January 9, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28089159/immunohistochemistry-for-egfr-mutation-detection-in-non-small-cell-lung-cancer
#19
Nina Turnšek Hitij, Izidor Kern, Aleksander Sadikov, Lea Knez, Karmen Stanič, Matjaž Zwitter, Tanja Cufer
INTRODUCTION: The sensitivity and specificity of immunohistochemistry (IHC) was compared with the standard polymerase chain reaction (PCR)-based method for detecting common activating epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer (NSCLC). Additionally, we evaluated predictive value of IHC EGFR mutation-positive status for EGFR tyrosine kinase inhibitor (TKI) treatment outcome and estimated cost-effectiveness for the upfront IHC testing. METHODS: The trial included 79 consecutive EGFR mutation-positive and 29 EGFR mutation-negative NSCLC cases diagnosed with reflex PCR-based testing...
December 2, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28088254/role-of-dietary-and-lifestyle-modifications-in-reflex-epilepsy-based-on-traditional-persian-medicine
#20
Majid Nimrouzi, Mehdi Pasalar
No abstract text is available yet for this article.
January 2017: Journal of Integrative Medicine
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