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https://www.readbyqxmd.com/read/28346718/modulation-of-the-rat-micturition-reflex-with-transcutaneous-ultrasound
#1
Daniel P Casella, Anne G Dudley, Douglass B Clayton, John C Pope, Stacy T Tanaka, John Thomas, Mark C Adams, John W Brock, Charles F Caskey
INTRODUCTION: Low intensity focused ultrasound has recently been identified as a novel method of stimulating targeted neurons. We hypothesized that ultrasound stimulation of the posterior tibial nerve would inhibit bladder contractions in an established rat model of rhythmic bladder contractions. METHODS: Cyclical detrusor contractions were initiated by placing a transurethral catheter in female rats and infusing saline into the bladder. Transcutaneous ultrasound pulses were then delivered to the lower extremity of a rat (overlying the posterior tibial nerve) using a single element spherically focused 250 kHz transducer...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28346013/the-physiology-of-blood-loss-and-shock-new-insights-from-a-human-laboratory-model-of-hemorrhage
#2
Alicia M Schiller, Jeffrey T Howard, Victor A Convertino
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes. Therefore, it is important to understand the time course and involvement of the various physiological mechanisms that are active during volume loss and that have the ability to stave off hemodynamic collapse. This review provides new insights about the physiology that underlies blood loss and shock in humans through the development of a simulated model of hemorrhage using lower body negative pressure. In this review, we present controlled experimental results through utilization of the lower body negative pressure human hemorrhage model that provide novel insights on the integration of physiological mechanisms critical to the compensation for volume loss...
April 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28344702/health-professions-education-and-globalization-a-call-for-reflexivity
#3
EDITORIAL
Brian Hodges
No abstract text is available yet for this article.
December 2016: Canadian Medical Education Journal
https://www.readbyqxmd.com/read/28344549/functional-brain-activation-in-response-to-a-clinical-vestibular-test-correlates-with-balance
#4
Fatemeh Noohi, Catherine Kinnaird, Yiri DeDios, Igor S Kofman, Scott Wood, Jacob Bloomberg, Ajitkumar Mulavara, Rachael Seidler
The current study characterizes brain fMRI activation in response to two modes of vestibular stimulation: Skull tap and auditory tone burst. The auditory tone burst has been used in previous studies to elicit either a vestibulo-spinal reflex [saccular-mediated colic Vestibular Evoked Myogenic Potentials (cVEMP)], or an ocular muscle response [utricle-mediated ocular VEMP (oVEMP)]. Research suggests that the skull tap elicits both saccular and utricle-mediated VEMPs, while being faster and less irritating for subjects than the high decibel tones required to elicit VEMPs...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28343938/testosterone-influences-volitional-but-not-reflexive-orienting-of-attention-in-human-males
#5
Steve Hansen, Jim McAuliffe, Bernard Goldfarb, Justin M Carré
The impact of testosterone (T) on the exogenous (Experiment 1) and endogenous (Experiment 2) orienting of visual attention in males was examined. Sixteen male participants completed both an exogenous and an endogenous cuing task on two separate days. About 2-3h prior to testing, either a placebo or a dose of T was administered. The inhibition of return (IOR) phenomenon was observed during the exogenous cuing task, but IOR was not influenced by T. During the endogenous task, participants demonstrated the expected cuing effects on both days...
March 23, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28343847/global-developmental-delay-and-intellectual-disability-associated-with-a-de-novo-top2b-mutation
#6
Ching-Wan Lam, Wai-Lan Yeung, Chun-Yiu Law
BACKGROUND: More than 100 genes had been identified for autism spectrum disorder (ASD). With the advancement of whole-exome/genome sequencing (WES/WGS), disease-causing gene in ASD can be identified in a holistic and unbiased approach. The identification of new ASD genes can further explore the molecular basis of ASD. METHODS: We report a 15yo girl with developmental delay, intellectual disability, hypotonia, microcephaly and autistic feature. She first presented at 6months old with primitive response to noise...
March 23, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28343653/swallow-induced-syncope-and-carotid-sinus-hypersensitivity-coincident-or-associated-conditions
#7
Eed Abu Zaid, Moti Haim, Hilmi Alnsasra, Yuval Konstantino
Swallow induced syncope is a rare clinical condition which is thought to result from an abnormal vagal reflex leading to bradycardia and cerebral hypoperfusion. It mostly occurs in patients with organic or functional disorders of the esophagus, and often requires permanent pacemaker implantation, along with treatment of the underlying esophageal pathology. In the following case, we report of a 71-year-old male with achalasia post per oral endoscopic myectomy, who presented with syncope and documented AV-block while eating solid food...
March 14, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28342959/early-lance-adams-syndrome-after-cardiac-arrest-prevalence-time-to-return-to-awareness-and-outcome-in-a-large-cohort
#8
Irene Aicua Rapun, Jan Novy, Daria Solari, Mauro Oddo, Andrea O Rossetti
INTRODUCTION: Early myoclonus after Cardiac Arrest (CA) is traditionally viewed as a poor prognostic sign (status myoclonus). However, some patients may present early Lance-Adams syndrome (LAS): under appropriate treatment, they can reach a satisfactory functional outcome. Our aim was to describe their profile, focusing on pharmacologic management in the ICU, time to return of awareness, and long-term prognosis. METHODS: Adults with early LAS (defined as generalized myoclonus within 96hours, with epileptiform EEG within 48hours after CA) were retrospectively identified in our CA registry between 2006 and 2016...
March 22, 2017: Resuscitation
https://www.readbyqxmd.com/read/28342562/tackling-racism-as-a-wicked-public-health-problem-enabling-allies-in-anti-racism-praxis
#9
Heather Came, Derek Griffith
Racism is a "wicked" public health problem that fuels systemic health inequities between population groups in New Zealand, the United States and elsewhere. While literature has examined racism and its effects on health, the work describing how to intervene to address racism in public health is less developed. While the notion of raising awareness of racism through socio-political education is not new, given the way racism has morphed into new narratives in health institutional settings, it has become critical to support allies to make informing efforts to address racism as a fundamental cause of health inequities...
March 16, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28342466/-challenges-benefits-and-limits-of-high-fidelity-simulation-in-emergency-medicine
#10
Christophe Cullati, Thierry Secheresse
Combining in-situ behaviour and reflexive practice during the debriefing, simulation is a powerful pedagogical tool. It enables a team to co-construct shared knowledge in a context of experiential learning and in a safe and reassuring environment.
March 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28342367/optimization-of-surface-electrodes-location-for-h-reflex-recordings-in-soleus-muscle
#11
Alberto Botter, Taian M Vieira
The Hoffmann reflex (H reflex) is extensively used to investigate the spinal motor neuron excitability in healthy and pathological subjects. Obtaining a representative and robust amplitude estimation of the H reflex is of marked relevance in clinical as well as in research applications. As for the motor responses, this issue is strictly related to the electrode positioning, especially for large, pinnate muscles such as the triceps surae. In this study we investigated the effect of electrode position on soleus H-reflex amplitude...
March 16, 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28341965/reliability-of-a-laryngo-pharyngeal-esthesiometer-and-a-method-for-measuring-laryngo-pharyngeal-mechano-sensitivity-in-a-prospectively-recruited-cohort-of-patients
#12
Luis F Giraldo-Cadavid, Javier Burguete, Felipe Rueda, Ana M Galvis, Natalia Castaneda, Luis M Agudelo-Otalora, William D Moscoso, Nelson Paez, Secundino Fernandez
There are not reliable methods for measuring laryngo-pharyngeal mechano-sensitivity (LPMS). We aimed to determine the reliability of a new method for measuring LPMS using a new laryngo-pharyngeal esthesiometer (LPEER) in a prospective cohort of dysphagic stroke and non-dysphagic patients. The patients underwent clinical and endoscopic evaluations of swallowing (FESSST). The LPMS assessments consisted of measurements by an expert and a novel rater of the laryngeal-adductor reflex threshold (LART), cough reflex threshold (CRT) and gag reflex threshold (GRT) using the LPEER...
March 24, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28341843/multistructure-index-characterization-of-heart-rate-and-systolic-blood-pressure-reveals-precursory-signs-of-syncope
#13
Danuta Makowiec, Beata Graff, Zbigniew R Struzik
Recurrent syncope - abrupt loss of consciousness - can have a serious impact on patients' quality of life, comparable with chronic illnesses. Vasovagal syncope (VVS) is a specific reflex syncope, in which an inappropriate reaction of the autonomic nervous system (ANS) plays a key role in the pathophysiology. In syncope diagnosis, an ideal diagnostic method should positively identify vasovagal sensitive patients, without the need to perform a specialised head-up tilt table (HUTT) test. We apply a novel methodology of multistructure index (MI) statistics for seamlessly evaluating the size spectrum of the asymmetry properties of magnitudes of neural reflexes responsible for maintaining the homeostatic dynamics of autonomic control...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28341233/neonatal-reflexes-and-behavior-in-hypertensive-rats-of-isiah-strain
#14
Diana S Ragaeva, Maria A Tikhonova, Olga M Petrova, Tatjana N Igonina, Irina N Rozkova, Eugeny Yu Brusentsev, Tamara G Amstislavskaya, Sergey Ya Amstislavsky
Hypertension is one of the most common diseases in humans, and there is a special concern on the consequences of maternal hypertensive conditions for the health of newborns. An inherited stress-induced arterial hypertension (ISIAH) rat strain has been selected but only a few studies have addressed behavior in these rats. Body weight, neurodevelopmental reflexes, and neuronal density in the hippocampus were compared in ISIAH and normotensive WAG rats during their suckling period. Systolic and diastolic blood pressure (SBP, DBP), adult rat performance in the open field (OF), elevated plus maze (EPM), and novel object recognition (NOR) tests were evaluated at the age of 12-14weeks old...
March 21, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28341090/transient-isolated-lower-bulbar-palsy-with-elevated-serum-anti-gm1-and-anti-gd1b-antibodies-during-aripiprazole-treatment
#15
Tae Hwan Han, Do Yeon Kim, Dong Woo Park, Jin-Hwa Moon
BACKGROUND: Transient bulbar palsy without involvement of the facial or extraocular muscles is a rare presentation. It is considered a form of cranial polyneuropathy, a variant of Guillain-Barré syndrome that is related to the autoimmune mechanisms induced by preceding infections or vaccinations. However, drug-induced cranial polyneuropathy has not previously been reported. We describe a boy with isolated bulbar palsy and positive serum antiganglioside antibodies during aripiprazole treatment...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/28340835/can-patients-who-develop-cerebral-death-in-fulminant-liver-failure-despite-liver-transplantation-be-previously-forseen
#16
K B Sarici, S Karakas, E Otan, V Ince, C Koc, S Koc, H Bayraktar, C Aydin, C Kayaalp, S Gungor, Y Kablan, S Yilmaz
BACKGROUND: The outcome of medical treatment is worse in fulminant liver failure (FLF) developing on acute or chronic ground. Recently, liver transplantations with the use of living and cadaveric donors have been performed in these diseases and good results obtained. In this study, we aimed to present the factors affecting the recovery of cerebral functions after liver transplantation in hepatic encephalopathy (HE) developing in FLF, to identify irreversible patient groups and to prevent unnecessary liver transplantation...
April 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28340220/her2-neu-status-determination-in-breast-cancer-a-single-institutional-experience-using-a-dual-testing-approach-with-immunohistochemistry-and-fluorescence-in-situ-hybridization
#17
James P Solomon, Marie Dell'Aquila, Oluwole Fadare, Farnaz Hasteh
Objectives: According to current guidelines, either immunohistochemistry (IHC) or in situ hybridization (ISH) can be used to determine human epidermal growth factor receptor 2 (Her2/neu) status in breast carcinoma. While the guidelines explicitly delineate result interpretation, there is no consensus on the most appropriate testing algorithm. Methods: The Her2/neu statuses of 369 consecutive cases of invasive breast cancer (from 351 patients) were assessed in a dual-testing algorithm that uses both IHC and fluorescence ISH (FISH)...
March 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339901/urine-cultures-based-on-a-reflex-testing-algorithm-utilizing-urinalysis-results-may-result-in-missed-diagnostic-opportunities
#18
Marcus Rushing, Vincent Cracolici, Dena Shibib, Vera Tesic, Angella Charnot-Katsikas, Kathleen Beavis
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339897/reflex-lupus-anticoagulant-and-coagulation-factor-testing-has-low-utility-in-the-preoperative-surgical-hemostasis-assessment
#19
Stephen P Persaud, Ronald Jackups
No abstract text is available yet for this article.
March 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28339341/the-diffusion-of-evidence-based-practice-reviewing-the-evidence-based-practice-networks-in-the-united-states-and-german-speaking-countries
#20
Christian Ghanem, Thomas R Lawson, Sabine Pankofer, Markos Maragkos, Ingo Kollar
Evidence-based practice (EBP) has had a major influence on U.S. social work while it has rarely been adapted in German-speaking countries. This study investigates how knowledge about EBP is diffused within and across geographical contexts. Network analysis methods reveals different diffusion patterns and provide reasons for these differences. For example, the U.S. discourse is self-contained and based on a more homogeneous knowledge base, while the German discourse is more heterogeneous and focuses on a notion of reflexive professionalism...
March 24, 2017: Journal of Evidence-informed Social Work
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