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https://www.readbyqxmd.com/read/28441452/systematic-review-finds-that-study-data-not-published-in-full-text-articles-have-unclear-impact-on-meta-analyses-results-in-medical-research
#1
Christine M Schmucker, Anette Blümle, Lisa K Schell, Guido Schwarzer, Patrick Oeller, Laura Cabrera, Erik von Elm, Matthias Briel, Joerg J Meerpohl
BACKGROUND: A meta-analysis as part of a systematic review aims to provide a thorough, comprehensive and unbiased statistical summary of data from the literature. However, relevant study results could be missing from a meta-analysis because of selective publication and inadequate dissemination. If missing outcome data differ systematically from published ones, a meta-analysis will be biased with an inaccurate assessment of the intervention effect. As part of the EU-funded OPEN project (www...
2017: PloS One
https://www.readbyqxmd.com/read/28441410/creating-and-parameterizing-patient-specific-deep-brain-stimulation-pathway-activation-models-using-the-hyperdirect-pathway-as-an-example
#2
Kabilar Gunalan, Ashutosh Chaturvedi, Bryan Howell, Yuval Duchin, Scott F Lempka, Remi Patriat, Guillermo Sapiro, Noam Harel, Cameron C McIntyre
BACKGROUND: Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both academic and industrial research, as well as clinical software systems. However, the exact methodology for creating patient-specific DBS models can vary substantially and important technical details are often missing from published reports. OBJECTIVE: Provide a detailed description of the assembly workflow and parameterization of a patient-specific DBS pathway-activation model (PAM) and predict the response of the hyperdirect pathway to clinical stimulation...
2017: PloS One
https://www.readbyqxmd.com/read/28441335/systematic-review-of-cognitive-behavioural-therapy-for-social-anxiety-disorder-in-psychosis
#3
REVIEW
Maria Michail, Max Birchwood, Lynda Tait
BACKGROUND: Social anxiety is highly prevalent among people with psychosis and linked with significant social disability and poorer prognosis. Although cognitive-behavioural therapy (CBT) has shown to be effective for the treatment of social anxiety in non-psychotic populations, there is a lack of evidence on the clinical effectiveness of CBT for the treatment of social anxiety when this is co-morbid in psychosis. METHODS: A systematic review to summarise and critically appraise the literature on the effectiveness of CBT interventions for the treatment of social anxiety in psychosis...
April 25, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28441333/how-are-service-dogs-for-adults-with-post-traumatic-stress-disorder-integrated-with-rehabilitation-in-denmark-a-case-study
#4
Chalotte Glintborg, Tia G B Hansen
A severe mental illness like Post Traumatic Stress Disorder (PTSD) is known to have psychosocial consequences that can lead to a decreased quality of life. Research in Animal-Assisted Therapy (AAT) has revealed that the presence of a dog can have a positive effect on health, e.g., increase quality of life and lessen depression and anxiety. However, canine companionship is not a catch-all solution. Previous research has revealed methodological limitations that prohibit any clear conclusions, as well as a sparsity of critical reflection in anecdotal reports and case studies, which means that more research is needed to contextualize the findings...
April 25, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28441253/the-impact-of-an-international-network-gynecologic-cancer-intergroup-for-clinical-research-on-global-capacity-for-gynecologic-cancer-clinical-trials
#5
Gavin C E Stuart, Henry C Kitchener, Jan B Vermorken, Michael J Quinn, William Small, Eric Pujade-Lauraine, Hansen Chou, Michelle Wong, Monica Bacon
OBJECTIVE: The objective of this study was to demonstrate that the construction of the Gynecologic Cancer InterGroup (GCIG) has increased collaboration and accrual to high-quality phase 3 trials at a global level. MATERIALS AND METHODS: The GCIG is a collaboration of 29 international cooperative clinical trial groups committed to conduct of high-quality phase 3 trials among women with gynecologic cancer. A complete bibliography of the reported phase 3 trials has been developed and is available on the GCIG Web site http://www...
May 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28440974/risk-estimation-for-lung-cancer-in-libya-analysis-based-on-standardized-morbidity-ratio-poisson-gamma-model-bym-model-and-mixture-model
#6
Maryam Ahmed Alhdiri, Nor Azah Samat, Zulkifley Mohamed
Cancer is the most rapidly spreading disease in the world, especially in developing countries, including Libya. Cancer represents a significant burden on patients, families, and their societies. This disease can be controlled if detected early. Therefore, disease mapping has recently become an important method in the fields of public health research and disease epidemiology. The correct choice of statistical model is a very important step to producing a good map of a disease. Libya was selected to perform this work and to examine its geographical variation in the incidence of lung cancer...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28439865/identification-of-protein-dna-interactions-using-enhanced-yeast-one-hybrid-assays-and-a-semiautomated-approach
#7
Allison Gaudinier, Michelle Tang, Anne-Maarit Bågman, Siobhan M Brady
Yeast one-hybrid assays are an in vitro gene-centered approach to map transcription factor-DNA interactions. Here we describe this method and adaptations to screen for interactions between plant transcriptional regulators and their targets. Of particular note, the use of yeast one-hybrid assays fills in an important gap in available methodologies. When one is interested in a specific biological process of interest, the yeast one-hybrid assay is the only method that allows researchers to identify upstream regulators of the biological process of interest...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28439834/an-assessment-of-the-next-generation-of-animal-mirna-target-prediction-algorithms
#8
Thomas Bradley, Simon Moxon
The advent of genome-wide next-generation sequencing technologies has revolutionized the genomic and transcriptomic fields. New technologies also present an opportunity for greater discovery and understanding of post-transcriptional processes, in particular, translational inhibition of transcripts by miRBP (microRNA-RNA binding protein) complexes. Not only have novel methodologies been developed for the direct sequencing of RBP-bound RNA, but a new class of miRNA (microRNA) target prediction algorithms trained on this data has emerged...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28439723/psychiatric-comorbidity-in-alcohol-use-disorders-results-from-the-german-s3-guidelines
#9
REVIEW
U W Preuss, E Gouzoulis-Mayfrank, U Havemann-Reinecke, I Schäfer, M Beutel, E Hoch, K F Mann
Alcohol use disorders (AUD) have a high comorbidity with mental disorders. Vice versa, alcohol consumption plays an important role in affective disorders, anxiety disorders, ADHD, schizophrenic psychosis, and other mental disorders. In developing the current interdisciplinary, evidence-based treatment guideline on screening, diagnostics, and treatment of AUD, available research on comorbid mental diseases in AUD has been compiled to generate recommendations for treatment. The guideline was prepared under the responsibility of the German Association for Psychiatry, Psychotherapy, and Psychosomatics (DGPPN) and the German Association for Addiction Research and Therapy (DG-Sucht)...
April 24, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28439293/socio-demographic-characteristics-clinical-profile-and-prevalence-of-existing-mental-illness-among-suicide-attempters-attending-emergency-services-at-two-hospitals-in-hawassa-city-south-ethiopia-a-cross-sectional-study
#10
Moges Ayehu, Tarekegn Solomon, Kinfe Lemma
BACKGROUND: Suicide is a major public health problem worldwide. It contributes for more than one million deaths each year. Since previous suicidal attempt was considered as the best predictor of future suicide, identifying factors behind suicidal attempt are helpful to design suicide prevention strategies. The aim of this study was to assess socio-demographic characteristics, clinical profile and prevalence of existing mental illness among patients presenting with suicidal attempt to emergency services of general hospitals in South Ethiopia...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28439243/relationships-between-behavioural-addictions-and-psychiatric-disorders-what-is-known-and-what-is-yet-to-be-learned
#11
Vladan Starcevic, Yasser Khazaal
This article provides a narrative review of the relationships between several behavioural addictions [pathological gambling, problematic Internet use (PIU), problematic online gaming, compulsive sexual behaviour disorder, compulsive buying, and exercise addiction] and psychiatric disorders. Associations between most behavioural addictions and depressive and anxiety disorders are strong and seem relatively non-specific. Strong links with substance use disorders may support the notion that some people are more prone to addictive behaviours, regardless of whether these involve substances or problematic activities...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28439242/comprehensive-psychopathological-assessment-based-on-the-association-for-methodology-and-documentation-in-psychiatry-amdp-system-development-methodological-foundation-application-in-clinical-routine-and-research
#12
REVIEW
Rolf-Dieter Stieglitz, Achim Haug, Erdmann Fähndrich, Michael Rösler, Wolfgang Trabert
The documentation of psychopathology is core to the clinical practice of the psychiatrist and clinical psychologist. However, both in initial as well as further training and specialization in their fields, this particular aspect of their work receives scanty attention only. Yet, for the past 50 years, the Association for Methodology and Documentation in Psychiatry (AMDP) System has been in existence and available as a tool to serve precisely the purpose of offering a systematic introduction to the terminology and documentation of psychopathology...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28438661/systematic-review-of-the-potential-adverse-effects-of-caffeine-consumption-in-healthy-adults-pregnant-women-adolescents-and-children
#13
Daniele Wikoff, Brian T Welsh, Rayetta Henderson, Gregory P Brorby, Janice Britt, Esther Myers, Jeffrey Goldberger, Harris R Lieberman, Charles O'Brien, Jennifer Peck, Milton Tenebein, Connie Weaver, Seneca Harvey, Jonathan Urban, Candace Doepker
To date, one of the most heavily cited assessments of caffeine safety in the peer-reviewed literature is that issued by Health Canada (Nawrot et al., 2003). Since then, >10,000 papers have been published related to caffeine, including hundreds of reviews on specific human health effects; however, to date, none have compared the wide range of topics evaluated by Nawrot et al. (2003). Thus, as an update to this foundational publication, we conducted a systematic review of data on potential adverse effects of caffeine published from 2001 to June 2015...
April 7, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28438466/the-effect-of-n-acetylcysteine-nac-on-human-cognition-a-systematic-review
#14
REVIEW
David R Skvarc, Olivia M Dean, Linda K Byrne, Laura Gray, Stephen Lane, Matthew Lewis, Brisa S Fernandes, Michael Berk, Andrew Marriott
Oxidative stress, neuroinflammation and neurogenesis are commonly implicated as cognitive modulators across a range of disorders. N-acetylcysteine (NAC) is a glutathione precursor with potent antioxidant, pro-neurogenesis and anti-inflammatory properties and a favourable safety profile. A systematic review of the literature specifically examining the effect of NAC administration on human cognition revealed twelve suitable articles for inclusion: four examining Alzheimer's disease; three examining healthy participants; two examining physical trauma; one examining bipolar disorder, one examining schizophrenia, and one examining ketamine-induced psychosis...
April 21, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28438312/comment-on-combination-of-cupric-ion-with-hydroxylamine-and-hydrogen-peroxide-for-the-control-of-bacterial-biofilms-on-ro-membranes-by-hye-jin-lee-hyung-eun-kim-changha-lee-water-research-110-2017-83-90
#15
Long Chen, Ying Peng, Min Tang, Feng Wu
The methodology employed by Lee et al. to terminate their bactericidal assays was found to be flawed via our demonstrations. Briefly, EDTA or sulfite combining with cupric ion did not fully terminate, and instead even boosted the P. aeruginosa death. We therefore suggested them to seek for other means of reaction termination, such as the combination of buffering agent PBS and Cu(II)-complexing agent EDTA.
April 11, 2017: Water Research
https://www.readbyqxmd.com/read/28438246/does-dual-task-coordination-performance-decline-in-later-life
#16
María V Sebastián, Roberto Mediavilla
BACKGROUND: This cross-sectional study examined whether changes occur in people’s capacity to coordinate two simultaneous tasks (dual-task) when transitioning from adulthood to later life. The central executive, Baddeley’s working memory model component, is responsible for this coordination. Contradictory results have been reported regarding the relationship between ageing and dual-task performance; but these seem to be related to methodological issues that have been addressed in this study...
May 2017: Psicothema
https://www.readbyqxmd.com/read/28438161/refolddb-a-new-and-sustainable-gateway-to-experimental-protocols-for-protein-refolding
#17
Hisashi Mizutani, Hideaki Sugawara, Ashley M Buckle, Takeshi Sangawa, Ken-Ichi Miyazono, Jun Ohtsuka, Koji Nagata, Tomoki Shojima, Shohei Nosaki, Yuqun Xu, Delong Wang, Xiao Hu, Masaru Tanokura, Kei Yura
BACKGROUND: More than 7000 papers related to "protein refolding" have been published to date, with approximately 300 reports each year during the last decade. Whilst some of these papers provide experimental protocols for protein refolding, a survey in the structural life science communities showed a necessity for a comprehensive database for refolding techniques. We therefore have developed a new resource - "REFOLDdb" that collects refolding techniques into a single, searchable repository to help researchers develop refolding protocols for proteins of interest...
April 24, 2017: BMC Structural Biology
https://www.readbyqxmd.com/read/28438063/measuring-the-needs-of-family-caregivers-of-people-with-dementia-an-assessment-of-current-methodological-strategies-and-key-recommendations
#18
Lauren R Bangerter, Joan M Griffin, Steven H Zarit, Rachel Havyer
While dementia caregivers are regarded as a population with high unmet needs, there is little consensus as to how caregivers' needs should be conceptualized and measured. This article describes how dementia caregivers' needs are currently assessed in the scientific literature with the goal of suggesting guidelines for the enhancement of future measurement of caregiver needs. A review of 26 articles identified overarching themes within measurement approaches including variation in methodological rigor, proxy indicators of need, dual needs assessment of caregiver and person with dementia (PWD), and third-party needs assessment...
April 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28437721/optimizing-follow-up-and-study-retention-in-the-21st-century-advances-from-the-front-line-in-alcohol-and-tobacco-research
#19
Lia J Smith, Patrick J McNamara, Andrea C King
AIMS: Longitudinal studies are integral in addiction research but retention of participants over time can be challenging. While statistical algorithms for missing data have advanced, they remain less desirable than collecting actual data with high retention rates. An update to methodological primers with consideration of evolving technology and privacy concerns is needed for 21st century researchers. METHODS: Comprehensive follow-up methodological strategies were conducted in four concurrent laboratory- and intervention-based studies across N=697 drinker and smokers enrolled in studies at the Clinical Addictions Research Laboratory at the University of Chicago...
April 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28437023/authors-overarching-reply-to-all-the-responses-received-to-the-systematic-literature-review-on-shaken-baby-syndrome
#20
Niels Lynøe, Göran Elinder, Boubou Hallberg, Måns Rosén, Pia Sundgren, Anders Eriksson
There have been a lot of views expressed about our paper on shaken baby syndrome, which was published in Acta Paediatrica (1). We acknowledge the concerns expressed by all of the authors who responded with regard to child welfare and the possibility that the diagnoses may be delayed in individual cases of child abuse. However, we are very troubled by the disregard displayed by those authors to the significant methodological problems inherent in published research on shaken baby syndrome. This article is protected by copyright...
April 24, 2017: Acta Paediatrica
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