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https://www.readbyqxmd.com/read/29677550/impacts-of-transportation-sector-emissions-on-future-u-s-air-quality-in-a-changing-climate-part-i-projected-emissions-simulation-design-and-model-evaluation
#1
Patrick Campbell, Yang Zhang, Fang Yan, Zifeng Lu, David Streets
Emissions from the transportation sector are rapidly changing worldwide; however, the interplay of such emission changes in the face of climate change are not as well understood. This two-part study examines the impact of projected emissions from the U.S. transportation sector (Part I) on ambient air quality in the face of climate change (Part II). In Part I of this study, we describe the methodology and results of a novel Technology Driver Model (see graphical abstract) that includes 1) transportation emission projections (including on-road vehicles, non-road engines, aircraft, rail, and ship) derived from a dynamic technology model that accounts for various technology and policy options under an IPCC emission scenario, and 2) the configuration/evaluation of a dynamically downscaled Weather Research and Forecasting/Community Multiscale Air Quality modeling system...
April 17, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29677114/investigation-of-laser-welding-of-ti-alloys-for-cognitive-process-parameters-selection
#2
Fabrizia Caiazzo, Alessandra Caggiano
Laser welding of titanium alloys is attracting increasing interest as an alternative to traditional joining techniques for industrial applications, with particular reference to the aerospace sector, where welded assemblies allow for the reduction of the buy-to-fly ratio, compared to other traditional mechanical joining techniques. In this research work, an investigation on laser welding of Ti⁻6Al⁻4V alloy plates is carried out through an experimental testing campaign, under different process conditions, in order to perform a characterization of the produced weld bead geometry, with the final aim of developing a cognitive methodology able to support decision-making about the selection of the suitable laser welding process parameters...
April 20, 2018: Materials
https://www.readbyqxmd.com/read/29676960/psychotherapy-targeting-depression-and-anxiety-for-use-in-palliative-care-a-meta-analysis
#3
Jessica J Fulton, Amie R Newins, Laura S Porter, Katherine Ramos
BACKGROUND: Research on the effectiveness of evidence-based practices in the treatment of depression and anxiety with palliative care populations is primarily limited to individuals having specific conditions such as cancer. OBJECTIVE: This meta-analysis examined the effect of psychotherapy on depression and anxiety among individuals with any condition appropriate for palliative care. METHODS: We searched PubMed, PsycINFO, Cochrane Library, and EMBASE databases until August 2017...
April 20, 2018: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29676934/cognitive-profiles-of-older-adults-with-a-prior-traumatic-brain-injury-versus-healthy-controls-a-meta-analysis
#4
Kelly Y An, Mich C E Monette
OBJECTIVE: To determine cognitive outcomes in older adults (≥ 50 years old) having sustained a traumatic brain injury (TBI) using meta-analysis. METHODS: MedLine and PsycInfo databases were searched to identify studies comparing neuropsychological profiles in older adults with and without a history of TBI across various injury severities and times post-injury. Ten studies (n = 717) meeting inclusion criteria were identified. Tests were divided into functional modalities and average effect sizes were calculated across studies on a test-by-test basis...
April 20, 2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29676899/large-hollow-cavity-luminous-nanoparticles-with-near-infrared-persistent-luminescence-and-tunable-sizes-for-tumor-afterglow-imaging-and-chemo-photodynamic-therapies
#5
Jun Wang, Jinlei Li, Jiani Yu, Hongwu Zhang, Bingbo Zhang
Persistent luminous nanoparticles (PLNPs) have been capturing increasing attention in biomedical imaging because of their long-life emission and concomitant benefits (e.g., zero-autofluorescence background, high signal-to-noise ratio). Although there are quite some synthetic methodologies to synthesize PLNPs, those for constructing functional structured PLNPs remain largely unexplored. Herein we report the design principle, synthesis route, and proof-of-concept applications of hollow structured PLNPs with near-infrared (NIR) persistent luminescence, namely afterglow, and tunable sizes for tumor afterglow imaging and chemical/photodynamic therapies...
April 20, 2018: ACS Nano
https://www.readbyqxmd.com/read/29676480/medication-state-at-the-time-of-the-offense-medication-noncompliance-insight-and-criminal-responsibility
#6
Caroline Titcomb Parrott, Michelle A Jones, Stanley L Brodsky, Clayton Shealy
This study used a mixed quantitative-qualitative methodology to examine whether mock jurors considered a defendant's meta-responsibility - specifically, the defendant's medication noncompliance and degree of insight into his/her schizophrenia - when determining the person's criminal responsibility. The degree of expert witness explanation regarding these factors was also varied. Participants (n = 173) were grouped into 30 juries, randomized across five conditions, and shown mock testimony and attorney arguments based on a real not guilty by reason of insanity court case...
April 20, 2018: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/29676183/synthesis-%C3%AE-glucosidase-inhibitory-glucose-consumption-promoting-activities-of-flavonoid-coumarin-hybrids
#7
Hua Sun, Xiaotong Song, Yunchang Tao, Ming Li, Ke Yang, Hang Zheng, Zongxin Jin, Robert H Dodd, Guojun Pan, Kui Lu, Peng Yu
AIM: The research of novel and potent antidiabetic agents is urgently needed for the control of the exploding diabetic population. We previously reported the synthesis and antidiabetic activity of natural 8-(6"-umbelliferyl)-apigenin (1), but its antidiabetic targets are not known. Therefore, four series of derivatives were synthesized and evaluated for their antidiabetic activities. Results & methodology: Compounds (5a) and (14a) were identified as new α-glucosidase and α-amylase dual inhibitors...
April 20, 2018: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/29676136/-network-meta-analysis-of-chinese-medical-injections-for-heart-failure
#8
Feng-Wen Yang, Jia-Han Zou, Yuan Wang, Chong-Xiang Sun, Long Ge, Jin-Hui Tian, Jun-Hua Zhang
To assess the clinical efficacy of Chinese medical injection (CMI) for heart failure by using network Meta-analysis method. The relative randomized controlled trials (RCTs) of CMI for heart failure were retrieved from China National Knowledge Infrastructure (CNKI), WanFang Database, Chinese Biomedical Literature Database (SinoMed), PubMed, Cochrane Library and EMbase in July 2017. RCTs on the comparison of two kinds of CMIs for heart failure were included. Two researchers independently completed the literature screening, data extraction and quality evaluation according to the pre-determined inclusion and exclusion criteria, and the results were crossed checked...
March 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29675864/molecular-based-identification-and-detection-of-salmonella-in-food-production-systems-current-perspectives
#9
REVIEW
Steven C Ricke, Sun Ae Kim, Zhaohao Shi, Si Hong Park
Salmonella remains a prominent cause of foodborne illnesses and can originate from a wide range of food products. Given the continued presence of pathogenic Salmonella in food production systems, there is a consistent need to improve identification and detection methods that can identify this pathogen at all stages in food systems. Methods for subtyping have evolved over the years, and the introduction of whole genome sequencing and advancements in PCR technologies has greatly improved the resolution for differentiating strains within a particular serovar...
April 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29675594/a-global-health-research-checklist-for-clinicians
#10
Rasha D Sawaya, Kristen A Breslin, Eiman Abdulrahman, Jennifer I Chapman, Dafina M Good, Lili Moran, Paul C Mullan, Oluwakemi Badaki-Makun
Global health research has become a priority in most international medical projects. However, it is a difficult endeavor, especially for a busy clinician. Navigating the ethics, methods, and local partnerships is essential yet daunting.To date, there are no guidelines published to help clinicians initiate and complete successful global health research projects. This Global Health Research Checklist was developed to be used by clinicians or other health professionals for developing, implementing, and completing a successful research project in an international and often low-resource setting...
April 19, 2018: International Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29674941/cosmology-and-fundamental-physics-with-the-euclid-satellite
#11
REVIEW
Luca Amendola, Stephen Appleby, Anastasios Avgoustidis, David Bacon, Tessa Baker, Marco Baldi, Nicola Bartolo, Alain Blanchard, Camille Bonvin, Stefano Borgani, Enzo Branchini, Clare Burrage, Stefano Camera, Carmelita Carbone, Luciano Casarini, Mark Cropper, Claudia de Rham, Jörg P Dietrich, Cinzia Di Porto, Ruth Durrer, Anne Ealet, Pedro G Ferreira, Fabio Finelli, Juan García-Bellido, Tommaso Giannantonio, Luigi Guzzo, Alan Heavens, Lavinia Heisenberg, Catherine Heymans, Henk Hoekstra, Lukas Hollenstein, Rory Holmes, Zhiqi Hwang, Knud Jahnke, Thomas D Kitching, Tomi Koivisto, Martin Kunz, Giuseppe La Vacca, Eric Linder, Marisa March, Valerio Marra, Carlos Martins, Elisabetta Majerotto, Dida Markovic, David Marsh, Federico Marulli, Richard Massey, Yannick Mellier, Francesco Montanari, David F Mota, Nelson J Nunes, Will Percival, Valeria Pettorino, Cristiano Porciani, Claudia Quercellini, Justin Read, Massimiliano Rinaldi, Domenico Sapone, Ignacy Sawicki, Roberto Scaramella, Constantinos Skordis, Fergus Simpson, Andy Taylor, Shaun Thomas, Roberto Trotta, Licia Verde, Filippo Vernizzi, Adrian Vollmer, Yun Wang, Jochen Weller, Tom Zlosnik
Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015-2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research...
2018: Living Reviews in Relativity
https://www.readbyqxmd.com/read/29674791/research-design-the-methodology-for-interdisciplinary-research-framework
#12
Hilde Tobi, Jarl K Kampen
Many of today's global scientific challenges require the joint involvement of researchers from different disciplinary backgrounds (social sciences, environmental sciences, climatology, medicine, etc.). Such interdisciplinary research teams face many challenges resulting from differences in training and scientific culture. Interdisciplinary education programs are required to train truly interdisciplinary scientists with respect to the critical factor skills and competences. For that purpose this paper presents the Methodology for Interdisciplinary Research (MIR) framework...
2018: Quality & Quantity
https://www.readbyqxmd.com/read/29674162/institutionalizing-health-impact-assessment-a-consultation-with-experts-on-the-barriers-and-facilitators-to-implementing-hia-in-italy
#13
Nunzia Linzalone, Adele Ballarini, Cristiano Piccinelli, Francesca Viliani, Fabrizio Bianchi
A Health Impact Assessment (HIA) is an evidence-based methodology that includes health promotion and protection goals in decision-making. HIA has been introduced and/or institutionalized to various extents in different countries. In order to promote HIA and preventive health assessments in Italy, a research methodology was followed to identify specific obstacles or facilitators. The experiences of various countries reported in the literature were analyzed in terms of facilitating or hindering the introduction and institutionalization of HIA...
April 16, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29674061/two-dimensional-weak-anion-exchange-chromatography-gel-electrophoresis-separations-coupling-to-inductively-coupled-plasma-mass-spectrometry-strategy-for-analysis-of-metalloproteins
#14
Xueting Yan, Bin He, Dingyi Wang, Ligang Hu, Lihong Liu, Chunyang Liao, Guibin Jiang
A two-dimensional (2-D, weak anion exchange chromatography-gel electrophoresis, WAX-GE) separations coupling to inductively coupled plasma mass spectrometry (ICP-MS) strategy was developed for efficient tracking of metalloproteins. Samples were fractionized with the primary dimension (WAX) and the collected fractions were subsequently subjected to the secondary dimension (GE) and finally detected with ICP-MS. The metalloproteins of interest from the secondary dimension were online split and collected for further manipulation...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29673539/methodological-considerations-and-future-insights-for-24-hour-dietary-recall-assessment-in-children
#15
REVIEW
Emma Foster, Jennifer Bradley
Dietary assessment has come under much criticism of late to the extent that it has been questioned whether self-reported methods of dietary assessment are worth doing at all. Widespread under-reporting of energy intake, limitations due to memory, changes to intake due to the burden of recording and social desirability bias all impact significantly on the accuracy of the dietary information collected. Under-reporting of energy intakes has long been recognized as a problem in dietary research with doubly labeled water measures of energy expenditure uncovering significant under-reporting of energy intakes across different populations and different dietary assessment methods...
March 2018: Nutrition Research
https://www.readbyqxmd.com/read/29673328/effect-of-laser-doppler-flowmetry-and-occlusion-time-on-outcome-variability-and-mortality-in-rat-middle-cerebral-artery-occlusion-inconclusive-results
#16
Edvin Ingberg, Hua Dock, Elvar Theodorsson, Annette Theodorsson, Jakob O Ström
BACKGROUND: Stroke is among the leading causes of death and disability. Although intense research efforts have provided promising treatment options in animals, most clinical trials in humans have failed and the therapeutic options are few. Several factors have been suggested to explain this translational difficulty, particularly concerning methodology and study design. Consistent infarcts and low mortality might be desirable in some, but not all, studies. Here, we aimed to investigate whether the use of laser Doppler flowmetry (LDF) and the occlusion time (60 vs...
April 19, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29673162/nanoscale-zinc-oxide-particles-for-improving-the-physiological-and-sanitary-quality-of-a-mexican-landrace-of-red-maize
#17
Juan Estrada-Urbina, Alejandro Cruz-Alonso, Martha Santander-González, Abraham Méndez-Albores, Alma Vázquez-Durán
In this research, quasi-spherical-shaped zinc oxide nanoparticles (ZnO NPs) were synthesized by a simple cost-competitive aqueous precipitation method. The engineered NPs were characterized using several validation methodologies: UV–Vis spectroscopy, diffuse reflection UV–Vis, spectrofluorometry, transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), and Fourier transform infrared (FTIR) spectroscopy with attenuated total reflection (ATR). A procedure was established to coat a landrace of red maize using gelatinized maize starch...
April 17, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29672911/the-quality-of-dying-and-death-measurement-instruments-a-systematic-psychometric-review
#18
REVIEW
Daniel Gutiérrez Sánchez, David Pérez Cruzado, Antonio I Cuesta-Vargas
AIMS: To identify instruments that could assess the quality of dying and death and their psychometric properties. Toassess the methodological quality of studies on measurement properties. BACKGROUND: A highquality of deathis regarded as a goal at the endoflife and, therefore, anassessment of the endoflife experience is essential. Many instruments have been developed to evaluate the quality of dying and death. The selection of the most appropriate measure to use in clinical and research settings being crucial...
April 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29672845/drug-induced-proarrhythmia-and-torsade-de-pointes-a-primer-for-students-and-practitioners-of-medicine-and-pharmacy
#19
REVIEW
J Rick Turner, Ignacio Rodriguez, Emily Mantovani, Gary Gintant, Peter R Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T Sager, Norman Stockbridge, Colette Strnadova
Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety-related withdrawals, and the actions taken by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and by regulatory agencies in terms of changing drug development practices and introducing new nonclinical and clinical tests to asses proarrhythmic liability...
April 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29672675/parapred-antibody-paratope-prediction-using-convolutional-and-recurrent-neural-networks
#20
Edgar Liberis, Petar Velickovic, Pietro Sormanni, Michele Vendruscolo, Pietro Liò
Motivation: Antibodies play essential roles in the immune system of vertebrates and are powerful tools in research and diagnostics. While hypervariable regions of antibodies, which are responsible for binding, can be readily identified from their amino acid sequence, it remains challenging to accurately pinpoint which amino acids will be in contact with the antigen (the paratope). Results: In this work, we present a sequence-based probabilistic machine learning algorithm for paratope prediction, named Parapred...
April 16, 2018: Bioinformatics
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