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https://www.readbyqxmd.com/read/29245084/application-of-analytical-quality-by-design-principles-for-the-determination-of-alkyl-p-toluenesulfonates-impurities-in-aprepitant-by-hplc-validation-using-total-error-concept
#1
Constantinos K Zacharis, Elli Vastardi
In the research presented we report the development of a simple and robust liquid chromatographic method for the quantification of two genotoxic alkyl sulphonate impurities (namely methyl p-toluenesulfonate and isopropyl p-toluenesulfonate) in Aprepitant API substances using the Analytical Quality by Design (AQbD) approach. Following the steps of AQbD protocol, the selected critical method attributes (CMAs) were the separation criterions between the critical peak pairs, the analysis time and the peak efficiencies of the analytes...
December 7, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29245079/what-technologies-do-people-engage-with-while-driving-and-why
#2
Katie J Parnell, Neville A Stanton, Katherine L Plant
This paper presents the findings of a semi-structured interview study that was conducted to identify drivers' self-reported likelihood of engaging with technologies that are now commonly found in modern automobiles. Previous research has focused on the effect these technological tasks have on driving performance, but there has been less focus on how, why and when drivers choose to engage with them. As distraction remains a significant contributor to road accidents, an understanding of why it occurs will give important insights into how it can be prevented...
December 12, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#3
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244757/expression-of-staphylococcal-enterotoxins-under-stress-encountered-during-food-production-and-preservation
#4
REVIEW
Jenny Schelin, Yusak Budi Susilo, Sophia Johler
Staphylococcal food poisoning (SFP) is the most prevalent cause of food-borne intoxications worldwide. Consumption of enterotoxins preformed in food causes violent vomiting and can be fatal in children and the elderly. While being repressed by competing bacteria in most matrices, Staphylococcus aureus benefits from crucial competitive advantages in foods with high osmolarity or low pH. During recent years, the long-standing belief in the feasibility of assessing SFP risk based on colony-forming units of S. aureus present in food products has been disproven...
December 15, 2017: Toxins
https://www.readbyqxmd.com/read/29244215/development-of-a-validated-liquid-chromatographic-method-for-quantification-of-sorafenib-tosylate-in-the-presence-of-stress-induced-degradation-products-and-in-biological-matrix-employing-analytical-quality-by-design-aqbd-approach
#5
Teenu Sharma, Rajneet Kaur Khurana, Atul Jain, O P Katare, Bhupinder Singh
The current research work envisages AQbD-enabled development of a simple, rapid, sensitive, specific, robust and cost-effective stability indicating reversed phase high performance liquid chromatographic (RP-HPLC) method for determining stress-induced forced degradation products of sorafenib tosylate (SFN). An Ishikawa fish bone diagram was constructed to embark upon analytical target profile (ATP) and critical analytical attributes (CAAs) i.e., peak area, theoretical plates, retention time (Rt ) and peak tailing...
December 15, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29244200/from-hohensch%C3%A3-nhausen-to-guantanamo-bay-psychology-s-role-in-the-secret-services-of-the-gdr-and-the-united-states
#6
Moritz Michels, Martin Wieser
This paper presents a historical analysis of the genesis, context, and function of "Operative Psychology," a little-known branch of applied psychology developed by employees of the Ministry of State Security in the German Democratic Republic. For 25 years, theories and practices of Operative Psychology were taught to elite agents at the Juridical Academy in Potsdam, introducing them to various "silent" psychological techniques of persuasion, interrogation, and repression. After highlighting the economic and political context that increased the need for "silent" techniques of observation and repression, an overview of the topics that were taught and researched at the chair for Operative Psychology is given...
December 15, 2017: Journal of the History of the Behavioral Sciences
https://www.readbyqxmd.com/read/29244005/ghost-global-hepatitis-outbreak-and-surveillance-technology
#7
Atkinson G Longmire, Seth Sims, Inna Rytsareva, David S Campo, Pavel Skums, Zoya Dimitrova, Sumathi Ramachandran, Magdalena Medrzycki, Hong Thai, Lilia Ganova-Raeva, Yulin Lin, Lili T Punkova, Amanda Sue, Massimo Mirabito, Silver Wang, Robin Tracy, Victor Bolet, Thom Sukalac, Chris Lynberg, Yury Khudyakov
BACKGROUND: Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Effective HCV outbreak investigation requires comprehensive surveillance and robust case investigation. We previously developed and validated a methodology for the rapid and cost-effective identification of HCV transmission clusters...
December 6, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29243563/safety-culture-patient-safety-and-quality-of-care-outcomes-a-literature-review
#8
Seung Eun Lee, Linda D Scott, V Susan Dahinten, Catherine Vincent, Karen Dunn Lopez, Chang Gi Park
This integrative literature review was conducted to examine the relationships between safety culture and patient safety and quality of care outcomes in hospital settings and to identify directions for future research. Using a search of six electronic databases, 17 studies that met the study criteria were selected for review. This review revealed semantic inconsistencies, infrequent use of a theory or theoretical framework, limited discussions of validity of instruments used, and significant methodological variations...
December 1, 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/29243526/relationship-between-persistent-negative-symptoms-and-findings-of-neurocognition-and-neuroimaging-in-schizophrenia
#9
Ezgi İnce, Alp Üçok
Negative symptoms are defined as loss or reduction of otherwise present behaviors or functions in illness situation, and they have constituted an important aspect of schizophrenia. Although negative symptoms have usually been considered as a single entity, neurobiological investigations yielded discrepant results. To overcome challenges that derive from this discrepancy, researchers have proposed several approaches to structure negative symptoms into more homogenous constructs. Concept of persistent negative symptoms (PNS) is one of the proposed approaches, and includes both primary and secondary negative symptoms that persist after adequate treatment...
January 2018: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/29243356/turning-frequency-in-adult-bedridden-patients-to-prevent-hospital-acquired-pressure-ulcer-a-scoping-review
#10
Chew H-S Jocelyn, Emelia Thiara, Violeta Lopez, Shefaly Shorey
The aim of this study was to identify current research on turning frequencies of adult bed-bound patients and inform future turning practices for hospitals based on evidence-based practice. We undertook a scoping review framework that provided a transparent and systematic methodology using 8 electronic databases (CINAHL, PubMed, Cochrane Library, ScienceDirect, PsycINFO, Scopus, ProQuest, and Web of Science) to identify articles published from 2000 to 2016. Articles were included if they focused on the prevention of hospital-acquired pressure ulcers related to the frequency of turning or repositioning of bed-bound patients...
December 15, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29243305/opioid-analgesic-dose-and-the-risk-of-misuse-overdose-and-death-a-narrative-review
#11
REVIEW
David Tyler Coyle, Chih-Ying Pratt, Josephine Ocran-Appiah, Alex Secora, Cynthia Kornegay, Judy Staffa
PURPOSE: Despite the rise in serious adverse events paralleling increased prescription opioid analgesic use in the United States over the past 2 decades, the association between opioid analgesic dose and the risk of serious adverse health outcomes is incompletely characterized. We sought to synthesize the medical literature for observational studies examining the association between opioid analgesic dose and the risk of serious adverse health outcomes, with particular attention to the outcomes of misuse, abuse, addiction, overdose, and death...
December 15, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29243155/trends-in-plant-research-using-molecular-markers
#12
REVIEW
Jose Antonio Garrido-Cardenas, Concepción Mesa-Valle, Francisco Manzano-Agugliaro
A deep bibliometric analysis has been carried out, obtaining valuable parameters that facilitate the understanding around the research in plant using molecular markers. The evolution of the improvement in the field of agronomy is fundamental for its adaptation to the new exigencies that the current world context raises. In addition, within these improvements, this article focuses on those related to the biotechnology sector. More specifically, the use of DNA markers that allow the researcher to know the set of genes associated with a particular quantitative trait or QTL...
December 14, 2017: Planta
https://www.readbyqxmd.com/read/29243044/conversion-of-standard-retrospective-patient-reported-outcomes-to-momentary-versions-cognitive-interviewing-reveals-varying-degrees-of-momentary-compatibility
#13
Victor Brun Boesen, Stine Birk Nissen, Mogens Groenvold, Jakob Bue Bjorner, Laszlo Hegedüs, Steen Joop Bonnema, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Torquil Watt
PURPOSE: The purpose of this study was to adapt different domains of an existing retrospective questionnaire to momentary versions, to use and assess cognitive interviewing for evaluating the new versions, and to compare momentary compatibility (i.e. an item's potential to be validly converted to a momentary version) across different scales. METHODS: Initial momentary versions of retrospective patient-reported outcomes were produced by converting present perfect tense wording to present tense wording...
December 14, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29242981/a%C3%A2-new-look-at-the-heart-novel-imaging-techniques
#14
REVIEW
C M Johnston, A J Krafft, M F Russe, E A Rog-Zielinska
The development and successful implementation of cutting-edge imaging technologies to visualise cardiac anatomy and function is a key component of effective diagnostic efforts in cardiology. Here, we describe a number of recent exciting advances in the field of cardiology spanning from macro- to micro- to nano-scales of observation, including magnetic resonance imaging, computed tomography, optical mapping, photoacoustic imaging, and electron tomography. The methodologies discussed are currently making the transition from scientific research to routine clinical use, albeit at different paces...
December 14, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/29242700/lidar-guided-archaeological-survey-of-a-mediterranean-landscape-lessons-from-the-ancient-greek-polis-of-kolophon-ionia-western-anatolia
#15
Benedikt Grammer, Erich Draganits, Martin Gretscher, Ulrike Muss
In 2013, an airborne laser scan survey was conducted in the territory of the Ionian city of Kolophon near the western coast of modern Turkey as part of an archaeological survey project carried out by the Mimar Sinan University of Istanbul (Turkey) and the University of Vienna (Austria). Several light detection and ranging (LiDAR) studies have been carried out in the temperate climate zones of Europe, but only a few in Mediterranean landscapes. Our study is based on the first LiDAR survey carried out for an archaeological purpose in Turkey and one of the first in the Mediterranean that have been planned, measured and filtered especially for archaeological research questions...
October 2017: Archaeological Prospection
https://www.readbyqxmd.com/read/29242292/comparative-oligo-fish-mapping-an-efficient-and-powerful-methodology-to-reveal-karyotypic-and-chromosomal-evolution
#16
Guilherme T Braz, Li He, Hainan Zhao, Tao Zhang, Kassandra Semrau, Jean-Marie Rouillard, Giovana A Torres, Jiming Jiang
Developing the karyotype of a eukaryotic species relies on identification of individual chromosomes, which has been a major challenge for most non-model plant and animal species. We developed a novel chromosome identification system by selecting and labeling oligonucleotides (oligos) located in specific regions on every chromosome. We selected a set of 54,672 oligos (45 nt) based on single copy DNA sequences in the potato genome. These oligos generated 26 distinct FISH signals that can be used as a 'barcode' or a 'banding pattern' to uniquely label each of the 12 chromosomes from both diploid and polyploid (4x and 6x) potato species...
December 13, 2017: Genetics
https://www.readbyqxmd.com/read/29242256/manual-review-of-electronic-medical-records-as-a-reference-standard-for-case-definition-development-a-validation-study
#17
Tyler Williamson, Rebecca C Miyagishima, Janeen D Derochie, Neil Drummond
BACKGROUND: The Canadian Primary Care Sentinel Surveillance Network (CPCSSN) previously carried out a validation study of case definitions for 8 chronic diseases (diabetes mellitus, hypertension, osteoarthritis, depression, dementia, chronic obstructive pulmonary disease, parkinsonism and epilepsy) using direct review of "raw" electronic medical record data. Although effective, this method is time-consuming and can present methodological and organizational challenges. We aimed to determine whether the processed and standardized data contained with the CPCSSN database might function as a reference standard for case definition validation...
December 11, 2017: CMAJ Open
https://www.readbyqxmd.com/read/29242239/defining-quality-in-cardiovascular-imaging-a-scientific-statement-from-the-american-heart-association
#18
REVIEW
Leslee J Shaw, Ron Blankstein, Jill E Jacobs, Jonathon A Leipsic, Raymond Y Kwong, Viviany R Taqueti, Rob S B Beanlands, Jennifer H Mieres, Scott D Flamm, Thomas C Gerber, John Spertus, Marcelo F Di Carli
The aims of the current statement are to refine the definition of quality in cardiovascular imaging and to propose novel methodological approaches to inform the demonstration of quality in imaging in future clinical trials and registries. We propose defining quality in cardiovascular imaging using an analytical framework put forth by the Institute of Medicine whereby quality was defined as testing being safe, effective, patient-centered, timely, equitable, and efficient. The implications of each of these components of quality health care are as essential for cardiovascular imaging as they are for other areas within health care...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29241512/development-of-post-hip-replacement-comfort-scale
#19
Hulya Saray Kilic, Sevinc Tastan
AIM: To develop and psychometrically test the Post Hip Replacement Comfort Scale (PHRCS). BACKGROUND: Evaluation of the patient comfort after hip replacement surgery is highly important in order to increase the quality of patient care. The review of the relevant literature shows that a scale that specifically measures the patient comfort after hip replacement surgery is absent. DESIGN: Methodological design was used. This study included the development of the scale and tested the psychometric properties of the scale...
December 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/29241386/modified-risk-associations-of-lipoproteins-and-apolipoproteins-by-chronic-low-grade-inflammation
#20
Altan Onat, Aysem Kaya, Evin Ademoglu
Lipoproteins and the apolipoproteins (apo) that they carry are major determinants of cardiovascular diseases (CVD) as well as metabolic, renal and inflammatory chronic disorders either directly or through mediation of risk factors. The notion that elevated low-density lipoprotein cholesterol (LDL-C) and apoB levels are related to the acquisition of CVD and, high-density lipoprotein cholesterol (HDL-C) and apoA-I indicate protection against CVD has been challenged in the past decade. Advanced age, adiposity, ethnicity or impaired glucose intolerance rendered autoimmune activation in an environment of pro-inflammatory state/oxidative stress and may disrupt the linear risk association between lipoproteins...
December 15, 2017: Expert Review of Cardiovascular Therapy
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