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Traumatic brain injury

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https://www.readbyqxmd.com/read/28098495/psychometric-characteristics-of-the-insomnia-severity-index-in-veterans-with-history-of-traumatic-brain-injury
#1
Christopher N Kaufmann, Henry J Orff, Raeanne C Moore, Lisa Delano-Wood, Colin A Depp, Dawn M Schiehser
OBJECTIVE/BACKGROUND: The Insomnia Severity Index (ISI) is a widely used self-report measure of insomnia symptoms. However, to date this measure has not been validated or well-characterized in veterans who have experienced traumatic brain injury (TBI). This study assessed the psychometric properties and convergent, divergent, construct, and discriminate validity of the ISI in veterans with a history of TBI. PARTICIPANTS: Eighty-three veterans with history of TBI were seen in the VA San Diego Healthcare System as part of a research protocol...
January 18, 2017: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/28098452/a-perspective-on-crocus-sativus-l-saffron-constituent-corcin-a-potent-water-soluble-antioxidant-and-potential-therapy-for-alzheimer-s-disease
#2
John W Finley, Song Gao
Alzheimer's Disease (AD) is the most common form of dementia in which the death of brain cells causes memory loss and cognitive decline. Several factors are thought to play roles in the development and course of AD. Existing medical therapies only alleviate and delay cognitive symptoms. Current research has been focused on developing antibodies to remove the targets of β-amyloid (Aβ) and tau protein. This approach has achieved removal of A, however, no long term success to AD patients reported. The biological properties of saffron, the dry stigma of the plant Crocus sativus L...
January 18, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28097990/lowering-body-temperature-improves-outcomes-in-adults-with-traumatic-brain-injury
#3
(no author information available yet)
Lowering the body temperature of adults who experience a traumatic brain injury can significantly improve chances of survival, new study results suggest.
January 18, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28097935/finite-element-simulations-of-the-head-brain-responses-to-the-top-impacts-of-a-construction-helmet-effects-of-the-neck-and-body-mass
#4
John Z Wu, Christopher S Pan, Bryan M Wimer, Charles L Rosen
Traumatic brain injuries are among the most common severely disabling injuries in the United States. Construction helmets are considered essential personal protective equipment for reducing traumatic brain injury risks at work sites. In this study, we proposed a practical finite element modeling approach that would be suitable for engineers to optimize construction helmet design. The finite element model includes all essential anatomical structures of a human head (i.e. skin, scalp, skull, cerebrospinal fluid, brain, medulla, spinal cord, cervical vertebrae, and discs) and all major engineering components of a construction helmet (i...
January 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28096246/chronic-traumatic-encephalopathy-is-latency-in-symptom-onset-explained-by-tau-propagation
#5
Joshua Kriegel, Zachary Papadopoulos, Ann C McKee
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive mild brain trauma. CTE, previously termed "dementia pugilistica," has been identified in American football, ice hockey, baseball, rugby and soccer players, boxers, wrestlers, and military personnel exposed to blast and other traumatic brain injuries. There is often a long latency period between an individual's exposure to repetitive brain trauma and the clinical symptoms of CTE. The pathology of CTE is characterized by a progression from isolated focal perivascular hyperphosphorylated tau lesions in the cerebral cortex to a widespread tauopathy that involves diffuse cortical and medial temporal lobe regions...
January 17, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28095923/nadph-oxidase-in-brain-injury-and-neurodegenerative-disorders
#6
REVIEW
Merry W Ma, Jing Wang, Quanguang Zhang, Ruimin Wang, Krishnan M Dhandapani, Ratna K Vadlamudi, Darrell W Brann
Oxidative stress is a common denominator in the pathology of neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and multiple sclerosis, as well as in ischemic and traumatic brain injury. The brain is highly vulnerable to oxidative damage due to its high metabolic demand. However, therapies attempting to scavenge free radicals have shown little success. By shifting the focus to inhibit the generation of damaging free radicals, recent studies have identified NADPH oxidase as a major contributor to disease pathology...
January 17, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28095735/criterion-validity-of-the-d-kefs-color-word-and-verbal-fluency-switching-paradigms-following-traumatic-brain-injury
#7
Luke B Anderson, Rebekah Jaroh, Hillary Smith, Carrie-Ann H Strong, Jacobus Donders
The present study was composed of two parts examining the clinical utility of the Delis-Kaplan Executive Function System (D-KEFS) Verbal Fluency and Color-Word subtests in traumatic brain injury (TBI). In the first part, the performance of 128 outpatients with mild to severe TBI on the Verbal Fluency and Color-Word subtests was examined in relation to two primary indicators of TBI severity: length of coma and the presence of intracranial lesions on neuroimaging through regression analysis. After controlling for education, ethnicity, and complicating premorbid and comorbid factors, length of coma predicted performance on the Color-Word Inhibition/Switching subtest, whereas the presence of diffuse lesions was related to Verbal Fluency Category Switching performance...
January 17, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28095731/n-palmitoylethanolamine-oxazoline-pea-oxa-as-a-new-therapeutic-strategy-to-control-neuroinflammation-neuroprotective-effects-in-experimental-models-of-spinal-cord-and-brain-injury
#8
Daniela Impellizzeri, Marika Cordaro, Giuseppe Bruschetta, Rosalba Siracusa, Rosalia Crupi, Emanuela Esposito, Salvatore Cuzzocrea
Modulation of N-acylethanolamine-hydrolyzing acid amidase (NAAA) represents a potential alternative strategy in the treatment of neuroinflammation. Recent studies showed that pharmacological modulation of NAAA could be achieved with the oxazoline of palmitoylethanolamide (PEA) (PEA-OXA). The aim of this study was to evaluate the neuroprotective effects of PEA-OXA in the secondary neuro-inflammatory events induced by spinal and brain trauma in mice. Animals were subjected to spinal cord and brain injury models and PEA-OXA (10 mg/kg) administered both intraperitoneally and orally 1 h and 6 h after trauma...
January 17, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28095052/increased-gamma-connectivity-during-working-memory-retention-following-traumatic-brain-injury
#9
Neil W Bailey, Nigel C Rogasch, Kate E Hoy, Jerome J Maller, Rebecca A Segrave, Caley M Sullivan, Paul B Fitzgerald
PRIMARY OBJECTIVE: Alterations to functional connectivity following a traumatic brain injury (TBI) may lead to impaired cognitive performance and major depressive disorder (MDD). In particular, functional gamma band connectivity is thought to reflect information binding important for working memory. The objective of this study was to determine whether altered functional gamma connectivity may be a factor in MDD following TBI (TBI-MDD). RESEARCH DESIGN: This study assessed individuals with TBI-MDD, as well as individuals with TBI alone and MDD alone using electroencephalographic recordings while participants performed a working memory task to assess differences in functional connectivity between these groups...
January 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28095032/the-trajectories-of-overall-disability-in-the-first-5-years-after-moderate-and-severe-traumatic-brain-injury
#10
Marit V Forslund, Cecilie Roe, Paul B Perrin, Solrun Sigurdardottir, Juan Lu, Svein Berntsen, Nada Andelic
PRIMARY OBJECTIVES: To assess longitudinal trajectories of overall disability after moderate-to-severe traumatic brain injury (TBI) and to examine whether those trajectories could be predicted by socio-demographic and injury characteristics. METHODS: Demographics and injury characteristics of 105 individuals with moderate-to-severe TBI were extracted from medical records. At the 1-, 2-, and 5-year follow-ups, TBI-related disability was assessed by the GOSE. A hierarchical linear model (HLM) was used to examine functional outcomes up to 5 years following injury and whether those outcomes could be predicted by: time, gender, age, relationship, education, employment pre-injury, occupation, GCS, cause of injury, length of post-traumatic amnesia (PTA), CT findings and injury severity score, as well as the interactions between each of these predictors and time...
January 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28095029/utilization-of-conventional-neuroimaging-following-youth-concussion
#11
Sean C Rose, Caroline E Schaffer, Julie A Young, Kelly A McNally, Anastasia N Fischer, Geoffrey L Heyer
BACKGROUND/OBJECTIVE: Conventional neuroimaging is not recommended for the routine diagnosis of concussion, but some patients with concussion undergo computed tomography (CT) or magnetic resonance imaging (MRI). The objective of this study was to explore the clinical factors that predict neuroimaging utilization in concussion. METHODS: Concussion-related CT and MRI data were analysed from 1953 patients, aged 10-19 years, who presented to a sports concussion clinic within 30 days of injury...
January 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28095027/severe-and-extensive-traumatic-axonal-injury-following-minor-and-indirect-head-trauma
#12
Sung Ho Jang, Han Do Lee
OBJECTIVES: This study reports on a patient with mild traumatic brain injury (TBI) who showed severe and extensive traumatic axonal injury (TAI) of various neural tracts following minor and indirect head trauma, which was demonstrated by diffusion tensor tractography (DTT). CASE DESCRIPTION: A 26-year-old female patient suffered from indirect head trauma resulting from flexion-hyperextension injury after being hit from behind by a slowly moving car. At the time of head trauma, she felt tingling sensation on her four extremities; however, she did not experience loss of consciousness...
January 17, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28094295/loss-of-pafr-prevents-neuroinflammation-and-brain-dysfunction-after-traumatic-brain-injury
#13
Xiang-Jie Yin, Zhen-Yan Chen, Xiao-Na Zhu, Jin-Jia Hu
Traumatic brain injury (TBI) is a principal cause of death and disability worldwide, which is a major public health problem. Death caused by TBI accounts for a third of all damage related illnesses, which 75% TBI occurred in low and middle income countries. With the increasing use of motor vehicles, the incidence of TBI has been at a high level. The abnormal brain functions of TBI patients often show the acute and long-term neurological dysfunction, which mainly associated with the pathological process of malignant brain edema and neuroinflammation in the brain...
January 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28093969/traumatic-brain-injury-preclinical-imaging-diagnostic-s-and-therapeutic-approaches
#14
Eric L Kaijzel, Ermond R van Beek, Marieke A Stammes, Ivo Que, Alan B Chan, Clemens W G M Löwik, Luis J Cruz
BACKGROUND: Traumatic brain injury (TBI) is a result of an external physical force to the head that traumatically injures the brain. It is a major public health problem worldwide and mainly results from falls, vehicle accidents and violence. Clinical problem: The management of TBI, causing a wide spectrum of possible health outcomes, has barely changed over the years as encouraging outcomes from many pre-clinical therapeutic and pharmacological studies have only rarely been translated to the clinical situation...
January 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28093771/improving-prospective-memory-performance-with-future-event-simulation-in-traumatic-brain-injury-patients
#15
Giovanna Mioni, Erica Bertucci, Antonella Rosato, Gill Terrett, Peter G Rendell, Massimo Zamuner, Franca Stablum
OBJECTIVE: Previous studies have shown that traumatic brain injury (TBI) patients have difficulties with prospective memory (PM). Considering that PM is closely linked to independent living it is of primary interest to develop strategies that can improve PM performance in TBI patients. METHOD: This study employed Virtual Week task as a measure of PM, and we included future event simulation to boost PM performance. Study 1 evaluated the efficacy of the strategy and investigated possible practice effects...
January 17, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28093370/a-comparison-of-locomotor-therapy-interventions-partial-body-weight-supported-treadmill-lokomat%C3%A2-and-g-eo%C3%A2-training-in-persons-with-traumatic-brain-injury
#16
Alberto Esquenazi, Stella Lee, Amanda Wikoff, Andrew Packel, Theresa Toczylowski, John Feeley
BACKGROUND: Literature in the application of gait training techniques in persons with traumatic brain injury is limited. Current techniques require of multiple staff and are physically demanding. The use of a robotic locomotor training may provide improved training capacity for this population. OBJECTIVE: To examine the impact of three different modes of locomotor therapy on gait velocity and spatiotemporal symmetry using: an end effector robot (G-EO™); a robotic exoskeleton (Lokomat®) and manual assisted partial-body weight supported treadmill training (PBWSTT) in participants with traumatic brain injury...
January 13, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28093052/erk-nrf2-ho-1-pathway-mediated-mitophagy-alleviates-traumatic-brain-injury-induced-intestinal-mucosa-damage-and-epithelial-barrier-dysfunction
#17
Yinlong Liu, Zhongyuan Bao, Xiupeng Xu, Honglu Chao, Chao Lin, Zheng Li, Yan Liu, Xiaoming Wang, Yongping You, Ning Liu, Jing Ji
Gastrointestinal dysfunction is one of several physiologic complications in patients with traumatic brain injury (TBI). TBI can result in increased intestinal permeability due to apoptosis of intestinal epithelial cells, which contain a large number of mitochondria for persisting barrier function. Autophagy of damaged mitochondria (mitophagy) controls the quality of the mitochondria and regulates cellular homeostasis. However, the exact mechanism of mitophagy that underlies the pathological changes induced by TBI is unknown...
January 16, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28092286/childhood-traumatic-brain-injury-and-the-associations-with-risk-behavior-in-adolescence-and-young-adulthood-a-systematic-review
#18
Eleanor Kennedy, Miriam Cohen, Marcus Munafò
OBJECTIVE: To systematically review the evidence that childhood traumatic brain injury (TBI) is associated with risk behavior in adolescence and young adulthood. Risk behavior included one or more of the following: use of substances, including alcohol, tobacco, and illicit substances; involvement in criminal behavior; and behavioral issues with conduct. METHODS: A literature search was conducted using these terms: child, pediatric, traumatic brain injury, head injury, adolescent, psychosocial, antisocial, conduct, substance use...
January 13, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28092022/relevance-of-neuroimaging-for-neurocognitive-and-behavioral-outcome-after-pediatric-traumatic-brain-injury
#19
Marsh Königs, Petra Jw Pouwels, L W Ernest van Heurn, Roel Bakx, R Jeroen Vermeulen, J Carel Goslings, Bwee Tien Poll-The, Marleen van der Wees, Coriene E Catsman-Berrevoets, Jaap Oosterlaan
This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8-14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mild(RF+), n = 20) or moderate/severe TBI (n = 17) at 2.8 years post-injury. Neuroimaging measures included: acute computed tomography (CT), volumetric analysis on post-acute conventional T1-weighted magnetic resonance imaging (MRI) and post-acute diffusion tensor imaging (DTI, analyzed using tract-based spatial statistics and voxel-wise regression)...
January 14, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28091809/a-review-of-penetrating-brain-trauma-epidemiology-pathophysiology-imaging-assessment-complications-and-treatment
#20
REVIEW
Mona T Vakil, Ajay K Singh
Gunshot injuries are the most common cause of penetrating brain injury (PBI) and carry a high morbidity and mortality. The incidence of PBI has increased over the last decade with an estimated 35,000 civilian deaths annually. Patients that survive to reach the hospital require rapid triage and imaging evaluation. CT findings in conjunction with the Glasgow Coma Scale are typically used to determine which patients are surgical candidates. Radiologists should be familiar with the various injury patterns and imaging findings which are poor prognostic indicators, notably brainstem, bilateral hemispheric, multilobar, or transventricular injuries...
January 14, 2017: Emergency Radiology
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