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Hepatic resection

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https://www.readbyqxmd.com/read/29050350/surgical-resection-for-hepatic-metastasis-from-gastric-cancer-a-multi-institution-study
#1
Ailin Song, Xiaofeng Zhang, Feng Yu, Debang Li, Wenyu Shao, Yanming Zhou
BACKGROUND: The beneficial effect of surgical resection for hepatic metastasis from gastric cancer (HMGC) remains elusive. This study was conducted to analyze surgical outcomes of HMGC and determine the prognostic factors associated with survival. RESULTS: The in-hospital mortality rate was zero, and the overall morbidity rate was 56%. The overall 1-, 3-, and 5-year survival rate after surgery was 87.5%, 47.6%, and 21.7%, respectively, with a median survival time of 34...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050064/bilateral-anatomic-resection-of-the-ventral-parts-of-the-paramedian-sectors-of-the-liver-with-total-caudate-lobectomy-for-deeply-centrally-located-liver-tumors-a-new-technique-maximizing-both-oncological-and%C3%A2-surgical-safety
#2
Junichi Shindoh, Yujiro Nishioka, Masaji Hashimoto
Systematic resection of the tumor-bearing portal territory is reportedly correlated with an improved survival of patients with liver tumors, especially in hepatocellular carcinoma. Despite advances in surgical management, however, anatomic resection of deeply/centrally located tumors remains a challenging procedure not only with technical difficulty but also because of decreased hepatic functional reserve frequently observed due to underlying liver disease. In this report, we have reported a novel technique that allows a promising approach for deeply/centrally located tumors with maximizing both the surgical and oncological safety...
October 19, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29049129/transjugular-intrahepatic-portosystemic-shunt-placement-before-abdominal-intervention-in-cirrhotic-patients-with-portal-hypertension-lessons-from-a-pilot-study
#3
Nadim Fares, Marie-Angèle Robic, Jean-Marie Péron, Fabrice Muscari, Philippe Otal, Bertrand Suc, Jean-Pierre Vinel, Christophe Bureau
BACKGROUND: Abdominal interventions are usually contraindicated in patients with cirrhosis and portal hypertension because of increased morbidity and mortality. Decreasing portal pressure with transjugular intrahepatic portosystemic shunt (TIPS) may improve patient outcomes. We report our experience with patients treated by neoadjuvant TIPS to identify those who would most benefit from this two-step procedure. PATIENTS AND METHODS: All patients treated by dedicated neoadjuvant TIPS between 2005 and March 2013 in two tertiary referral hospitals were included...
October 18, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29049080/extra-glissonian-approach-for-total-laparoscopic-left-hepatectomy-a-prospective-cohort-study
#4
Huan Wei Chen, Fei Wen Deng, Jian Yuan Hu, Jie Yuan Li, Eric Chun Hung Lai, Wan Yee Lau
Laparoscopic liver resection under hemihepatic vascular inflow control has advantages over Pringle's maneuver, especially in patients with cirrhosis. From January 2016 to August 2016, 7 patients who underwent total laparoscopic left hepatectomy under hemihepatic vascular inflow occlusion using the extra-glissonian approach were included in this study. All were hepatitis B carriers and 4 had cirrhosis. The mean operation time was 247 minutes. The mean transection time was 110 minutes. No patient needed additional Pringle's maneuver...
October 18, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29047142/relevance-of-liver-limited-disease-in-metastatic-colorectal-cancer-subgroup-findings-of-the-fire-3-aio-krk0306-trial
#5
Julian Walter Holch, Ingrid Ricard, Sebastian Stintzing, Ludwig Fischer von Weikersthal, Thomas Decker, Alexander Kiani, Ursula Vehling-Kaiser, Salah-Eddin Al-Batran, Tobias Heintges, Christian Lerchenmüller, Christoph Kahl, Frank Kullmann, Werner Scheithauer, Michael Scholz, Sebastian Müller, Hartmut Link, Andreas Rost, Heinz-Gert Höffkes, Markus Moehler, Reinhard Udo Lindig, Lisa Miller-Phillips, Thomas Kirchner, Andreas Jung, Jobst Christian von Einem, Dominik Paul Modest, Volker Heinemann
In metastatic colorectal cancer (mCRC), liver-limited disease (LLD) is associated with a higher chance of metastectomy leading to long-term survival. However, limited data describes the prognostic and predictive relevance of initially unresectable LLD with regard to targeted first-line therapy. The present analysis investigated the relevance of initially unresectable LLD in mCRC patients treated with targeted therapy against either the epidermal growth factor receptor (EGFR) or vascular epithelial growth factor (VEGF)...
October 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29046795/comparison-of-clinicopathological-characteristics-between-cirrhotic-and-non-cirrhotic-patients-with-intrahepatic-cholangiocarcinoma-a-large-scale-retrospective-study
#6
Lei Yuan, Xianwu Luo, Xinyuan Lu, Bin Yi, Kaijian Chu, Quanyu Cai, Xiaoqing Jiang
The effect of cirrhosis on the characteristics of intrahepatic cholangiocarcinoma (ICC) has not been fully elucidated. The purpose of this study was to investigate how cirrhosis affects the clinicopathological characteristics and survival of surgically treated ICC patients. A total of 1,312 ICC patients surgically treated between January 2007 and December 2011 at a single institution were retrospectively reviewed and the clinicopathological data were compared between cirrhotic and non-cirrhotic patients. Univariate and multivariate analyses were performed to identify significant and independent prognostic factors in this cohort...
October 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29042794/comparison-of-microwave-ablation-and-hepatic-resection-for-hepatocellular-carcinoma-a-meta-analysis
#7
REVIEW
Manka Zhang, Huimin Ma, Jian Zhang, Lingling He, Xiaohui Ye, Xin Li
BACKGROUND AND AIMS: Hepatic resection (HRN) and microwave ablation (MWA) have significant advantages in treating hepatocellular carcinoma; however, it remains unclear which way produces better outcomes. This meta-analysis of cohort studies compared the treatments in terms of effectiveness and safety. METHODS: Six electronic databases (PubMed, Medline, EMBASE, Web of Science, EBSCO, and The Cochrane Library) were retrieved for studies comparing MWA and HRN. The meta-analysis was conducted based on statement of preferred reporting items for systematic reviews and meta-analyses...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29042529/value-of-preoperative-indocyanine-green-clearance-test-for-predicting-post-hepatectomy-liver-failure-in-noncirrhotic-patients
#8
Cem Ibis, Dogan Albayrak, Tayfun Sahiner, Yigit Soytas, Basak Gurtekin, Nukhet Sivrikoz
BACKGROUND Liver failure is the most feared complication following hepatectomy. Post-hepatectomy liver failure (PHLF) is closely related to the remnant liver volume, and functional reserve. There are several methods for predicting PHLF prior to liver resection. The indocyanine green (ICG) clearance test was popularized in patients with hepatocellular cancer (HCC). We aim to demonstrate the value of preoperative ICG clearance measurement via pulse spectrophotometer (LIMON®) in prediction of PHLF in noncirrhotic patients prior to liver resection...
October 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29039050/the-protective-effect-of-fish-oil-lipid-emulsions-on-intestinal-failure-associated-liver-disease-in-a-rat-model-of-short-bowel-syndrome
#9
Seiro Machigashira, Tatsuru Kaji, Shun Onishi, Waka Yamada, Keisuke Yano, Koji Yamada, Ryuta Masuya, Takafumi Kawano, Kazuhiko Nakame, Motoi Mukai, Satoshi Ieiri
PURPOSE: Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis. METHODS: Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group)...
October 16, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29038776/torsion-of-an-accessory-hepatic-lobe-with-embedded-gallbladder-in-an-11-month-old-boy
#10
Chiman Lal Thakral, Ganji Shivalingam, Faizan Manzoor Dar, Nimish Thakral
An accessory lobe of the liver is a rare entity in clinical practice which is diagnosed incidentally. Infrequently, it may present as torsion with a clinical picture of an acute abdomen, a palpable mass, and may be associated with liver function abnormalities. Many of these patients have a history of previous surgery for congenital abdominal wall defects such as omphalocele. We present an extremely rare case of torsion of an accessory hepatic lobe in an 11-month-old male patient who presented in a state of shock...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29035907/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#11
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
October 13, 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29033422/a-case-of-hepatic-pseudolymphoma-with-an-occult-hepatitis-b-virus-infection
#12
Hideo Kunimoto, Daisuke Morihara, Shin-Ichiro Nakane, Takashi Tanaka, Keiji Yokoyama, Akira Anan, Yasuaki Takeyama, Makoto Irie, Satoshi Shakado, Tomoaki Noritomi, Morishige Takeshita, Kengo Yoshimitsu, Shotaro Sakisaka
A 49-year-old woman who was asymptomatic was found to have a small liver tumor on abdominal ultrasonography (US) at her annual health checkup. US revealed a hypoechoic, solid, mass measuring 17-mm in size in segment 6. The tumor markers associated with liver malignancy were negative. An infectious disease screen was negative for hepatitis B surface antigen, but positive for antibody to hepatitis B core antigen. Imaging studies using computed tomography (CT), magnetic resonance imaging (MRI), and CT angiography suggested a malignant liver tumor, such as hepatocellular carcinoma...
October 16, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29030793/right-sided-bochdalek-hernia-in-an-elderly-adult-a-case-report-with-a-review-of-surgical-management
#13
Kazuki Moro, Mikako Kawahara, Yusuke Muneoka, Yu Sato, Chie Kitami, Shigeto Makino, Atsushi Nishimura, Yasuyuki Kawachi, Emmanuel Gabriel, Keiya Nikkuni
BACKGROUND: Bochdalek hernias are one of the most common types of diaphragmatic hernia, with most cases diagnosed during the neonatal period. In contrast, diagnosis of a Bochdalek hernia in an adult is rare and is typically observed on the left side of the diaphragm. Even more rare is the diagnosis of a right-sided Bochdalek hernia in an adult, where there is concurrent visceral malformation in most cases. CASE PRESENTATION: We describe a case of an 89-year-old female who presented with abdominal pain...
October 13, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29028787/relationship-between-pd-l1-expression-and-cd8-t-cell-immune-responses-in-hepatocellular-carcinoma
#14
Chun-Yu Huang, Ying Wang, Guang-Yu Luo, Feng Han, Yong-Qiang Li, Zhong-Guo Zhou, Guo-Liang Xu
As PD-1/PD-L1 immune checkpoint inhibitors exhibited promising clinical outcomes in various types of solid tumors, PD-1/PD-L1 blockades have been explored for the treatment of hepatocellular carcinoma (HCC). However, the association of PD-L1 with antitumor immunoregulation is not clearly defined in HCC. Here, we evaluated the characteristics of PD-L1 expression, CD8 T-cell infiltration and their relationship in HCC. A total of 411 resected tumor specimens from HCC patients were immunostained for PD-L1 and CD8...
November 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29027381/evaluation-of-a-new-energy-device-for-parenchymal-transection-in-laparoscopic-liver-resection
#15
Amr Badawy, Satoru Seo, Rei Toda, Hiroaki Fuji, Takamichi Ishii, Kojiro Taura, Kentaro Yasuchika, Toshimi Kaido, Shinji Uemoto
INTRODUCTION: THUNDERBEAT (TB) is a novel device that uses both ultrasonic and advanced bipolar energies for hemostasis. Several recent human studies have proved the safety and efficacy of TB in different surgical procedures, but there have been no similar studies about its efficacy in hepatic parenchymal transection. Therefore, the aim of the study was to assess the safety and efficacy of the TB device in laparoscopic liver resection. METHODS: This retrospective study compared TB and ultrasonic Harmonic devices in 80 patients who underwent laparoscopic liver resection from 2010 to 2016 in our institution...
October 12, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29025383/repair-of-bile-duct-injury-with-autologous-vein-graft-and-stent
#16
Bin Xie, Haiping Luo, Xinglong Yang, Yanping Zhao, Chongwu He, Xiaobin Wan, Zhitao Xu, Xingwei Yu, Wubo Liu, Qiang Liu
OBJECTIVES: We investigated the effects of autologous vein transplant on bile duct injury repair, through observation of the hepatic and biliary system tissue morphology changes and animal survival after bile duct injury repair. MATERIALS AND METHODS: Rabbits were equally divided into groups. Group A had cholecystectomy and common bile duct resection (length of 0.5 cm), transplant of an autologous vein (length of 0.5 cm), and stent implant. Group B had cholecystectomy and common bile duct resection (length of 1...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29024839/hepatic-artery-aneurysm-causing-gastrointestinal-haemorrhage-case-report-and-literature-review
#17
Saulius Palubinskas, Simon Ladefoged Rasmussen
INTRODUCTION: True hepatic artery aneurysms (HAAs) are rare, and when complicated by gastrointestinal haemorrhage, it becomes an even rarer disease entity. The mortality is high and imaging may fail to provide the diagnosis. We present a case of a true hepatic artery aneurysm complicated by a fistula to the duodenum which was first recognised during surgery. PRESENTATION OF CASE: A 77-year-old man presented with upper gastrointestinal haemorrhage. Upper endoscopy revealed an ulceration in the duodenal bulb, which was refractory to endoscopic treatment...
October 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29024228/de-novo-hepatocellular-carcinoma-post-multivisceral-transplantation-in-a-child
#18
P Tran, S Zhou, L Wang, M Finegold, L Mascarenas, S Alexopolous, Y Genyk, N Kerkar
De novo hepatocellular carcinoma (HCC) post-transplantation in patients without viral hepatitis is extremely rare, with only three reported adult cases in the English literature. Here, we present a case of de novo HCC that developed in a 7-year-old female, who at 8 months of age received a liver, small bowel, spleen, and pancreas transplantation 6.5 years ago for gastroschisis and total parenteral nutrition (TPN)-related cirrhosis. The post-transplant course was complicated by Epstein-Barr virus (EBV) infection, post-transplant lymphoproliferative disease, and subsequent development of multifocal EBV-associated post-transplant smooth muscle tumors (EBV-PTSMT) in the small bowel 1 year and 10 months after transplantation, respectively...
November 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/29023828/impact-of-surveillance-for-hepatocellular-carcinoma-on-survival-in-patients-with-compensated-cirrhosis
#19
Ju Dong Yang, Ajitha Mannalithara, Andrew J Piscitello, John B Kisiel, Gregory J Gores, Lewis R Roberts, W Ray Kim
Surveillance for hepatocellular carcinoma (HCC) has been recommended in patients with cirrhosis. In this work, we examine the extent to which the competing risk of hepatic decompensation influences the benefit of HCC surveillance, by investigating the impact of availability of liver transplantation (LTx) and rate of progression of hepatic decompensation on survival gain from HCC surveillance. A multistate Markov model was constructed simulating a cohort of 50-year old patients with compensated cirrhosis. The primary outcome of interest was all-cause and HCC-specific mortality...
October 12, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023812/polycystic-liver-disease-hepatic-venous-outflow-obstruction-lesions-of-the-non-cystic-parenchyma-have-major-consequences
#20
Louise Barbier, Maxime Ronot, Béatrice Aussilhou, François Cauchy, Claire Francoz, Prof Valérie Vilgrain, Olivier Soubrane, Valérie Paradis, Jacques Belghiti
BACKGROUND: In patients with polycystic liver disease, development of cysts induces hepatic venous outflow obstruction (HVOO) and parenchymal modifications, challenging the paradigm of a normal non-cystic liver parenchyma. The aims were to reappraise the pathology of the non-cystic parenchyma, by focusing on HVOO lesions; and to investigate the association with outflow obstruction at imaging and perioperative course after liver resection. METHODS: This is a retrospective study conducted in one tertiary center between 1993 and 2014...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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