keyword
MENU ▼
Read by QxMD icon Read
search

Autism GI disorders

keyword
https://www.readbyqxmd.com/read/29614380/serotonin-as-a-link-between-the-gut-brain-microbiome-axis-in-autism-spectrum-disorders
#1
REVIEW
Narek Israelyan, Kara Gross Margolis
Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a correlation between GI dysfunction and the degree of social impairment in ASD. The etiology of GI abnormalities in ASD is unclear, though the association between GI dysfunction and ASD-associated behaviors suggest that overlapping developmental defects in the brain and the intestine and/or a defect in communication between the enteric and central nervous systems (ENS and CNS, respectively), known as the gut-brain axis, could be responsible for the observed phenotypes...
March 31, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29600698/role-of-microbiota-in-the-autism-spectrum-disorders
#2
Daniela Campion, Paola Ponzo, Carlo Alessandria, Giorgio M Saracco, Federico Balzola
Autism Spectrum Disorder (ASD) defines a set of neurodevelopmental disorders characterized by persistent deficits in social communication and interaction, along with repetitive patterns of behavior. Symptoms generally appear in the early developmental period and cause significant impairment in individual and social functioning. In recent years the increased prevalence of ASD, along with the evidence of a significant link between autism and gastrointestinal (GI) disturbances, raised a special interest in exploringì the reciprocal influences between gut and brain...
March 30, 2018: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/29571898/differential-immune-responses-and-microbiota-profiles-in-children-with-autism-spectrum-disorders-and-co-morbid-gastrointestinal-symptoms
#3
Destanie R Rose, Houa Yang, Gloria Serena, Craig Sturgeon, Bing Ma, Milo Careaga, Heather K Hughes, Kathy Angkustsiri, Melissa Rose, Irva Hertz-Picciotto, Judy Van de Water, Robin L Hansen, Jacques Ravel, Alessio Fasano, Paul Ashwood
OBJECTIVES: Many studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these findings to ASD children without GI issues or similarly aged typical developing children. The aim of this study was to determine whether there are biological signatures in terms of immune dysfunction and microbiota composition in children with ASD with GI symptoms...
March 20, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29541439/network-specific-sex-differentiation-of-intrinsic-brain-function-in-males-with-autism
#4
Dorothea L Floris, Meng-Chuan Lai, Tanmay Nath, Michael P Milham, Adriana Di Martino
Background: The male predominance in the prevalence of autism spectrum disorder (ASD) has motivated research on sex differentiation in ASD. Multiple sources of evidence have suggested a neurophenotypic convergence of ASD-related characteristics and typical sex differences. Two existing, albeit competing, models provide predictions on such neurophenotypic convergence. These two models are testable with neuroimaging. Specifically, the Extreme Male Brain (EMB) model predicts that ASD is associated with enhanced brain maleness in both males and females with ASD (i...
2018: Molecular Autism
https://www.readbyqxmd.com/read/29385740/effects-of-combining-medication-and-pivotal-response-treatment-on-aberrant-behavior-in-children-with-autism-spectrum-disorder
#5
Mohammad Rezaei, AliReza Moradi, Mehdi Tehrani-Doost, HamidReza Hassanabadi, Reza Khosroabadi
Abstract: The purpose of this study was to investigate the effects of combined risperidone (RIS) and pivotal response treatment (PRT) on children with autism spectrum disorder (ASD). A total of 34 children diagnosed with ASD according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V) (mean age of 12.36 years) were randomly assigned to either of two groups; the first group (n = 17) received combined PRT-RIS while the second group (n = 17) received RIS only. Behavioral problems were evaluated with the Aberrant Behavior Checklist (ABC), whereas global improvement (GI) was measured with the Clinical Global Impressions (CGI)...
January 30, 2018: Children
https://www.readbyqxmd.com/read/29274915/differences-in-fecal-microbial-metabolites-and-microbiota-of-children-with-autism-spectrum-disorders
#6
Dae-Wook Kang, Zehra Esra Ilhan, Nancy G Isern, David W Hoyt, Daniel P Howsmon, Michael Shaffer, Catherine A Lozupone, Juergen Hahn, James B Adams, Rosa Krajmalnik-Brown
Evidence supporting that gut problems are linked to ASD symptoms has been accumulating both in humans and animal models of ASD. Gut microbes and their metabolites may be linked not only to GI problems but also to ASD behavior symptoms. Despite this high interest, most previous studies have looked mainly at microbial structure, and studies on fecal metabolites are rare in the context of ASD. Thus, we aimed to detect fecal metabolites that may be present at significantly different concentrations between 21 children with ASD and 23 neurotypical children and to investigate its possible link to human gut microbiome...
February 2018: Anaerobe
https://www.readbyqxmd.com/read/29155492/the-prevalence-of-gluten-free-diet-use-among-preschool-children-with-autism-spectrum-disorder
#7
Eric Rubenstein, Laura Schieve, Chyrise Bradley, Carolyn DiGuiseppi, Eric Moody, Kathleen Thomas, Julie Daniels
Our objective was to estimate prevalence of current or ever use of a gluten free diet (GFD) in children aged 30-68 months with autism spectrum disorder (ASD) and population controls (POP); and to identify characteristics associated with ever having used GFD among children with ASD. We used data from the Study to Explore Early Development (SEED), a multi-site, case-control study of children with ASD. Caregivers reported GFD use by their children through structured questionnaires about diet patterns, gastrointestinal (GI) issues, and ASD-specific treatments...
January 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29102384/increased-stool-immunoglobulin-a-level-in-children-with-autism-spectrum-disorders
#8
Jiaxiu Zhou, Fusheng He, Feng Yang, Zheng Yang, Yingjun Xie, Shaoming Zhou, Jingwen Liang, Ruihuan Xu, Yan Wang, Hailiang Guo, Wenhao Zhou, Mingbang Wang
BACKGROUND: There are currently no effective treatments for the core symptoms of autism spectrum disorders (ASDs). However, alleviating gastrointestinal (GI) problems, which are prevalent in ASD patients, can significantly improve the core symptoms of autism. Previous studies have associated GI disorders in ASD patients with abnormal gut microbiota, although few disease-related microorganisms have been identified. Considering that the gut microbiome affects the intestinal immune system and the patient's behavior, and that immunoglobulin A (IgA) is the main antibody secreted by intestinal immune cells, we investigated stool IgA content as a means of understanding the gut immune status of ASD patients...
October 25, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29091821/are-gastrointestinal-and-sleep-problems-associated-with-behavioral-symptoms-of-autism-spectrum-disorder
#9
Xiao-Lei Yang, Shuang Liang, Ming-Yang Zou, Cai-Hong Sun, Pan-Pan Han, Xi-Tao Jiang, Wei Xia, Li-Jie Wu
Many children with autism spectrum disorder (ASD) suffer from concurrent medical symptoms, including gastrointestinal (GI) and sleeping problems. However, there is limited information on the correlation between co-morbidities and autistic behavioral symptoms. In this study, we estimated the prevalence of GI and sleep problems in Chinese ASD children, examined the impacts of GI and sleep problems on autistic behavioral symptoms, and investigated the factors associated with GI and sleep problems. The survey included 169 ASD and 172 healthy children...
January 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29028817/mitochondrial-dysfunction-in-the-gastrointestinal-mucosa-of-children-with-autism-a-blinded-case-control-study
#10
Shannon Rose, Sirish C Bennuri, Katherine F Murray, Timothy Buie, Harland Winter, Richard Eugene Frye
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and can cause GI dysfunction potentially through disruption of mitochondrial function as microbiome metabolites modulate mitochondrial function and mitochondrial dysfunction is highly associated with GI symptoms. In this study, we compared mitochondrial function in rectal and cecum biopsies under the assumption that certain microbiome metabolites, such as butyrate and propionic acid, are more abundant in the cecum as compared to the rectum...
2017: PloS One
https://www.readbyqxmd.com/read/28946927/food-and-the-gut-relevance-to-some-of-the-autisms
#11
Paul Whiteley
Complex, diverse and rarely appearing without comorbidity, the autism spectrum disorders continue to be a source of research interest. With core symptoms variably impacting on social communication skills, the traditional focus of many research efforts has centred on the brain and how genetic and environmental processes impact on brain structure, function and/or connectivity to account for various behavioural presentations. Alongside emerging ideas on autistic traits being present in various clinical states, the autisms, and the overrepresentation of several comorbid conditions impacting on quality of life, other research avenues have opened up...
September 26, 2017: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/28867997/autism-spectrum-disorder-related-functional-connectivity-changes-in-the-language-network-in-children-adolescents-and-adults
#12
Yubu Lee, Bo-Yong Park, Oliver James, Seong-Gi Kim, Hyunjin Park
Autism spectrum disorder (ASD) is a neurodevelopmental disability with global implication. Altered brain connectivity in the language network has frequently been reported in ASD patients using task-based functional magnetic resonance imaging (fMRI) compared to typically developing (TD) participants. Most of these studies have focused on a specific age group or mixed age groups with ASD. In the current study, we investigated age-related changes in functional connectivity related measure, degree centrality (DC), in the language network across three age groups with ASD (113 children, 113 adolescents and 103 adults) using resting-state fMRI data collected from the autism brain imaging data exchange repository...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28861640/bone-mineral-density-in-boys-diagnosed-with-autism-spectrum-disorder-a-case-control-study
#13
Kelly Barnhill, Lucas Ramirez, Alan Gutierrez, Wendy Richardson, C Nathan Marti, Amy Potts, Rebeca Shearer, Claire Schutte, Laura Hewitson
This study compared bone mineral density (BMD) of the spine obtained by dual-energy X-ray absorptiometry (DEXA), nutritional status, biochemical markers, and gastrointestinal (GI) symptoms in 4-8 year old boys with Autism Spectrum Disorder (ASD) with a group of age-matched, healthy boys without ASD. Boys with ASD had significantly lower spine BMD compared to controls but this was not correlated with any biochemical markers, dietary intake of calcium and vitamin D, elimination diet status, or GI symptomology...
November 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28856868/gastrointestinal-symptoms-in-autism-spectrum-disorder-a-review-of-the-literature-on-ascertainment-and-prevalence
#14
REVIEW
Calliope Holingue, Carol Newill, Li-Ching Lee, Pankaj J Pasricha, M Daniele Fallin
There is no standard approach to measuring GI symptoms in individuals with ASD, despite postulated interactions. The objectives of this study were to (a) describe the range of GI symptom ascertainment approaches in studies of ASD, (b) describe the range of prevalence estimates across studies, and (c) assess associations between ascertainment approach and prevalence estimates. Studies published from 1/1/1980 to 1/31/2017 were collected via PubMed. Eligibility included studies with at least ten individuals with ASD that measured GI symptoms or conditions...
January 2018: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28799094/hydrogen-breath-test-to-detect-small-intestinal-bacterial-overgrowth-a-prevalence-case-control-study-in-autism
#15
Li Wang, Yu-Mei Yu, You-Qi Zhang, Jie Zhang, Na Lu, Na Liu
The aim of this study is to assess the prevalence of small intestinal bacterial overgrowth (SIBO) by hydrogen breath test in patients with autism spectrum disorders (ASD) with respect to a consistent control group. From 2011 to 2013, 310 children with ASD and 1240 sex- and age-matched typical children were enrolled in this study to undergo glucose breath test. The study participants were considered to exhibit SIBO when an increase in H2 of ≥20 ppm or CH4 of ≥10 ppm with respect to the fasting value was observed up to 60 min after the ingestion of glucose...
August 10, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28686541/the-role-of-probiotics-in-children-with-autism-spectrum-disorder-a-prospective-open-label-study
#16
Sanaa Y Shaaban, Yasmin G El Gendy, Nayra S Mehanna, Waled M El-Senousy, Howaida S A El-Feki, Khaled Saad, Osama M El-Asheer
OBJECTIVE: There are limited data on the efficacy of probiotics in children with ASD, therefore, this study aims to evaluate the efficacy and tolerability of probiotics in an Egyptian cohort of children with ASD. METHODS: Gastrointestinal (GI) flora were assessed by quantitative real-time PCR of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (ATEC) before and after 3 months of supplementation of probiotics nutritional supplement formula (each gram contains 100 × 10(6) colony forming units of three probiotic strains; Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacteria longum)...
July 7, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28680792/using-animal-models-to-study-the-role-of-the-gut-brain-axis-in-autism
#17
REVIEW
Jess Nithianantharajah, Gayathri K Balasuriya, Ashley E Franks, Elisa L Hill-Yardin
PURPOSE OF REVIEW: Individuals with autism spectrum disorders (ASD) commonly also suffer from gastrointestinal (GI) dysfunction; however, few animal model studies have systematically examined both ASD and GI dysfunction. In this review, we highlight studies investigating GI dysfunction and alterations in gut microbiota in animal models of ASD with the aim of determining if routinely used microbiology and enteric neurophysiology assays could expand our understanding of the link between the two...
2017: Current Developmental Disorders Reports
https://www.readbyqxmd.com/read/28551756/extracerebral-dysfunction-in-animal-models-of-autism-spectrum-disorder
#18
Elisa L Hill-Yardin, Sonja J McKeown, Gaia Novarino, Andreas M Grabrucker
Genetic factors might be largely responsible for the development of autism spectrum disorder (ASD) that alone or in combination with specific environmental risk factors trigger the pathology. Multiple mutations identified in ASD patients that impair synaptic function in the central nervous system are well studied in animal models. How these mutations might interact with other risk factors is not fully understood though. Additionally, how systems outside of the brain are altered in the context of ASD is an emerging area of research...
2017: Advances in Anatomy, Embryology, and Cell Biology
https://www.readbyqxmd.com/read/28536957/brief-report-association-between-autism-spectrum-disorder-gastrointestinal-problems-and-perinatal-risk-factors-within-sibling-pairs
#19
Johan Isaksson, Erik Pettersson, Elzbieta Kostrzewa, Rochellys Diaz Heijtz, Sven Bölte
Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD (N = 217), participated in a web survey covering mother's weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period...
August 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28526761/a-retrospective-chart-review-of-the-features-of-pten-hamartoma-tumour-syndrome-in-children
#20
Emily Hansen-Kiss, Sarah Beinkampen, Brent Adler, Thomas Frazier, Thomas Prior, Steven Erdman, Charis Eng, Gail Herman
OBJECTIVE: It is recognised that 5% - 10 % of children with macrocephaly and autism spectrum disorder (ASD) and/or intellectual disability (ID) have a heterozygous pathogenic mutation in the PTEN tumour suppressor gene that is associated with PTEN hamartoma tumour syndrome. However, the clinical features and course in children with a pathogenic PTEN mutation are unclear and have not been well documented. STUDY OBJECTIVES: We undertook a retrospective chart review of children (< 18  years) with pathogenic PTEN mutations to ascertain clinical findings, clinical course and possible outcomes...
July 2017: Journal of Medical Genetics
keyword
keyword
54890
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"