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https://www.readbyqxmd.com/read/28437561/semiparametric-probit-models-with-univariate-and-bivariate-current-status-data
#1
Hao Liu, Jing Qin
Multivariate current-status data are frequently encountered in biomedical and public health studies. Semiparametric regression models have been extensively studied for univariate current-status data, but most existing estimation procedures are computationally intensive, involving either penalization or smoothing techniques. It becomes more challenging for the analysis of multivariate current-status data. In this article, we study the maximum likelihood estimations for univariate and bivariate current-status data under the semiparametric probit regression models...
April 24, 2017: Biometrics
https://www.readbyqxmd.com/read/28437430/cerebellar-volume-as-imaging-outcome-in-progressive-multiple-sclerosis
#2
Matilde Inglese, Maria Petracca, Enricomaria Mormina, Anat Achiron, Rebecca Straus-Farber, Shmuel Miron, Michelle Fabian, Stephen Krieger, Aaron Miller, Fred Lublin, Maria Pia Sormani
BACKGROUND AND PURPOSE: To assess whether cerebellar volumes changes could represent a sensitive outcome measure in primary-progressive MS. MATERIAL AND METHODS: Changes in cerebellar volumes over one-year follow-up, estimated in 26 primary-progressive MS patients and 20 controls with Freesurfer longitudinal pipeline, were assessed using Wilcoxon test and tested for their correlation with disability worsening by a logistic regression. Clinical worsening was defined as EDSS score increase or change of >20% for 25-foot walk test or 9-hole peg test scores at follow-up...
2017: PloS One
https://www.readbyqxmd.com/read/28436538/longitudinal-magnetic-resonance-imaging-in-progressive-supranuclear-palsy-a-new-combined-score-for-clinical-trials
#3
Günter U Höglinger, Jakob Schöpe, Maria Stamelou, Jan Kassubek, Teodoro Del Ser, Adam L Boxer, Stefan Wagenpfeil, Hans-Jürgen Huppertz
BACKGROUND: Two recent, randomized, placebo-controlled phase II/III trials (clinicaltrials.gov: NCT01110720, NCT01049399) of davunetide and tideglusib in progressive supranuclear palsy (PSP) generated prospective, 1-year longitudinal datasets of high-resolution T1-weighted three-dimensional MRI. OBJECTIVE: The objective of this study was to develop a quantitative MRI disease progression measurement for clinical trials. METHODS: The authors performed a fully automated quantitative MRI analysis employing atlas-based volumetry and provide sample size calculations based on data collected in 99 PSP patients assigned to placebo in these trials...
April 24, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28435752/preliminary-hawai-i-public-health-workforce-supply-and-demand-assessment
#4
Katherine W Braden, Valerie Yontz, Kelley Withy
Ensuring the adequacy of the public health workforce requires an understanding of its size and composition, as well as the population's demand for services. The current article describes research undertaken as a first step toward developing an estimate of the supply of and demand for Hawai'i's public health workforce. Using an organizational-level survey, data was obtained from a subset of 34 organizations considered to be major providers of population-based public health services in Hawai'i. The results indicate that estimates of the existing public health workforce range from 3,429 to 3,846 workers...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28433405/epidemiology-of-toxoplasma-gondii-among-blood-donors-in-iran-a-systematic-review-and-meta-analysis
#5
REVIEW
Akram Mansouri, Mohammad Reza Adhami Mojarad, Gholamreza Badfar, Lila Abasian, Shoboo Rahmati, Wesam Kooti, Mohammad Hossein YektaKooshali, Ali Soleymani, Milad Azami
INTRODUCTION: Asymptomatic Toxoplasma gondii transmitted from blood donors to receiving patients has become a concern. Numerous articles have been published on the epidemiology of T. gondii in blood donors in Iran and a systematic review of the results shows quite different findings, hence this study was conducted to determine the seroprevalence of T. gondii in Iranian blood donors using meta-analysis. METHODS: We searched for epidemiological studies that were published until July 2016 in eight English databases including: Scopus, PubMed, Ovid, Science Direct, Cochrane, Web of Science, Springer, Wiley Online Library, and four Iranian databases: Magiran, Iranmedex, SID and Medlib as well as Google Scholar...
March 29, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28433021/to-kink-or-not-a-search-for-long-chain-cumulenones-using-microwave-spectral-taxonomy
#6
Michael C McCarthy, Luyao Zou, Marie-Aline Martin-Drumel
A systematic search for carbon-chain cumulenones beyond H2C4O has been undertaken using microwave spectral taxonomy in combination with a pulsed jet discharge source. No evidence was found for the C2υ isomer of H2C5O or its longer derivatives, but HC(O)C4H, the longer variant of propynal, HC(O)CCH, was identified instead. Its rotational and leading centrifugal distortion constants have been derived to high accuracy from detection of both a- and b-type lines; those below 40 GHz were measured using a Fabry-Perot cavity, while lines between 40 and 72 GHz were recorded by double resonance techniques...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28431324/achievable-separation-performance-and-analysis-time-in-current-liquid-chromatographic-practice-for-monoclonal-antibody-separations
#7
Szabolcs Fekete, Jean-Luc Veuthey, Davy Guillarme
The separation performance of a chromatographic system is often described in terms of column efficiency and peak capacity. Thanks to the new developments in column technology over the past few years, the achievable peak capacity drastically improved and the analysis time can be significantly shortened. Indeed, highly efficient wide-pore reversed-phase (RPLC) materials packed with small fully porous and superficially porous particles can be successfully used for the analytical characterization of therapeutic proteins...
April 12, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28430712/apolipoprotein-e-variants-and-genetic-susceptibility-to-combat-related-post-traumatic-stress-disorder-a-meta-analysis
#8
Yang Roby
BACKGROUND: Apolipoprotein E (APOE) has recently been studied as a risk factor for association with developing combat-related post-traumatic stress disorder (PTSD) in the military population. These studies have yielded inconsistent findings. The present study carried out a meta-analysis to establish whether the APOE polymorphism confers increased susceptibility to combat-related PTSD. METHODS: PubMed, Medline, Embase, PsycInfo, and Google Scholar were searched for potential publications relating to patients with PTSD in military settings with combat exposure...
April 18, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/28430629/vascular-endothelial-growth-factor-a-polymorphisms-are-associated-with-increased-risk-of-coronary-heart-disease-a-meta-analysis
#9
Yafeng Wang, Qiuyu Huang, Jianchao Liu, Yanan Wang, Gongfeng Zheng, Ling Lin, Hui Yu, Weifeng Tang, Ziyang Huang
Coronary heart disease (CHD) is a common complex disease resulting from the interaction of multiple environmental and genetic factors. To assess the potential relationship of vascular endothelial growth factor (VEGFA) rs699947 C>A, rs3025039 C>T and rs2010963 G>C polymorphisms with CHD risk, a comprehensive meta-analysis was conducted. A systematic search of EMBASE and PubMed online database for publications on VEGFA polymorphisms and risk of CHD was carried out. Crude Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated to determine the association...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429644/a-systematic-review-of-discomfort-due-to-toe-or-ear-clipping-in-laboratory-rodents
#10
Kimberley E Wever, Florentine J Geessink, Michelle A E Brouwer, Alice Tillema, Merel Ritskes-Hoitinga
Toe clipping and ear clipping (also ear notching or ear punching) are frequently used methods for individual identification of laboratory rodents. These procedures potentially cause severe discomfort, which can reduce animal welfare and distort experimental results. However, no systematic summary of the evidence on this topic currently exists. We conducted a systematic review of the evidence for discomfort due to toe or ear clipping in rodents. The review methodology was pre-specified in a registered review protocol...
January 1, 2017: Laboratory Animals
https://www.readbyqxmd.com/read/28429605/parent-perspectives-on-home-participation-of-high-functioning-children-with-autism-spectrum-disorder-compared-with-a-matched-group-of-children-without-autism-spectrum-disorder
#11
Snæfrídur T Egilson, Gunnhildur Jakobsdóttir, Linda B Ólafsdóttir
Few studies have focused on home participation of high-functioning children with autism spectrum disorder. We employed a mixed-methods design to explore and compare parent perspectives on (1) participation of children with and without autism spectrum disorder in activities at home, (2) the environmental features and resources that affect these children's home participation and (3) the strategies parents use to help their children participate at home. The Participation and Environment Measure for Children and Youth (PEM-CY) was used to gather online survey and qualitative data from parents of 99 high-functioning children with autism spectrum disorder and 241 children without autism spectrum disorder...
April 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/28429137/women-s-alcohol-consumption-and-cumulative-incidence-of-live-birth-following-in-vitro-fertilization
#12
L E Dodge, S A Missmer, K L Thornton, M R Hacker
OBJECTIVE: The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF). DESIGN: This study is a retrospective cohort study. SETTING: This study was performed in a private academically affiliated IVF center. PATIENTS: Patients included women presenting for their first IVF cycle from July 2004 through October 2012. INTERVENTION: Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption...
April 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28427463/combination-of-sofosbuvir-pegylated-interferon-and-ribavirin-for-treatment-of-hepatitis-c-virus-genotype-1-infection-a-systematic-review-and-meta-analysis
#13
Fardin Dolatimehr, Hamidreza Karimi-Sari, Mohammad Saeid Rezaee-Zavareh, Seyed Moayed Alavian, Bita Behnava, Mohammad Gholami-Fesharaki, Heidar Sharafi
BACKGROUND: Hepatitis C virus (HCV) infection is an important cause of chronic liver disease which has been affected 3% of world's population. Some studies have shown that adding Sofosbuvir (SOF), an HCV polymerase inhibitor to the conventional therapy of Pegylated-interferon (PegIFN) plus Ribavirin (RBV) can increase the rate of sustained virologic response (SVR) among HCV-infected patients. This study was conducted to determine the effect of combination therapy with PegIFN and RBV plus SOF for chronic hepatitis C genotype 1 infection using systematic review with meta-analysis...
April 20, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28427044/on-the-reverse-micelle-effect-in-liquid-scintillation-counting
#14
Youcef Nedjadi, Jean-Pascal Laedermann, François Bochud, Claude Bailat
This work looks into the tracks of electrons in nanoemulsive scintillating media using the Monte Carlo Geant4-DNA code which simulates event-by-event interactions of electrons in liquid water down to the eV, without resorting to the condensed history method. It demonstrates that the average number of micelles in which electrons deposit energy is quite large, increasing with their emission energy, decreasing with micelle size, and rising with micelle concentration. The probability of an electron ending its track in a micelle is found to be rather large and micelle size-dependent below 1keV, and approximating the aqueous fraction at higher energies...
April 12, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28424937/model-to-predict-cause-specific-mortality-in-patients-with-head-and-neck-adenoid-cystic-carcinoma-a-competing-risk-analysis
#15
Weidong Shen, Naoko Sakamoto, Limin Yang
PURPOSE: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease. METHODS: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset...
April 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28424064/effectiveness-of-triple-therapy-with-direct-acting-antivirals-for-hepatitis-c-genotype-1-infection-application-of-propensity-score-matching-in-a-national-hcv-treatment-registry
#16
Emma Gray, David J Pasta, Suzanne Norris, Aisling O'Leary
BACKGROUND: Observational studies are used to measure the effectiveness of an intervention in non-experimental, real world scenarios at the population level and are recognised as an important component of the evidence pyramid. Such data can be accrued through prospective cohort studies and a patient registry is a proven method for this type of study. The national hepatitis C (HCV) registry was established in Ireland in 2012 with the aim of monitoring the clinical and economic outcomes from new, high cost regimens for the treatment of HCV infection...
April 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28421453/psychological-determinants-of-medication-adherence-in-stroke-survivors-a-systematic-review-of-observational-studies
#17
Elise Crayton, Marion Fahey, Mark Ashworth, Sarah Jane Besser, John Weinman, Alison J Wright
BACKGROUND: Medications targeting stroke risk factors have shown good efficacy, yet adherence is suboptimal. To improve adherence, its determinants must be understood. To date, no systematic review has mapped identified determinants into the Theoretical Domains Framework (TDF) in order to establish a more complete understanding of medication adherence. PURPOSE: The aim of this study was to identify psychological determinants that most influence stroke survivors' medication adherence...
April 18, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28420380/educational-status-as-determinant-of-men-s-knowledge-about-vasectomy-in-dangila-town-administration-amhara-region-northwest-ethiopia
#18
Abrham Jemberie Temach, Gedefaw Abeje Fekadu, Anemaw Asrat Achamyeleh
BACKGROUND: Although vasectomy is effective and less expensive contraceptive method, only few men are using it in Africa. The main reason for low level use may be low knowledge about vasectomy among men. Only few studies tried to investigate level of knowledge of vasectomy among married men in Ethiopia. But these studies have limitations in measuring knowledge. This study was therefore designed to assess knowledge of vasectomy among married men in Dangila town. METHOD: A community based cross sectional study was conducted in Dangila town...
April 18, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28418779/determining-a-successful-nasal-airway-surgery-calculation-of-the-patient-centered-minimum-important-difference
#19
Hedyeh Ziai, James P Bonaparte
Objective Determine whether the patient-identified minimum important difference (MID) in Nasal Obstruction Symptom Evaluation (NOSE) score differs from a statistically calculated estimate of MID in patients with septal deviation undergoing nasal airway surgery. Study Design Prospective cohort. Setting Tertiary academic referral center. Subjects Patients with nasal obstruction due to septal deviation. Methods Patients completed the NOSE questionnaire preoperatively and indicated the change from their baseline score that they would consider the minimum improvement required to define the septoplasty with turbinate reduction as successful...
April 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28416099/statin-use-and-risk-of-new-onset-diabetes-a-meta-analysis-of-observational-studies
#20
M Casula, F Mozzanica, L Scotti, E Tragni, A Pirillo, G Corrao, A L Catapano
BACKGROUND AND AIMS: Meta-analyses of randomized control trials investigating the association between incident diabetes and statin use showed an increased risk of new-onset diabetes (NOD) from 9% to 13% associated with statins. However, short follow-up period, unpowered sample size, and lack of pre-specified diagnostic criteria for diabetes detection could be responsible of an underestimation of this risk. We conducted a meta-analysis of published observational studies to evaluate the association between statins use and risk of NOD...
March 10, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
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