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Esophageal Cancer Recurance

Dimitrios E Sigounas, Sandeep Siddhi, John N Plevris
BACKGROUND AND STUDY AIMS: Biodegradable (BD) esophageal stents were recently developed mainly for refractory benign strictures, but experience and available literature are limited. PATIENTS AND METHODS: This was a retrospective observational study. All patients who had BD stents inserted due to refractory benign esophageal strictures or malignant strictures, or were awaiting radical radiotherapy/chemotherapy or neo-adjuvant therapy and esophagectomy between March 2011 and July 2015 were included...
June 2016: Endoscopy International Open
Elżbieta Andrysiak-Mamos, Ewa Żochowska, Agnieszka Kaźmierczyk-Puchalska, Michał Popow, Dorota Kaczmarska-Turek, Janusz Pachucki, Tomasz Bednarczuk, Anhelli Syrenicz
INTRODUCTION: Hypocalcaemia is a common postoperative complication, both after the resection of parathyroid adenoma associated with primary hyperparathyroidism and after total thyroidectomy due to thyroid cancer or nodular goitre. For a few years, in patients with postoperative hypoparathyroidism and severe hypocalcaemia, who cannot discontinue intravenous calcium preparations even with the use of high vitamin D doses, attempts have been made to add recombinant human parathormone (rhPTH) to the treatment schedule...
2016: Endokrynologia Polska
Naoya Yoshida, Yoshifumi Baba, Hironobu Shigaki, Kazuto Harada, Masaaki Iwatsuki, Yasuo Sakamoto, Yuji Miyamoto, Junji Kurashige, Keisuke Kosumi, Ryuma Tokunaga, Masayuki Watanabe, Hideo Baba
BACKGROUND: Esophagectomy following neoadjuvant chemotherapy (NAC) is a standard treatment for resectable advanced esophageal cancer in Japan. However, approximately 10 % of patients with resectable advanced esophageal cancer experience recurrence within 6 months. METHODS: One hundred twenty-eight patients with resectable advanced esophageal cancer underwent NAC between October 2008 and July 2015 in Kumamoto University Hospital. Among them, 82 patients with esophageal squamous cell carcinoma (SCC), who underwent curative esophagectomy without adjuvant treatment, were eligible...
June 2, 2016: International Journal of Clinical Oncology
Aanand D Naik, Lindsey A Martin, Jennifer Moye, Michele J Karel
OBJECTIVES: To identify a taxonomy of health-related values that frame goals of care of older, multimorbid adults who recently faced cancer diagnosis and treatment. DESIGN: Qualitative analysis of data from a longitudinal cohort study of multimorbid cancer survivors. SETTING: Cancer registries from regional Department of Veterans Affairs networks in New England and southeast Texas. PARTICIPANTS: Multimorbid adults who completed interviews 12 months after diagnosis of head and neck, colorectal, gastric, or esophageal cancer and after cancer treatment (N = 146)...
March 2016: Journal of the American Geriatrics Society
Itasu Ninomiya, Koichi Okamoto, Tomoya Tsukada, Jun Kinoshita, Katsunobu Oyama, Sachio Fushida, Harushi Osugi, Tetsuo Ohta
The aim of the present study was to clarify the therapeutic effect of thoracoscopic esophagectomy with radical lymph node dissection based on the recurrence pattern, and identify the risk factors for relapse-free survival in patients with esophageal cancer. The recurrence patterns in 140 patients who underwent complete thoracoscopic radical esophagectomy between January 2003 and December 2012 were investigated. The risk factors for recurrence were examined by univariate and multivariate analysis. Mediastinal recurrence in association with initial lymphatic metastasis was precisely analyzed...
February 2016: Molecular and Clinical Oncology
Yusuke Sato, Satoru Motoyama, Hajime Saito, Yoshihiro Minamiya
There is no doubt that, along with surgery, chemoradiotherapy is an important treatment for esophageal squamous cell carcinoma (ESCC). Patients who respond well to chemoradiotherapy obtain great benefits toward overcoming their cancer, and so a more favorable prognosis. On the other hand, patients who do not respond well have wasted valuable time and experienced severe toxicity and seriously diminished quality of life, only to have their cancer recur with an unfavorable prognosis. For this reason, a reliable biomarker of chemoradiosensitivity in ESCC has long been sought...
2016: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Ansheng Ling, Fanglai Zhu, Ping Wu, Chongwen Fang, Fuliu Cao
OBJECTIVE: To evaluate the safety and prognosis for patients with early esophageal cancer and precancerous lesions after endoscopic submucosal dissection (ESD).
 METHODS: A total of 89 patients were admitted to the Department of internal medicine in the First People's Hospital of Anqing from August 2008 to August 2011. All patients were treated with ESD at the early stage of esophageal cancer and precancerous lesions. The patients' laboratory data and relevant medical history were collected...
January 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
Gabriella Alexandersson von Döbeln, Magnus Nilsson, Gunnar Adell, Gjermund Johnsen, Ingunn Hatlevoll, Jon Tsai, Lars Lundell, Mikael Lund, Pehr Lind
PURPOSE: Curative treatment of esophageal cancer is accompanied by frequent and sometimes severe side effects. However, prospectively collected data on side effects are scarce. The aim of this study was to evaluate if pulmonary function and exercise capacity were affected in the acute setting after neoadjuvant treatment and if there were long-lasting effects after neoadjuvant treatment and surgery. We also aimed to investigate whether the addition of radiation therapy to chemotherapy would aggravate side effects...
May 2016: Practical Radiation Oncology
Denggui Wen, Liwei Zhang, Xiaoling Wang, Yongwei Li, Caifeng Ma, Xu Liu, Junli Zhang, Xiaoduo Wen, Yi Yang, Fuzhi Zhang, Shijie Wang, Baoen Shan
BACKGROUND AND AIM: This study aimed to estimate the time to precursor progression and to identify significant predicators. METHODS: One hundred thirty-three precursor and 311 normal cases detected in a population-based screening were surveyed for 5.5 years. Precursor progression was defined as worsening of dysplasia or development of a new precursor. Time to precursor progression was estimated by the Kaplan-Meier method. Significant predicators were estimated by Cox proportional regression...
December 2015: Journal of Gastroenterology and Hepatology
Takashi Takenoya, Yukari Kobayashi, Kouichi Suda, Kazuki Shimizu, Masahiro Kikuichi
A 62-year-old man with lower rectal cancer underwent abdominoperineal resection and dissection of the lateral pelvic lymph nodes. The cancer was staged at pT3pN0cM0, pStage II and did not show recurrence. Two years later, the patient had dysphagia and was diagnosed with esophageal cancer based on upper gastrointestinal endoscopy. Positron emission tomography-computed tomography (PET/CT) performed to detect distant metastasis revealed fluorodeoxyglucose (FDG) uptake in the left obturator lymph nodes, indicating rectal cancer recurrence...
November 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Khaldoun Almhanna, Sarah Hoffe, Jonathan Strosberg, William Dinwoodie, Kenneth Meredith, Ravi Shridhar
BACKGROUND: Neoadjuvant concurrent chemoradiotherapy (CCRT) has become the standard treatment for esophageal cancer (EC) in North America. The cisplatin/5-flurouracil (5-FU) combination has been the most commonly used regimen. For the last 15 years we incorporated a daily continuous infusion of 5-FU and 2 doses of cisplatin into our neoadjuvant CCRT for potentially resectable EC. PATIENTS AND METHODS: Between July 1997 and June 2012, 129 patients with locally advanced EC (T3 or N1 and higher), received neoadjuvant CCRT with cisplatin 75 mg/m(2) on day 1 and day 29 and continuous infusion of 5-FU (225 mg/m(2)/day) on the days of radiation...
February 2015: Journal of Gastrointestinal Oncology
Naoyuki Nogami, Nagio Takigawa, Katsuyuki Hotta, Yoshihiko Segawa, Yuka Kato, Toshiyuki Kozuki, Isao Oze, Daizo Kishino, Keisuke Aoe, Hiroshi Ueoka, Shoichi Kuyama, Shingo Harita, Toshiaki Okada, Shinobu Hosokawa, Koji Inoue, Kenichi Gemba, Takuo Shibayama, Masahiro Tabata, Mitsuhiro Takemoto, Susumu Kanazawa, Mitsune Tanimoto, Katsuyuki Kiura
BACKGROUND: Although cisplatin-based chemotherapy combined with thoracic irradiation (TRT) is a standard treatment for unresectable, locally advanced non-small cell lung cancer (NSCLC), this treatment outcome has remained unsatisfactory. We had previously conducted a phase I trial of cisplatin plus S-1, an oral 5-fluorouracil derivative, and TRT, which were safe and effective. METHODS: In this phase II trial, 48 patients with stage III NSCLC received cisplatin (40mg/m(2) on days 1, 8, 29 and 36) and S-1 (80mg/m(2) on days 1-14 and 29-42) and TRT (60Gy)...
February 2015: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Hiroshi Nemoto, Genshu Tate, Takahiro Umemoto, Taketo Matsubara, Hiroki Mizukami, Mitsuo Saito, Gaku Kigawa, Akihiko Matsumiya, Junichi Tanaka
A 69-year-old man was diagnosed with advanced esophageal cancer(well-differentiated squamous cell carcinoma). Neoadjuvant chemotherapy consisting of nedaplatin and 5-fluorouracil(5-FU)was initiated. After two courses of chemotherapy, the patient was judged to have achieved a clinical complete response. The patient then decided against undergoing surgery and opted instead to continue with the chemotherapy, receiving five courses in total. However, the esophageal cancer recurred, and subtotal esophagectomy was performed in January 2011...
July 2014: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Cui Li Lin, Kenneth Meredith, Jason Klapman
GOALS: The goal of this study was to determine the luminal recurrence rate of asymptomatic patients undergoing annual surveillance esophagogastroduodenoscopy (EGD). BACKGROUND: Current guidelines recommend surveillance EGD in postesophagectomy patients with esophageal cancer if there is clinical suspicion of local recurrence. However, many patients undergo annual surveillance EGD despite the recommendations to the contrary. STUDY: A query was performed of all patients who underwent esophagectomy between January 2000 and April 2010 at Moffitt Cancer Center...
September 2015: Journal of Clinical Gastroenterology
Takeshi Shimakawa, Shinichi Asaka, Atsuko Usuda, Kentaro Yamaguchi, Kazuhiko Yoshimatsu, Shunichi Shiozawa, Takao Katsube, Yoshihiko Naritaka
There are very few reports of esophageal G-CSF-producing cancer. This report describes a case of G-CSF-producing esophageal squamous cell carcinoma we recently encountered. A 70-year-old male patient had Stage III esophageal squamous cell carcinoma. The patient received preoperative chemotherapy, and therapeutic response for the primary lesion was rated as complete response and that of the lymph node metastasis as stable disease. A radical operation was then performed. A relapse to neutrophilia occurred as liver metastasis recurred postoperation, and serum G-CSF level was high...
May 2014: International Surgery
Yongshun Chen, Xiaohong Li, Haijun Yang, Yubing Xia, Leiming Guo, Xiaoyuan Wu, Chunyu He, You Lu
There is cumulative evidence that stromal reaction in cancer has an important diagnostic and prognostic significance. The aims of this study were to analyze the expression of basic fibroblast growth factor (FGF-2), CD31, and α-smooth muscle actin (SMA) in esophageal cancer patients and to establish their significance as indicators of disease recurrence after definitive chemoradiation (CRT). Protein expressions of FGF-2, CD31, and SMA were evaluated by immunohistochemistry and Western blot analysis in 70 patients, 20 with esophageal squamous cell carcinoma (ESCC) and 50 with locally recurrent ESCC after definitive CRT...
July 2014: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Vani J A Konda, Mariano Gonzalez Haba Ruiz, Ann Koons, John Hart, Shu-Yuan Xiao, Uzma D Siddiqui, Mark K Ferguson, Mitchell Posner, Marco G Patti, Irving Waxman
BACKGROUND & AIMS: Barrett's esophagus (BE) with high-grade dysplasia (HGD) or intramucosal carcinoma (IMC) is treated by complete eradication of areas of BE by endoscopic mucosal resection (EMR). By using this approach, histologic analysis also can be performed. We investigated the effectiveness, safety, and durability of this approach, as well as its use in diagnosis after a single referral. METHODS: We collected data from 107 patients who were referred to the Center for Endoscopic Research and Therapeutics at the University of Chicago for BE (mean length, 3...
December 2014: Clinical Gastroenterology and Hepatology
Frieder Berr, Andrej Wagner, Tobias Kiesslich, Paul Friesenbichler, Daniel Neureiter
BACKGROUNDS/AIMS: Endoscopic submucosal dissection (ESD) of early cancer allows precise staging and avoids recurrence or surgery. Tutored by experts, ESD has rapidly spread in Japan, but still demands untutored learning in Western countries. A step-up approach starts with easiest gastric neoplasias, but fails on their low prevalence in Western countries. A prevalence-based approach includes challenging colonic neoplasias. METHODS: We analyzed an untutored series of initial 50 ESD procedures by an experienced endoscopist on consecutive lesions referred according to prevalence...
2014: Digestion
Hideomi Yamashita, Kae Okuma, Akihiro Nomoto, Mami Yamashita, Hiroshi Igaki, Keiichi Nakagawa
We report on a patient who remained cancer-free for an extended time after palliative radiotherapy (RT) and chemotherapy (nedaplatin plus 5-fluorouracil) treatment for stage IV (cT3N3M1) esophageal squamous cell carcinoma. Although multiple lymph nodes outside the RT field recurred, the local primary tumor within the RT field did not recur, even 17 mo after palliative RT of 30 Gy in 10 fractions. In this case, acute toxicity, such as myelosuppression or esophagitis, was not enhanced by increasing the fraction dose from 1...
February 15, 2014: World Journal of Gastrointestinal Oncology
Shuhua Cai, Anhui Shi, Rong Yu, Guangying Zhu
PURPOSE: To analyze the feasibility of omitting clinical target volume (CTV) for limited small cell lung cancer treated with chemotherapy and intensity modulated radiotherapy. METHODS AND MATERIALS: 89 patients were treated from January 1, 2008 to August 31, 2011, 54 cases were irradiated with target volume without CTV, and 35 cases were irradiated with CTV. Both arms were irradiated post chemotherapy tumor extent and omitted elective nodal irradiation; dose prescription was 95% PTV56-63 Gy/28-35 F/5...
2014: Radiation Oncology
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