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JOURNAL ARTICLE
Shirish M Gadgeel, Delvys Rodríguez-Abreu, Balazs Halmos, Marina C Garassino, Takayasu Kurata, Ying Cheng, Erin Jensen, Mark Shamoun, Kumar Rajagopalan, Luis Paz-Ares
BACKGROUND: We report long-term outcomes from a pooled analysis of patients with previously untreated metastatic non‒small-cell lung cancer (NSCLC) with programmed cell death ligand 1 (PD-L1) tumor proportion score (TPS) <1% enrolled in phase 3 studies of pembrolizumab plus chemotherapy versus placebo plus chemotherapy. METHODS: This exploratory pooled analysis included individual patient data from the KEYNOTE-189 global (NCT02578680) and Japan extension (NCT03950674) studies of metastatic nonsquamous NSCLC without EGFR or ALK alterations and the KEYNOTE-407 global (NCT02775435) and China extension (NCT03875092) studies of metastatic squamous NSCLC...
April 18, 2024: Journal of Thoracic Oncology
#22
JOURNAL ARTICLE
Ángela González Álvarez, Alba Martinezi Quer, Lea Ellegaard-Jensen, Rumakanta Sapkota, Pedro N Carvalho, Anders Johansen
Harmful cyanobacterial blooms have increased globally, releasing hazardous cyanotoxins that threaten the safety of water resources. Constructed wetlands (CWs) are a nature-based and low-cost solution to purify and remove cyanotoxins from water. However, bio-mechanistic understanding of the biotransformation processes expected to drive cyanotoxin removal in such systems is poor, and primarily focused on bacteria. Thus, the present study aimed at exploring the fungal contribution to microcystin-LR and cylindrospermopsin biodegradation in CWs...
April 18, 2024: Science of the Total Environment
#23
JOURNAL ARTICLE
Khedidja Messabih, Nadia Bendjaballah-Lalaoui, Youcef Boucheffa
The Li4 SiO4 seems to be an excellent sorbent for CO2 capture at post-combustion. Our work contributes to understanding the effect of the natural Algerian diatomite as a source of SiO2 in the synthesis of Li4 SiO4 for CO2 capture at high temperature. For this purpose, we use various molar % (stoichiometric and excess) of calcined natural diatomite and pure SiO2 . To select the best composition, CO2 sorption isotherms at 500 °C on the prepared Li4 SiO4 are obtained using TGA measurements under various flows of CO2 in N2 ...
April 20, 2024: Environmental Science and Pollution Research International
#24
JOURNAL ARTICLE
T Michael O'Shea, Elizabeth T Jensen, Joe X Yi, Barry Lester, Judy L Aschner, Annemarie Stroustrup, Xueying Zhang, Monica McGrath, Keia Sanderson, Robert M Joseph, Rachana Singh, Amanda L Thompson, Julie Hofheimer, Betty Vohr, Elisabeth McGowan, Hudson Santos, Rebecca C Fry
OBJECTIVE: To evaluate associations between change in weight z-score after neonatal intensive care unit (NICU) discharge and neurodevelopmental outcomes and obesity at 12-48 months of age among individuals born very preterm. STUDY DESIGN: This secondary analysis used data from infants born very preterm participating in the Environmental influences on Child Health Outcomes cohort (n=1400). Growth during infancy was calculated as change in weight z-score between NICU discharge and follow-up at a mean of 27 months of age...
April 17, 2024: Journal of Pediatrics
#25
JOURNAL ARTICLE
Jeanne Vuaille, Per Abrahamsen, Signe M Jensen, Efstathios Diamantopoulos, Tomke S Wacker, Carsten T Petersen
No-till and mulching are typical management operations in conservation agriculture (CA). To model pesticide degradation and leaching under a CA scenario, as compared to a conventional-tillage scenario (CT), the mulch module of the agro-hydrological model Daisy was extended. A Daisy soil column was parameterized with measurements of topsoil, mulch, and a realistic subsoil, and tested against published experimental data of pesticide fate in laboratory soil columns covered by mulch. Uncertainty and sensitivity analyses of the new Daisy version were conducted for a series of weather, soil, pesticide, and mulch parameters, using 4939 Monte Carlo simulations under each scenario...
April 17, 2024: Science of the Total Environment
#26
JOURNAL ARTICLE
Karl E Zahn, Ryan B Jensen, Richard D Wood, Sylvie Doublie
No abstract text is available yet for this article.
April 18, 2024: Molecular Cell
#27
REVIEW
Caroline Moos, Charlotte Abrahamsen, Bjarke Viberg, Charlotte Myhre Jensen
BACKGROUND: Distal radius fractures are a common presentation in emergency departments. Synthesis of qualitative research of treatment, care and rehabilitation this fracture presents from the patient perspective could improve clinical practice and care. The purpose of this systematic review was to synthesize the qualitative literature on patient experiences after sustaining a distal radius fracture. METHODS: We searched Embase, MEDLINE, CINAHL, Psycinfo and CINAHL to identify qualitative studies published from database conception to May 2023...
April 13, 2024: International Journal of Orthopaedic and Trauma Nursing
#28
JOURNAL ARTICLE
Nayana Christudas Beena, Nicolas P L Magnard, Danilo Puggioni, Roberto Dos Reis, Kaustav Chatterjee, Xun Zhan, Vinayak P Dravid, James M Rondinelli, Kirsten M Ø Jensen, Sara E Skrabalak
Mixed metal oxyhalides are an exciting class of photocatalysts, capable of the sustainable generation of fuels and remediation of pollutants with solar energy. Bismuth oxyhalides of the types Bi4 MO8 X (M = Nb and Ta; X = Cl and Br) and Bi2 AO4 X (A = most lanthanides; X = Cl, Br, and I) have an electronic structure that imparts photostability, as their valence band maxima (VBM) are composed of O 2p orbitals rather than X n p orbitals that typify many other bismuth oxyhalides. Here, flux-based synthesis of intergrowth Bi4 NbO8 Cl-Bi2 GdO4 Cl is reported, testing the hypothesis that both intergrowth stoichiometry and M identity serve as levers toward tunable optoelectronic properties...
April 19, 2024: Inorganic Chemistry
#29
JOURNAL ARTICLE
Maurice J Meade, Sven Jensen, Xiangqun Ju, David Hunter, Lisa Jamieson
OBJECTIVES: To assess the quality and accuracy of information contained within the websites of providers of marketed orthodontic products. MATERIALS AND METHODS: Twenty-one websites of orthodontic appliance and adjunct (product) providers were identified. The website content was assessed via two validated quality-of-information instruments (DISCERN and the Journal of the American Medical Association [JAMA] benchmarks) and an accuracy-of-information instrument. Website content was qualitatively analyzed for themes and subthemes...
May 1, 2024: Angle Orthodontist
#30
JOURNAL ARTICLE
Siddhant Kumar, Elizabeth H Jensen, Susan Watts, Michael Parsa
Medical students rotating through emergency departments as part of their clinical education are typically evaluated using an on-shift evaluation tool. The National Clinical Assessment Tool for Medical Students in the Emergency Department (NCAT-EM) is the current standard of evaluation for medical students in the emergency department, regardless of level of training. This study aims to evaluate whether the NCAT-EM can detect differences in skill levels between third-year medical students (MS3s) and fourth-year medical students (MS4s) rotating at a level 1 trauma center and teaching institution...
March 2024: Curēus
#31
JOURNAL ARTICLE
Benjamin J Wainwright, Josh Leon, Ernie Vilela, K J E Hickman, Jensen Caldwell, Behlee Aimone, Porter Bischoff, Marissa Ohran, Magnolia W Morelli, Irma S Arlyza, Onny N Marwayana, Geoffrey Zahn
BACKGROUND: The processes that shape microbial biogeography are not well understood, and concepts that apply to macroorganisms, like dispersal barriers, may not affect microorganisms in the same predictable ways. To better understand how known macro-scale biogeographic processes can be applied at micro-scales, we examined seagrass associated microbiota on either side of Wallace's line to determine the influence of this cryptic dispersal boundary on the community structure of microorganisms...
April 18, 2024: Environmental microbiome
#32
MULTICENTER STUDY
Michael D Keller, Patrick J Hanley, Yueh-Yun Chi, Paibel Aguayo-Hiraldo, Christopher C Dvorak, Michael R Verneris, Donald B Kohn, Sung-Yun Pai, Blachy J Dávila Saldaña, Benjamin Hanisch, Troy C Quigg, Roberta H Adams, Ann Dahlberg, Shanmuganathan Chandrakasan, Hasibul Hasan, Jemily Malvar, Mariah A Jensen-Wachspress, Christopher A Lazarski, Gelina Sani, John M Idso, Haili Lang, Pamela Chansky, Chase D McCann, Jay Tanna, Allistair A Abraham, Jennifer L Webb, Abeer Shibli, Amy K Keating, Prakash Satwani, Pawel Muranski, Erin Hall, Michael J Eckrich, Evan Shereck, Holly Miller, Ewelina Mamcarz, Rajni Agarwal, Satiro N De Oliveira, Mark T Vander Lugt, Christen L Ebens, Victor M Aquino, Jeffrey J Bednarski, Julia Chu, Suhag Parikh, Jennifer Whangbo, Michail Lionakis, Elias T Zambidis, Elizabeth Gourdine, Catherine M Bollard, Michael A Pulsipher
Viral infections remain a major risk in immunocompromised pediatric patients, and virus-specific T cell (VST) therapy has been successful for treatment of refractory viral infections in prior studies. We performed a phase II multicenter study (NCT03475212) for the treatment of pediatric patients with inborn errors of immunity and/or post allogeneic hematopoietic stem cell transplant with refractory viral infections using partially-HLA matched VSTs targeting cytomegalovirus, Epstein-Barr virus, or adenovirus...
April 18, 2024: Nature Communications
#33
JOURNAL ARTICLE
Helena Amstrup Jensen, Torsten Grønbech Nielsen, Martin Lind
BACKGROUND: The objective of this study is to investigate the risk of revision surgery when delaying anterior cruciate ligament reconstruction (ACLR) past 3 months or 6 months after injury. MATERIALS AND METHODS: A total of 30,280 patients with isolated ACLR were identified in the Danish Knee Ligament Reconstruction Registry and divided into four groups; ACLR < 3 months, > 3 months, < 6 months, or > 6 months after injury...
April 18, 2024: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
#34
JOURNAL ARTICLE
Stine Søgaard Normann, Iben Have Beck, Flemming Nielsen, Marianne Skovsager Andersen, Niels Bilenberg, Tina Kold Jensen, Helle Raun Andersen
BACKGROUND: Organophosphates and pyrethroids are two major groups of insecticides used for crop protection worldwide. They are neurotoxicants and exposure during vulnerable windows of brain development may have long-term impact on human neurodevelopment. Only few longitudinal studies have investigated associations between prenatal exposure to these substances and intelligence quotient (IQ) at school age in populations with low, mainly dietary, exposure. OBJECTIVE: To investigate associations between maternal urinary concentrations of insecticide metabolites at gestational week 28 and IQ in offspring at 7-years of age...
April 16, 2024: Neurotoxicology and Teratology
#35
JOURNAL ARTICLE
Samuel A Bradley, Frederik G Hansson, Beata J Lehka, Daniela Rago, Pedro Pinho, Huadong Peng, Khem B Adhikari, Ahmad K Haidar, Lea G Hansen, Daria Volkova, Maxence Holtz, Sergi Muyo Abad, Xin Ma, Konstantinos Koudounas, Sébastien Besseau, Nicolas Gautron, Céline Mélin, Jillian Marc, Caroline Birer Williams, Vincent Courdavault, Emil D Jensen, Jay D Keasling, Jie Zhang, Michael K Jensen
Monoterpene indole alkaloids (MIAs) make up a highly bioactive class of metabolites produced by a range of tropical and subtropical plants. The corynanthe-type MIAs are a stereochemically complex subclass with therapeutic potential against a large number of indications including cancer, psychotic disorders, and erectile dysfunction. Here, we report yeast-based cell factories capable of de novo production of corynanthe-type MIAs rauwolscine, yohimbine, tetrahydroalstonine, and corynanthine. From this, we demonstrate regioselective biosynthesis of 4 fluorinated derivatives of these compounds and de novo biosynthesis of 7-chlororauwolscine by coexpression of a halogenase with the biosynthetic pathway...
April 18, 2024: ACS Synthetic Biology
#36
JOURNAL ARTICLE
Bjarke Jensen, Michiel Blok, Igor R Efimov, Bastiaan J Boukens
No abstract text is available yet for this article.
April 18, 2024: European Heart Journal Cardiovascular Imaging
#37
JOURNAL ARTICLE
Arnold Matovu Dungu, Camilla Koch Ryrsø, Maria Hein Hegelund, Adin Sejdic, Andreas Vestergaard Jensen, Peter Lommer Kristensen, Rikke Krogh-Madsen, Daniel Faurholt-Jepsen, Birgitte Lindegaard
BACKGROUND: Adiponectin is secreted by adipocytes and is inversely associated with obesity. Given the association between low body mass index (BMI) and higher mortality risk after community-acquired pneumonia (CAP), we hypothesized that high adiponectin levels are associated with a higher risk of adverse clinical outcomes in patients with CAP. METHODS: In a prospective cohort study of 502 patients hospitalized with CAP, adiponectin was measured in serum at admission...
2024: Frontiers in Medicine
#38
JOURNAL ARTICLE
Knut Thorshaug, Terje Didriksen, Ingvild Thue Jensen, Patricia Almeida Carvalho, Juan Yang, Mathieu Grandcolas, Alain Ferber, Andy M Booth, Özlem Ağaç, Hüseyin Alagöz, Nursev Erdoğan, Anıl Kuban, Branson D Belle
Composite coatings containing reduced graphene oxide (rGO) and 3-(aminopropyl)triethoxysilane functionalised rGO (APTES-rGO) were prepared by sol-gel technology and deposited on Al 2024 T-3. Covalent functionalisation of GO by APTES occurred by formation of amide bonds, accompanied by GO reduction. The thin sheets were retained. The hydrophilicity of the coating increased when APTES-rGO was added. The opposite was observed when GO was added. A key finding is that the rGO flakes agglomerate and lie in a random orientation in the coating, whereas the APTES-rGO flakes are more evenly distributed in the matrix and appear to lie along the plane of the substrate...
April 16, 2024: Nanoscale advances
#39
JOURNAL ARTICLE
Helen M Lillie, Chelsea L Ratcliff, Andy J King, Manusheela Pokharel, Jakob D Jensen
BACKGROUND: In May 2020, news outlets reported misinformation about the Centers for Disease Control (CDC) related to COVID-19. Correcting misinformation about outbreaks and politics is particularly challenging. Affective belief echoes continue to influence audiences even after successful correction. Narrative and emotional flow scholarship suggest that a narrative corrective with a positive ending could reduce belief echoes. Therefore, this study investigated the efficacy of a narrative corrective with a relief ending for correcting misinformation about the CDC...
April 18, 2024: Journal of Public Health
#40
JOURNAL ARTICLE
Cameron S Lewis, Greta Joy, Paw Jensen, Allison Barraclough, Nunzio Franco, Dipti Talaulikar, Eliza A Hawkes, Tarec Christoffer El-Galaly, Diego Villa, Michael Dickinson, John F Seymour, Chan Y Cheah
Primary gastric diffuse large B-cell lymphoma (PG-DLBCL) accounts for the majority of extra-nodal DLBCL. Even so, literature is lacking on early, localised presentations. We studied a cohort of patients with stage I disease, diagnosed between 2006 and 2018, from six centres between Australia, Canada and Denmark. Our goal was to characterise outcomes, review treatment and investigate the role of interim positron emission tomography (iPET). Thirty-seven eligible patients were identified. The median duration of follow-up was 42...
April 17, 2024: British Journal of Haematology
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