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https://www.readbyqxmd.com/read/29457780/comment-on-nanoscale-mapping-of-optical-band-gaps-using-monochromated-electron-energy-loss-spectroscopy-by-zhan-graner%C3%A3-d-venkatachalapathy-johansen-jensen-kuznetsov-and-prytz-in-nanotechnology-28-2017-105703
#1
Thomas Walther
Comment on ‘Nanoscale mapping of optical band gaps using monochromated electron energy loss spectroscopy’ by Zhan, Granerød, Venkatachalapathy, Johansen, Jensen, Kuznetsov and Prytz in Nanotechnology 28 (2017) 105703 
 by 
 Thomas Walther, Department,of Electronic & Electrical Enginenering, University of Sheffield, Sheffield, UK.
February 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29457758/appraising-cervical-mucus-a-new-approach-to-evaluating-contraceptives
#2
Leo Han, Emily Padua, Alison Edelman, Jeffrey T Jensen
PURPOSE: Timing of sample collection represents a major source of variability in studies evaluating the effects of administered agents on cervical mucus in naturally-cycling women. We sought to create and validate an artificial model of the cervical mucus cycle using exogenous E2 and P4 replacement in ovarian suppressed women. MATERIALS AND METHODS: We conducted a prospective experiment (clinicaltrials.gov, NCT02969590) examining cervical mucus changes in six women during natural and artificial menstrual cycles [leuprolide acetate, estradiol transdermal patch (0...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29457576/hypoalbuminaemia-as-a-marker-of-trans-capillary-leakage-in-community-acquired-bacteraemia-patients
#3
K O Gradel, P J Vinholt, B Magnussen, C Pedersen, T G Jensen, H J Kolmos, A T Lassen
Community-acquired bacteraemia patients (n = 2472), Denmark, 2000-2008. Albumin, C-reactive protein (CRP) and haemoglobin (Hb) measured 2000-2010. We assessed daily mean levels of albumin, CRP and Hb from 30 days before to 30 days after bacteraemia and correlations between albumin vs. CRP and albumin vs. Hb. In linear regression models, we evaluated the contribution of CRP, Hb, chronic and acute variables to the albumin level variations. The mean albumin level (33.6 g/l) was steady before day 1, declined to 29...
February 19, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29456765/peripheral-blood-epi-signature-of-claes-jensen-syndrome-enables-sensitive-and-specific-identification-of-patients-and-healthy-carriers-with-pathogenic-mutations-in-kdm5c
#4
Laila C Schenkel, Erfan Aref-Eshghi, Cindy Skinner, Peter Ainsworth, Hanxin Lin, Guillaume Paré, David I Rodenhiser, Charles Schwartz, Bekim Sadikovic
Background: Claes-Jensen syndrome is an X-linked inherited intellectual disability caused by mutations in the KDM5C gene. Kdm5c is a histone lysine demethylase involved in histone modifications and chromatin remodeling. Males with hemizygous mutations in KDM5C present with intellectual disability and facial dysmorphism, while most heterozygous female carriers are asymptomatic. We hypothesized that loss of Kdm5c function may influence other components of the epigenomic machinery including DNA methylation in affected patients...
2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/29456546/genome-wide-association-studies-and-comparison-of-models-and-cross-validation-strategies-for-genomic-prediction-of-quality-traits-in-advanced-winter-wheat-breeding-lines
#5
Peter S Kristensen, Ahmed Jahoor, Jeppe R Andersen, Fabio Cericola, Jihad Orabi, Luc L Janss, Just Jensen
The aim of the this study was to identify SNP markers associated with five important wheat quality traits (grain protein content, Zeleny sedimentation, test weight, thousand-kernel weight, and falling number), and to investigate the predictive abilities of GBLUP and Bayesian Power Lasso models for genomic prediction of these traits. In total, 635 winter wheat lines from two breeding cycles in the Danish plant breeding company Nordic Seed A/S were phenotyped for the quality traits and genotyped for 10,802 SNPs...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29456545/the-dangers-of-being-a-small-oligotrophic-and-light-demanding-freshwater-plant-across-a-spatial-and-historical-eutrophication-gradient-in-southern-scandinavia
#6
Kaj Sand-Jensen, Hans Henrik Bruun, Tora Finderup Nielsen, Ditte M Christiansen, Per Hartvig, Jens C Schou, Lars Baastrup-Spohr
European freshwater habitats have experienced a severe loss of plant diversity, regionally and locally, over the last century or more. One important and well-established driver of change is eutrophication, which has increased with rising population density and agricultural intensification. However, reduced disturbance of lake margins may have played an additional key role. The geographical variation in water chemistry, which has set the scene for - and interacted with - anthropogenic impact, is much less well understood...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29456419/zipf-mandelbrot-law-f-divergences-and-the-jensen-type-interpolating-inequalities
#7
Neda Lovričević, Ðilda Pečarić, Josip Pečarić
Motivated by the method of interpolating inequalities that makes use of the improved Jensen-type inequalities, in this paper we integrate this approach with the well known Zipf-Mandelbrot law applied to various types of f -divergences and distances, such are Kullback-Leibler divergence, Hellinger distance, Bhattacharyya distance (via coefficient), [Formula: see text]-divergence, total variation distance and triangular discrimination. Addressing these applications, we firstly deduce general results of the type for the Csiszár divergence functional from which the listed divergences originate...
2018: Journal of Inequalities and Applications
https://www.readbyqxmd.com/read/29454773/relationship-between-left-atrial-functional-measures-and-incident-atrial-fibrillation-in-the-general-population-the-copenhagen-city-heart-study
#8
Flemming J Olsen, Rasmus Møgelvang, Gorm B Jensen, Jan S Jensen, Tor Biering-Sørensen
OBJECTIVES: This study sought to investigate whether left atrial (LA) functional measures predict atrial fibrillation (AF) in the general population. BACKGROUND: Increasing evidence suggests LA functional measures are predictors of AF in several patient groups. METHODS: In a community-based cohort study, approximately 2,000 individuals underwent a transthoracic echocardiogram. Conventional echocardiographic measures and extended LA measures, including the minimal and maximal LA volumes (LAVmin and LAVmax , respectively) and left atrial emptying fraction (LAEF), were performed...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29454619/delineation-of-the-functional-properties-and-the-mechanism-of-action-of-aa29504-an-allosteric-agonist-and-positive-allosteric-modulator-of-gaba-a-receptors
#9
Emma Rie Olander, Nawid Madjroh, Lennart Bunch, Pella Cecilia Söderhielm, Anders A Jensen
The retigabine analog 2-amino-4-(2,4,6-trimethylbenzylamino)-phenyl]-carbamic acid ethyl ester (AA29504) is a positive allosteric modulator (PAM) of γ-aminobutyric acidA receptors (GABAA Rs), and the modulator has been used in ex vivo/in vivo studies to probe the physiological roles of native δ-containing GABAA Rs. In this study, the functional properties and mode of action of AA29504 were investigated at human GABAA Rs expressed in Xenopus oocytes by two-electrode voltage clamp electrophysiology. AA29504 was found to be an allosteric GABAA R agonist displaying low intrinsic activities at 3-30 μM...
February 15, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29454507/pediatric-early-warning-score-systems-nurses-perspective-a-focus-group-study
#10
EDITORIAL
Claus Sixtus Jensen, Pia Bonde Nielsen, Hanne Vebert Olesen, Hans Kirkegaard, Hanne Aagaard
PURPOSE: Pediatric early warning score (PEWS) systems are used to monitor pediatric patients' vital signs and facilitate the treatment of patients at risk of deteriorating. The aim of this study was to gain knowledge about nurses' experiences with PEWS and to highlight factors facilitating and impeding the use of PEWS tools in clinical practice. DESIGN AND METHODS: An exploratory qualitative design was chosen using focus group interviews to gain a deeper understanding of nurses' experiences with PEWS...
February 14, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29453859/diminished-cxcr5-expression-in-peripheral-blood-of-patients-with-sj%C3%A3-gren-s-syndrome-may-relate-to-both-genotype-and-salivary-gland-homing
#11
Lara A Aqrawi, Margarita Ivanchenko, Albin Björk, Jorge I Ramírez Sepúlveda, Juliana Imgenberg-Kreuz, Marika Kvarnström, Philipp Haselmayer, Janicke Liaaen Jensen, Gunnel Nordmark, Karine Chemin, Kathrine Skarstein, Marie Wahren-Herlenius
Genetic investigations of Sjögren's syndrome (SS) have identified a susceptibility locus at p23.3 of chromosome 11, which contains the CXCR5 gene. CXCR5 is a chemokine receptor expressed on B and T cell subsets, and binds the chemotactic ligand CXCL13. We here aimed to link the genetic association with functional effects and explore the CXCR5/CXCL13 axis in SS. Expression quantitative trait loci analysis of the 11q23.3 locus was performed using B cell mRNA expression data from genotyped individuals. Lymphocyte surface markers were assessed by flow cytometry, and CXCL13 levels by a proximity extension assay...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29453659/fracture-risk-in-women-with-type-ii-diabetes-results-from-a-historical-cohort-with-fracture-follow-up
#12
Jakob Præst Holm, Thomas Jensen, Lars Hyldstrup, Jens-Erik Beck Jensen
PURPOSE: To examine the independent association between type II diabetes and fracture risk in a population of predominantly postmenopausal women referred to a specialist clinic for osteoporosis evaluation. METHODS: Type II diabetes associated fracture risk were evaluated among to 229 patients with type II diabetes in a cohort of 6285 women followed on average (until major osteoporotic fracture (MOF), death or end of study) for 5.8 years. Information of fracture risk factors was obtained from a clinical database and from national registries...
February 16, 2018: Endocrine
https://www.readbyqxmd.com/read/29452143/unusual-self-assembly-of-the-recombinant-chlamydia-trachomatis-major-outer-membrane-protein-momp-based-fusion-antigen-cth522-into-protein-nanoparticles
#13
Fabrice Rose, Kasper Karlsen, Pernille Rønde Jensen, Rasmus Uffe Jakobsen, Grith Krøyer Wood, Kasper Dyrberg Rand, Helene Godiksen, Peter Andersen, Frank Follmann, Camilla Foged
Sexually transmitted Chlamydia trachomatis (Ct) infects more than 100 million people annually, and untreated chlamydia infections can cause severe complications. Therefore, there is an urgent need for a chlamydia vaccine. The Ct major outer membrane protein (MOMP) is highly immunogenic but is a challenging vaccine candidate by being an integral membrane protein, and the immunogenicity depends on a correctly folded structure. We investigated the biophysical properties of the recombinant MOMP-based fusion antigen CTH522, which is tested in early human clinical trials...
February 13, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29451594/nontuberculous-mycobacteria-in-milk-from-positive-cows-in-the-intradermal-comparative-cervical-tuberculin-test-implications-for-human-tuberculosis-infections
#14
Carmen Alicia Daza Bolaños, Marília Masello Junqueira Franco, Antonio Francisco Souza Filho, Cássia Yumi Ikuta, Edith Mariela Burbano-Rosero, José Soares Ferreira Neto, Marcos Bryan Heinemann, Rodrigo Garcia Motta, Carolina Lechinski de Paula, Amanda Bonalume Cordeiro de Morais, Simony Trevizan Guerra, Ana Carolina Alves, Fernando José Paganini Listoni, Márcio Garcia Ribeiro
Although the tuberculin test represents the main in vivo diagnostic method used in the control and eradication of bovine tuberculosis, few studies have focused on the identification of mycobacteria in the milk from cows positive to the tuberculin test. The aim of this study was to identify Mycobacterium species in milk samples from cows positive to the comparative intradermal test. Milk samples from 142 cows positive to the comparative intradermal test carried out in 4,766 animals were aseptically collected, cultivated on Lowenstein-Jensen and Stonebrink media and incubated for up to 90 days...
2018: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/29450193/a-method-for-quantification-of-epithelium-colonization-capacity-by-pathogenic-bacteria
#15
Rune M Pedersen, Rasmus B Grønnemose, Kristian Stærk, Cecilie A Asferg, Thea B Andersen, Hans J Kolmos, Jakob Møller-Jensen, Thomas E Andersen
Most bacterial infections initiate at the mucosal epithelium lining the gastrointestinal, respiratory, and urogenital tracts. At these sites, bacterial pathogens must adhere and increase in numbers to effectively breach the outer barrier and invade the host. If the bacterium succeeds in reaching the bloodstream, effective dissemination again requires that bacteria in the blood, reestablish contact to distant endothelium sites and form secondary site foci. The infectious potential of bacteria is therefore closely linked to their ability to adhere to, colonize, and invade epithelial and endothelial surfaces...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29449506/whole-body-magnetic-resonance-imaging-in-axial-spondyloarthritis-reduction-of-sacroiliac-spinal-and-entheseal-inflammation-in-a-placebo-controlled-trial-of-adalimumab
#16
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J Sørensen, Bente Jensen, Jakob M Møller, Lone Balding, Ole R Madsen, Karsten Asmussen, Grith Eng, Niklas R Jørgensen, Susanne J Pedersen
OBJECTIVE: To investigate whether adalimumab (ADA) reduces whole-body (WB-) magnetic resonance imaging (MRI) indices for inflammation in the entheses, peripheral joints, sacroiliac joints, spine, and the entire body in patients with axial spondyloarthritis (axSpA). METHODS: An investigator-initiated, randomized, placebo-controlled, double-blinded 48-week followup trial included 49 patients with axSpA, who had Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449216/adjustable-delivery-of-pro-angiogenic-fgf-2-by-collagen-alginate-microspheres
#17
Zaheer Ali, Anik Islam, Peter Sherrell, Mark Le-Moine, Georgios Lolas, Konstantinos Syrigos, Mehrdad Rafat, Lasse D Jensen
Therapeutic induction of blood vessel growth (angiogenesis) in ischemic tissues holds great potential for treatment of myocardial infarction and stroke. Achieving sustained angiogenesis and vascular maturation has, however, been highly challenging. Here we demonstrate that collagen:alginate hydrogels containing therapeutic, pro-angiogenic FGF-2, and formulated as microspheres, is a promising and clinically relevant vehicle for therapeutic angiogenesis. By titrating the amount of readily dissolvable and degradable collagen with more slowly degradable alginate in the hydrogel mixture, the degradation rates of the biomaterial controlling the release kinetics of embedded pro-angiogenic FGF-2 can be adjusted...
February 15, 2018: Biology Open
https://www.readbyqxmd.com/read/29448472/permutation-glass
#18
Mobolaji Williams
The field of disordered systems in statistical physics provides many simple models in which the competing influences of thermal and nonthermal disorder lead to new phases and nontrivial thermal behavior of order parameters. In this paper, we add a model to the subject by considering a disordered system where the state space consists of various orderings of a list. As in spin glasses, the disorder of such "permutation glasses" arises from a parameter in the Hamiltonian being drawn from a distribution of possible values, thus allowing nominally "incorrect orderings" to have lower energies than "correct orderings" in the space of permutations...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29447819/lingual-tonsillectomy-in-children-with-down-syndrome-is-it-safe
#19
Jonathan R Skirko, Emily L Jensen, Norman R Friedman
OBJECTIVE: Evaluate peri-operative course and morbidity in children with Down syndrome (DS) who underwent a lingual tonsillectomy (LT) for residual obstructive sleep apnea (rOSA). METHODS: Retrospective case series for children with DS who underwent LT for rOSA from April 2011 to July 2016. Our primary outcomes were length of stay, readmission and complications. Surgical effectiveness was evaluated by change in the obstructive apnea-hypopnea-index(OAHI) and oxygen saturation nadir...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447273/molecular-epidemiology-and-drug-sensitivity-pattern-of-mycobacterium-tuberculosis-strains-isolated-from-pulmonary-tuberculosis-patients-in-and-around-ambo-town-central-ethiopia
#20
Melaku Tilahun, Gobena Ameni, Kassu Desta, Aboma Zewude, Lawrence Yamuah, Markos Abebe, Abraham Aseffa
INTRODUCTION: Tuberculosis (TB) is caused by M. tuberculosis complex and remains a major global public health problem. The epidemic remains a threat to sub-Saharan Africa, including Ethiopia, with further emergence of drug resistant TB. We investigated the drug sensitivity pattern and molecular epidemiology of mycobacterial strains isolated from pulmonary TB patients in and around Ambo town in Oromia Region, Central Ethiopia. METHODS: A cross-sectional study was conducted involving 105 consecutive new smear positive pulmonary TB patients diagnosed at Ambo Hospital and surrounding Health Centers between May 2014 and March 2015 upon informed consent...
2018: PloS One
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