keyword
https://read.qxmd.com/read/38536821/the-use-of-kudoh-method-for-culture-of-mycobacterium-tuberculosis-and-mycobacterium-africanum-in-the-gambia
#1
JOURNAL ARTICLE
Tijan Jobarteh, Jacob Otu, Ensa Gitteh, Francis S Mendy, Tutty Isatou Faal-Jawara, Boatema Ofori-Anyinam, Binta Sarr, Abi Janet Riley, Abigail Ayorinde, Bouke C de Jong, Beate Kampmann, Ousman Secka, Florian Gehre
BACKGROUND: Mycobacterium tuberculosis culturing remains the gold standard for laboratory diagnosis of tuberculosis. Tuberculosis remains a great public health problem in developing countries like The Gambia, as most of the methods currently used for bacterial isolation are either time-consuming or costly. OBJECTIVE: To evaluate the Kudoh swab method in a West African setting in Gambia, with a particular focus on the method's performance when culturing Mycobacterium africanum West Africa 2 (MAF2) isolates...
2024: PloS One
https://read.qxmd.com/read/38536495/correction-to-histamine-h2%C3%A2-receptor-antagonism-improves-conduit-artery-endothelial-function-and-reduces-plasma-aldosterone-level-without-lowering-arterial-blood-pressure-in-angiotensin-ii-hypertensive-mice
#2
Kasper B Assersen, Boye L Jensen, Camilla Enggaard, Paul M Vanhoutte, Pernille B L Hansen
No abstract text is available yet for this article.
March 27, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38535206/comparison-of-crispr-mad7-and-crispr-cas9-for-gene-disruptions-in-komagataella-phaffii
#3
JOURNAL ARTICLE
Kirill Smirnov, Florian Weiss, Anna-Maria Hatzl, Lukas Rieder, Kjeld Olesen, Sanne Jensen, Anton Glieder
CRISPR (clustered regularly interspaced short palindromic repeats)-based technologies are powerful, programmable tools for site-directed genome modifications. After successful adaptation and efficient use of CRISPR-Cas9 for genome engineering in methylotrophic yeast Komagataella phaffii , a broader variety of employable endonucleases was desired to increase the experimental flexibility and to provide alternatives in case there are specific legal restrictions in industrial research due to the intellectual property rights (IPRs) of third parties...
March 5, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38533884/the-variational-quantum-eigensolver-self-consistent-field-method-within-a-polarizable-embedded-framework
#4
JOURNAL ARTICLE
Erik Rosendahl Kjellgren, Peter Reinholdt, Aaron Fitzpatrick, Walter N Talarico, Phillip W K Jensen, Stephan P A Sauer, Sonia Coriani, Stefan Knecht, Jacob Kongsted
We formulate and implement the Variational Quantum Eigensolver Self Consistent Field (VQE-SCF) algorithm in combination with polarizable embedding (PE), thereby extending PE to the regime of quantum computing. We test the resulting algorithm, PE-VQE-SCF, on quantum simulators and demonstrate that the computational stress on the quantum device is only slightly increased in terms of gate counts compared to regular VQE-SCF. On the other hand, no increase in shot noise was observed. We illustrate how PE-VQE-SCF may lead to the modeling of real chemical systems using a simulation of the reaction barrier of the Diels-Alder reaction between furan and ethene as an example...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38533874/-not-available
#5
JOURNAL ARTICLE
Anders Bonde Jensen, Peer Christiansen, Pernille Bech, Bobby Zachariae
Improved survival after breast cancer treatment comes at a cost in the form of increased risk of late effects. A number of these are summarised in this review. The late effects can be divided in 1) late effects after locoregional treatment, e.g., lymphoedema, impaired shoulder movement, and pain; 2) consequences of systemic treatment, e.g. polyneuropathy, problems related to premature menopause, and increased risk of cardio-vascular disease; and 3) general late effects, commonly seen across all cancer types, including fatigue, insomnia, and cognitive impairment...
March 18, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533855/-not-available
#6
JOURNAL ARTICLE
Mario Ranjeevan, Thor Petersen, Sigurdur Skarphédinsson, Henrik Boye Jensen
Lyme neuroborreliosis (LNB) is the most prevalent nervous system bacterial infection in Denmark. In a young man with LNB, brain MRI and cerebrospinal fluid (CSF) demonstrated findings compatible with multiple sclerosis. This case report underlines the requirement for testing for intrathecal Borrelia antibody production when the number of cells in the CSF is low or even normal. It also demonstrates the unchanged diagnostic delay of NBL observed during the last 20 years.
March 25, 2024: Ugeskrift for Laeger
https://read.qxmd.com/read/38533696/code-of-ethics-and-professional-standards-of-conduct-for-emergency-management-professionals
#7
JOURNAL ARTICLE
Sandy Maxwell Smith, Shirley Feldmann-Jensen
The Code of Ethics and Professional Standards of Conduct for Emergency Management Professionals (2022) was recently created to further delineate the ethical boundaries and conduct expectations for professional emergency management practice. Significantly, the code of ethics provides an essential foundation toward recognition as a profession with hallmarks of monopoly, autonomy, and authority. The code and standards of conduct establish a clear definition of the role emergency management has in overseeing a complex, diverse risk portfolio that protects lives, livelihoods, and quality of life...
2024: Journal of Emergency Management: JEM
https://read.qxmd.com/read/38533240/reorientational-dynamics-in-y-bh-4-3-%C3%A2-x-nh-3-x-0-3-and-7-the-impact-of-nh-3-on-bh-4-dynamics
#8
JOURNAL ARTICLE
J B Grinderslev, U Häussermann, T R Jensen, A Faraone, M Nagao, M Karlsson, T J Udovic, M S Andersson
The reorientational dynamics of Y(BH4 )3 · x NH3 ( x = 0, 3, and 7) was studied using quasielastic neutron scattering (QENS) and neutron spin echo (NSE). The results showed that changing the number of NH3 ligands drastically alters the reorientational mobility of the BH4 - anion. From the QENS experiments, it was determined that the BH4 - anion performs 2-fold reorientations around the C2 axis in Y(BH4 )3 , 3-fold reorientations around the C3 axis in Y(BH4 )3 ·3NH3 , and either 2-fold reorientations around the C2 axis or 3-fold reorientations around the C3 axis in Y(BH4 )3 ·7NH3 ...
March 21, 2024: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://read.qxmd.com/read/38533072/the-madagascar-palm-genome-provides-new-insights-on-the-evolution-of-apocynaceae-specialized-metabolism
#9
JOURNAL ARTICLE
Clément Cuello, Hans J Jansen, Cécile Abdallah, Duchesse-Lacours Zamar Mbadinga, Caroline Birer Williams, Mickael Durand, Audrey Oudin, Nicolas Papon, Nathalie Giglioli-Guivarc'h, Ron P Dirks, Michael Krogh Jensen, Sarah Ellen O'Connor, Sébastien Besseau, Vincent Courdavault
Specialized metabolites possess diverse interesting biological activities and some cardenolides- and monoterpene indole alkaloids- (MIAs) derived pharmaceuticals are currently used to treat human diseases such as cancers or hypertension. While these two families of biocompounds are produced by specific subfamilies of Apocynaceae , one member of this medicinal plant family, the succulent tree Pachypodium lamerei Drake (also known as Madagascar palm), does not produce such specialized metabolites. To explore the evolutionary paths that have led to the emergence and loss of cardenolide and MIA biosynthesis in Apocynaceae , we sequenced and assembled the P...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532374/12-month-follow-up-of-intensive-outpatient-treatment-for-ptsd-combining-prolonged-exposure-therapy-emdr-and-physical-activity
#10
JOURNAL ARTICLE
Julie Rendum Klaeth, Andreas Gjerde Jensen, Trude Julie Brynhildsvoll Auren, Stian Solem
BACKGROUND: Preliminary evidence shows promising treatment outcomes at short-term follow-up for intensive posttraumatic stress disorder (PTSD) treatment, but long-term follow-up studies are sparse. This study is a sequel to a previous pilot study and open trial, set out to investigate treatment outcomes at 12-month follow-up for outpatients completing an 8-day intensive treatment for PTSD. METHODS: All patients were diagnosed with PTSD and had multiple previous psychotherapy attempts (M = 3...
March 26, 2024: BMC Psychiatry
https://read.qxmd.com/read/38531322/sensory-neurobiology-muscles-power-pheromone-sensation
#11
JOURNAL ARTICLE
Jennifer Jensen, Lisa Stowers
While we understand how the five main sensory organs enable and facilitate stimulus detection, little is known about how the vomeronasal organ enables pheromone sensation. A new study finds specialized muscles poised to coordinate stimulus delivery, dynamics, and arousal.
March 25, 2024: Current Biology: CB
https://read.qxmd.com/read/38531132/temporal-variations-in-micropollutant-inlet-concentrations-matter-when-planning-the-design-and-compliance-assessment-of-stormwater-control-measures
#12
JOURNAL ARTICLE
Ditte Marie Reinholdt Jensen, Lena Mutzner, Yuansong Wei, Peter Steen Mikkelsen, Luca Vezzaro
Stormwater Control Measures (SCMs) contribute to reducing micropollutant emissions from separate sewer systems. SCM planning and design are often performed by looking at the hydrological performance. Assessment of pollutant removal and the ability to comply with discharge concentration limits is often simplified due to a lack of data and limited monitoring resources. This study analyses the impact of using different time resolutions of input stormwater concentrations when assessing the compliance of SCMs against water quality standards...
March 25, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38530092/toward-an-ultimate-solution-for-peptide-retention-time-prediction-the-effect-of-column-temperature-on-separation-selectivity
#13
JOURNAL ARTICLE
Carina Villacrés, Benilde Mizero, Victor Spicer, Rosa Viner, Julian Saba, Bhavinkumar Patel, Sergei Snovida, Penny Jensen, Andreas Huhmer, Oleg V Krokhin
We studied the effect of the column temperature on the selectivity of reversed-phase peptide separation in bottom-up proteomics. The number of peptide identifications from 2 h liquid chromatography with tandem mass spectrometry (LC-MS/MS) acquisitions reaches a plateau at 45-55 °C, driven simultaneously by improved separation efficiency, a gradual decrease in peptide retention, and possible on-column degradation of peptides at elevated temperatures. Performing 2D LC-MS/MS acquisitions at 25, 35, 45, and 55 °C resulted in the identification of ∼100,000 and ∼120,000 unique peptides for nonmodified and tandem mass tags (TMT)-labeled samples, respectively...
March 26, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38529680/the-silhouettes-fatigue-scale-further-validation-in-spanish-speaking-university-students-and-adults-with-chronic-pain
#14
JOURNAL ARTICLE
Elisabet Sánchez-Rodríguez, Josep Roman-Juan, Elena Castarlenas, Ester Solé, Mark P Jensen, Jordi Miró
PURPOSE: The aim of this study was to evaluate the psychometric properties of the Silhouettes Fatigue Scale (SFS) when used to assess fatigue in undergraduates and middle-aged adults with chronic pain. MATERIALS AND METHODS: A total of 426 undergraduates and 207 middle-aged individuals with chronic pain participated in this study. Participants were asked to respond to a survey including the SFS as well as another validated measure of fatigue, questionnaires about pain catastrophizing and pain interference, and questions about pain (i...
March 26, 2024: Disability and Rehabilitation
https://read.qxmd.com/read/38529496/evaluation-of-cerebrospinal-fluid-alpha-synuclein-seed-amplification-assay-in-psp-and-cbs
#15
D P Vaughan, R Fumi, M Theilmann Jensen, T Georgiades, L Wu, D Lux, R Obrocki, J Lamoureux, O Ansorge, Ksj Allinson, T T Warner, Z Jaunmuktane, A Misbahuddin, P N Leigh, Bcp Ghosh, K P Bhatia, A Church, C Kobylecki, Mtm Hu, J B Rowe, C Blauwendraat, H R Morris, E Jabbari
BACKGROUND: Seed amplification assay (SAA) testing has become an important biomarker in the diagnosis of alpha-synuclein related neurodegenerative disorders. OBJECTIVES: To assess the rate of alpha-synuclein SAA positivity in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), and analyse the clinical and pathological features of SAA positive and negative cases. METHODS: 106 CSF samples from clinically diagnosed PSP (n=59), CBS (n=37) and indeterminate parkinsonism cases (n=10) were analysed using alpha-synuclein SAA...
February 29, 2024: medRxiv
https://read.qxmd.com/read/38528864/exploring-key-job-demands-and-resources-in-norwegian-child-mental-health-services-a-cross-sectional-study-of-associations-with-and-relationship-between-compassion-satisfaction-burnout-secondary-traumatic-stress-and-turnover-intention
#16
JOURNAL ARTICLE
Samira Aminihajibashi, Tine K Jensen, Ane-Marthe Solheim Skar
BACKGROUND: Burnout, secondary traumatic stress, and high turnover rates among child mental health clinicians are a challenge, not only for the individual therapist and the organization but also for the successful implementation of evidence-based practices. However, little is known about which and how job-and implementation-related factors are associated with burnout, secondary traumatic stress, and turnover intention as well as compassion satisfaction among child therapists. In the present study, we aimed to explore these factors and related mechanisms by integrating the "professional quality of life" and the "job demands-resources" models of occupational health...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38528831/parent-strategies-to-help-emerging-adults-manage-stress-are-associated-with-their-mental-health-a-dyadic-coping-perspective
#17
JOURNAL ARTICLE
Melissa A Lippold, Michaeline Jensen, Gregory E Chase, Kacey Wyman, Melissa R Jenkins, Somya Mohanty, Guy Bodenmann
Emerging adults (EAs) are at high risk for mental health challenges and frequently reach out to their parents for support. Yet little is known about how parents help emerging adults manage and cope with daily stressors and which strategies help and which hinder EA mental health. In this cross-sectional pilot study of students at a 2- and 4-year college (ages 18-25, N = 680, mean age = 19.0), we extend models of dyadic coping from intimate relationships to the parent-emerging adult relationship and test whether six specific parent strategies to help emerging adults manage stress are associated with EA mental health...
March 26, 2024: Family Process
https://read.qxmd.com/read/38528814/reduction-in-intake-of-discretionary-foods-and-drinks-among-danish-schoolchildren-dietary-results-from-the-real-life-cluster-randomised-controlled-trial-are-you-too-sweet
#18
JOURNAL ARTICLE
Sidse Marie Sidenius Bestle, Anne Dahl Lassen, Anja Pia Biltoft-Jensen, Jeppe Matthiessen, Sarah Jegsmark Gibbons, Bodil Just Christensen, Bjarne Kjær Ersbøll, Ellen Trolle
OBJECTIVE: Evaluate the effectiveness of the multicomponent intervention trial "Are You Too Sweet?" in reducing discretionary foods and drinks intake among young schoolchildren. DESIGN: The study was a 3.5-month two-arm cluster randomised controlled trial among primary school children and their families. School health nurses provided guidance to families regarding discretionary foods and drinks for the children. Moreover, families were given a variety of knowledge- and capability-building materials to utilize at home...
March 26, 2024: Public Health Nutrition
https://read.qxmd.com/read/38528439/-we-had-conversations-we-wouldn-t-have-had-otherwise-exploring-home-dwelling-people-with-dementia-and-family-members-experiences-of-deliberating-on-ethical-issues-in-a-literature-based-intervention
#19
JOURNAL ARTICLE
Sofie Smedegaard Skov, Marie Eva Berg, Josefine Ranfelt Andersen, Frederik Schou-Juul, Anja M B Jensen, Anna Paldam Folker, Sigurd Lauridsen
AIM: To explore home-dwelling people with dementia and family members' perceptions of the feasibility and acceptability of an intervention using dementia-related literature excerpts to facilitate conversations on ethical issues related to living with dementia. BACKGROUND: Ethical issues in dementia care emerge throughout the illness. In the early stages, they may involve decisions about disclosing the illness to the family, shifting roles and responsibilities, and considerations of transitioning to a nursing home...
March 25, 2024: Journal of Clinical Nursing
https://read.qxmd.com/read/38528061/menopausal-status-induces-vaginal-dysbiosis-in-women-with-human-papillomavirus-infection
#20
JOURNAL ARTICLE
Kyeong A So, Soo Young Hur, Chi Heum Cho, Jae Kwan Lee, Seok Ju Seong, Dae Hoon Jeong, Moran Ki, Tae Jin Kim
In this study, we examined the difference in the vaginal microbiota of women infected with human papillomavirus (HPV), according to menopausal status. A total of 75 cervicovaginal swab samples from 38 pre- and 37 postmenopausal women with HPV infection were obtained from the Korean HPV cohort. Vaginal microbiota analysis, including microbial diversity and specific bacterial abundances, was performed using 16S rRNA gene sequencing. The mean age of the pre- and postmenopausal women were 29.5 and 55.8 years, respectively (p < 0...
March 26, 2024: Scientific Reports
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