Zixiao Yin, Tianshuo Yuan, Anchao Yang, Yichen Xu, Guanyu Zhu, Qi An, Ruoyu Ma, Yifei Gan, Lin Shi, Yutong Bai, Ning Zhang, Chunxue Wang, Yin Jiang, Fangang Meng, Wolf-Julian Neumann, Huiling Tan, Jian-Guo Zhang
BACKGROUND: Rapid eye movement (REM) sleep behaviour disorder (RBD) is one of the most common sleep problems and represents a key prodromal marker in Parkinson's disease (PD). It remains unclear whether and how basal ganglia nuclei, structures that are directly involved in the pathology of PD, are implicated in the occurrence of RBD. METHOD: Here, in parallel with whole-night video polysomnography, we recorded local field potentials from two major basal ganglia structures, the globus pallidus internus and subthalamic nucleus, in two cohorts of patients with PD who had varied severity of RBD...
April 19, 2024: Journal of Neurology, Neurosurgery, and Psychiatry