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Cornea cataract anterior segment

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https://www.readbyqxmd.com/read/28632845/iris-malformation-and-anterior-segment-dysgenesis-in-mice-and-humans-with-a-mutation-in-pi-3-kinase
#1
Marie H Solheim, Allen C Clermont, Jonathon N Winnay, Erlend Hallstensen, Anders Molven, Pål R Njølstad, Eyvind Rødahl, C Ronald Kahn
Purpose: To determine the ocular consequences of a dominant-negative mutation in the p85α subunit of phosphatidylinositol 3-kinase (PIK3R1) using a knock-in mouse model of SHORT syndrome, a syndrome associated with short stature, lipodystrophy, diabetes, and Rieger anomaly in humans. Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85α (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28588680/early-clinical-characteristics-of-bacterial-endophthalmitis-in-retinopathy-of-prematurity-after-intravitreal-bevacizumab-injection-a-case-report
#2
Jianxun Wang, Daoman Xiang
Intravitreal bevacizumab injection (IVB) is emerging as a safe and effective therapy for retinopathy of prematurity (ROP); however, follow-up investigations after IVB have indicated that endophthalmitis, a rare and devastating complication, may develop. The present study reports a case of an infant with ROP who developed endophthalmitis after IVB infection. The infant was administered with an intravitreal injection of broad-spectrum antibiotics to treat the endophthalmitis. A favorable anatomic outcome was achieved after follow-up...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28540021/minimally-invasive-surgery-for-the-removal-of-posterior-intraocular-foreign-bodies
#3
Jesus Hernan Gonzalez-Cortes, Yunuen Bages-Rousselon, Jesus Emiliano Gonzalez-Cantu, Jesus Mohamed-Hamsho
This is a prospective clinical assay that included six patients who were diagnosed with penetrating corneal injury, traumatic cataract, and posterior segment intraocular foreign body (IOFB). Following anterior segment repair and extraction of traumatic cataract by clear cornea phacoemulsification, a standard 25-gauge transconjunctival pars plana vitrectomy was performed to find and release the IOFB. With active suction using a 25-gauge silicone tipped cannula, the foreign body was retrieved and safely placed in the anterior chamber...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28491472/the-effect-of-corneal-refractive-surgery-on-glaucoma
#4
REVIEW
Vassilios Kozobolis, Aristeidis Konstantinidis, Haris Sideroudi, G Labiris
Laser-assisted refractive procedures have become very popular in the last two decades. As a result, a "generation" of patients with altered corneal properties is emerging. These patients will require both cataract extraction and glaucoma follow-up in the future. Since the glaucoma examination largely depends on the corneal properties, the reshaped postrefractive surgery cornea poses a challenge in the diagnosis, follow-up, and management of the glaucomatous patient. In order to overcome this problem, every patient who is planned to undergo corneal refractive surgery must have a thorough glaucoma examination in order for the ophthalmologist to be able to monitor their patients for possible glaucoma development and/or progression...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28465835/a-rabbit-model-study-to-determine-the-efficacy-of-a-prototype-corneal-endothelium-protector-during-cataract-surgery
#5
Annabel C Y Chew, Anita Chan, Monisha E Nongpiur, Gary Peh, Veluchamy A Barathi, Nyein C Lwin, Charles Ong, Shamira Perera
Purpose. We evaluated the efficacy and safety of a mechanical device, the P-chute, in corneal endothelium preservation during phacoemulsification in a rabbit model. Methods. Twenty-four rabbits were randomly assigned into 2 groups. One eye of each rabbit underwent phacoemulsification that simulated the removal of a dense nucleus, with or without the P-chute. Serial slit-lamp examinations, anterior segment optical coherence tomography (ASOCT) scans, and specular microscopy were performed. Three rabbits from each group were sacrificed on postoperative days (PODs) 1, 5, 7, and 14...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28062421/intraoperative-oct-assisted-descemetopexy-with-stromal-vent-incisions-and-intracameral-gas-injection-for-case-of-non-resolving-descemet-s-membrane-detachment
#6
Archita Singh, Murugesan Vanathi, Suman Sahu, Saranya Devi
Descemet's membrane detachment (DMD) though uncommon in the present day scenario of advancing surgical techniques is a significant complication that requires prompt diagnosis and management. A middle-aged man presented to our hospital with poor gain of vision following cataract surgery. There was significant corneal oedema with DMD which was confirmed on anterior segment optical coherence tomography. We describe a modified continuous intraoperative-guided approach for the management of DMD in cases with oedematous hazy corneas...
January 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/27227394/anterior-segment-optical-coherence-tomography-of-patients-with-late-onset-tunnel-fungal-infections-with-endophthalmitis-after-cataract-surgery
#7
Mami Kitahata, Takashi Suzuki, Naoko Oka, Koji Toriyama, Yuichi Ohashi
PURPOSE: To report the use of anterior segment optical coherence tomography for characterization of late-onset tunnel fungal infections with endophthalmitis after cataract surgery. METHODS: Case reports. RESULTS: A 77-year-old female (case 1) and a 76-year-old male (case 2) who received cataract surgery 15 and 1 year before their initial visits, respectively, were treated with topical steroids based on a diagnosis of uveitis, because they showed growing white lesions on the upper iris and beneath the cataract scleral wound...
August 2016: Cornea
https://www.readbyqxmd.com/read/27138378/distribution-of-axial-length-anterior-chamber-depth-and-corneal-curvature-in-an-aged-population-in-south-china
#8
Hui Chen, Haotian Lin, Zhuoling Lin, Jingjing Chen, Weirong Chen
BACKGROUND: Ocular biometry is important for preoperative assessment in cataract and anterior segment surgery. The purpose of this study was to investigate normative ocular biometric parameters and their associations in an older Chinese population. METHODS: This was a cross-sectional observational study. From 2013 to 2014, we recruited inhabitants aged 50 years or older in Guangzhou, China. Among 1,117 participants in the study, data from 1,015 phakic right eyes were used for analyses...
May 1, 2016: BMC Ophthalmology
https://www.readbyqxmd.com/read/27019091/comparison-of-effect-of-nepafenac-and-diclofenac-ophthalmic-solutions-on-cornea-tear-film-and-ocular-surface-after-cataract-surgery-the-results-of-a-randomized-trial
#9
Atsushi Kawahara, Tsugiaki Utsunomiya, Yuji Kato, Yoshinori Takayanagi
BACKGROUND: The aim of this study was to compare the effects of nepafenac ophthalmic suspension 0.1% (Nevanac) and diclofenac sodium ophthalmic solution 0.1% (Diclod) on the cornea, tear film, and ocular surface after cataract surgery. METHODS: A total of 60 eyes (60 patients) were selected for this study, with no ocular diseases other than cataract (scheduled for cataract surgery by one surgeon). Patients were randomly enrolled to receive nepafenac or diclofenac in the perioperative period, and cataract surgery was performed using torsional microcoaxial phacoemulsification and aspiration with intraocular lens implantation via a transconjunctival single-plane sclerocorneal incision at the 12 o'clock position...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27010265/characterization-of-anterior-segment-ophthalmologic-lesions-identified-in-free-ranging-dolphins-and-those-under-human-care
#10
Carmen M H Colitz, Michael T Walsh, Stephen D McCulloch
Cetaceans in the wild and under human care develop a variety of ocular lesions. Although they have echolocation, cetacean species have good sight, making ocular health an important part of overall health care. The cornea is the primary site of abnormalities in both populations. Typical lesions of cetaceans under human care are characterized in this retrospective review of cases. One hundred eighty animals (n = 360 eyes) were chosen from the author's ophthalmologic examination reports from different geographic areas; they included Atlantic bottlenose dolphins (Tursiops truncatus), Pacific bottle nose dolphins (Tursiopstruncatus gilli), Indopacific bottlenose dolphins (Steno bredanensis), Indopacific humpback dolphins (Sousa chinensis), and roughtooth dolphins (Steno bredanensis)...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/26998714/effect-of-the-rho-associated-kinase-inhibitor-eye-drop-ripasudil-on-corneal-endothelial-wound-healing
#11
Naoki Okumura, Yugo Okazaki, Ryota Inoue, Kazuya Kakutani, Shinichiro Nakano, Shigeru Kinoshita, Noriko Koizumi
PURPOSE: Ripasudil (Glanatec), a selective rho-associated coiled coil-containing protein kinase (ROCK) inhibitor, was approved as a glaucoma and ocular hypertension treatment in Japan in 2014. The purpose of this study was to investigate the feasibility of using ripasudil eye drops to treat corneal endothelial injuries. METHODS: Cultured human corneal endothelial cells (HCECs) were treated with ripasudil, and 5-bromo-2'-deoxyuridine (BrdU) incorporation was evaluated by ELISA...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26686949/non-invasive-ocular-rigidity-measurement-a-differential-tonometry-approach
#12
Efstathios T Detorakis, Emmanuela Tsaglioti, George Kymionis
PURPOSE: Taking into account the fact that Goldmann applanation tonometry (GAT) geometrically deforms the corneal apex and displaces volume from the anterior segment whereas Dynamic Contour Tonometry (DCT) does not, we aimed at developing an algorithm for the calculation of ocular rigidity (OR) based on the differences in pressure and volume between deformed and non-deformed status according to the general Friedenwald principle of differential tonometry. METHODS: To avoid deviations of GAT IOP from true IOP in eyes with corneas different from the "calibration cornea" we applied the previously described Orssengo-Pye algorithm to calculate an error coefficient "C/B"...
2015: Acta Medica (Hradec Králové)
https://www.readbyqxmd.com/read/26447982/impact-of-corneal-endothelial-dysfunctions-on-intraocular-oxygen-levels-in-human-eyes
#13
Andrew J W Huang, Ying-Bo Shui, Yu-Ping Han, Fang Bai, Carla J Siegfried, David C Beebe
PURPOSE: We studied the implications of corneal endothelial dysfunctions on oxidative stress in the anterior segment via in vivo measurements of oxygen partial pressure (pO2) in the anterior chamber (AC) of human eyes. METHODS: We recruited 51 patients undergoing cataract surgery and/or endothelial keratoplasty (EK). Endothelial cell density (ECD; n = 33) and central corneal thickness (CCT; n = 41) were measured on patients with relatively clear corneas. Before surgery, an oxygen sensor was introduced into the AC via a peripheral corneal paracentesis...
October 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26322816/incision-site-descemet-membrane-detachment-during-and-after-phacoemulsification-risk-factors-and-management
#14
Namrata Sharma, Pooja Bandivadekar, Tushar Agarwal, Ritu Shah, Jeewan S Titiyal
OBJECTIVE: To evaluate the occurrence of localized incision-site Descemet membrane detachment (DMD) during and after phacoemulsification and to study its relationship with phacoemulsification parameters. METHODS: Forty-three, consecutive uneventful cases of phacoemulsification through 2.8-mm clear corneal incision were included in this prospective study. Preoperatively, the grade of cataract was assessed. The phacoemulsification parameters noted were phacoemulsification time, aspiration time, cumulative dissipated energy (CDE), ultrasound time, and total fluid volume...
September 2015: Eye & Contact Lens
https://www.readbyqxmd.com/read/26268356/role-of-b-scan-ultrasonography-in-the-localization-of-intraocular-foreign-bodies-in-the-anterior-segment-a-report-of-three-cases
#15
Kaijun Wang, Jun Liu, Min Chen
BACKGROUND: The accurate localization of intraocular foreign bodies (IOFBs) is very important for the management of ocular trauma patients. B-scan ultrasonography is usually used to detect IOFBs in the posterior segment. Here, we report three cases with IOFBs in the anterior segment near the posterior lens capsule, which were accurately localized by B-scan ultrasonography under dynamic transversal scanning. CASE PRESENTATION: All three patients had a history of ocular trauma, and their clinical symptoms were compatible with the persistence of IOFBs...
August 14, 2015: BMC Ophthalmology
https://www.readbyqxmd.com/read/25574173/toxic-anterior-segment-syndrome-following-phacoemulsification-secondary-to-overdose-of-intracameral-gentamicin
#16
Yaran Koban, Selim Genc, Gorkem Bilgin, Halil Huseyin Cagatay, Metin Ekinci, Melin Gecer, Zeliha Yazar
Objective. To report a case of toxic anterior segment syndrome (TASS) that was caused by inadvertent anterior chamber and cornea stromal injection with high dose gentamicin following cataract surgery. Methods. Case report. Results. We report a 72-year-old female patient who developed TASS that was caused by high dose gentamicin (20 mg/0.5 mL), which was inadvertently used during the formation of the anterior chamber and hydration of the corneal incision. Unlike previous cases, hyphema and hemorrhagic fibrinous reaction were seen in the anterior chamber...
2014: Case Reports in Medicine
https://www.readbyqxmd.com/read/25569912/normalizing-videos-of-anterior-eye-segment-surgeries
#17
Gwénolé Quellec, Katia Charriére, Mathieu Lamard, Béatrice Cochener, Guy Cazuguel
Anterior eye segment surgeries are usually video-recorded. If we are able to efficiently analyze surgical videos in real-time, new decision support tools will emerge. The main anatomical landmarks in these videos are the pupil boundaries and the limbus, but segmenting them is challenging due to the variety of colors and textures in the pupil, the iris, the sclera and the lids. In this paper, we present a solution to reliably normalize the center and the scale in videos, without explicitly segmenting these landmarks...
2014: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/25535407/prevalence-and-causes-of-visual-impairment-and-rate-of-wearing-spectacles-in-schools-for-children-of-migrant-workers-in-shanghai-china
#18
Jiangnan He, Lina Lu, Haidong Zou, Xiangui He, Qiangqiang Li, Weijie Wang, Jianfeng Zhu
BACKGROUND: To assess the prevalence of visual impairment and rate of wearing spectacles in schools for children of migrant workers in Shanghai, China. METHODS: Children from grade 1 to 5 in schools for children of migrant workers were randomly chosen for ocular examinations. All children were screened for uncorrected visual acuity and presenting visual acuity. After screening, the children whose uncorrected visual acuity was 20/40 or less received ocular motility evaluation, cycloplegic refraction/non-cycloplegic refraction, and external eye, anterior segment, media, and fundus examinations...
2014: BMC Public Health
https://www.readbyqxmd.com/read/25461296/central-corneal-thickness-correlates-with-oxygen-levels-in-the-human-anterior-chamber-angle
#19
Carla J Siegfried, Ying-Bo Shui, Fang Bai, David C Beebe
PURPOSE: To measure oxygen (pO2) in eyes of patients undergoing intraocular surgery and identify correlations with central corneal thickness (CCT). DESIGN: Prospective, cross-sectional study. METHODS: setting: Institutional. patient population: 124 patients undergoing cataract and/or glaucoma surgery. observation procedure: Prior to surgery, an oxygen sensor was introduced into the anterior chamber (AC) via peripheral corneal paracentesis...
March 2015: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/25411932/fibrous-proliferation-into-anterior-segment-after-acute-angle-closure-glaucoma
#20
Jia yu Ng, Sathish Srinivasan, Fiona Roberts
PURPOSE: To report clinicopathological features and management of a case of extensive fibrovascular proliferation into the anterior segment after acute angle-closure glaucoma (AACG). METHODS: Interventional case report with pathological correlation. A 61-year-old white woman was referred with persistent corneal opacity in the right eye 3 months after AACG. Slit-lamp biomicroscopy of the right eye revealed corneal opacity with a retrocorneal membrane involving the posterior cornea, anterior iris, shallow anterior chamber, and dense mature cataract...
January 2015: Cornea
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