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Hurthle cell thyroid

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https://www.readbyqxmd.com/read/29120653/-thyroid-carcinomas-the-present-view-on-diagnostics-and-therapy
#1
Petr Vlček, Dana Nováková, Rami Katra
Thyroid carcinoma (TC) represents 1-2 % of all human tumors, and is the seventh most common tumor. Women are in large majority among new patients. For women, this is the fifth most common tumor. In the Czech Republic, 1 143 new cases of TC were diagnosed in 2015. It is the tumor with the highest increase in incidence. Among newly diagnosed tumors, most of those are differentiated thyroid gland carcinomas (DTCs) originating from follicular thyroid cells. These tumors are follicular and papillary carcinomas and Hurthle carcinoma, accounting for 95 % of new cases...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29102432/follicular-thyroid-cancer-and-h%C3%A3-rthle-cell-carcinoma-challenges-in-diagnosis-treatment-and-clinical-management
#2
REVIEW
Giorgio Grani, Livia Lamartina, Cosimo Durante, Sebastiano Filetti, David S Cooper
Follicular thyroid cancer is the second most common differentiated thyroid cancer histological type and has been overshadowed by its more common counterpart-papillary thyroid cancer-despite its unique biological behaviour and less favourable outcomes. In this Review, we comprehensively review the literature on follicular thyroid cancer to provide an evidence-based guide to the management of these tumours, to highlight the lack of evidence behind guideline recommendations, and to identify changes and challenges over the past decades in diagnosis, prognosis, and treatment...
October 25, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29092022/pulmonary-metastasectomy-for-thyroid-cancer-as-salvage-therapy-for-radioactive-iodine-refractory-metastases
#3
Isabelle Moneke, Jussuf T Kaifi, Raphael Kloeser, Patrick Samson, Benedikt Haager, Sebastian Wiesemann, Sven Diederichs, Bernward Passlick
OBJECTIVES: Distant metastasis arising from thyroid cancer is rare but has been associated with significantly reduced long-term survival, especially when refractory to radioactive iodine ablation. We provide one of the largest studies worldwide reporting the outcome after salvage pulmonary metastasectomy for this entity, aiming to identify prognostic factors and to analyse surgical indication. METHODS: We retrospectively analysed the medical records of 43 patients who had undergone pulmonary metastasectomy for radioactive iodine-refractory thyroid cancer from 1985 to 2016...
October 30, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29025986/-18-f-fluorodeoxyglycose-avid-thyroid-incidentalomas-the-importance-of-contextual-interpretation
#4
David A Pattison, Michael Bozin, Alexandra Gorelik, Michael S Hofman, Rodney J Hicks, Anita Skandarajah
Background: FDG-avid thyroid incidentalomas (TI) are seen in approximately 2.5% of patients imaged for staging or response assessment of malignancy and represent thyroid cancer in approximately 35% of cases. Consequently, the 2015 ATA guidelines strongly recommend investigation of all FDG-avid nodules ≥1cm with US and fine needle aspiration cytology (FNA). This study aims to assess the overall and thyroid cancer specific survival in a large cohort of patients with FDG-avid TI with long-term follow-up to assess the validity of this approach...
October 12, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29020892/are-evidence-based-guidelines-reflected-in-clinical-practice-an-analysis-of-prospectively-collected-data-of-the-italian-thyroid-cancer-observatory
#5
Livia Lamartina, Cosimo Durante, Giuseppe Lucisano, Giorgio Grani, Rocco Bellantone, Celestino Pio Lombardi, Alfredo Pontecorvi, Emanuela Arvat, Francesco Felicetti, Maria C Zatelli, Roberta Rossi, Efisio Puxeddu, Silvia Morelli, Massimo Torlontano, Umberto Crocetti, Teresa Montesano, Raffaele Giubbini, Fabio Orlandi, Gianluca Aimaretti, Fabio Monzani, Marco Attard, Cecilia Francese, Alessandro Antonelli, Paolo Limone, Ruth Rossetto, Laura Fugazzola, Domenico Meringolo, Rocco Bruno, Salvatore Tumino, Graziano Ceresini, Marco Centanni, Salvatore Monti, Domenico Salvatore, Giovanna Spiazzi, Caterina Mian, Luca Persani, Daniele Barbaro, Antonio Nicolucci, Sebastiano Filetti
OBJECTIVES: The goal of evidence-based practice guidelines is to optimize the management of emerging diseases, such as differentiated thyroid cancer (DTC). The aim of this study was to assess therapeutic approaches for DTC in Italy and to see how closely these practices conformed to those recommended in the 2009 American Thyroid Association (ATA) guidelines. METHODS: The Italian Thyroid Cancer Observatory was established to collect data prospectively on thyroid cancers consecutively diagnosed in participating centers (uniformly distributed across the nation)...
November 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28965201/eif1ax-mutation-in-a-patient-with-h%C3%A3-rthle-cell-carcinoma
#6
Michael C Topf, Zi-Xuan Wang, Kevin Furlong, Jeffrey L Miller, Madalina Tuluc, Edmund A Pribitkin
The EIF1AX gene is a novel cancer gene that has been reported in the tumorigenesis of papillary thyroid carcinoma, follicular variant papillary thyroid carcinoma, and anaplastic thyroid carcinoma. A 71-year-old woman presented with a right thyroid mass, which was follicular neoplasm on cytology. The fine needle aspirate of the nodule was examined by next-generation sequencing and found to harbor EIF1AX and TP53 mutations. Right thyroid lobectomy was performed with final pathology showing Hürthle cell carcinoma with capsular and vascular invasion...
September 30, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28962946/mitochondrial-dna-common-deletion-in-post-fna-infarcted-oncocytic-thyroid-tumors
#7
Luca Conti, Simona Vatrano, Luca Bertero, Lavinia Masu, Donatella Pacchioni, Lorenzo Daniele, Giovanni De Rosa, Paola Cassoni, Marco Volante, Mauro Papotti
Thyroid fine needle aspiration (FNA) can rarely induce morphological changes potentially hindering the histopathological diagnosis, especially in Hurthle cell tumors (HCT), which may easily undergo post-FNA infarction or necrosis. HCTs contain mitochondrion (mt)-rich cells that may bear mtDNA mutations, the most frequent being the so-called "common deletion" (CD). The aim of this study was to determine the presence and extent of the mtDNA CD in a series of thyroid HCT that underwent extensive infarction following FNA procedure, in comparison with a control series of HCT lacking post-FNA ischemic/hemorrhagic alterations...
September 26, 2017: Human Pathology
https://www.readbyqxmd.com/read/28946558/ultrasonic-diagnosis-for-thyroid-h%C3%A3-rthle-cell-tumor
#8
Peng Li, Ping Liu, Hui Zhang
OBJECTIVE: This study aims to evaluate the diagnostic value of ultrasound in thyroid Hürthle cell tumors. METHODS: A retrospective analysis was carried out on 27 patients with thyroid Hürthle cell tumors, in terms of the size, shape, boundary, echo, aspect ratio, cystic degeneration, calcification, peripheral halo sign and blood supply of the tumor, through surgical pathological validation. Then, these were compared with postoperative pathological results. RESULTS: The maximum diameter of the thyroid Hürthle cell tumors is between 0...
September 7, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28938489/prognostic-classifier-based-on-genome-wide-dna-methylation-profiling-in-well-differentiated-thyroid-tumors
#9
Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fábio Albuquerque Marchi, Caroline Moraes Beltrami, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Context: Even though the majority of well-differentiated thyroid carcinoma (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidence suggests that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 nonneoplastic thyroid tissues (NTs), 17 benign thyroid lesions (BTLs), and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated, and 3 anaplastic)...
November 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28913847/incidence-malignancy-rates-of-diagnoses-and-cyto-histological-correlations-in-the-new-italian-reporting-system-for-thyroid-cytology-an-institutional-experience
#10
P Straccia, A Santoro, E D Rossi, C Brunelli, C Mosseri, T Musarra, A Pontecorvi, C P Lombardi, G Fadda
OBJECTIVE: FNA biopsy is considered as the most accurate method for the selection of patients with thyroid nodules that need for surgery or for the wait and see management. The aim of the present study is to clarify the risk of malignancy for the cytological data classified according to the 2014 Italian reporting system. METHODS: We report a retrospective analysis of 4043 patients in our institution's experience during the period April 2014 through December 2016 with the Italian reporting system for thyroid cytology...
September 15, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28878853/bilateral-renal-metastasis-of-h%C3%A3-rthle-cell-thyroid-cancer-with-discordant-uptake-between-i-131-sodium-iodide-and-f-18-fdg
#11
Apichaya Claimon, Minseok Suh, Gi Jeong Cheon, Dong Soo Lee, E Edmund Kim, June-Key Chung
Renal metastasis of thyroid cancer is extremely rare. We report the case of a 62-year-old woman with Hürthle cell thyroid cancer (HCTC) with lungs, bones, and bilateral kidneys metastases. The renal metastatic lesions were clearly demonstrated by (131)I whole body scan (WBS) with SPECT/CT. However, they exhibited false-negative results in (18)F-FDG PET/CT, kidney ultrasonography, and contrast-enhanced CT scan. The findings imply that tumors have low glucose metabolism and are able to accumulate radioiodine, which is not commonly found in the relatively aggressive nature of HCTC...
September 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28857358/h%C3%A3-rthle-cell-carcinoma-in-an-unattached-thyroid-lobe-a-diagnostic-challenge
#12
Sofia Lypiridou, Theodosis Papavramidis, Antonios Michalopoulos, Aikaterini Foka-Karagiannopoulou, Triantafyllia Koletsa
No abstract text is available yet for this article.
August 31, 2017: Pathology International
https://www.readbyqxmd.com/read/28821191/impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-features-on-adequacy-criteria-and-risk-of-malignancy-of-thyroid-fine-needle-aspiration
#13
Andrew A Renshaw, Edwin W Gould
Objectives: The impact of noninvasive follicular thyroid neoplasm with papillary-like features (NIFTP) on nondiagnostic and benign diagnoses is not well characterized. Methods: The results of all thyroid fine-needle aspirates (FNAs) performed from 1997 to June 2016 with corresponding resections were reviewed. Results: From 12,764 aspirates, there were 8,106 (64%) benign diagnoses with 412 (5%) resections and 1,888 (14.8%) nondiagnostic diagnoses with 329 (17%) resections...
September 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28802094/oncocytic-variant-of-medullary-thyroid-carcinoma-a-rare-tumor-with-numerous-diagnostic-mimics-by-fine-needle-aspiration
#14
Sharon B Sams, Kenneth D Tompkins, Sarah Mayson, Christopher D Raeburn, Sanjana Mehrotra
Oncocytic variant of medullary thyroid carcinoma is rare form of thyroid carcinoma that is easily misdiagnosed on fine needle aspiration specimens due to it is low incidence and cytomorphologic overlap with other more common Hurtle cell lesions. A correct initial diagnosis by fine needle aspiration is imperative as the clinical treatment for medullary carcinoma differs significantly from the mimickers. We present a case of this rare variant tumor that on initial fine needle aspiration was described as a Hurthle cell lesion and was subsequently correctly classified on the resection specimen...
August 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28736886/size-of-thyroid-carcinoma-by-histotype-and-variants-a-population-based-study-in-a-mildly-iodine-deficient-area
#15
Michela Marina, Gian Paolo Ceda, Luigi Corcione, Paolo Sgargi, Maria Michiara, Enrico Maria Silini, Graziano Ceresini
BACKGROUND: Data relating the size of thyroid cancer with histological types and variants are scarce. METHODS: All incident thyroid cancer diagnosed between 2003 and 2012 in a mildly iodine-deficient area were derived from a population-based tumor registry. Undifferentiated/anaplastic thyroid cancer and incidental cases were excluded. Major diameter of thyroid cancer, as assessed by pathological examination, was stratified in classes: ≤10 mm; 11-20 mm; 21-40 mm; and >40 mm...
July 24, 2017: Head & Neck
https://www.readbyqxmd.com/read/28680210/incidentally-detected-thyroid-follicular-neoplasm-on-somatostatin-receptor-imaging-and-post-therapy-scan
#16
Apurva Sood, Harpreet Singh, Ashwani Sood, Rajender Kumar Basher, Bhagwant Rai Mittal
Peptide receptor radionuclide therapy (PRRT) either using Lu-177 or Y-90 peptide radiopharmaceuticals has emerged as promising treatment modality in patients with inoperable metastatic neuroendocrine tumour (NET) including medullary thyroid cancer, because of overexpression of somatostatin receptor 2 (sstr-2) on these cells. The several investigators have used PRRT in non-iodine avid differentiated thyroid cancer patients with limited success, where other treatment modalities have failed, probably due to faint sstr-2 expression in these lesions...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28660408/phosphorylated-mechanistic-target-of-rapamycin-p-mtor-and-noncoding-rna-expression-in-follicular-and-h%C3%A3-rthle-cell-thyroid-neoplasm
#17
Adam Covach, Sanjay Patel, Heather Hardin, Ricardo V Lloyd
Oncocytic (Hürthle cell) and follicular neoplasms are related thyroid tumors with distinct molecular profiles. Diagnostic criteria separating adenomas and carcinomas for these two types of neoplasms are similar, but there may be some differences in the biological behavior of Hürthle cell and follicular carcinomas. Recent studies have shown that noncoding RNAs may have diagnostic and prognostic utility in separating benign and malignant Hürthle cell and follicular neoplasms. In this study, we examined expression of various noncoding RNAs including metastasis associated lung adenocarcinoma transcript 1 (MALAT1) and miR-RNA-885-5p (miR-885) in distinguishing between benign and malignant neoplasms...
June 28, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28567111/cytomorphologic-features-distinguishing-bethesda-category-iv-thyroid-lesions-from-parathyroid
#18
Simon Sung, Anjali Saqi, Elizabeth M Margolskee, John P Crapanzano
BACKGROUND: Thyroid follicular cells share similar cytomorphological features with parathyroid. Without a clinical suspicion, the distinction between a thyroid neoplasm and an intrathyroidal parathyroid can be challenging. The aim of this study was to assess the distinguishing cytomorphological features of parathyroid (including intrathyroidal) and Bethesda category IV (Beth-IV) thyroid follicular lesions, which carry a 15%-30% risk of malignancy and are often followed up with surgical resection...
2017: CytoJournal
https://www.readbyqxmd.com/read/28554832/evolution-of-the-histologic-classification-of-thyroid-neoplasms-and-its-impact-on-clinical-management
#19
REVIEW
B Xu, R Ghossein
The vast majority of low grade follicular cell derived thyroid carcinomas follows an indolent clinical course and is associated with very low mortality. Risk stratification using multiple clinical and pathologic characteristics has become the standard of care to guide appropriate management and avoid overtreatment. Over the past few decades, the field of thyroid pathology has witnessed several major changes that significantly impacted upon patients' care. These are: 1) The reclassification of non-invasive encapsulated follicular variant of papillary thyroid carcinoma as noninvasive follicular thyroid neoplasm with papillary-like nuclear features; 2) the diagnosis of Hurthle cell carcinoma based on the presence of capsular and vascular invasion; 3) a detailed definition of poorly differentiated thyroid carcinoma, taking into consideration mitosis and necrosis; and 4) the emphasis on a detailed pathologic analysis such as the extent of vascular invasion and extrathyroidal extension...
May 18, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28545571/survival-and-prognostic-factors-for-survival-cancer-specific-survival-and-disease-free-interval-in-239-patients-with-hurthle-cell-carcinoma-a-single-center-experience
#20
Branisav Oluic, Ivan Paunovic, Zlatibor Loncar, Vladimir Djukic, Aleksandar Diklic, Milan Jovanovic, Zeljko Garabinovic, Nikola Slijepcevic, Branislav Rovcanin, Dusan Micic, Aleksandar Filipovic, Vladan Zivaljevic
BACKGROUND: Hurthle cell carcinoma makes up 3 to 5% of all thyroid cancers and is considered to be a true rarity. The aim of our study was to analyze clinical characteristics and survival rates of patients with Hurthle cell carcinoma. METHODS: Clinical data regarding basic demographic characteristics, tumor grade, type of surgical treatment and vital status were collected. Methods of descriptive statistics and Kaplan-Meier survival curves were used for statistical analysis...
May 25, 2017: BMC Cancer
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