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https://www.readbyqxmd.com/read/29346645/performance-of-an-easy-to-use-prediction-model-for-renal-patient-survival-an-external-validation-study-using-data-from-the-era-edta-registry
#1
Aline C Hemke, Martin B A Heemskerk, Merel van Diepen, Anneke Kramer, Johan de Meester, James G Heaf, José Maria Abad Diez, Marta Torres Guinea, Patrik Finne, Philippe Brunet, Bjørn E Vikse, Fergus J Caskey, Jamie P Traynor, Ziad A Massy, Cécile Couchoud, Jaap W Groothoff, Maurizio Nordio, Kitty J Jager, Friedo W Dekker, Andries J Hoitsma
Background: An easy-to-use prediction model for long-term renal patient survival based on only four predictors [age, primary renal disease, sex and therapy at 90 days after the start of renal replacement therapy (RRT)] has been developed in The Netherlands. To assess the usability of this model for use in Europe, we externally validated the model in 10 European countries. Methods: Data from the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry were used...
January 16, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29346618/evidence-of-adaptive-evolution-and-relaxed-constraints-in-sex-biased-genes-of-south-american-and-west-indies-fruit-flies-diptera-tephritidae
#2
Carlos Congrains, Emeline B Campanini, Felipe R Torres, Víctor B Rezende, Aline M Nakamura, Janaína L de Oliveira, André L A Lima, Samira Chahad-Ehlers, Iderval S Sobrinho, Reinaldo A de Brito
Several studies have demonstrated that genes differentially expressed between sexes (sex-biased genes) tend to evolve faster than unbiased genes, particularly in males. The reason for this accelerated evolution is not clear, but several explanations have involved adaptive and non-adaptive mechanisms. Furthermore, the differences of sex-biased expression patterns of closely related species are also little explored out of Drosophila. To address the evolutionary processes involved with sex-biased expression in species with incipient differentiation, we analyzed male and female transcriptomes of Anastrepha fraterculus and A...
January 15, 2018: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29346580/smoking-sex-and-non-small-cell-lung-cancer-steroid-hormone-receptors-in-tumor-tissue-s0424
#3
Ting-Yuan David Cheng, Amy K Darke, Mary W Redman, Gary R Zirpoli, Warren Davis, Rochelle Payne Ondracek, Wiam Bshara, Angela R Omilian, Robert Kratzke, Mary E Reid, Julian R Molina, Jill M Kolesar, Yuhchyau Chen, Robert M MacRae, James Moon, Philip Mack, David R Gandara, Karen Kelly, Regina M Santella, Kathy S Albain, Christine B Ambrosone
Background: To what extent steroid hormones contribute to lung cancer in male and female never smokers and smokers is unclear. We examined expression of hormone receptors in lung tumors by sex and smoking. Methods: Patients with primary non-small cell lung cancer were recruited into an Intergroup study in the United States and Canada, led by SWOG (S0424). Tumors from 813 cases (450 women and 363 men) were assayed using immunohistochemistry for estrogen receptor (ER)-α, ER-β, progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2)...
January 13, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29346554/functional-roles-of-sex-biased-growth-hormone-regulated-micrornas-mir-1948-and-mir-802-in-young-adult-mouse-liver
#4
Pengying Hao, David J Waxman
Sex-specific temporal patterns of pituitary GH secretion determine the sex-biased transcription of hundreds of genes in the liver and impart significant sex differences in liver physiology, metabolism and disease. Sex differences in hepatic gene expression vary widely, ranging from <2-fold to >1,000-fold in the mouse. Here, we use small RNA sequencing to discover 24 sex-biased mouse liver miRNAs, and then investigate the roles of two of these miRNAs in GH-regulated liver sex differences. Studies in pre-pubertal and young adult mice, and in mice where pituitary hormones are ablated or where sex-specific hepatic GH signaling is dysregulated, demonstrated that the male-biased miR-1948 and the female-biased miR-802 are both regulated by sex-specific pituitary GH secretory patterns, acquire sex specificity at puberty, and are dependent on the GH-activated transcription factor STAT5 for their sex-specific expression...
January 16, 2018: Endocrinology
https://www.readbyqxmd.com/read/29346407/relaxin-reverses-inflammatory-and-immune-signals-in-aged-hearts
#5
Brian Martin, Beth Ann Gabris-Weber, Rajiv Reddy, Guillermo Romero, Ansuman Chattopadhyay, Guy Salama
BACKGROUND: 'Healthy' aging drives structural and functional changes in the heart including maladaptive electrical remodeling, fibrosis and inflammation, which lower the threshold for cardiovascular diseases such as heart failure (HF) and atrial fibrillation (AF). Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive remodeling in aging and HF...
2018: PloS One
https://www.readbyqxmd.com/read/29346385/combined-effectiveness-of-anthelmintic-chemotherapy-and-wash-among-hiv-infected-adults
#6
Arianna R Means, Lisette van Lieshout, Eric Brienen, Krista Yuhas, James P Hughes, Paul Ndungu, Benson Singa, Judd L Walson
INTRODUCTION: Current global helminth control guidelines focus on regular deworming of targeted populations for morbidity control. However, water, sanitation, and hygiene (WASH) interventions may also be important for reducing helminth transmission. We evaluated the impact of different potential helminth protective packages on infection prevalence, including repeated treatment with albendazole and praziquantel with and without WASH access. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cohort study nested within a randomized trial of empiric deworming of HIV-infected adults in Kenya...
January 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29346307/knowledge-and-attitudes-of-general-practitioners-and-sexual-health-care-professionals-regarding-human-papillomavirus-vaccination-for-young-men-who-have-sex-with-men
#7
Samuel W D Merriel, Carrie Flannagan, Joanna M Kesten, Gilla K Shapiro, Tom Nadarzynski, Gillian Prue
Men who have sex with men (MSM) may be at higher risk for human papillomavirus (HPV)-associated cancers. Healthcare professionals' recommendations can affect HPV vaccination uptake. Since 2016, MSM up to 45 years have been offered HPV vaccination at genitourinary medicine (GUM) clinics in a pilot programme, and primary care was recommended as a setting for opportunistic vaccination. Vaccination prior to potential exposure to the virus (i.e., sexual debut) is likely to be most efficacious, therefore a focus on young MSM (YMSM) is important...
January 18, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29345962/role-of-selected-polymorphisms-in-determining-muscle-fiber-composition-in-japanese-men-and-women
#8
Hiroshi Kumagai, Takuro Tobina, Noriko Ichinoseki-Sekine, Ryo Kakigi, Takamasa Tsuzuki, Hirofumi Zempo, Keisuke Shiose, Eiichi Yoshimura, Hideaki Kumahara, Makoto Ayabe, Yasuki Higaki, Ryo Yamada, Hiroyuki Kobayashi, Akira Kiyonaga, Hisashi Naito, Hiroaki Tanaka, Noriyuki Fuku
Genetic polymorphisms and sex differences are suggested to affect muscle fiber composition; however, no study has investigated the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences. Therefore, the present study examined the effects of genetic polymorphisms on muscle fiber composition with respect to sex differences in Japanese population. The present study included 211 healthy Japanese individuals (102 men and 109 women). Muscle biopsies were obtained from the vastus lateralis to determine the proportion of myosin heavy chain isoforms (MHC-I, MHC-IIa, and MHC-IIx)...
January 18, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29345960/pacing-strategies-by-age-in-marathon-cross-country-skiing
#9
Pantelis Theodoros Nikolaidis, Beat Knechtle
OBJECTIVES: Pacing strategies have mainly been investigated for runners, but little is known for cross-country skiers. The aim of the present study was to investigate whether differences in pacing strategies do exist between younger and older cross-country skiers competing in the 42km 'Engadin Ski Marathon'. METHODS: Pacing was studied in 105,565 cross-country skiers (classified in 5-year age groups) competing between 1998 and 2016 in this race by examining changes of mean section velocity in 10km (Change A, i...
January 18, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29345858/cardiopulmonary-fitness-is-strongly-associated-with-body-cell-mass-and-fat-free-mass
#10
Armin Köhler, Ryan King, Martin Bahls, Stefan Groß, Antje Steveling, Simone Gärtner, Sabine Schipf, Sven Gläser, Henry Völzke, Stephan B Felix, Marcello Ricardo Paulista Markus, Marcus Dörr
BACKGROUND: Peak oxygen uptake (VO2peak) is commonly indexed by total body weight (TBW) to determine cardiopulmonary fitness (CPF). This approach may lead to misinterpretation, particularly in obese subjects. We investigated the normalization of VO2peak by different body composition markers. METHODS: We analyzed combined data of 3,848 subjects (1,914 women; 49.7%), aged 20-90, from two independent cohorts of the population-based Study of Health in Pomerania (SHIP-2 and SHIP-TREND)...
January 18, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29345724/effects-of-cognitive-training-on-cognition-and-quality-of-life-of-older-persons-with-dementia
#11
Eeva-Liisa Kallio, Hannareeta Öhman, Marja Hietanen, Helena Soini, Timo E Strandberg, Hannu Kautiainen, Kaisu H Pitkälä
OBJECTIVES: To evaluate the effect of cognitive training on cognition and health-related quality of life (HRQoL) in community-dwelling persons with dementia. DESIGN: Single-blind randomized controlled trial with 3- and 9-month follow-up. SETTING: Adult day care centers in Helsinki, Finland. PARTICIPANTS: Older individuals with mild to moderate dementia living at home and attending adult day care twice a week (N = 147; mean age 83, 72% female, 63% at mild stage of dementia)...
January 18, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29345722/morphometric-properties-of-the-tensor-fascia-lata-muscle-in-human-fetuses
#12
Orhan Beger, Turan Koç, Burhan Beger, Deniz Uzmansel, Zeliha Kurtoğlu
In neonatal and early childhood surgeries such as meningomyelocele repairs, closing deep wounds and oncological treatment, tensor fasciae lata (TFL) flaps are used. However, there are not enough data about structural properties of TFL in fetuses, which can be considered as the closest to neonates in terms of sampling. This study's main objective is to gather data about morphological structures of TFL in human fetuses to be used in newborn surgery. Fifty formalin-fixed fetuses (24 Male - 26 Female) with gestational age ranging from 18 - 30 weeks (mean 22...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29345718/evaluation-of-the-morphological-characteristic-and-sex-differences-of-sternum-by-multi-detector-computed-tomography
#13
Sibel Ateşoğlu, Mustafa Deniz, Ayşe İmge Uslu
BACKGROUND: Sternum is one of the skeleton parts which have frequently congenital anomalies and variations are commonly used by researchers in determining sex. We evaluated the morphological characteristics and sex-related changes of the sternum in adult individuals using multidetector CT in our study. MATERIALS AND METHODS: 200 adults (103 female and 97 male) aged between 18-87 years were evaluated. Utilizing the morphological characteristics of the sternum based on the multi-slice images; length, width and the thickness of Manubrium, length, width and the thickness of Corpus Sterni, total length of Sternum, Sternal angle, Sternal index, length of the xiphoid process, the thickness of xiphoid process, the number of indents of xiphoid process were measured and a total of 20 parameters were evaluated by adding age, height and weight to these variables...
January 18, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29345552/preceding-race-efforts-affect-pacing-and-short-track-speed-skating-performance
#14
Marco J Konings, Florentina J Hettinga
PURPOSE: In real-life competitive situations, athletes are required to continuously make decisions about how and when to invest their available energy resources. This study attempted to identify how different competitive environments invite elite short-track speed skaters to modify their pacing behaviour during head-to-head competition. METHODS: Lap times of elite 500, 1000 and 1500 m short-track speed skating competitions between 2011-2016 (n=34095 races) were collected...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29345382/overweight-and-obesity-in-patients-with-atrial-fibrillation-sex-differences-in-1-year-outcomes-in-the-eorp-af-general-pilot-registry
#15
Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Elisa Fantecchi, Joan Meeder, Malgorzata Kurpesa, Monica Mariana Baluta, Marco Proietti, Luigi Tavazzi, Aldo P Maggioni, Gregory Y H Lip
BACKGROUND: The impact of overweight and obesity on outcomes in "real world" patients with atrial fibrillation (AF) is not fully defined. Second, sex differences in AF outcomes may also exist. METHODS AND RESULTS: The aim was to investigate outcomes at 1-year follow-up for AF patients enrolled in the EORP-AF Registry, according to BMI (kg/m2 ), comparing patients with normal BMI (18.5 to < 25 kg/m2), overweight (25 to < 30 kg/m2 ) and obesity (≥30 kg/m2 ), in relation to sex differences...
January 18, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29345308/positive-size-speed-relationships-in-gametes-and-vegetative-cells-of-chlamydomonas-reinhardtii-implications-for-the-evolution-of-sperm
#16
Catherine E Seed, Joseph L Tomkins
It is commonly held that differences in gametes of the two sexes (anisogamy) evolved from ancestors whose gametes were similar in size and behaviour (isogamy). Underlying many hypotheses explaining anisogamy are assumed relationships between cell size and speed in the ancestral isogamous population. Using the isogamous alga Chlamydomonas reinhardtii, we explored size-speed distributions in vegetative and gamete cells of ten cell lines, and clonal data from within two cell lines. We applied an independent speed selection approach to gamete populations of C...
January 18, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29345154/trends-and-repetition-of-non-fatal-suicidal-behaviour-analyses-of-the-gold-coast-university-hospital-s-emergency-department
#17
Kairi Kõlves, David Crompton, Kathryn Turner, Nicolas J C Stapelberg, Ashar Khan, Gail Robinson, Diego de Leo
Objective The aim of the current paper is to analyse time trends of non-fatal suicidal behaviour (NFSB) and its repetition at the Gold Coast in 2005-2015. Methods Data on presentations for NFSB were obtained from the Emergency Department (ED) Information System. Potential cases were identified through keyword searches, which were further scrutinised and coded. Annual person-based age-standardised rates for NFSB were calculated. Chi-square test, Poisson regression and Cox proportional hazards regression were used...
January 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/29344942/maternal-care-affects-chicks-development-differently-according-to-sex-in-quail
#18
Nadège Aigueperse, Florent Pittet, Céline Nicolle, Cécilia Houdelier, Sophie Lumineau
Maternal behavior is known to influence the behavioral development of young. Recently, it was demonstrated that maternal behavior also differed according to sex chicks and brood sex composition. So, here, we explored if these factors influenced behavioral development of chicks quail when they were brooded, and what characteristics of chicks and foster females could best explain this development. We studied three sets of chick pairs brooded by foster females: unisex male, unisex female, and mixed broods. We found that both emotivity profile and sociality depended on the sex: females were more reactive and less social than males...
January 18, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29344788/intracorporeal-versus-extracorporeal-anastomosis-after-laparoscopic-left-colectomy-for-splenic-flexure-cancer-results-from-a-multi-institutional-audit-on-181-consecutive-patients
#19
Marco Milone, Pierluigi Angelini, Giovanna Berardi, Morena Burati, Francesco Corcione, Paolo Delrio, Ugo Elmore, Maria Lemma, Michele Manigrasso, Alfredo Mellano, Andrea Muratore, Ugo Pace, Daniela Rega, Riccardo Rosati, Ernesto Tartaglia, Giovanni Domenico De Palma
Although intracorporeal anastomosis has been demonstrated to be safe and effective after right colectomy, limited data are available about its efficacy after left colectomy for colon cancer located in splenic flexure. A multi-institutional audit was designed, including 92 patients who underwent laparoscopic left colectomy with intracorporeal anastomosis (IA) compared with 89 matched patients who underwent a laparoscopic left colectomy with extracorporeal anastomosis (EA). There was no significant difference in terms of age, sex, BMI, and ASA score between the two groups...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344535/sexual-experience-of-iranian-women-in-their-middle-life-a-qualitative-approach
#20
Sedigheh Moghasemi, Giti Ozgoli, Fazlollah Ahmadi, Masomeh Simbar
Background: Sexual problems are common among the middle-aged women; however, there is no deep understanding of sexuality in midlife. The current study aimed to investigate Iranian women's attitudes and experiences about sexual life changes in midlife. Methods: This is a descriptive qualitative study. Seventeen women aged 40 -65 years old were purposively selected from urban health centers in Gorgan, Iran, in 2015. Face-to-face, semi-structured and in-depth interviews were conducted for data collection until data saturation was attained...
January 2018: International Journal of Community Based Nursing and Midwifery
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