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https://www.readbyqxmd.com/read/29775928/tributyltin-impaired-reproductive-success-in-female-zebrafish-through-disrupting-oogenesis-reproductive-behaviors-and-serotonin-synthesis
#1
Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Liu
Tributyltin (TBT), an organotin acting as aromatase (Cyp19a1) inhibitor, has been found to disrupt gametogenesis and reproductive behaviors in several fish species. However, few studies addressing the mechanisms underlying the impaired gametogenesis and reproduction have been reported. In this study, female adults of zebrafish (Danio rerio) were continuously exposed to two nominal concentrations of TBT (100 and 500 ng/L, actual concentrations: 90.8 ± 1.3 ng/L and 470.3 ± 2.7 ng/L, respectively) for 28 days...
May 12, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29775877/communication-and-social-interaction-anxiety-enhance-interleukin-1-beta-and-cortisol-reactivity-during-high-stakes-public-speaking
#2
Brandon J Auer, Jessica L Calvi, Nicolas M Jordan, David Schrader, Jennifer Byrd-Craven
BACKGROUND: Worry or fear related to speaking in front of others, or more broadly, communicating and interacting with others, is common. At elevated levels, however, it may contribute to heightened stress reactivity during acute speaking challenges. The purpose of this study was to examine multi-system physiological stress reactivity in the context of high-stakes public speaking while considering the impact of hypothesized individual difference risk factors. METHODS: University student participants (n = 95) delivering speeches as a heavily-weighted component of their final grade had saliva samples collected immediately prior to speaking, immediately after, and 20 min after speech completion...
May 8, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29775846/reproductive-stage-and-sex-steroid-hormone-levels-influence-the-expression-of-mesenchymal-stromal-cell-msc-markers-in-the-equine-endometrium
#3
B Elisabeth Rink, Juliane Kuhl, Cristina L Esteves, Hilari M French, Elaine Watson, Christine Aurich, F Xavier Donadeu
Mesenchymal stem or stromal cells (MSCs) play key roles in tissue homeostasis. In the cyclic equine endometrium, this may be regulated by changes in serum concentrations of sex steroid hormones. This study was designed to investigate the changes in endometrial expression of MSC markers during reproductive cycles in mares and the influence of sex steroid hormones on endometrial MSC proliferation in vitro. Endometrial biopsies were collected from pony mares at different reproductive stages (estrus; day 5 and 13 after ovulation; seasonal anestrus; 20 h and 7days post-partum; n = 5 per stage) and were analyzed by RT-qPCR...
May 4, 2018: Theriogenology
https://www.readbyqxmd.com/read/29775828/size-season-and-origin-of-gastropods-matter-in-imposex-assessments
#4
Martina Rossato, Mércia Barcelos Costa, Ítalo Braga de Castro, Grasiela Lopes Leães Pinho
Through controlled exposure to tributyltin (TBT), the effects of season, size, and population origin were evaluated on imposex incidence in Stramonita brasiliensis. Four experiments were carried out with organisms collected from three different sites on the Brazilian coast (Torres - Rio Grande do Sul, Farol de Santa Marta - Santa Catarina, and Aracruz - Espírito Santo). S. brasiliensis were anesthetized, sexed, measured, classified by size in small (< 30 mm), medium (≥ 30 to ≤ 40 mm), or big (> 40 mm) and injected in the foot muscle with 0...
May 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29775772/occurrence-genotyping-and-health-risk-of-cryptosporidium-and-giardia-in-recreational-lakes-in-tianjin-china
#5
Shumin Xiao, Pengna Yin, Yan Zhang, Xiaoyun Zhao, Liping Sun, Hongying Yuan, Jingfang Lu, Sike Hu
Cryptosporidium and Giardia are critical parasites in the etiology of diarrhea worldwide, and often cause waterborne outbreaks. The presence of Cryptosporidium and Giardia in recreational lakes was investigated with molecular characterization, and a comprehensive quantitative microbial risk assessment (QMRA) of protozoan infections was performed, considering multiple exposure pathways, differences in age, sex, and disease severity, and the genotypes of the protozoa. Forty-three (82.7%) and 51 (98.1%) water samples were positive for Cryptosporidium oocysts and Giardia cysts, respectively, with average counts of 3...
May 10, 2018: Water Research
https://www.readbyqxmd.com/read/29775752/the-genetics-and-molecular-pathogenesis-of-systemic-lupus-erythematosus-sle-in-populations-of-different-ancestry
#6
REVIEW
George N Goulielmos, Maria I Zervou, Vassilis M Vazgiourakis, Yogita Ghodke-Puranik, Alexandros Garyfallos, Timothy B Niewold
Systemic lupus erythematosus (SLE; OMIM 152700) is a highly heterogeneous disorder, characterized by differences in autoantibody profile, serum cytokines, and a multi-system involvement commonly affecting the skin, renal, musculoskeletal, and hematopoetic systems clinical manifestations involving. Disease features range from mild manifestations, such as rash or arthritis, to life-threatening end-organ manifestations, such as glomerulonephritis or thrombosis, and it is difficult to predict which manifestations will affect a given patient...
May 15, 2018: Gene
https://www.readbyqxmd.com/read/29775442/-copeptin-in-children-with-chronic-kidney-disease
#7
Piotr Skrzypczyk, Magdalena Okarska-Napierała, Elżbieta Górska, Anna Stelmaszczyk-Emmel, Małgorzata Pańczyk-Tomaszewska
Studies in adult patients suggest that copeptin (C-terminal fragment of antidiuretin propeptide) is related to kidney and cardiovascular diseases. AIM: The aim was to assess copeptin concentration in children with chronic kidney disease (CKD). MATERIALS AND METHODS: In a group of 38 children with CKD (age: from 4.70 to 18.00 mean 12.23±4.19 years) we evaluated: serum copeptin concentration [ng/mL], age, sex, etiology of CKD, presence of arterial hypertension (AH), medications, glomerular filtration rate (GFR), hemoglobin, calcium-phosphorus metabolism parameters, and lipids...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29775407/effect-of-healthy-aging-and-sex-on-middle-cerebral-artery-blood-velocity-dynamics-during-moderate-intensity-exercise
#8
Jaimie L Ward, Jesse C Craig, Yumei Liu, Eric Dennis Vidoni, Rebecca Malesky, David C Poole, Sandra A Billinger
Cerebral blood flow (CBF) velocity measured in the middle cerebral artery (MCAV ) increases with finite kinetics during moderate intensity exercise and both the amplitude and dynamics of the response provide invaluable insights into the controlling mechanisms. The MCAV response following exercise onset is well fit to an exponential model in young individuals but remains to be characterized in their older counterparts. The responsiveness of vasomotor control degrades with advancing age, especially in skeletal muscle, and we tested the hypothesis that older subjects would evince a slower and reduced MCAV response to exercise...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29775132/evaluation-of-lateral-atlantodental-interval-asymmetry-in-the-pediatric-age-group-normative-values
#9
Stephen K Mendenhall, Andrew Huh, Janit Pandya, Vincent Alentado, Karl Balsara, Chang Ho, Andrew Jea
OBJECTIVE The revelation of normative radiographic measurements for the developing pediatric spine is incomplete. The purpose of this analysis was to determine the normal range of asymmetry of the lateral atlantodental interval (LADI) and define age- and sex-related differences. METHODS A total of 3072 children aged 0-18 years who underwent CT scanning of the cervical spine were identified at Riley Hospital for Children between 2005 and 2017. Patients were stratified by sex and age (in years) into 36 cohorts...
May 18, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29775019/-the-expression-and-clinical-progression-of-androgen-estrogen-and-prolactin-receptor-in-laryngeal-squamous-cell-carcinoma
#10
M J Fei, Y N Xu, J D Wang
Objective: The aim of this study is to analyze the different expression and function of androgen receptors (AR) and estrogen receptor (ER-α) in laryngeal squamous cell carcinoma (LSCC). In combination with the expression of prolactin receptor (PRLR), we analyzed the prognostic impact of three receptors on the laryngeal carcinoma. Method: In this study, immunohistochemistry and reverse transcription polymerase chain reaction (RT-PC) analysis were performed on the tumor tissues and adjacent normal tissues in 112 LSCC patients (95 males and 17 females)...
February 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774534/adverse-selection-into-and-within-the-individual-health-insurance-market-in-california-in-2014
#11
Vicki Fung, Cassandra G K Peitzman, Julie Shi, Catherine Y Liang, William H Dow, Alan M Zaslavsky, Bruce H Fireman, Stephen F Derose, Michael E Chernew, Joseph P Newhouse, John Hsu
OBJECTIVE: The Affordable Care Act (ACA) introduced reforms to mitigate adverse selection into and within the individual insurance market. We examined the traits and predicted medical spending of enrollees in California post-ACA. DATA SOURCES: Survey of 2,103 enrollees in individual market plans, on- and off-exchange, in 2014. STUDY DESIGN: We compared actual versus potential participants using data from the 2014 California Health Interview Survey on respondents who were individually insured or uninsured...
May 17, 2018: Health Services Research
https://www.readbyqxmd.com/read/29774458/effects-of-rs591323-on-serotonin-transporter-availability-in-healthy-male-subjects
#12
Kyoungjune Pak, Hyun-Yeol Nam, Seunghyeon Shin, Keunyoung Kim, Myung Jun Lee, Eun-Joo Kim, Jae Meen Lee, Seong-Jang Kim, In Joo Kim
OBJECTIVES: We aimed to investigate the association between genetic factors of SNPs dopamine transporter (DAT) and serotonin transporter (SERT) availabilities in healthy controls. METHODS: The study population consisted of healthy controls with screening 123 I-FP-CIT single-photon emission computed tomography. Specific binding of 123 I-FP-CIT regarding DAT and SERT was calculated using a region of interest analysis. VOI template was applied to measure specific binding ratios (SBRs) of caudate nucleus, putamen, striatum, midbrain, and pons...
May 17, 2018: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29774377/effect-of-childhood-socioeconomic-conditions-on-cancer-onset-in-later-life-an-ambidirectional-cohort-study
#13
Bernadette W A van der Linden, Delphine S Courvoisier, Boris Cheval, Stefan Sieber, Piet Bracke, Idris Guessous, Claudine Burton-Jeangros, Matthias Kliegel, Stéphane Cullati
OBJECTIVES: Living in low socioeconomic conditions during childhood is associated with poor health outcomes in later life. Whether this link also applies to cancer is unclear. We examined whether childhood socioeconomic conditions (CSCs) are associated with cancer risk in later life and whether this effect remained after adjusting for adulthood socioeconomic conditions (ASCs). METHODS: Data for 26,431 individuals ≥ 50 years old included in SHARE were analysed...
May 17, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29774296/integrated-risk-mapping-and-landscape-characterisation-of-lymphatic-filariasis-and-loiasis-in-south-west-nigeria
#14
Tara A Brant, Patricia N Okorie, Olushola Ogunmola, Nureni Bolaji Ojeyode, S B Fatunade, Emmanuel Davies, Yisa Saka, Michelle C Stanton, David H Molyneux, J Russell Stothard, Louise A Kelly-Hope
Nigeria has the heaviest burden of lymphatic filariasis (LF) in sub-Saharan Africa, which is caused by the parasite Wuchereria bancrofti and transmitted by Anopheles mosquitoes. LF is targeted for elimination and the national programme is scaling up mass drug administration (MDA) across the country to interrupt transmission. However, in some regions the co-endemicity of the filarial parasite Loa loa (loiasis) is an impediment due to the risk of severe adverse events (SAEs) associated with the drug ivermectin...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774295/serological-investigation-of-visceral-leishmania-infection-in-human-and-its-associated-risk-factors-in-welkait-district-western-tigray-ethiopia
#15
Abrha Bsrat, Mebrahtu Berhe, Endalemaw Gadissa, Habtamu Taddele, Yohannes Tekle, Yohannes Hagos, Adugna Abera, Messele G/Micael, Tehetna Alemayhu, Getachew Gugsa, Abraham Aseffa
Visceral leishmaniasis (VL) is major neglected public health problem in terms of geographical spread and incidence in Ethiopia. Magnitude, public health impact and dynamics of VL were not well studied in Welkait District, Western Tigray, though the area is known for VL. Hence, this study aimed to determine sero-prevalence of human VL and associated risk factors in Welkait as new foci. A cross sectional study design was employed in this study. Two stage stratified random sampling method was used to select study participants...
February 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774271/gatekeepers-for-infertility-treatment-views-of-art-providers-concerning-referrals-by-non-art-providers
#16
Robert Klitzman
Many patients who might benefit from treatment using assisted reproductive technology (ART) do not receive it, raising critical questions of why, and how best to overcome existing barriers. In-depth interviews of approximately 1 h each were conducted with 27 ART providers (17 physicians and 10 other healthcare providers). These interviewees suggest that non-ART providers may serve as gatekeepers in a complex system, involving not only individual-level, but also dyadic and institutional, processes and factors related to provider-patient relationships...
April 2018: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774261/same-sex-parenting-assisted-reproduction-and-gender-asymmetry-reflecting-on-the-differential-effects-of-legislation-on-gay-and-lesbian-family-formation-in-spain
#17
Elixabete Imaz
This article takes an anthropological approach to examine how laws governing family formation in Spain affect same-sex couples seeking to become parents, in particular the cultural causes and implications of such laws. It highlights how the same laws are has a different impact on gay couples and lesbian couples. Legislation combines with other factors to favour and expand the possibilities of accessing motherhood for women in lesbian couples while limiting the possibilities of parenthood for men in gay couples...
June 2017: Reproductive Biomedicine & Society Online
https://www.readbyqxmd.com/read/29774241/active-learning-increases-children-s-physical-activity-across-demographic-subgroups
#18
John B Bartholomew, Esbelle M Jowers, Gregory Roberts, Anna-Mária Fall, Vanessa L Errisuriz, Sharon Vaughn
Purpose: Given the need to find more opportunities for physical activity within the elementary school day, this study was designed to asses the impact of I-CAN!, active lessons on: 1) student physical activity (PA) outcomes via accelerometry; and 2) socioeconomic status (SES), race, sex, body mass index (BMI), or fitness as moderators of this impact. Methods: Participants were 2,493 fourth grade students (45.9% male, 45.8% white, 21.7% low SES) from 28 central Texas elementary schools randomly assigned to intervention (n=19) or control (n=9)...
January 2018: Translational Journal of the American College of Sports Medicine
https://www.readbyqxmd.com/read/29773993/diabetic-cardiomyopathy-impact-of-biological-sex-on-disease-development-and-molecular-signatures
#19
REVIEW
Ryan Toedebusch, Anthony Belenchia, Lakshmi Pulakat
Diabetic cardiomyopathy refers to a unique set of heart-specific pathological variables induced by hyperglycemia and insulin resistance. Given that cardiovascular disease (CVD) is the leading cause of death in the world, and type 2 diabetes incidence continues to rise, understanding the complex interplay between these two morbidities and developing novel therapeutic strategies is vital. Two hallmark characteristics specific to diabetic cardiomyopathy are diastolic dysfunction and cardiac structural mal-adaptations, arising from cardiac cellular responses to the complex toxicity induced by hyperglycemia with or without hyperinsulinemia...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29773976/facing-the-challenges-of-neuropeptide-gene-knockouts-why-do-they-not-inhibit-reproduction-in-adult-teleost-fish
#20
REVIEW
Vance L Trudeau
Genetic manipulation of teleost endocrine systems started with transgenic overexpression of pituitary growth hormone. Such strategies enhance growth and reduce fertility, but the fish still breed. Genome editing using transcription activator-like effector nuclease in zebrafish and medaka has established the role of follicle stimulating hormone for gonadal development and luteinizing hormone for ovulation. Attempts to genetically manipulate the hypophysiotropic neuropeptidergic systems have been less successful...
2018: Frontiers in Neuroscience
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