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https://www.readbyqxmd.com/read/28210781/adolescent-cocaine-exposure-enhances-goal-tracking-behavior-and-impairs-hippocampal-cell-genesis-selectively-in-adult-bred-low-responder-rats
#1
M Julia García-Fuster, Aram Parsegian, Stanley J Watson, Huda Akil, Shelly B Flagel
RATIONALE: Environmental challenges during adolescence, such as drug exposure, can cause enduring behavioral and molecular changes that contribute to life-long maladaptive behaviors, including addiction. Selectively bred high-responder (bHR) and low-responder (bLR) rats represent a unique model for assessing the long-term impact of adolescent environmental manipulations, as they inherently differ on a number of addiction-related traits. bHR rats are considered "addiction-prone," whereas bLR rats are "addiction-resilient," at least under baseline conditions...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28208620/a-review-of-wearable-technologies-for-elderly-care-that-can-accurately-track-indoor-position-recognize-physical-activities-and-monitor-vital-signs-in-real-time
#2
REVIEW
Zhihua Wang, Zhaochu Yang, Tao Dong
Rapid growth of the aged population has caused an immense increase in the demand for healthcare services. Generally, the elderly are more prone to health problems compared to other age groups. With effective monitoring and alarm systems, the adverse effects of unpredictable events such as sudden illnesses, falls, and so on can be ameliorated to some extent. Recently, advances in wearable and sensor technologies have improved the prospects of these service systems for assisting elderly people. In this article, we review state-of-the-art wearable technologies that can be used for elderly care...
February 10, 2017: Sensors
https://www.readbyqxmd.com/read/28196273/sex-and-adolescent-ethanol-exposure-influence-pavlovian-conditioned-approach
#3
Aric C Madayag, Sierra J Stringfield, Kathryn J Reissner, Charlotte A Boettiger, Donita L Robinson
BACKGROUND: Alcohol use among adolescents is widespread and a growing concern due to long-term behavioral deficits, including altered Pavlovian behavior, that potentially contribute to addiction vulnerability. We tested the hypothesis that adolescent intermittent ethanol (AIE) exposure alters Pavlovian behavior in males and females as measured by a shift from goal-tracking to sign-tracking. Additionally, we investigated GLT-1, an astrocytic glutamate transporter, as a potential contributor to a sign-tracking phenotype...
February 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28193693/unresponsive-choline-transporter-as-a-trait-neuromarker-and-a-causal-mediator-of-bottom-up-attentional-biases
#4
Ajeesh Koshy Cherian, Aaron Kucinski, Kyle Pitchers, Brittney Yegla, Vinay Parikh, Youngsoo Kim, Paulina Valuskova, Sarika Gurnani, Craig W Lindsley, Randy D Blakely, Martin Sarter
Some rats (sign-trackers; STs) are prone to attribute incentive salience to reward cues, which can manifest as a propensity to approach and contact Pavlovian cues, and for addiction-like behavior. STs also exhibit poor attentional performance, relative to goal-trackers (GTs), which is associated with attenuated acetylcholine (ACh) levels in prefrontal cortex (Paolone et al., 2013). Here, we demonstrate a cellular mechanism, linked to ACh synthesis, that accounts for attenuated cholinergic capacity in STs. First, we found that electrical stimulation of the basal forebrain increased cortical choline transporter (CHT)-mediated choline transport in GTs, paralleled by a redistribution of CHTs to the synaptic plasma membrane...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28180934/measuring-acne-using-coproporphyrin-iii-protoporphyrin-ix-and-lesion-specific-inflammation-an-exploratory-study
#5
Sachin V Patwardhan, C Richter, A Vogt, U Blume-Peytavi, D Canfield, J Kottner
Propionibacterium acnes: (P. acnes) produce Porphyrins; however, fluorescence measurement of Porphyrins from Ultraviolet-A (UVA) images has failed to establish a correlation. Acne clinical research and imaging has ignored the spectral excitation-emission characteristics and the exact pattern of the Porphyrins synthesized by P. acnes. In this exploratory study, for the first time, the possible relationships of Coproporphyrin III (CpIII) and Protoporphyrin IX (PpIX) fluorescence as well as acne lesion-specific inflammation measurements with clinical signs of acne are investigated...
February 8, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28180069/young-adolescents-with-autism-show-abnormal-joint-attention-network-a-gaze-contingent-fmri-study
#6
E Oberwelland, L Schilbach, I Barisic, S C Krall, K Vogeley, G R Fink, B Herpertz-Dahlmann, K Konrad, M Schulte-Rüther
Behavioral research has revealed deficits in the development of joint attention (JA) as one of the earliest signs of autism. While the neural basis of JA has been studied predominantly in adults, we recently demonstrated a protracted development of the brain networks supporting JA in typically developing children and adolescents. The present eye-tracking/fMRI study now extends these findings to adolescents with autism. Our results show that in adolescents with autism JA is subserved by abnormal activation patterns in brain areas related to social cognition abnormalities which are at the core of ASD including the STS and TPJ, despite behavioral maturation with no behavioral differences...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28163801/evolutionary-biosemiotics-and-multilevel-construction-networks
#7
Alexei A Sharov
In contrast to the traditional relational semiotics, biosemiotics decisively deviates towards dynamical aspects of signs at the evolutionary and developmental time scales. The analysis of sign dynamics requires constructivism (in a broad sense) to explain how new components such as subagents, sensors, effectors, and interpretation networks are produced by developing and evolving organisms. Semiotic networks that include signs, tools, and subagents are multilevel, and this feature supports the plasticity, robustness, and evolvability of organisms...
December 2016: Biosemiotics
https://www.readbyqxmd.com/read/28161491/shoulder-and-elbow-kinematics-during-the-mallet-score-in-obstetrical-brachial-plexus-palsy
#8
Olivier Herisson, Nathalie Maurel, Amadou Diop, Morgane Le Chatelier, Adeline Cambon-Binder, Franck Fitoussi
BACKGROUND: The physical signs of obstetrical brachial plexus palsy range from temporary upper-limb dysfunction to a lifelong impairment and deformity in one arm. The aim of this study was to analyze the kinematics of the upper limb and to evaluate the contribution of glenohumeral and scapulothoracic joints of obstetrical brachial plexus palsy children. METHODS: Six children participated in this study: 2 males and 4 females with a mean age of 11.7years. Three patients had a C5, C6 lesion and 3 had a C5, C6, C7 lesion...
January 15, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28153542/adaptive-integral-robust-control-and-application-to-electromechanical-servo-systems
#9
Wenxiang Deng, Jianyong Yao
This paper proposes a continuous adaptive integral robust control with robust integral of the sign of the error (RISE) feedback for a class of uncertain nonlinear systems, in which the RISE feedback gain is adapted online to ensure the robustness against disturbances without the prior bound knowledge of the additive disturbances. In addition, an adaptive compensation integrated with the proposed adaptive RISE feedback term is also constructed to further reduce design conservatism when the system also exists parametric uncertainties...
January 30, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28152909/quality-assurance-metrics-in-clinical-trial-conduct
#10
Susanna Sellmann, Lindsay Philip, Cristina Guglielmi, Pamela Degendorfer, Amit M Oza
: 274 Background: Quality assurance (QA) in clinical trials is a safeguard against non-compliance, which impacts patient safety and data integrity. On an institutional level, compiling quality findings provides insight to gaps within existing processes, protocol compliance, and educational content. A QA metrics methodology has been implemented, which is streamlined with the ICH-GCP, and institutional Standard Operating Procedures (SOPs) and policies. METHODS: Individual findings are assigned an alphanumerical code, based on severity and category, and a reference for each Quality Assurance Review (QAR)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152671/determination-of-multidirectional-myocardial-deformations-in-cats-with-hypertrophic-cardiomyopathy-by-using-two-dimensional-speckle-tracking-echocardiography
#11
Ryohei Suzuki, Yohei Mochizuki, Hiroki Yoshimatsu, Takahiro Teshima, Hirotaka Matsumoto, Hidekazu Koyama
Objectives Hypertrophic cardiomyopathy, a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of myocardial deformation with two-dimensional speckle-tracking echocardiography in cats with various stages of hypertrophic cardiomyopathy has not yet been reported. This study was designed to measure quantitatively multidirectional myocardial deformations of cats with hypertrophic cardiomyopathy. Methods Thirty-two client-owned cats with hypertrophic cardiomyopathy and 14 healthy cats serving as controls were enrolled and underwent assessment of myocardial deformation (peak systolic strain and strain rate) in the longitudinal, radial and circumferential directions...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28152342/ambient-intelligence-framework-for-real-time-speech-to-sign-translation
#12
Mwaffaq Otoom, Mohammad A Alzubaidi
Sign language can be used to facilitate communication with and between deaf or hard of hearing (Deaf/HH). With the advent of video streaming applications in smart TVs and mobile devices, it is now possible to use sign language to communicate over worldwide networks. In this article, we develop a prototype assistive device for real-time speech-to-sign translation. The proposed device aims at enabling Deaf/HH people to access and understand materials delivered in mobile streaming videos through the applications of pipelined and parallel processing for real-time translation, and the application of eye-tracking based user-satisfaction detection to support dynamic learning to improve speech-to-signing translation...
February 2, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28149413/left-atrial-enlargement-in-young-high-level-endurance-athletes-another-sign-of-athlete-s-heart
#13
Wojciech Król, Ilona Jędrzejewska, Marcin Konopka, Krystyna Burkhard-Jagodzińska, Andrzej Klusiewicz, Andrzej Pokrywka, Jolanta Chwalbińska, Dariusz Sitkowski, Mirosław Dłużniewski, Artur Mamcarz, Wojciech Braksator
Enlargement of the left atrium is perceived as a part of athlete's heart syndrome, despite the lack of evidence. So far, left atrial size has not been assessed in the context of exercise capacity. The hypothesis of the present study was that LA enlargement in athletes was physiological and fitness-related condition. In addition, we tried to assess the feasibility and normal values of left atrial strain parameters and their relationship with other signs of athlete's heart. The study group consisted of 114 international-level rowers (17...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28138834/seeing-the-conflict-an-attentional-account-of-reasoning-errors
#14
André Mata, Mário B Ferreira, Andreas Voss, Tanja Kollei
In judgment and reasoning, intuition and deliberation can agree on the same responses, or they can be in conflict and suggest different responses. Incorrect responses to conflict problems have traditionally been interpreted as a sign of faulty problem-solving-an inability to solve the conflict. However, such errors might emerge earlier, from insufficient attention to the conflict. To test this attentional hypothesis, we manipulated the conflict in reasoning problems and used eye-tracking to measure attention...
January 30, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28132404/right-ventricular-function-during-acute-exacerbation-of-severe-equine-asthma
#15
A Decloedt, H Borowicz, M Slowikowska, K Chiers, G van Loon, A Niedzwiedz
BACKGROUND: Pulmonary hypertension has been described in horses with severe equine asthma but its effect on the right ventricle has not been fully elucidated. OBJECTIVES: To evaluate right ventricular structure and function after a one-week period of pulmonary hypertension secondary to acute exacerbation of severe equine asthma. STUDY DESIGN: Prospective study. METHODS: A clinical episode of severe equine asthma was induced experimentally in six susceptible horses...
January 28, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/28129180/surface-reconstruction-via-fusing-sparse-sequence-of-depth-images
#16
Long Yang, Qingan Yan, Yanping Fu, Chunxia Xiao
Handheld scanning using commodity depth cameras provides a flexible and low-cost manner to get 3D models. The existing methods scan a target by densely fusing all the captured depth images, yet most frames are redundant. The jittering frames inevitably embedded in handheld scanning process will cause feature blurring on the reconstructed model and even trigger the scan failure (i.e., camera tracking losing). To address these problems, in this paper, we propose a novel sparse-sequence fusion (SSF) algorithm for handheld scanning using commodity depth cameras...
January 25, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28128492/beyond-attachment-roles-of-dc-sign-in-dengue-virus-infection
#17
Ping Liu, Marc Ridilla, Pratik Patel, Laurie Betts, Emily Gallichotte, Lidea Shahidi, Nancy L Thompson, Ken Jacobson
DC-SIGN, a C-type lectin expressed on the plasma membrane by human immature dendritic cells, is a receptor for numerous viruses including Ebola, SARS, and dengue. A controversial question has been whether DC-SIGN functions as a complete receptor for both binding and internalization of dengue virus (DENV) or whether it is solely a cell surface attachment factor, requiring either hand-off to another receptor or a co-receptor for internalization. To examine this question, we used four cell types: human immature dendritic cells and NIH3T3 cells expressing either wild type DC-SIGN or two internalization-deficient DC-SIGN mutants, in which either the three cytoplasmic internalization motifs are silenced by alanine substitutions or the cytoplasmic region is truncated...
January 27, 2017: Traffic
https://www.readbyqxmd.com/read/28126275/time-driven-activity-based-cost-of-fast-track-total-hip-and-knee-arthroplasty
#18
Signe E Andreasen, Henriette B Holm, Mira Jørgensen, Kirill Gromov, Per Kjærsgaard-Andersen, Henrik Husted
BACKGROUND: Fast-track total hip and knee arthroplasty (THA and TKA) has been shown to reduce the perioperative convalescence resulting in less postoperative morbidity, earlier fulfillment of functional milestones, and shorter hospital stay. As organizational optimization is also part of the fast-track methodology, the result could be a more cost-effective pathway altogether. As THA and TKA are potentially costly procedures and the numbers are increasing in an economical limited environment, the aim of this study is to present baseline detailed economical calculations of fast-track THA and TKA and compare this between 2 departments with different logistical set-ups...
December 29, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28116695/update-on-the-management-of-chronic-constipation
#19
REVIEW
Jenna Koliani-Pace, Brian E Lacy
Chronic constipation (CC) is a highly prevalent disorder encountered by health care providers of all specialties. The diagnosis can be confidently made by taking a careful history, evaluating for warning signs and symptoms, performing an examination, including a digital rectal exam, and using the Rome IV criteria. Treatment should begin at the first visit; most patients require few diagnostic tests to make, or confirm, the diagnosis of CC. Assuming that the patient has persistent symptoms of constipation, despite using traditional therapy (fiber, osmotic agents), then patients should be offered one of the newer treatments, rather than repeating prior treatments, which is a common practice...
January 23, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28110990/quick-sofa-scores-predict-mortality-in-adult-emergency-department-patients-with-and-without-suspected-infection
#20
Adam J Singer, Jennifer Ng, Henry C Thode, Rory Spiegel, Scott Weingart
STUDY OBJECTIVE: The Quick Sequential Organ Failure Assessment (qSOFA) score (composed of respiratory rate ≥22 breaths/min, systolic blood pressure ≤100 mm Hg, and altered mental status) may identify patients with infection who are at risk of complications. We determined the association between qSOFA scores and outcomes in adult emergency department (ED) patients with and without suspected infection. METHODS: We performed a single-site, retrospective review of adult ED patients between January 2014 and March 2015...
January 19, 2017: Annals of Emergency Medicine
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