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https://www.readbyqxmd.com/read/28345337/light-up-mitophagy-in-live-cells-with-dual-functional-theranostic-phosphorescent-iridium-iii-complexes
#1
Mu-He Chen, Fang-Xin Wang, Jian-Jun Cao, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao
Phosphorescent Ir(III) complexes are ideal candidates to construct novel multifunctional theranostic platforms that enable the integration of imaging capabilities and anticancer properties. Selective autophagy of mitochondria, termed mitophagy, is an important cellular process that selectively degrades dysfunctional mitochondria. Until now, the regulation of mitophagy is still poorly understood. Herein, we present two phosphorescent cyclometalated iridium(III) complexes (Ir1 and Ir2) that can accumulate in mitochondria and induce mitophagy...
March 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28329432/user-compliance-with-documenting-on-a-track-and-trigger-based-observation-and-response-chart-a-two-phase-multi-site-audit-study
#2
Doug Elliott, Emily Allen, Sharon McKinley, Lin Perry, Christine Duffield, Margaret Fry, Robyn Gallagher, Rick Iedema, Michael Roche
AIMS: To examine user compliance and completeness of documentation with a newly designed Observation and Response Chart and whether a rapid response system call was triggered when clinically indicated. BACKGROUND: Timely recognition and responses to patient deterioration in hospital general wards remains a challenge for health care systems globally. Evaluating practice initiatives to improve recognition and response are required. DESIGN: Two-phase audit...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28328492/digital-tracking-of-cognitive-decline-researchers-are-co-opting-computers-in-their-efforts-to-detect-early-signs-of-dementia
#3
Michele Solis
Pinpointing where healthy brain aging leaves off and dementia begins is difficult. Is a slip in memory an expected outcome for a too-busy person or a warning of something else? If an empty-nester loses the motivation to cook, is it a sign that the person is enjoying retirement after a lifetime spent cooking or an early sign of a cognitive decline?
March 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28270380/exacerbations-in-chronic-obstructive-pulmonary-disease-identification-and-prediction-using-a-digital-health-system
#4
Syed Ahmar Shah, Carmelo Velardo, Andrew Farmer, Lionel Tarassenko
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive, chronic respiratory disease with a significant socioeconomic burden. Exacerbations, the sudden and sustained worsening of symptoms, can lead to hospitalization and reduce quality of life. Major limitations of previous telemonitoring interventions for COPD include low compliance, lack of consensus on what constitutes an exacerbation, limited numbers of patients, and short monitoring periods. We developed a telemonitoring system based on a digital health platform that was used to collect data from the 1-year EDGE (Self Management and Support Programme) COPD clinical trial aiming at daily monitoring in a heterogeneous group of patients with moderate to severe COPD...
March 7, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28269619/a-wearable-computing-platform-for-developing-cloud-based-machine-learning-models-for-health-monitoring-applications
#5
Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari
Wearable sensors have the potential to enable clinical-grade ambulatory health monitoring outside the clinic. Technological advances have enabled development of devices that can measure vital signs with great precision and significant progress has been made towards extracting clinically meaningful information from these devices in research studies. However, translating measurement accuracies achieved in the controlled settings such as the lab and clinic to unconstrained environments such as the home remains a challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269355/long-term-vital-sign-measurement-using-a-non-contact-vital-sign-sensor-inside-an-office-cubicle-setting
#6
T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie
Heart and respiration rates can be wirelessly measured by extracting the phase shift caused by the periodic displacement of a patient's chest wall. We have developed a phased-array Doppler-based non-contact vital sign (NCVS) sensor capable of long-term vital signs monitoring using an automatic patient tracking and movement detection algorithm. Our NCVS sensor achieves non-contact heart rate monitoring with accuracies of over 90% (i.e, within ±5 Beats-Per-Minute vs. a reference sensor) across a large number of data points collected over various days of the week inside a typical office cubicle setting at a distance of 1...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269059/vital-sign-monitoring-utilizing-eulerian-video-magnification-and-thermography
#7
Bauyrzhan Aubakir, Birzhan Nurimbetov, Iliyas Tursynbek, Huseyin Atakan Varol
In this paper we present a proof of concept for non-contact extraction of vital signs using RGB and thermal images obtained from a smart phone. Using our method, heart rate, respiratory rate and forehead temperature can be measured concurrently. Face detection and tracking is leveraged in order to allow natural motion of patients. Heart rate is estimated via processing of visible band RGB video using Eulerian Video Magnification technique. Respiratory rate and the temperature is measured using thermal video...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267336/phase-acrobatics-the-influence-of-excitonic-resonance-and-gold-nonresonant-background-on-heterodyne-detected-vibrational-sum-frequency-generation-emission
#8
Christopher C Rich, Kathryn A Lindberg, Amber T Krummel
We show how heterodyne-detected vibrational sum frequency generation (HD-VSFG) spectroscopy can discriminate between the excitonic and monomeric properties of a helical, nanotube molecular aggregate by monitoring the phase of the VSFG emission associated with different polarization configurations. By keeping track of the "phase acrobatics" associated with the added phase of the nonresonant SFG emission of gold as well as that of the double-resonance conditions achieved when the SF frequency is resonant with an electronic exciton transition, we discover that for aggregates of tetra(sulfonatophenyl)porphyrin (TSPP) the PPP-polarized spectra exhibit double-resonance conditions while SSP-polarized spectra exhibit resonance only with the ground-state vibration...
March 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28264002/a-simulation-study-to-evaluate-the-performance-of-five-statistical-monitoring-methods-when-applied-to-different-time-series-components-in-the-context-of-control-programs-for-endemic-diseases
#9
Ana Carolina Lopes Antunes, Dan Jensen, Tariq Halasa, Nils Toft
Disease monitoring and surveillance play a crucial role in control and eradication programs, as it is important to track implemented strategies in order to reduce and/or eliminate a specific disease. The objectives of this study were to assess the performance of different statistical monitoring methods for endemic disease control program scenarios, and to explore what impact of variation (noise) in the data had on the performance of these monitoring methods. We simulated 16 different scenarios of changes in weekly sero-prevalence...
2017: PloS One
https://www.readbyqxmd.com/read/28257413/uncovering-precision-phenotype-biomarker-associations-in-traumatic-brain-injury-using-topological-data-analysis
#10
Jessica L Nielson, Shelly R Cooper, John K Yue, Marco D Sorani, Tomoo Inoue, Esther L Yuh, Pratik Mukherjee, Tanya C Petrossian, Jesse Paquette, Pek Y Lum, Gunnar E Carlsson, Mary J Vassar, Hester F Lingsma, Wayne A Gordon, Alex B Valadka, David O Okonkwo, Geoffrey T Manley, Adam R Ferguson
BACKGROUND: Traumatic brain injury (TBI) is a complex disorder that is traditionally stratified based on clinical signs and symptoms. Recent imaging and molecular biomarker innovations provide unprecedented opportunities for improved TBI precision medicine, incorporating patho-anatomical and molecular mechanisms. Complete integration of these diverse data for TBI diagnosis and patient stratification remains an unmet challenge. METHODS AND FINDINGS: The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot multicenter study enrolled 586 acute TBI patients and collected diverse common data elements (TBI-CDEs) across the study population, including imaging, genetics, and clinical outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28250963/-there-were-more-wires-than-him-the-potential-for-wireless-patient-monitoring-in-neonatal-intensive-care
#11
Oliver Bonner, Kathryn Beardsall, Nathan Crilly, Joan Lasenby
BACKGROUND: The neonatal intensive care unit (NICU) can be one of the most stressful hospital environments. Alongside providing intensive clinical care, it is important that parents have the opportunity for regular physical contact with their babies because the neonatal period is critical for parent-child bonding. At present, monitoring technology in the NICU requires multiple wired sensors to track each baby's vital signs. This study describes the experiences that parents and nurses have with the current monitoring methods, and reports on their responses to the concept of a wireless monitoring system...
February 2017: BMJ Innovations
https://www.readbyqxmd.com/read/28249595/non-contact-synchronous-dynamic-measurement-of-respiratory-rate-and-heart-rate-based-on-dual-sensitive-regions
#12
Bing Wei, Xuan He, Chao Zhang, Xiaopei Wu
BACKGROUND: Currently, many imaging photoplethysmography (IPPG) researches have reported non-contact measurements of physiological parameters, such as heart rate (HR), respiratory rate (RR), etc. However, it is accepted that only HR measurement has been mature for applications, and other estimations are relatively incapable for reliable applications. Thus, it is worth keeping on persistent studies. Besides, there are some issues commonly involved in these approaches need to be explored further...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28238545/drawing-a-line-in-the-sand-effectiveness-of-off-highway-vehicle-management-in-california-s-sonoran-desert
#13
Nathan A Custer, Lesley A DeFalco, Kenneth E Nussear, Todd C Esque
Public land policies manage multiple uses while striving to protect vulnerable plant and wildlife habitats from degradation; yet the effectiveness of such policies are infrequently evaluated, particularly for remote landscapes that are difficult to monitor. We assessed the use and impacts of recreational vehicles on Mojave Desert washes (intermittent streams) in the Chemehuevi Desert Wildlife Management Area (DWMA) of southern California. Wash zones designated as open and closed to off-highway vehicle (OHV) activity were designed in part to protect Mojave desert tortoise (Gopherus agassizii) habitat while allowing recreation in designated areas...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28237917/detection-of-motor-impairment-in-parkinson-s-disease-via-mobile-touchscreen-typing
#14
Teresa Arroyo-Gallego, Maria Jesus Ledesma-Carbayo, Alvaro Sanchez-Ferro, Ian Butterworth, Carlos Sanchez-Mendoza, Michele Matarazzo, Paloma Montero, Roberto Lopez-Blanco, Veronica Puertas-Martin, Rocio Trincado, Luca Giancardo
Mobile technology is opening a wide range of opportunities for transforming the standard of care for chronic disorders. Using smartphones as tools for longitudinally tracking symptoms could enable personalization of drug regimens and improve patient monitoring. Parkinson's disease (PD) is an ideal candidate for these tools. At present, evaluation of PD signs requires trained experts to quantify motor impairment in the clinic, limiting the frequency and quality of the information available for understanding the status and progression of the disease...
February 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28227877/a-wearable-computing-platform-for-developing-cloud-based-machine-learning-models-for-health-monitoring-applications
#15
Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari, Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari
Wearable sensors have the potential to enable clinical-grade ambulatory health monitoring outside the clinic. Technological advances have enabled development of devices that can measure vital signs with great precision and significant progress has been made towards extracting clinically meaningful information from these devices in research studies. However, translating measurement accuracies achieved in the controlled settings such as the lab and clinic to unconstrained environments such as the home remains a challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227597/long-term-vital-sign-measurement-using-a-non-contact-vital-sign-sensor-inside-an-office-cubicle-setting
#16
T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, N A Malone, J Tsay, J Lopez, T Nguyen, R E Banister, D Y C Lie, T Hall, J Lopez, N A Malone, T Nguyen, J Tsay, D Y C Lie, R E Banister
Heart and respiration rates can be wirelessly measured by extracting the phase shift caused by the periodic displacement of a patient's chest wall. We have developed a phased-array Doppler-based non-contact vital sign (NCVS) sensor capable of long-term vital signs monitoring using an automatic patient tracking and movement detection algorithm. Our NCVS sensor achieves non-contact heart rate monitoring with accuracies of over 90% (i.e, within ±5 Beats-Per-Minute vs. a reference sensor) across a large number of data points collected over various days of the week inside a typical office cubicle setting at a distance of 1...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227276/vital-sign-monitoring-utilizing-eulerian-video-magnification-and-thermography
#17
Bauyrzhan Aubakir, Birzhan Nurimbetov, Iliyas Tursynbek, Huseyin Atakan Varol, Bauyrzhan Aubakir, Birzhan Nurimbetov, Iliyas Tursynbek, Huseyin Atakan Varol, Bauyrzhan Aubakir, Iliyas Tursynbek, Birzhan Nurimbetov
In this paper we present a proof of concept for non-contact extraction of vital signs using RGB and thermal images obtained from a smart phone. Using our method, heart rate, respiratory rate and forehead temperature can be measured concurrently. Face detection and tracking is leveraged in order to allow natural motion of patients. Heart rate is estimated via processing of visible band RGB video using Eulerian Video Magnification technique. Respiratory rate and the temperature is measured using thermal video...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222805/use-of-activity-tracking-in-major-visceral-surgery-the-enhanced-perioperative-mobilization-epm-trial-study-protocol-for-a-randomized-controlled-trial
#18
Steffen Wolk, Theresa Meißner, Sebastian Linke, Benjamin Müssle, Ann Wierick, Andreas Bogner, Dorothée Sturm, Nuh N Rahbari, Marius Distler, Jürgen Weitz, Thilo Welsch
BACKGROUND: Enhanced recovery after surgery (ERAS) programs are aimed at minimizing postoperative stress and accelerating postoperative recovery by implementing multiple perioperative principles. "Early mobilization" is one such principle, but the quality of assessment and monitoring is poor, and evidence of improved outcome is lacking. Activity trackers allow precise monitoring and automatic feedback to the patients to enhance their motivation for early mobilization. The aim of the study is to monitor and increase the postoperative mobilization of patients by giving them continuous automatic feedback in the form of a step count using activity-tracking wristbands...
February 21, 2017: Trials
https://www.readbyqxmd.com/read/28216124/the-pattern-and-degree-of-capsular-fibrous-sheaths-surrounding-cochlear-electrode-arrays
#19
Reuven Ishai, Barbara S Herrmann, Joseph B Nadol, Alicia M Quesnel
An inflammatory tissue reaction around the electrode array of a cochlear implant (CI) is common, in particular at the electrode insertion region (cochleostomy) where mechanical trauma often occurs. However, the factors determining the amount and causes of fibrous reaction surrounding the stimulating electrode, especially medially near the perimodiolar location, are unclear. Temporal bone (TB) specimens from patients who had undergone cochlear implantation during life with either Advanced Bionics (AB) Clarion (TM) or HiRes90K(TM) (Sylmar, CA, USA) devices that have a half-band and a pre-curved electrode, or Cochlear (TM) Nucleus (Sydney, Australia) device that have a full-band and a straight electrode were evaluated...
February 16, 2017: Hearing Research
https://www.readbyqxmd.com/read/28215191/is-computerized-cognitive-testing-useful-in-children-and-adolescents-with-moderate-to-severe-traumatic-brain-injury
#20
Vickie Plourde, Brian L Brooks
OBJECTIVES: Children and adolescents with moderate-to-severe traumatic brain injury (TBI) present with short and long-term neuropsychological deficits following their injury. The aim of this study was to investigate the utility of a brief computerized test battery for evaluating cognitive functioning sub-acutely following a TBI. METHODS: Participants (n=33) sustained a moderate-to-severe TBI, were between 8 and 18 years old, and were assessed using CNS Vital Signs (CNSVS) within 6 months post-injury (median=0...
February 20, 2017: Journal of the International Neuropsychological Society: JINS
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