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https://www.readbyqxmd.com/read/29660416/cognitive-effects-of-transcranial-direct-current-stimulation-treatment-in-patients-with-major-depressive-disorder-an-individual-patient-data-meta-analysis-of-randomised-sham-controlled-trials
#1
REVIEW
Donel M Martin, Adriano Moffa, Stevan Nikolin, Djamila Bennabi, André R Brunoni, William Flannery, Emmanuel Haffen, Shawn M McClintock, Marina L Moreno, Frank Padberg, Ulrich Palm, Colleen K Loo
Transcranial direct current stimulation (tDCS) has emerged as a promising new treatment for major depression. While recent randomised, sham-controlled studies found tDCS to have antidepressant effects, it remains to be determined whether a tDCS treatment course may also enhance cognitive function independent of mood effects in depressed patients. This systematic review and individual patient data (IPD) meta-analysis examined cognitive outcomes from randomised, sham-controlled trials of tDCS treatment for major depression...
April 13, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29658441/efficacy-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-in-the-treatment-of-apathy-in-patients-with-alzheimer-s-disease-study-protocol-for-a-randomized-trial
#2
Jean-Paul Nguyen, Claire Boutoleau-Bretonniere, Jean-Pascal Lefaucheur, Alcira Suarez, Helene Gaillard, Guillaume Chapelet, Sebastien Abad, Aurelien Van Langhenhove, Julian Nizard, Laure de Decker
BACKGROUND: Apathy, commonly defined as loss of motivation, is a symptom frequently encountered in Alzheimer's disease (AD). The treatment of apathy remains challenging in the absence of any truly effective medications. Transcranial magnetic stimulation (rTMS) or transcranial direct current stimulation (tDCS) can improve cognitive disorders, but do not appear to improve apathy. Isolated cognitive training also appears to have no effect on apathy. We propose to test the efficacy of a new procedure for the treatment of apathy in AD patients consisting of a combination of tDCS and cognitive training, based on the latest guidelines for the design of therapeutic trials in this field...
April 16, 2018: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29651240/cognitive-neuroscience-of-attention-deficit-hyperactivity-disorder-adhd-and-its-clinical-translation
#3
REVIEW
Katya Rubia
This review focuses on the cognitive neuroscience of Attention Deficit Hyperactivity Disorder (ADHD) based on functional magnetic resonance imaging (fMRI) studies and on recent clinically relevant applications such as fMRI-based diagnostic classification or neuromodulation therapies targeting fMRI deficits with neurofeedback (NF) or brain stimulation. Meta-analyses of fMRI studies of executive functions (EFs) show that ADHD patients have cognitive-domain dissociated complex multisystem impairments in several right and left hemispheric dorsal, ventral and medial fronto-cingulo-striato-thalamic and fronto-parieto-cerebellar networks that mediate cognitive control, attention, timing and working memory (WM)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29649503/modulating-fluid-intelligence-performance-through-combined-cognitive-training-and-brain-stimulation
#4
Anna-Katharine Brem, Jessamy Norton-Ford Almquist, Karen Mansfield, Franziska Plessow, Francesco Sella, Emiliano Santarnecchi, Umut Orhan, James McKanna, Misha Pavel, Santosh Mathan, Nick Yeung, Alvaro Pascual-Leone, Roi Cohen Kadosh, On Behalf Of Honeywell Sharp Team Authors
It is debated whether cognitive training of specific executive functions leads to far transfer effects, such as improvements in fluid intelligence (Gf). Within this context, transcranial direct current stimulation and recently also novel protocols such as transcranial random noise and alternating current stimulation are being investigated with regards to their ability to enhance cognitive training outcomes. We compared the effects of four different transcranial electrical brain stimulation protocols in combination with nine daily computerized training sessions on Gf...
April 9, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29642493/effects-of-tdcs-on-real-time-bci-detection-of-pedaling-motor-imagery
#5
Maria de la Soledad Rodriguez-Ugarte, Eduardo Iáñez, Mario Ortiz-Garcia, José M Azorín
The purpose of this work is to strengthen the cortical excitability over the primary motor cortex (M1) and the cerebro-cerebellar pathway by means of a new transcranial direct current stimulation (tDCS) configuration to detect lower limb motor imagery (MI) in real time using two different cognitive neural states: relax and pedaling MI. The anode is located over the primary motor cortex in Cz, and the cathode over the right cerebro-cerebellum. The real-time brain-computer interface (BCI) designed is based on finding, for each electrode selected, the power at the particular frequency where the most difference between the two mental tasks is observed...
April 8, 2018: Sensors
https://www.readbyqxmd.com/read/29615855/null-effects-on-working-memory-and-verbal-fluency-tasks-when-applying-anodal-tdcs-to-the-inferior-frontal-gyrus-of-healthy-participants
#6
Samuel J Westwood, Cristina Romani
Transcranial direct current stimulation (tDCS) is a technique used to modify cognition by modulating underlying cortical excitability via weak electric current applied through the scalp. Although many studies have reported positive effects with tDCS, a number of recent studies highlight that tDCS effects can be small and difficult to reproduce. This is especially the case when attempting to modulate performance using single applications of tDCS in healthy participants. Possible reasons may be that optimal stimulation parameters have yet to be identified, and that individual variation in cortical activity and/or level of ability confound outcomes...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29605579/noninvasive-stimulation-of-the-ventromedial-prefrontal-cortex-modulates-emotional-face-processing
#7
Constantin Winker, Maimu A Rehbein, Dean Sabatinelli, Mira Dohn, Julius Maitzen, Carsten H Wolters, Volker Arolt, Markus Junghofer
The ventromedial prefrontal cortex (vmPFC) is associated with emotional states that can be characterized as positive affect. Moreover, a variety of psychiatric disorders that are associated with disturbed reactions toward reward- or safety-signaling stimuli reveal functional or structural anomalies within this area. Thus, neuromodulation of this region via transcranial direct current stimulation (tDCS) offers an attractive opportunity to noninvasively influence pleasant emotional and reward processing. Recent experiments revealed hemodynamic and electrophysiological evidence for valence specific modulations of emotional scene processing after excitatory and inhibitory tDCS of the vmPFC...
March 29, 2018: NeuroImage
https://www.readbyqxmd.com/read/29588995/the-adjunctive-application-of-transcranial-direct-current-stimulation-in-the-management-of-de-novo-refractory-epilepsia-partialis-continua-in-adolescent-onset-polg-related-mitochondrial-disease
#8
Yi Shiau Ng, Henriette van Ruiten, H Ming Lai, Rebecca Scott, Venkateswaran Ramesh, Karen Horridge, Robert W Taylor, Doug M Turnbull, Gráinne S Gorman, Robert McFarland, Mark R Baker
Focal status epilepticus in POLG -related mitochondrial disease is highly refractory to pharmacological agents, including general anesthesia. We report the challenges in managing a previously healthy teenager who presented with de novo epilepsia partialis continua and metabolic stroke resulting from the homozygous p.Ala467Thr POLG mutation, the most common pathogenic variant identified in the Caucasian population. We applied transcranial direct current stimulation (tDCS; 2 mA; 20 min) daily as an adjunctive therapy because her focal seizures failed to respond to five antiepileptic drugs at maximal doses...
March 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29588984/effect-of-neurostimulation-on-cognition-and-mood-in-refractory-epilepsy
#9
REVIEW
Alvin Y Chan, John D Rolston, Vikram R Rao, Edward F Chang
Epilepsy is a common, debilitating neurological disorder characterized by recurrent seizures. Mood disorders and cognitive deficits are common comorbidities in epilepsy that, like seizures, profoundly influence quality of life and can be difficult to treat. For patients with refractory epilepsy who are not candidates for resection, neurostimulation, the electrical modulation of epileptogenic brain tissue, is an emerging treatment alternative. Several forms of neurostimulation are currently available, and therapy selection hinges on relative efficacy for seizure control and amelioration of neuropsychiatric comorbidities...
March 2018: Epilepsia Open
https://www.readbyqxmd.com/read/29587149/neurophysiological-and-cognitive-effects-of-transcranial-direct-current-stimulation-in-three-girls-with-rett-syndrome-with-chronic-language-impairments
#10
Rosa Angela Fabio, Antonio Gangemi, Tindara Capri, Sarojini Budden, Alessandra Falzone
BACKGROUND: this study was based on both neurophysiological decelerated activity and communication deficits in Rett Syndrome (RTT). AIMS: the aim was to examine the neurophysiological and cognitive effects of Transcranial Direct Current Stimulation (tDCS) in three girls with RTT with chronic language impairments. METHODS AND PROCEDURES: we proposed an integrated intervention: tDCS and cognitive empowerment applied to language in order to enhance speech production (new functional sounds and new words)...
March 24, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29552509/effects-of-transcranial-direct-current-stimulation-on-working-memory-and-negative-symptoms-in-schizophrenia-a-phase-ii-randomized-sham-controlled-trial
#11
J S Gomes, A P Trevizol, D V Ducos, A Gadelha, B B Ortiz, A O Fonseca, H T Akiba, C C Azevedo, L S P Guimaraes, P Shiozawa, Q Cordeiro, A Lacerda, A M Dias
Background: The lack of efficacy of pharmacological treatments for cognitive and negative symptoms in schizophrenia highlights the need for new interventions. We investigated the effects of tDCS on working memory and negative symptoms in patients with schizophrenia. Method: Double-blinded, randomized, sham-controlled clinical trial, investigating the effects of 10 sessions of tDCS in schizophrenia subjects. Stimulation used 2 mA, for 20 min, with electrodes of 25 cm2 wrapped in cotton material soaked in saline solution...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29550374/transcranial-direct-current-stimulation-of-the-medial-prefrontal-cortex-modulates-the-propensity-to-help-in-costly-helping-behavior
#12
Chong Liao, Song Wu, Yue-Jia Luo, Qing Guan, Fang Cui
Social decision-making engages traditional decision-making processes (e.g. valuation), as well as social cognition processes (e.g. inferring the affective and mental states of another person). Neuroimaging and neuro-stimulation studies have suggested the involvement of the medial prefrontal cortex (mPFC) in a variety of social decision-making tasks. Yet no study has investigated the effect of the cortical excitability of mPFC in the decision-making of costly helping behavior. Here, we used tDCS to demonstrate the causal relationship between the cortical excitability of mPFC and costly helping decision-making...
March 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29535340/exploring-the-effects-of-anodal-and-cathodal-high-definition-transcranial-direct-current-stimulation-targeting-the-dorsal-anterior-cingulate-cortex
#13
Wing Ting To, Justin Eroh, John Hart, Sven Vanneste
The dorsal anterior cingulate cortex (dACC) has been identified as a core region affected by many disorders, representing a promising target for neuromodulation. High Definition-transcranial Direct Current Stimulation (HD-tDCS) is a non-invasive neuromodulation technique that has already shown promising outcomes and has been tested to engage deeper structures. This study investigates whether it is possible to modulate dACC activity using anodal and cathodal HD-tDCS. Furthermore, it examines what effects anodal and cathodal HD-tDCS targeting dACC have on cognitive and emotional processing...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29534975/the-role-of-left-dorsolateral-prefrontal-cortex-in-language-processing
#14
Jana Klaus, Dennis J L G Schutter
In addition to the role of left frontotemporal areas in language processing, there is increasing evidence that language comprehension and production require cognitive control and working memory resources involving the left dorsolateral prefrontal cortex (DLPFC). The aim of this study was to investigate the role of the left DLPFC in both language comprehension and production. In a double-blind, sham-controlled crossover experiment, thirty-two participants received cathodal or sham transcranial direct current stimulation (tDCS) to the left DLPFC while performing a language comprehension and a language production task...
May 1, 2018: Neuroscience
https://www.readbyqxmd.com/read/29533819/randomized-trial-of-transcranial-alternating-current-stimulation-for-treatment-of-auditory-hallucinations-in-schizophrenia
#15
Juliann M Mellin, Sankaraleengam Alagapan, Caroline Lustenberger, Courtney E Lugo, Morgan L Alexander, John H Gilmore, L Fredrik Jarskog, Flavio Fröhlich
BACKGROUND: Approximately 30% of patients with schizophrenia experience auditory hallucinations that are refractory to antipsychotic medications. Here, we evaluated the feasibility and efficacy of transcranial alternating current stimulation (tACS) that we hypothesized would improve auditory hallucination symptoms by enhancing synchronization between the frontal and temporo-parietal areas of the left hemisphere. METHOD: 22 participants were randomized to one of three arms and received twice daily, 20 min sessions of sham, 10 Hz 2 mA peak-to-peak tACS, or 2 mA tDCS over the course of 5 consecutive days...
March 10, 2018: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/29528599/-transcranial-direct-current-stimulation-tdcs-psychiatric-use
#16
C Kornreich, P Cole, H Kajosch
Transcranial Direct Current Stimulation (tDCS) is a cheap, easy to use, and relatively safe noninvasive brain stimulation technique. It is increasingly used in several indications in psychiatry and neurology, mainly for depression, chronic pain and cognitive decline due to degenerative brain diseases. Its efficacy is probable in depression and must still be confirmed in numerous other indications. Lowcost devices for the general public are easy to find on the internet and are frequently used for non-therapeutic indications, like the improvement of video gamers' performances...
2018: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/29477590/clinical-pilot-study-of-transcranial-direct-current-stimulation-combined-with-cognitive-emotional-training-for-medication-resistant-depression
#17
D M Martin, J Z Teng, T Y Lo, A Alonzo, T Goh, B M Iacoviello, M M Hoch, C K Loo
BACKGROUND: While the clinical results from transcranial direct current stimulation (tDCS) for the treatment of depression have been promising, antidepressant effects in patients with medication resistance have been suboptimal. There is therefore a need to further optimise tDCS for medication resistant patients. In this clinical pilot study we examined the feasibility, safety, and clinical efficacy of combining tDCS with a psychological intervention which targets dysfunctional circuitry related to emotion regulation in depression, Cognitive Emotional Training (CET)...
February 17, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29432784/cognitive-and-neuromodulation-strategies-for-unhealthy-eating-and-obesity-systematic-review-and-discussion-of-neurocognitive-mechanisms
#18
REVIEW
Laura Forcano, Fernanda Mata, Rafael de la Torre, Antonio Verdejo-Garcia
We systematically reviewed research on cognitive training and neuromodulation interventions for reducing food craving/intake, unhealthy diet and weight, and discussed their mechanisms of action. We reviewed 50 studies involving six cognitive trainings: Approach and Attentional Bias Modification, Implementation Intentions, Response Inhibition, Episodic Future Thinking and Working Memory; and four neuromodulation approaches: Transcranial Magnetic Stimulation (TMS), transcranial Direct Current Stimulation (tDCS), Deep Brain Stimulation (DBS) and Neurofeedback...
February 9, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29429396/using-transcranial-direct-current-stimulation-to-improve-verbal-working-memory-a-detailed-review-of-the-methodology
#19
Roanne Hurley, Liana Machado
INTRODUCTION: Transcranial direct current stimulation (tDCS) is a noninvasive electrical brain stimulation technique that has been used extensively over prefrontal cortex in an effort to enhance verbal working memory (WM). However, inconsistent and contradictory outcomes from similar stimulation protocols have created a strong need to examine methodologies in greater detail. This review undertook an in-depth look at both positive and negative prefrontal tDCS-WM findings in adult populations to shed light on methodological parameters that may be driving the inconsistent outcomes in the literature...
February 12, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29401230/differential-age-effects-of-transcranial-direct-current-stimulation-on-associative-memory
#20
Ryan C Leach, Matthew P McCurdy, Michael C Trumbo, Laura E Matzen, Eric D Leshikar
Objectives: Older adults experience associative memory deficits relative to younger adults (Old & Naveh-Benjamin, 2008). The aim of this study was to test the effect of transcranial direct current stimulation (tDCS) on face-name associative memory in older and younger adults. Method: Experimenters applied active (1.5 mA) or sham (0.1 mA) stimulation with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) during a face-name encoding task, and measured both cued recall and recognition performance...
February 1, 2018: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
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