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https://www.readbyqxmd.com/read/29046007/-dietary-recommendations-in-metabolic-vascular-syndrome
#1
Katharina Lechner, Nicole Erickson, Benjamin Lechner, Florian Horn
Cardiovascular disease is the number one cause of death globally. Poor diet constitutes a key factor in the initiation and progression of cardiovascular disease and has become the leading risk factor for disability and death worldwide. Therefore, addressing suboptimal nutrition is of key prognostic relevance in primary and secondary prevention of metabolic vascular syndrome.Metabolic vascular syndrome is a multidimensional network of acquired cardiometabolic risk factors closely related to insulin resistance (IR) and concomitant hyperinsulinemia...
October 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29045950/leonurine-prevents-atherosclerosis-via-promoting-the-expression-of-abca1-and-abcg1-in-a-ppar%C3%AE-lxr%C3%AE-signaling-pathway-dependent-manner
#2
Ting Jiang, Kun Ren, Qian Chen, Heng Li, Rong Yao, Hu Hu, Yun-Cheng Lv, Guo-Jun Zhao
BACKGROUND/AIMS: Previous studies have demonstrated that leonurine, a unique alkaloid compound of Herba leonuri, can exert anti-oxidative and anti-inflammatory effects on the development of atherosclerosis (AS). This study was designed to investigate the effects of leonurine on cholesterol efflux from THP-1 macrophage-derived foam cells and development of atherosclerotic lesions in apoE-/- mice, and further determine the potential mechanisms. METHODS: Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL)...
October 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29040951/perfluoroalkyl-substances-bone-density-and-cardio-metabolic-risk-factors-in-obese-8-12-year-old-children-a-pilot-study
#3
Naila Khalil, James R Ebert, Masato Honda, Miryoung Lee, Ramzi W Nahhas, Antti Koskela, Thomas Hangartner, Kurunthachalam Kannan
BACKGROUND AND OBJECTIVE: Perfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA), have been associated with adverse bone, and metabolic changes in adults. However association of PFASs with bone health in children is understudied. Considering their role as endocrine disruptors, we examined relationships of four PFASs with bone health in children. METHODS: In a cross sectional pilot study, 48 obese children aged 8-12 years were enrolled from Dayton's Children Hospital, Ohio...
October 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/29038168/fasting-vs-non-fasting-and-low-density-lipoprotein-cholesterol-accuracy
#4
Vasanth Sathiyakumar, Jihwan Park, Asieh Golozar, Mariana Lazo, Renato Quispe, Eliseo Guallar, Roger S Blumenthal, Steven R Jones, Seth S Martin
Background -Recent recommendations favoring non-fasting lipid assessment may impact low-density lipoprotein-cholesterol (LDL-C) estimation. The novel method of LDL-C estimation (LDL-CN) uses a flexible approach to derive patient-specific triglyceride (TG) to very low-density lipoprotein-cholesterol ratios. This adaptability may confer an accuracy advantage in non-fasting patients over the fixed approach of the classical Friedewald method (LDL-CF). Methods -We used a US cross-sectional sample of 1,545,634 patients (959,153 fasting ≥10-12 hours; 586,481 non-fasting) from the second harvest of the Very Large Database of Lipids study to assess for the first time the impact of fasting status on novel LDL-C accuracy...
October 16, 2017: Circulation
https://www.readbyqxmd.com/read/29038147/imputation-of-baseline-ldl-cholesterol-concentration-in-patients-with-familial-hypercholesterolemia-on-statins-or-ezetimibe
#5
Isabelle Ruel, Sumayah Aljenedil, Iman Sadri, Émilie de Varennes, Robert A Hegele, Patrick Couture, Jean Bergeron, Eric Wanneh, Alexis Baass, Robert Dufour, Daniel Gaudet, Diane Brisson, Liam R Brunham, Gordon A Francis, Lubomira Cermakova, James M Brophy, Arnold Ryomoto, G B John Mancini, Jacques Genest
BACKGROUND: Familial hypercholesterolemia (FH) is the most frequent genetic disorder seen clinically and is characterized by increased LDL cholesterol (LDL-C) (>95th percentile), family history of increased LDL-C, premature atherosclerotic cardiovascular disease (ASCVD) in the patient or in first-degree relatives, presence of tendinous xanthomas or premature corneal arcus, or presence of a pathogenic mutation in the LDLR, PCSK9, or APOB genes. A diagnosis of FH has important clinical implications with respect to lifelong risk of ASCVD and requirement for intensive pharmacological therapy...
October 16, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29037448/effects-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibition-with-bococizumab-on-lipoprotein-particles-in-hypercholesterolemic-subjects
#6
Hong Wan, Barry Gumbiner, Tenshang Joh, Tom Riel, Chandrasekhar Udata, Philippe Forgues, Pamela D Garzone
PURPOSE: Monoclonal antibody inhibitors of proprotein convertase subtilisin/kexin type 9 (PCSK9) elicit significant reductions in serum LDL-C levels. However, little is known about their effects on lipoprotein particles. The purpose of this analysis was to evaluate the effect of PCSK9 inhibition with bococizumab (RN316/PF-04950615), a humanized monoclonal antibody to PCSK9, on LDL, VLDL, and HDL particle concentration and size in hypercholesterolemic subjects. METHODS: Data from 3 double-blind, placebo-controlled, randomized studies were analyzed...
October 13, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/29037431/effect-of-chlorella-supplementation-on-cardiovascular-risk-factors-a%C3%A2-meta-analysis-of-randomized-controlled-trials
#7
Aziz A Fallah, Elham Sarmast, Saied Habibian Dehkordi, Javad Engardeh, Leila Mahmoodnia, Arsalan Khaledifar, Tina Jafari
BACKGROUND & AIMS: The effect of Chlorella supplementation on cardiovascular risk factors of subjects with different health status has not been conclusively studied. Therefore, the efficacy of Chlorella supplementation on cardiovascular risk factors was assessed through a meta-analysis. METHODS: A literature search on five electronic databases was performed and related randomized controlled trials (RCTs) published until 15 January 2017 were identified. For each study, the effect size of each outcome was presented as Un-standardized mean difference and 95% confidence interval (CI)...
October 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29037163/diagnostic-performance-of-various-familial-hypercholesterolaemia-diagnostic-criteria-compared-to-dutch-lipid-clinic-criteria-in-an-asian-population
#8
Suraya Abdul-Razak, Radzi Rahmat, Alicezah Mohd Kasim, Thuhairah Abdul Rahman, Suhaila Muid, Nadzimah Mohd Nasir, Zubin Ibrahim, Sazzli Kasim, Zaliha Ismail, Rohana Abdul Ghani, Abdul Rais Sanusi, Azhari Rosman, Hapizah Nawawi
BACKGROUND: Familial hypercholesterolaemia (FH) is a genetic disorder with a high risk of developing premature coronary artery disease that should be diagnosed as early as possible. Several clinical diagnostic criteria for FH are available, with the Dutch Lipid Clinic Criteria (DLCC) being widely used. Information regarding diagnostic performances of the other criteria against the DLCC is scarce. We aimed to examine the diagnostic performance of the Simon-Broom (SB) Register criteria, the US Make Early Diagnosis to Prevent Early Deaths (US MEDPED) and the Japanese FH Management Criteria (JFHMC) compared to the DLCC...
October 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29036232/rare-and-common-variants-of-apob-and-pcsk9-in-korean-patients-with-extremely-low-low-density-lipoprotein-cholesterol-levels
#9
Chan Joo Lee, Yunbeom Lee, Sungha Park, Seok-Min Kang, Yangsoo Jang, Ji Hyun Lee, Sang-Hak Lee
BACKGROUND: Screening of variants, related to lipid metabolism in patients with extreme cholesterol levels, is a tool used to identify targets affecting cardiovascular outcomes. The aim of this study was to examine the prevalence and characteristics of rare and common variants of APOB and PCSK9 in Korean patients with extremely low low-density lipoprotein-cholesterol (LDL-C) levels. METHODS: Among 13,545 participants enrolled in a cardiovascular genome cohort, 22 subjects, whose LDL-C levels without lipid-lowering agents were ≤1 percentile (48 mg/dL) of Korean population, were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/29035785/association-of-blood-polychlorinated-biphenyls-and-cholesterol-levels-among-canadian-inuit
#10
Kavita Singh, Hing Man Chan
BACKGROUND: It has generally been thought that Inuit populations have low risk of cardiovascular disease due to high consumption of omega-3 fatty acids found in traditional marine-based diets. However, results of recent surveys showed that Inuit populations are experiencing increasing rates of cardiovascular disease and related risk factors. OBJECTIVE: The purpose of this study was to investigate if blood polychlorinated biphenyls (PCBs) are associated with high cholesterol and related parameters in Canadian Inuit, known risk factors for cardiovascular disease...
October 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/29034644/the-effect-of-eicosapentaenoic-acid-on-the-serum-levels-and-enzymatic-activity-of-paraoxonase-1-in-the-patients-with-type-2-diabetes-mellitus
#11
Mohammad Hassan Golzari, Saeed Hosseini, Fariba Koohdani, Ali-Akbar Saboor Yaraghi, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh-Honarvar, Mahmoud Djalali
Paraoxonase 1 is known as one of the most important ant oxidative enzymes associated with HDL-c, and because of its antioxidant and antiinflammatory activities. EPA has the antioxidant, anti inflammatory, antithrombogenic, and antiarteriosclerotic properties. Therefore, we investigated the effect of EPA supplementation on the serum levels and activity of PON1 in type 2 diabetic patients. This study was designed as a randomized, double-blind, and placebo-controlled clinical trial. Thirty-six patients with type 2 diabetes were given written; informed consent randomly was classified into 2 groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034200/promising-effect-of-rosa-damascena-extract-on-high-fat-diet-induced-nonalcoholic-fatty-liver
#12
Ida Davoodi, Roja Rahimi, Mohammad Abdollahi, Fatemeh Farzaei, Mohammad Hosein Farzaei, Zahra Memariani, Fariba Najafi
NAFLD is a chronic liver disease that affects a high proportion of the world's population which causes metabolic and hepatic damages. Rosa damascena Mill is traditionally used as a dietary supplement for liver disorders. This study was carried out to determine the beneficial effect of standardized extract of R. damascena on animal model of nonalcoholic fatty liver disease (NAFLD). NAFLD was induced by high-fat diet (HFD) in Wistar rats. HFD rats showed an increase (p < 0.05) in the plasma lipid levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL), and reduced the high-density lipoprotein (HDL) levels...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29029608/association-of-trace-metal-elements-with-lipid-profiles-in-type-2-diabetes-mellitus-patients-a-cross-sectional-study
#13
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: It is well known that dyslipidemia and chronic hyperglycemia increase the onset of diabetes and diabetic complication. The aim of this study is to see the association of trace metals elements and lipid profile among type 2 diabetes mellitus patients. METHODS: The study was conducted on 214 type 2 diabetic patients at Jimma University Specialized Hospital, Jimma, Ethiopia. All the eligible study participants responded to the structured interviewer administered questionnaire and fasting venous blood was drawn for biochemical analysis...
October 13, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29029491/bmi-and-serum-lipid-parameters-predict-increasing-risk-and-aggressive-prostate-cancer-in-chinese-people
#14
Ruizhe Zhao, Gong Cheng, Bing Wang, Chao Qin, Yun Liu, Yongsheng Pan, Jun Wang, Lixin Hua, Weidong Zhu, Zengjun Wang
OBJECTIVES: To determine if obesity and serum lipid parameters are associated with increased risk and more aggressive prostate cancer in Chinese population. MATERIALS AND METHODS: We conducted a retrospective cohort analysis including 3102 patients. Kruskal-Wallis test for continuous variables and the chi-squared tests for categorical variables were used for univariate comparison of the differences in patient characteristics across BMI categories between different groups...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029165/depicting-new-pharmacological-strategies-for-familial-hypercholesterolaemia-involving-lipoprotein-a
#15
Alpo Vuorio, Gerald F Watts, Petri T Kovanen
Approximately 35 million people worldwide suffer from heterozygous familial hypercholesterolaemia (HeFH), a condition characterized by genetically determined life-long elevation of plasma low-density lipoprotein cholesterol (LDL-C). One in three of these patients also inherit an elevated plasma concentration of lipoprotein (a) [Lp(a)], a lipoprotein particle with atherogenic, inflammatory and prothrombotic properties. Accordingly, the combination of high plasma LDL-C and Lp(a) can markedly accelerate premature atherosclerotic cardiovascular disease (ASCVD)...
October 3, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028484/cholesterol-target-value-attainment-and-lipid-lowering-therapy-in-patients-with-stable-or-acute-coronary-heart-disease-results-from-the-dyslipidemia-international-study-ii
#16
Anselm K Gitt, Dominik Lautsch, Jean Ferrières, Gaetano M De Ferrari, Ami Vyas, Carl A Baxter, Lori D Bash, Veronica Ashton, Martin Horack, Wael Almahmeed, Fu-Tien Chiang, Kian Keong Poh, Philippe Brudi, Baishali Ambegaonkar
BACKGROUND AND AIMS: Low-density lipoprotein cholesterol (LDL-C) is a major contributor to cardiovascular disease. In the Dyslipidemia International Study II (DYSIS II), we determined LDL-C target value attainment, use of lipid-lowering therapy (LLT), and cardiovascular outcomes in patients with stable coronary heart disease (CHD) and those suffering from an acute coronary syndrome (ACS). METHODS: DYSIS II included patients from 18 countries. Patients with either stable CHD or an ACS were enrolled if they were ≥18 years old and had a full lipid profile available...
August 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29028083/association-between-advanced-oxidation-protein-products-aopp-and-vascular-calcification-in-uremic-patients
#17
L Lin, G-J Zhao, L-L Qin
OBJECTIVE: To investigate the correlation between serum advanced oxidation protein products (AOPP) and vascular calcification in uremic patients. PATIENTS AND METHODS: The general data of included subjects were collected, and the serum AOPP, intact parathyroid hormone (iPTH), creatinine (Cre), Urea, calcium (Ca), phosphorus (P), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterin (LDL-C), hemoglobin (Hb) and albumin (ALB) were detected...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#18
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29026486/martin-s-equation-as-the-most-suitable-method-for-estimation-of-low-density-lipoprotein-cholesterol-levels-in-korean-adults
#19
Mijeong Kang, Jongwoo Kim, Seon Yeong Lee, Kyunam Kim, Junehyung Yoon, Hongseok Ki
BACKGROUND: Friedewald equation is the most widely used method for estimating low-density lipoprotein cholesterol (LDL-C) level. However, due to potential over- or underestimation, many studies have used a modified equation. This study aimed to compare estimates by 4 different equations to directly measured LDL-C concentrations in order to propose the most appropriate method for LDL-C estimation in the Korean population. METHODS: We studied data of 4,350 subjects that included total cholesterol, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and LDL-C concentrations that had been measured at one university hospital in Seoul...
September 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29025201/the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-overweight-korean-children-and-adolescents
#20
Dong-Yoon Yoo, Yu Sun Kang, Eun Byul Kwon, Eun-Gyong Yoo
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8...
September 2017: Annals of Pediatric Endocrinology & Metabolism
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