Jan W Eriksson, Maria J Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundström, Giovanni Fanni, Martin H Lundqvist, Björn C L Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risérus, Håkan Ahlström
AIMS/HYPOTHESIS: Obesity surgery (OS) and diet-induced weight loss rapidly improve insulin resistance. We aim to investigate the impact of either Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) surgery compared with a diet low in energy (low-calorie diet; LCD) on body composition, glucose control and insulin sensitivity, assessed both at the global and tissue-specific level in individuals with obesity but not diabetes. METHODS: In this parallel group randomised controlled trial, patients on a waiting list for OS were randomised (no blinding, sealed envelopes) to either undergo surgery directly or undergo an LCD before surgery...
April 24, 2024: Diabetologia