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https://www.readbyqxmd.com/read/29228430/mediation-of-inflammation-obesity-and-fatty-liver-disease-by-advanced-glycation-endoproducts
#1
D-D Xiong, M Zhang, N Li, J-F Gai, L Mao, M Li
OBJECTIVE: Fatty liver may induce various complications including chronic hepatitis or liver cirrhosis, and is frequently occurred in obesity individuals. Advanced glycosylation end products (AGEs) were known to play a critical role in multiple liver diseases. This study, therefore, aimed to study the effect of AGEs on obesity, related liver cirrhosis and inflammation, on an obesity fatty liver rat model. MATERIALS AND METHODS: A total of 60 Sprague Dawley (SD) rats were randomly divided into control, model and AGEs inhibitor groups (n=20 each)...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228000/an-in-vivo-assessment-of-the-cholesterol-lowering-efficacy-of-lactobacillus-plantarum-ecgc-13110402-in-normal-to-mildly-hypercholesterolaemic-adults
#2
Adele Costabile, Ivan Buttarazzi, Sofia Kolida, Sara Quercia, Jessica Baldini, Jonathan R Swann, Patrizia Brigidi, Glenn R Gibson
Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention...
2017: PloS One
https://www.readbyqxmd.com/read/29227868/systemic-mastocytosis-associates-with-cardiovascular-events-despite-lower-plasma-lipid-levels
#3
Swasti Indhirajanti, Paul L A van Daele, Sven Bos, Monique T Mulder, Ilze Bot, Jeanine E Roeters van Lennep
BACKGROUND AND AIMS: Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls. METHODS: In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29227169/descriptive-study-of-the-relationship-between-the-subclinical-carotid-disease-and-biomarkers-carotid-femoral-pulse-wave-velocity-in-patients-with-hypertension
#4
XiaoXiao Zhao, Liujin Bo, Hongwei Zhao, Lihong Li, Yingyan Zhou, Hongyu Wang
BACKGROUND: Carotid intima-media thickness (cIMT) is a significant early prediction signal for preclinical atherosclerosis. Plasma homocysteine (Hcy) level is an independent risk factor for cardiovascular diseases. Pulse wave velocity (PWV), an index of arterial stiffness (AS), has showed its value in the evaluation of AS in vascular-related diseases. The data regarding the relationships between cIMT and other indices of vascular damage are limited and partly controversial. We aim to investigate the relationships between cIMT and other indices of vascular damage such as Hcy and carotid femoral PWV (CF-PWV)...
December 11, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29226894/identifying-undiagnosed-or-undertreated-patients-with-familial-hypercholesterolemia-from-the-laboratory-records-of-a-tertiary-medical-center
#5
Cem Haymana, Hamza Berlik, Yalçın Güneş, Orhan Enes Tunçez, Cihat Aytekin, Zafer Tapıkara, Hüseyin Güzel, Özlem Öztürk, Cem Barçın, Taner Özgürtaş, Ömer Azal, Alper Sönmez
OBJECTIVE: Familial hypercholesterolemia (FH) is a life-threatening genetic disease associated with elevated low-density lipoprotein cholesterol (LDL-C) and premature coronary heart disease that is undiagnosed and undertreated around the world. This study aimed to examine the demographic characteristics, awareness, and treatment adherence of undiagnosed or undertreated FH patients based on laboratory records. METHODS: In a 16-month retrospective survey using laboratory records, patients with elevated LDL-C (>250 mg/dL) were identified (n=395)...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226890/relationship-between-the-extent-of-coronary-artery-disease-and-in-stent-restenosis-in-patients-with-acute-st-segment-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#6
Erkan Yıldırım, Murat Çelik, Uygar Çağdaş Yüksel, Barış Buğan, Yalçın Gökoğlan, Suat Görmel, Salim Yaşar, Mustafa Koklu, Atila İyisoy, Cem Barçın
OBJECTIVE: The pathophysiological mechanism of in-stent restenosis (ISR) is different from atherosclerosis of native coronary arteries. The aim of this study was to evaluate the relationship between ISR and the extent of coronary artery disease (CAD), and to identify other risk factors associated with ISR in ST-segment elevation myocardial infarction (STEMI) patients. METHODS: A total of 372 consecutive patients presenting with first acute STEMI who were successfully treated with primary percutaneous coronary intervention within 12 hours from the onset of symptoms and who had an angiographic follow-up at 3 months were included in the study...
December 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29226278/effects-of-multiple-freeze-thaw-cycles-on-measurements-of-potential-novel-biomarkers-associated-with-adverse-pregnancy-outcomes
#7
Sandra L Rebholz, John T Melchior, Jeffrey A Welge, Alan T Remaley, W Sean Davidson, Laura A Woollett
World-wide, millions of women enter preterm labor or have small newborns. Effective biomarkers are needed to identify women at risk for these adverse outcomes. A time and cost effective way to examine any potentially new biomarkers in samples collected during prior studies or trials that had been assayed for other metabolites would be highly useful. Thus, the current study aimed to determine if samples that had been previously thawed and re-frozen could be re-assayed for novel biomarkers, those being lipoprotein composition (sizing, proteome, lipids) and combined cholesterol and cytokine concentrations...
2017: Journal of Clinical and Laboratory Medicine
https://www.readbyqxmd.com/read/29226217/lipid-profile-in-tuberculosis-patients-with-and-without-human-immunodeficiency-virus-infection
#8
Gebremedhin Gebremicael, Yemane Amare, Feyissa Challa, Atsbeha Gebreegziabxier, Girmay Medhin, Mistire Wolde, Desta Kassa
Background: Understanding whether the preceding low lipid profile leads to active tuberculosis (TB) or active TB leads to low lipid profile is crucial. Methods: Lipid profile concentrations were determined from 159 study participants composed of 93 active TB patients [44 HIV coinfected (HIV+TB+) and 49 HIV negative (HIV-TB+)], 41 tuberculin skin test (TST) positive cases [17 HIV coinfected (HIV+TST+) and 24 HIV negative (HIV-TST+)], and 25 healthy controls (HIV-TST-)...
2017: International Journal of Chronic Diseases
https://www.readbyqxmd.com/read/29226174/proprotein-convertase-subtilisin-kexin-9-levels-in-relation-to-systemic-immune-activation-and-subclinical-coronary-plaque-in-hiv
#9
Markella V Zanni, Lauren A Stone, Mabel Toribio, Dodie E Rimmelin, Jake Robinson, Tricia H Burdo, Kenneth Williams, Kathleen V Fitch, Janet Lo, Steven K Grinspoon
Background: Proprotein convertase subtilisin/kexin 9 (PCSK9) is known to mediate homeostasis of low-density lipoprotein cholesterol (LDL-c), but it may also participate in immune reactivity and atherogenesis. Methods: We compared circulating PCSK9 levels among asymptomatic individuals with and without HIV. Further, within each group, we assessed the relationship between PCSK9 levels, traditional cardiovascular disease risk factors, immune activation, and subclinical coronary atherosclerotic plaque...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29225514/elevation-of-small-dense-low-density-lipoprotein-cholesterol-a-possible-antecedent-of-atherogenic-lipoprotein-phenotype-in-type-2-diabetes-patients-in-jos-north-central-nigeria
#10
Kenneth O Inaku, Obasola O Ogunkeye, Fayeofori M Abbiyesuku, Evelyn K Chuhwak, Christian O Isichei, Lucius C Imoh, Noel O Amadu, Alexander O Abu
Background: The global prevalence of type 2 diabetes is increasing. Dyslipidaemia is a known complication of diabetes mellitus manifesting frequently as cardiovascular diseases and stoke. Elevation of small, dense low density lipoprotein has been recognised as a component of the atherogenic lipoprotein phenotype associated with cardiovascular complications. We speculate that the elevation of this lipoprotein particle may be the antecedent of the atherogenic lipoprotein phenotype. This study therefore aims to determine the pattern of dyslipidaemia among diabetes mellitus patients in Jos, North-Central Nigeria...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29224987/tobacco-smoke-exposure-association-with-lipid-profiles-and-adiposity-among-u-s-adolescents
#11
Ashley L Merianos, Roman A Jandarov, Jane C Khoury, E Melinda Mahabee-Gittens
PURPOSE: We investigated the association between tobacco smoke exposure (TSE) as measured by serum cotinine and lipoprotein cholesterols and adiposity in adolescents. METHODS: We performed a secondary analysis of 1999-2012 National Health and Nutrition Examination Survey data including participants 12-19 years old. We examined TSE: unexposed (<.05 ng/mL), passively exposed (.05-2.99 ng/mL), and actively exposed (≥3 ng/mL); lipid profiles: total cholesterol, high-density lipoprotein cholesterol (HDL-C), non-HDL-C, low-density lipoprotein cholesterol (LDL-C), and triglycerides; and adiposity: body mass index z-score (BMIZ), waist circumference (WC), and waist-to-height ratio (WHtR)...
December 7, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/29224833/hemostasis-and-lipoprotein-indices-signify-exacerbated-lung-injury-in-tuberculosis-with-diabetes-comorbidity
#12
Zhengwei Dong, Jingyun Shi, Anca Dorhoi, Jie Zhang, Adiilah K Soodeen-Lalloo, Wenlin Chen, Hongyun Yin, Wei Sha, Weitong Li, Ruijuan Zheng, Zhonghua Liu, Hua Yang, Lianhua Qin, Jie Wang, Xiaochen Huang, Chunyan Wu, Stefan H E Kaufmann, Yonghong Feng
BACKGROUND: Exacerbated immunopathology is a frequent consequence of tuberculosis (TB) that is complicated by diabetes mellitus (DM), yet the underlying mechanisms are still poorly defined. METHODS: In the two groups of age- and gender-matched TB patients with (DM-TB) and without DM (NDM-TB), we microscopically evaluated the areas of caseous necrosis and graded the extent of perinecrotic fibrosis in lung biopsies from the sputum smear-negative (SN) patients. We scored acid-fast bacilli in smear-positive (SP) patients and compiled computed tomography data from both SN-TB and SP-TB patients...
December 7, 2017: Chest
https://www.readbyqxmd.com/read/29224024/association-of-the-tg-hdl-c-and-non-hdl-c-hdl-c-ratios-with-chronic-kidney-disease-in-an-adult-chinese-population
#13
Jia Wen, Yiyin Chen, Yun Huang, Yao Lu, Xing Liu, Honghao Zhou, Hong Yuan
BACKGROUND/AIMS: Evidence indicates a role for dyslipidemia in the development of chronic kidney disease (CKD). However, the association of lipid abnormalities and their ratios with kidney disease using the new CKD Epidemiology Collaboration (CKD-EPI) equation is not well understood. METHODS: This cross-sectional study included 48,054 adult subjects. CKD was defined as an estimated glomerular filtration rate <60 ml/min/1.73 m2 or dipstick-positive proteinuria...
December 8, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29223956/residual-risk-of-atherosclerotic-cardiovascular-events-in-relation-to-reductions-in-very-low-density-lipoproteins
#14
Patrick R Lawler, Akintunde O Akinkuolie, Paulo Harada, Robert J Glynn, Daniel I Chasman, Paul M Ridker, Samia Mora
BACKGROUND: It is uncertain whether pharmacological reductions in very-low-density lipoproteins (VLDLs), and their component triglyceride and cholesterol could reduce residual risk of atherosclerotic cardiovascular disease (ASCVD) events among individuals in whom low-density lipoprotein cholesterol (LDL-C) has been adequately lowered. We examined whether individuals with greater on-statin reductions in VLDL-related measures-beyond reductions in LDL-C-were at further reduced risk of ASCVD...
December 9, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29223765/prognostic-role-of-serum-total-cholesterol-and-high-density-lipoprotein-cholesterol-in-cancer-survivors-a-systematic-review-and-meta-analysis
#15
REVIEW
Pingting Zhou, Bo Li, Bin Liu, Tianrui Chen, Jianru Xiao
BACKGROUND: The alterations of lipid profile in cancer has been reported to be associated with cancer development. However, the prognostic value of serum lipid markers level in cancer is currently under debate. Here we performed a meta-analysis to investigate the prognostic significance of serum blood total cholesterol (TC), Triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) for cancer. METHODS: We systematically searched in PubMed and EMBASE for follow-up studies to evaluate the association between blood TC, TG, HDL-C, LDL-C and overall survival (OS) or disease-free survival (DFS) in patients with cancer...
December 6, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29221604/effect-of-evolocumab-on-lipoprotein-particles
#16
Peter P Toth, Naveed Sattar, Dirk J Blom, Seth S Martin, Steven R Jones, Maria Laura Monsalvo, Mary Elliott, Mike Davis, Ransi Somaratne, David Preiss
The level of low-density lipoprotein cholesterol (LDL-C) reflects the cholesterol carried mainly by low-density lipoprotein particles (LDL-P). LDL-C, however, does not always correlate with LDL-P because of the variable amounts of cholesterol per particle. Consideration of LDL-P concentrations in addition to LDL-C may help guide therapeutic decisions in a select number of patients. Evolocumab is a fully human monoclonal antibody directed against proprotein convertase subtilisin-kexin type 9 that lowers both LDL-C and cardiovascular events...
November 8, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29219813/unfavourable-blood-pressure-and-ldl-cholesterol-levels-in-obese-non-diabetic-individuals
#17
B H R Wolffenbuttel, S N Slagter, R P van Waateringe, A P van Beek, J V van Vliet-Ostaptchouk, M M van der Klauw
BACKGROUND: Early diagnosis and treatment of high blood pressure (BP) and cholesterol is important to reduce cardiovascular risk. We compared BP and LDL-cholesterol (LDL-C) as well as the quality of treatment between obese subjects and normal weight and overweight individuals. METHODS: 87,648 participants of the Lifelines study were categorised according to obesity (normal weight/ overweight/obesity) and age. Mean systolic BP and LDL-C were calculated depending on treatment, BMI, age and sex...
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29218707/food-effect-on-rosuvastatin-disposition-and-low-density-lipoprotein-cholesterol
#18
Cheynne C McLean, Wendy A Teft, Bridget L Morse, Steven E Gryn, Robert A Hegele, Richard B Kim
Rosuvastatin is commonly prescribed for the treatment of hypercholesterolemia and hepatic transporter-mediated accumulation in the liver enhances its efficacy. Current guidelines indicate no preference for fed or fasted rosuvastatin administration. We investigated the association between food intake and rosuvastatin disposition in healthy subjects and low-density lipoprotein cholesterol (LDL-C) lowering effects among patients taking rosuvastatin. We demonstrate administration with food resulted in a near 40% reduction of rosuvastatin exposure in healthy Asian (n=12) and Caucasian (n=11) subjects...
December 8, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29217412/glucagon-like-peptide-1-receptor-agonists-reduced-the-low-density-lipoprotein-cholesterol-in-japanese-patients-with-type-ii-diabetes-mellitus-treated-with-statins
#19
Yukiko Hasegawa, Mika Hori, Tomoko Nakagami, Mariko Harada-Shiba, Yasuko Uchigata
BACKGROUND: Patients with type II diabetes mellitus (T2DM) often have hypercholesterolemia, and their serum low-density lipoprotein cholesterol (LDL-C) levels are not always well-controlled even by statin treatment. The glucose-lowering glucagon-like peptide-1 receptor agonists (GLP-1RAs) are reported to change the lipid profiles in T2DM patients, but their effects have been unclear. OBJECTIVE: We examined whether GLP-1RAs affect serum cholesterol levels in T2DM patients with/without statin treatment...
November 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29212549/hypertriglyceridemia-and-atherosclerosis
#20
REVIEW
Jia Peng, Fei Luo, Guiyun Ruan, Ran Peng, Xiangping Li
Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of death and it has been confirmed that increased low density lipoprotein cholesterol (LDL-C) is an independent risk factor for atherosclerosis. Recently, the increasing evidence has showed that hypertriglyceridemia is associated with incremental ASCVD risk. But the proatherogenic mechanism of triglyceride (TG) remains unclear. Therefore, this article focuses on the clinical studies and proatherogenic mechanism related to hypertriglyceridemia, in order to provide reference for the prevention and treatment of ASCVD...
December 6, 2017: Lipids in Health and Disease
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