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https://www.readbyqxmd.com/read/28828418/the-anti-obesity-properties-of-the-proanthocyanidin-extract-from-the-leaves-of-chinese-bayberry-myrica-rubra-sieb-et-zucc
#1
Xiaozhou Zhou, Shiguo Chen, Xingqian Ye
The anti-obesity effects of different proanthocyanidin extracts (PE) from Chinese bayberry (Myrica rubra Sieb.et Zucc.) leaves were evaluated in a high-fat (HF) diet-induced obese rat model. The leaves of Chinese bayberry (LCB), a non-desaccharified proanthocyanidin extract (NDPE), and a desaccharified proanthocyanidin extract (DPE) were compared with orlistat, a conventional anti-obesity drug used as a positive control. The rats from all of the PE-treated groups showed obvious weight loss, with the greatest weight loss in the DPE group (P < 0...
August 22, 2017: Food & Function
https://www.readbyqxmd.com/read/28827781/optimal-target-level-of-low-density-lipoprotein-cholesterol-for-vascular-function-in-statin-na%C3%A3-ve-individuals
#2
Shogo Matsui, Masato Kajikawa, Eisuke Hida, Tatsuya Maruhashi, Yumiko Iwamoto, Akimichi Iwamoto, Nozomu Oda, Shinji Kishimoto, Takayuki Hidaka, Yasuki Kihara, Kazuaki Chayama, Chikara Goto, Yoshiki Aibara, Ayumu Nakashima, Farina Binti Mohamad Yusoff, Kensuke Noma, Yukihito Higashi
We investigated (1) the relationship between low-density lipoprotein cholesterol (LDL-C) and vascular function in patients receiving and those not receiving statin therapy and (2) optimal level of LDL-C for maintenance of vascular function. Flow-mediated vasodilation (FMD) and nitroglycerine-induced vasodilation (NID) were inversely correlated with LDL-C in the 957 statin naïve subjects but not in the 392 subjects receiving statin therapy. In statin naïve subjects, non-high LDL-C (≤100 mg/dL) was independently associated with a decrease in adjusted odds ratio of the low tertile of FMD (OR: 0...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28826575/apolipoprotein-b-is-associated-with-carotid-atherosclerosis-progression-independent-of-individual-cholesterol-measures-in-a-9-year-prospective-study-of-multi-ethnic-study-of-atherosclerosis-participants
#3
Brian T Steffen, Weihua Guan, Alan T Remaley, James H Stein, Mathew C Tattersall, Joel Kaufman, Michael Y Tsai
BACKGROUND: High blood cholesterol contributes to atherosclerosis, yet reliance on the lipid panel alone may mischaracterize individuals with elevated lipoprotein particle numbers. OBJECTIVE: The aim of the article was to determine whether elevated lipoprotein or apolipoprotein measures are associated with carotid atherosclerosis and plaque progression independent of cardiovascular (CV) risk factors including standard lipids in a subcohort of 2228 Multi-Ethnic Study of Atherosclerosis participants...
July 12, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28826569/effects-of-morning-vs-evening-statin-administration-on-lipid-profile-a-systematic-review-and-meta-analysis
#4
Kamal Awad, Maria-Corina Serban, Peter Penson, Dimitri P Mikhailidis, Peter P Toth, Steven R Jones, Manfredi Rizzo, George Howard, Gregory Y H Lip, Maciej Banach
BACKGROUND: Evidence about the optimal time of day at which to administer statins is lacking. OBJECTIVE: The objective of this study is to synthesize evidence about effects of morning vs evening statin administration on lipid profile. METHODS: We searched PubMed, SCOPUS, Web of Science, and Embase databases (from inception up to July 24, 2016) to identify the relevant studies. Mean differences (MDs) between the change scores in lipid parameters were pooled using a fixed-effect model...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28826567/evaluating-the-atherogenic-burden-of-individuals-with-a-friedewald-estimated-low-density-lipoprotein-cholesterol-70%C3%A2-mg-dl-compared-with-a-novel-low-density-lipoprotein-estimation-method
#5
Seamus P Whelton, Jeffrey W Meeusen, Leslie J Donato, Allan S Jaffe, Amy Saenger, Lori J Sokoll, Roger S Blumenthal, Steven R Jones, Seth S Martin
BACKGROUND: A number of national and international guidelines recommend treatment to low-density lipoprotein cholesterol (LDL-C) <70 mg/dL. Comparing the performance of the Friedewald and a novel LDL-C estimate at these concentrations in a nationally representative and clinical cohorts can inform best practices. OBJECTIVES: The objectives of the study were to evaluate concordance between Friedewald-estimated LDL-C and novel-estimated LDL-C and compare with other atherogenic parameters when the estimated LDL-C is <70 mg/dL...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28826313/effect-of-omega-3-polyunsaturated-fatty-acids-supplementation-on-body-composition-and-circulating-levels-of-follistatin-like-1-in-males-with-coronary-artery-disease-a-randomized-double-blind-clinical-trial
#6
Shirin Jafari Salim, Shahab Alizadeh, Mahmoud Djalali, Ebrahim Nematipour, Mohammad Hassan Javanbakht
Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45-65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study...
August 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28826253/effects-of-pcsk9-inhibitors-on-other-than-low-density-lipoprotein-cholesterol-lipid-variables
#7
Theodosios D Filippatos, Anastazia Kei, Christos V Rizos, Moses S Elisaf
Low-density lipoprotein cholesterol (LDL-C) is a major cardiovascular risk factor, but other lipid variables such as triglycerides (TRGs), high-density lipoprotein cholesterol (HDL-C) and lipoprotein a [Lp(a)] also affect cardiovascular risk. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors significantly lower LDL-C concentration but also modestly improve the concentrations of TRGs and HDL-C and more robustly decrease Lp(a) levels. The review presents the associated mechanisms of the beneficial effects of PCSK9 inhibitors on the other than LDL-C lipid variables, including the effects on lipid/apolipoprotein secretion and clearance and the heteroexchange between lipoproteins, as well as the possible effects on other variables involved in lipid metabolism such as sortilin...
January 1, 2017: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28822527/coronary-artery-disease-in-women
#8
REVIEW
Lekha Adik Pathak, Salil Shirodkar, Ronak Ruparelia, Jaideep Rajebahadur
BACKGROUND: Despite the importance of CAD for women, there is persistent perception that CAD is a man's disease. Contributing to this notion is the observation of differences in incidence rates according to age; the incidence of CAD in women is lower than men, but rises steadily after fifth decade. The distribution of CAD risk factors varies between men and women across age ranges and failure to consider these differences may have contributed to the belief that women are at lower risk of CAD compared with men...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822512/implications-of-the-2013-acc-aha-cholesterol-guidelines-on-contemporary-clinical-practice-for-patients-with-atherosclerotic-coronary-and-peripheral-arterial-disease
#9
Prasad Gunasekaran, Vinodh Jeevanantham, Suresh Sharma, Rashmi Thapa, Kamal Gupta
BACKGROUND: Cholesterol management guidelines from the American College of Cardiology/American Heart Association (ACC/AHA-2013) recommend fixed statin dosing (dose depends on age ≤ or >75years) compared to the earlier adult treatment panel III (ATPIII) guidelines which recommended specific low-density lipoprotein-cholesterol (LDL-C) targets. Clinical implications of this recommendation are not known. METHODS: We retrospectively compared cholesterol levels and statin utilization across cohorts with coronary artery disease (CAD) (n=9563), peripheral arterial disease (PAD) (n=596) and CAD+PAD (n=975) by applying both guidelines...
July 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28822166/-clinical-observation-of-modified-da-chaihu-decoction-in-treating-essential-hypertension-with-anxiety
#10
Xiang-Dong Zhang, Wang-Qiang Cheng, Yong-Gang Wang, Zheng Zhang
To observe the clinical efficacy of modified Da Chaihu decoction in treating essential hypertension with anxiety, the randomized, controlled, clinical trial was performed in this study. One hundred and twenty-six hypertensive patients with anxiety meeting the inclusive criteria were randomized into the treatment group and the control group. All of the included patients in the above 2 groups were treated by amlodipine besylate tablets. Patients in the treatment group were given Chinese herbal medicine modified Da Chaihu decoction every day...
June 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28821856/smoking-obstructive-sleep-apnea-syndrome-and-their-combined-effects-on-metabolic-parameters-evidence-from-a-large-cross-sectional-study
#11
Huaming Zhu, Huajun Xu, Rui Chen, Suru Liu, Yunyan Xia, Yiqun Fu, Xinyi Li, Yingjun Qian, Jianyin Zou, Hongliang Yi, Jian Guan
Metabolic disorders have been separately associated with obstructive sleep apnea syndrome (OSAS) and smoking. However, no study has examined their interactions with metabolic parameters, including insulin resistance and dyslipidemia. To investigate whether the combination of OSAS and smoking results in an additive detriment in metabolic disorder parameters, we enrolled consecutive adult men during 2014-2015. Fasted blood samples were taken to determine glucose, insulin, and lipid levels. A questionnaire including an item on smoking pack-year exposure was administered, and the Epworth Sleepiness Scale and overnight polysomnography were performed...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821713/evaluating-the-causal-relation-of-apoa-iv-with-disease-related-traits-a-bidirectional-two-sample-mendelian-randomization-study
#12
Salome Mack, Stefan Coassin, Julien Vaucher, Florian Kronenberg, Claudia Lamina
Apolipoprotein A-IV (apoA-IV) has been observed to be associated with lipids, kidney function, adiposity- and diabetes-related parameters. To assess the causal relationship of apoA-IV with these phenotypes, we conducted bidirectional Mendelian randomization (MR) analyses using publicly available summary-level datasets from GWAS consortia on apoA-IV concentrations (n = 13,813), kidney function (estimated glomerular filtration rate (eGFR), n = 133,413), lipid traits (HDL cholesterol, LDL cholesterol, triglycerides, n = 188,577), adiposity-related traits (body-mass-index (n = 322,206), waist-hip-ratio (n = 210,088)) and fasting glucose (n = 133,010)...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821087/in-vivo-antihyperlipidemic-and-antioxidant-activity-of-porphyran-in-hyperlipidemic-mice
#13
Xiaomei Wang, Weida Li, Li Xiao, Chundong Liu, Huimin Qi, Zhongshan Zhang
The hypolipidemic and antioxidant effects of porphyran from the red algae Porphyra haitanensis as a dietary supplement were evaluated in mice. The levels of serum TC, TG and LDL-C in MP group increased significantly (p<0.05 or p<0.01) by 28.5%, 29.4% and 33.5% compared with the model group. These significant rises were accompanied by significant declines of plasma HDL-C by 21.6% compared with the model group. In addition, the liver content of malondialdehyde significantly decreased, while the superoxide dismutase, catalase, glutathione peroxidase activities significantly increased...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28817948/effects-of-dietary-supplementation-of-resveratrol-on-performance-egg-quality-yolk-cholesterol-and-antioxidant-enzyme-activity-of-laying-hens
#14
Z H Feng, J G Gong, G X Zhao, X Lin, Y C Liu, K W Ma
1. This experiment was conducted to evaluate the effects of dietary supplementation of resveratrol on laying performance, egg quality, egg yolk cholesterol and antioxidant enzyme activities of laying hens. 2. A total of 360 Beijing PINK-1 laying hens (60 weeks old) were randomly distributed among 5 dietary treatments, each of which included 6 replicates of 12 hens. Dietary treatments were basal diet supplemented with 0 (control), 0.5, 1.0, 2.0 and 4.0 g/kg diet resveratrol. The study lasted for 9 weeks including 1 week of adaptation and 8 weeks of the main experimental period...
August 18, 2017: British Poultry Science
https://www.readbyqxmd.com/read/28817301/patients-views-of-a-behavioral-intervention-including-financial-incentives
#15
Judy A Shea, Aderinola Adejare, Kevin G Volpp, Andrea B Troxel, Darra Finnerty, Karen Hoffer, Thomas Isaac, Meredith Rosenthal, Thomas D Sequist, David A Asch
OBJECTIVES: Clinical trials are increasingly testing the effectiveness of paying patients' financial incentives for achieving desired clinical outcomes. Some researchers and providers are concerned that patient financial incentives will harm the doctor-patient relationship. How patients feel about these approaches, and these trials, is largely unknown. This study examined patients' perceptions of a compound behavioral and financial incentive intervention used in a large multicenter trial to lower low-density lipoprotein cholesterol (LDL-C), including their perceptions of benefits and challenges and the study's effect on patients' relationship with their primary care physicians (PCPs)...
June 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28816989/disease-duration-of-rheumatoid-arthritis-is-a-predictor-of-vascular-stiffness-a-cross-sectional-study-in-patients-without-known-cardiovascular-comorbidities-a-strobe-compliant-article
#16
Mónica Vázquez-Del Mercado, Eduardo Gomez-Bañuelos, Efrain Chavarria-Avila, Ernesto Cardona-Muñoz, Carlos Ramos-Becerra, Adrián Alanis-Sanchez, David Cardona-Muller, Fernando Grover-Paez, Felipe de J Perez-Vazquez, Rosa-Elena Navarro-Hernandez, Jorge M Valadez-Soto, Adan A Saldaña-Millan, Lorena Gonzalez-Rosas, Gabriel Ramos-Lopez, Marcelo H Petri, Magnus Bäck
The aim of this study was to analyze the impact of disease duration on carotid to femoral pulse wave velocity (cfPWV) in rheumatoid arthritis (RA) patients without either known traditional cardiovascular risk factors or previous comorbidities.Patients with RA diagnosis attending the rheumatology outpatient clinic of Hospital Civil Juan I. Menchaca, Guadalajara, Mexico, were analyzed. A total of 106 RA patients without known traditional cardiovascular risk factors were selected. All subjects were evaluated for RA disease duration, RA disease activity score on 28 joints (DAS28), serum lipids, rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) antibodies...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28816530/hemoglobin-a1c-blood-pressure-and-ldl-cholesterol-control-among-hispanic-latino-adults-with-diabetes-results-from-the-hispanic-community-health-study-study-of-latinos-hchs-sol
#17
Sarah Stark Casagrande, Larissa Aviles-Santa, Leonor Corsino, Martha L Daviglus, Linda C Gallo, Rebeca A Espinoza Giacinto, Maria M Llabre, Samantha A Reina, Peter J Savage, Neil Schneiderman, Gregory A Talavera, Catherine C Cowie
OBJECTIVE: To determine the prevalence of Hispanic/Latino adults with diabetes who meet target A1c, blood pressure (BP), and LDL cholesterol (LDL-C) recommendations, and ACE (angiotensin-converting enzyme inhibitors)/ARB (angiotensin receptor blocker) and statin medication use, by heritage and sociodemographic and diabetes-related characteristics. METHODS: Data were cross-sectional, collected between 2008-2011, and included adults age 18-74 years who reported a physician diagnosis of diabetes in the Hispanic Community Health Study/Study of Latinos (N=2,148)...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28816230/plasma-pcsk9-levels-are-unrelated-to-arterial-stiffness-in-a-community-based-4-8-year-prospective-study
#18
J Han, X Wang, P Ye, R Cao, X Yang, W Xiao, Y Zhang, Y Bai, H Wu
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important circulating serine protease in low-density lipoprotein cholesterol (LDL-C) metabolism. Increased plasma PCSK9 levels lead to increased plasma levels of LDL-C and an increased risk of cardiovascular disease (CVD). LDL-C is positively correlated with arterial stiffness, a surrogate endpoint of CVD. However, whether plasma levels of PCSK9 could influence arterial stiffness is still unclear. Our study examined the relationship between plasma levels of PCSK9 and arterial stiffness (carotid-femoral pulse wave velocity (cf-PWV)) in a community-based population...
August 17, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28815384/association-between-discordance-of-ldl-c-and-non-hdl-c-and-clinical-outcomes-in-patients-with-stent-implantation-from-the-fu-registry
#19
Michiyo Shiiba, Bo Zhang, Shin-Ichiro Miura, Amane Ike, Daisuke Nose, Takashi Kuwano, Satoshi Imaizumi, Makoto Sugihara, Atushi Iwata, Hiroaki Nishikawa, Akira Kawamura, Kazuyuki Shirai, Shin'ichiro Yasunaga, Keijiro Saku
It is not yet clear whether the discordance of low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (non-HDL-C) predicts the follow-up clinical outcome (major adverse cardiovascular events: MACEs) in patients with coronary stent implantation. Among 2015 patients with coronary stent implantation (Fukuoka University [FU]-Registry), excluding those with acute coronary syndrome or hemodialysis, we selected 801 patients who had undergone successful stent implantation with a follow-up until 18 months, and classified them into 3 groups according to baseline LDL-C and non-HDL-C levels [percentile(P)non-HDL-C more than (P)LDL-C, (P)non-HDL-C equal to (P)LDL-C, and (P)non-HDL-C less than (P) LDL-C]...
August 16, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28814932/achievement-of-ldl-cholesterol-goal-and-adherence-to-statin-by-diabetes-patients-in-kelantan
#20
Zainab Mat Yudin, Lili Husniati Yaacob, Norul Badriah Hassan, Saiful Bahari Ismail, Nani Draman, Siti Suhaila Mohd Yusoff
BACKGROUND: Statins are a class of potent drugs that can be used to reduce cholesterol, especially low-density lipoprotein cholesterol (LDL-C). However, their effectiveness is limited if adherence to treatment is poor. The objectives of the study are to estimate the proportion of diabetic patient who has achieved LDL-C goal and to determine the association of LDL-C achievement with socio demographic factors and statin therapy adherence. METHODS: This is a cross-sectional study involving 234 patients with type 2 diabetes mellitus (T2DM) and dyslipidaemia attending an outpatient clinic in a hospital in Kelantan...
May 2017: Malaysian Journal of Medical Sciences: MJMS
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