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Crohn fistula

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https://www.readbyqxmd.com/read/28225051/low-muscle-mass-at-initiation-of-anti-tnf-therapy-for-inflammatory-bowel-disease-is-associated-with-early-treatment-failure-a-retrospective-analysis
#1
D Q Holt, P Varma, B J G Strauss, A S Rajadurai, G T Moore
BACKGROUND/OBJECTIVES: Delayed treatment failure occurs in a significant proportion of inflammatory bowel disease (IBD) patients treated with tumor necrosis factor-alpha (TNF) antagonists. Identification of predictors of loss of response (LOR) may help to optimize therapy. We sought to determine whether body composition parameters at the commencement of anti-TNF therapy were associated with earlier treatment failure. SUBJECTS/METHODS: A retrospective cohort study was performed on 68 patients who had undergone cross-sectional abdominal imaging coincident with the commencement of anti-TNF drugs...
February 22, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28218881/mr-imaging-of-perianal-crohn-disease
#2
Shannon P Sheedy, David H Bruining, Eric J Dozois, William A Faubion, Joel G Fletcher
Pelvic magnetic resonance (MR) imaging is currently the standard for imaging perianal Crohn disease. Perianal fistulas are a leading cause of patient morbidity because closure often requires multimodality treatments over a prolonged period of time. This review summarizes clinically relevant anal sphincter anatomy, imaging methods, classification systems, and treatment objectives. In addition, the MR appearance of healing perianal fistulas and fistula complications is described. Difficult imaging tasks including the assessment of rectovaginal fistulas and ileoanal anastomoses are highlighted, along with illustrative cases...
March 2017: Radiology
https://www.readbyqxmd.com/read/28216137/low-predictive-value-of-histopathological-scoring-system-for-complications-development-in-children-with-crohn-s-disease
#3
Ondrej Fabian, Ondrej Hradsky, Kristyna Potuznikova, Alena Kalfusova, Lenka Krskova, Ludmila Hornofova, Josef Zamecnik, Jiri Bronsky
OBJECTIVES: In pediatric Crohn's disease (PCD), the benefit of microscopy in disease activity assessment and prediction of clinical outcome is, due to the focality and transmurality of the inflammation, disputable. We investigated whether histopathological scoring system predicts complications in pediatric CD and correlates with endoscopical and clinical scores. METHODS: We performed a retrospective study on 63 patients. Endoscopy in the time of diagnosis was evaluated using the Simple Endoscopic Score (SES) and histopathology with the Global Histology Activity Score, both in its original version (GHAS) and its modification (modGHAS)...
January 15, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214210/pathologic-features-of-colorectal-carcinomas-associated-with-crohn-s-disease-in-korean-population
#4
Jiyoon Kim, Ho-Su Lee, Sang Hyoung Park, Suk-Kyun Yang, Byong Duk Ye, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Yong Sik Yoon, Chang Sik Yu, Jihun Kim
BACKGROUND: Colorectal cancer (CRC) has been known to complicate Crohn's disease (CD). Several reports in Western population revealed that CRC in CD were characterized by much younger onset and equal distribution of tumors along the entire colon. However, clinicopathologic features of CD-associated CRC in Korean population have not been well documented yet. METHODS: Among 2968 Korean CD patients, 16 patients (0.54%) were found to develop CRC during follow up. We reviewed clinicopathologic features of the 16 CRC patients...
December 21, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28211593/higher-infliximab-trough-levels-are-associated-with-perianal-fistula-healing-in-patients-with-crohn-s-disease
#5
A J Yarur, V Kanagala, D J Stein, F Czul, M A Quintero, D Agrawal, A Patel, K Best, C Fox, K Idstein, M T Abreu
BACKGROUND: Infliximab has been found to be efficacious in the treatment of fistulas in the setting of Crohn's disease, even though some patients do not benefit from therapy. AIM: To assess the correlation between perianal fistula healing and trough levels of infliximab. METHODS: In this cross-sectional study, we identified patients with Crohn's disease who had perianal fistulas and were treated with infliximab for at least 24 weeks. We excluded patients who underwent a faecal diversion procedure or proctectomy...
February 17, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28203422/colobronchial-fistula-the-pathogenesis-clinical-presentations-diagnosis-and-treatment
#6
Jinbo Zhao, Nan Ma, Zhengwei Zhao, Jie Lei, Qiang Lu, Feng Tian, Yongan Zhou, Yong Han, Xiaofei Li
BACKGROUND: Colobronchial fistula (CBF) is rare and easy to be delayed in clinic. There is no systemic study about this disease. The pathogenesis, clinical presentations, diagnosis and treatment of CBF were analyzed in this study. METHODS: The clinical data from 37 cases of CBF, which included one case in our institute and the other 36 cases in literature from January 1960 to August 2016, were reviewed and analyzed. The etiology, clinical presentations, diagnostic and therapeutic methods, and outcomes were summarized...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28198748/time-trends-in-the-epidemiology-and-outcome-of-perianal-fistulizing-crohn-s-disease-in-a-population-based-cohort
#7
Kevin W A Göttgens, Steven F G Jeuring, Rosel Sturkenboom, Mariëlle J L Romberg-Camps, Liekele E Oostenbrug, Daisy M A E Jonkers, Laurents P S Stassen, Ad A M Masclee, Marieke J Pierik, Stéphanie O Breukink
OBJECTIVE: Perianal disease is a debilitating condition that frequently occurs in Crohn's disease (CD) patients. It is currently unknown whether its incidence has changed in the era of frequent immunomodulator use and biological availability. We studied the incidence and outcome of perianal and rectovaginal fistulas over the past two decades in our population-based Inflammatory Bowel Disease South-Limburg cohort. PATIENTS AND METHODS: All 1162 CD patients registered in the Inflammatory Bowel Disease South-Limburg registry were included...
February 14, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28175206/p681-assessing-internet-based-information-used-to-aid-patient-decision-making-in-surgery-for-perianal-crohn-s-fistula
#8
J Marshall, D Baker, M Lee, G Jones, A Lobo, S Brown
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175177/p672-surgical-and-anti-tnfs-combined-therapy-prevents-crohn-s-perianal-fistula-recurrence-a-systematic-review-and-meta-analysis
#9
P-P Xu, Y Qiu, Y-L Jia, L Xu, C-Y He, Z Han
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175158/p626-ustekinumab-for-the-treatment-of-perianal-fistulas-in-patients-with-crohn-s-disease
#10
R Battat, T Bessissow, M Strohl, U Kopylov, A Bitton, A Cohen, E Seidman, W Afif
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175104/p494-multicentre-cohort-study-to-evaluate-the-need-for-re-intervention-following-multimodal-treatment-in-crohn-s-disease-with-perianal-fistula
#11
S Sebastian, C Black, D Pugliese, A Armuzzi, K Sahnan, S M Elkady, K H Katsanos, D K Christodoulou, C Selinger, G Maconi, G Fiorino, U Kopylov, Y Davidov, M M Bosca-Watts, P Ellul, M Muscat, K Karmiris, N S Fearnhead, V Allgar, A L Hart, S Ben-Horin, S Danese
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175027/p211-differences-in-therapeutic-approaches-and-outcomes-in-paediatric-and-adult-onset-crohn-s-disease-with-perianal-fistula-comparison-of-2-multicentre-fistula-cohorts
#12
S Sebastian, C Black, M V Nair, T Drskova, O Hradsky, C Tzivinikos, K Sahnan, R Muhammed, D Devadason, R S Parmar, K Crook, A Akbar, M Thomson, D Pugliese, A Armuzzi, K H Katsanos, D K Christodoulou, C Selinger, G Maconi, G Fiorino, U Kopylov, M M Bosca-Watts, K Karmiris, P Ellul, S Ben-Horin, S Danese, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174981/op008-an-innovative-treatment-for-refractory-perianal-fistulas-in-crohn-s-disease-local-micro-reinjection-of-autologous-fat-and-adipose-derived-stromal-vascular-fraction
#13
M Serrero, C Philandrianos, C Visee, J Veran, P Orsoni, F Sabatier, J-C Grimaud
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173073/p712-risk-factors-for-the-development-of-fistulae-and-stenoses-in-crohn-s-disease-patients-in-the-swiss-ibd-cohort
#14
J Zeitz, N Fournier, C Labenz, L Biedermann, P Frei, B Misselwitz, S Scharl, S Vavricka, M Sulz, M Fried, G Rogler, M Scharl
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172919/p240-presentation-and-surgical-interventions-for-crohn-s-disease-with-perianal-fistula-in-the-biologics-era-results-from-a-multicentre-study
#15
C Black, D Pugliese, K Sahnan, A Armuzzi, S M Elkady, A L Hart, K H Katsanos, D K Christodoulou, C Selinger, G Maconi, G Fiorino, Y Davidov, U Kopylov, S Ben-Horin, P Navarro, M M Bosca-Watts, M Muscat, P Ellul, K Karmiris, V Allgar, S Danese, N S Fearnhead, S Sebastian
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172874/p398-an-objective-measure-of-response-to-treatment-for-patients-with-crohn-s-perianal-fistulas-on-anti-tnf-treatment
#16
K Sahnan, P F Lung, S O Adegbola, D Burling, J Burn, P J Tozer, A Gupta, O D Faiz, R K Phillips, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172633/p222-sequential-mri-volume-measurements-of-perianal-fistulae-in-crohn-s-disease
#17
C Black, A Razack, S Sebastian
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172582/p701-late-onset-crohn-s-disease-is-associated-with-high-risk-of-intestinal-perforation-and-low-risk-of-perianal-fistula-as-compared-with-early-onset-crohn-s-disease-the-connect-cohort
#18
H M Kim, H-S Kim, J S Kim, Y S Kim, J H Cheon, B D Ye, Y H Kim, D S Han
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172537/p493-efficacy-of-anti-tnf-for-internal-fistula-in-crohn-s-disease-results-from-a-retrospective-multicenter-cohort-study
#19
T Kobayashi, A Hishida, H Tanaka, S Bamba, A Yamada, F Toshimitsu, S Shinichiro, N Kamata, T Yoshino, T Hibi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172497/p432-therapeutic-approaches-for-perianal-fistula-in-paediatric-and-adolescent-onset-crohn-s-disease-a%C3%A2-multicentre-cohort-study
#20
S Sebastian, C Tzivinikos, T Drskova, O Hradsky, M V Nair, K Sahnan, R Muhammed, D Devadason, R S Parmar, K Crook, A Akbar, M Thomson, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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