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https://www.readbyqxmd.com/read/28738450/the-effect-of-pressure-on-organic-reactions-in-fluids-a-new-theoretical-perspective
#1
REVIEW
Bo Chen, Roald Hoffmann, Roberto Cammi
This Review brings a new perspective to the study of chemical reactions in compressed fluid media. We begin by reviewing the substantial insight gained from more than 50 years of experimental studies on organic reactions in solution under pressure. These led to a proper estimation of the critical roles of volume of activation (Δ(≠) V) and reaction volume (ΔV) in understanding pressure effect on rates and equilibria of organic reactions. A recently developed computational method, the XP-PCM (extreme pressure polarizable continuum model) method, capable of carrying out quantum mechanical calculations of reaction pathways of molecules under pressure, is introduced...
July 24, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28738316/-what-kept-me-going-a-qualitative-study-of-avoidant-responses-to-war-related-adversity-and-perpetration-of-violence-by-former-forcibly-recruited-children-and-youth-in-the-acholi-region-of-northern-uganda
#2
Helle Harnisch, Edith Montgomery
This qualitative study investigates what, according to 36 former forcibly recruited women and men, enabled them to "keep on going" during and after their forced recruitment in the twenty-year-long civil war in northern Uganda. Furthermore, the study conveys the ways most of the former forcibly recruited kept on going and today cope with ongoing war-related adversity and difficult reintegration processes without relying on psycho-social intervention. Thirty-five of the 36 women and men were forcibly recruited when they were children by the Lord's Resistance Army (LRA) from the Acholi region of northern Uganda...
July 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28737672/mesoporous-silica-nanoparticles-as-drug-delivery-vehicles-in-cancer
#3
REVIEW
Anna Watermann, Juergen Brieger
Even though cancer treatment has improved over the recent decades, still more specific and effective treatment concepts are mandatory. Surgical removal is not always possible, metastases are challenging and chemo- and radiotherapy can not only have severe side-effects but also resistances may occur. To cope with these challenges more efficient therapies with fewer side-effects are required. One promising approach is the use of drug delivery vehicles. Here, mesoporous silica nanoparticles (MSN) are discussed as biodegradable drug carrier to improve efficacy and reduce side-effects...
July 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28737570/clinical-presentation-of-acute-gastroenteritis-in-children-with-functional-abdominal-pain-disorders
#4
Miguel Saps, Stijn Mintjens, Cenk K Pusatcioglu, Daniel M Cohen, Petra Sternberg
Visceral hypersensitivity and abnormal coping are common in children with functional abdominal pain disorders (FAPDs). Thus, it would be expected that children with visceral hypersensitivity would report more pain if their gut is acutely inflamed. The aim of the study was to compare clinical symptoms and somatization of children with and without FAPDs at time of an episode of acute gastroenteritis. Seventy children with acute gastroenteritis and their parents completed the Rome III Diagnostic Questionnaire for Pediatric Functional GI Disorders and the Children's Somatization Inventory...
August 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28737545/the-perinatal-neonatal-care-journey-for-parents-of-preterm-infants-what-is-working-and-what-can-be-improved
#5
Linda S Franck, Alison McNulty, Fiona Alderdice
Preterm birth is traumatic for parents, but there are few reports of parents' views on how the healthcare journey can be improved. This secondary thematic analysis used focus group data from parent consultation on proposed neonatal services standards for Northern Ireland to discover parents' experiences and recommendations for the perinatal, neonatal, and home care phases. Parents of preterm infants (n = 40) described their healthcare journey as positive overall and were grateful for the caring and competent care providers they encountered...
July 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/28737120/psychometric-properties-of-the-perceived-stress-scale-in-a-sample-of-german-dementia-patients-and-their-caregivers
#6
Friederike Deeken, Andreas Häusler, Johanna Nordheim, Michael Rapp, Nina Knoll, Nina Rieckmann
BACKGROUND: The aim of the present study was to investigate the psychometric characteristics of the Perceived Stress Scale (PSS) in a sample of dementia patients and their spousal caregivers. METHODS: We investigated the reliability and validity of the 14-item PSS in a sample of 80 couples, each including one spouse who had been diagnosed with mild to moderate dementia (mean age 75.55, SD = 5.85, 38.7% female) and one spousal caregiver (mean age 73.06, SD = 6.75, 61...
July 24, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28736867/volunteer-peer-support-and-befriending-for-carers-of-people-living-with-dementia-an-exploration-of-volunteers-experiences
#7
Raymond Smith, Vari Drennan, Ann Mackenzie, Nan Greenwood
With ageing populations and greater reliance on the voluntary sector, the number of volunteer-led peer support and befriending services for carers of people with dementia in England is set to increase. However, little is known about the experiences of the volunteers who deliver these interventions, many of whom are former carers. Using in-depth semi-structured interviews with 10 volunteer peer supporters and befrienders, this exploratory study investigated volunteers' experiences of delivering the support, the types of relationships they form with carers and their perceptions of its impact upon them and on carers...
July 24, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28736806/a-skill-set-for-supporting-displaced-children-in-psychological-recovery-after-disasters
#8
REVIEW
Betty Pfefferbaum, Anne K Jacobs, Russell T Jones, Gilbert Reyes, Karen F Wyche
Helping children, adolescents, and families displaced following a natural disaster is a daunting task made more challenging by the relatively small research base to inform services and interventions. This paper describes the current literature pertaining to intervention practices used with displaced youth. Where gaps in the literature exist, we pull from the more general research on relocation and post-disaster intervention to assist practitioners in tailoring their efforts. Specifically discussed are ways to enhance youth resilience, to help youth build new social connections and adjust to change and uncertainty while coping with trauma-related symptoms, and to meet needs through the systems in which children are embedded...
September 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28736789/spiritual-distress-and-spiritual-care-in-advanced-heart-failure
#9
REVIEW
Ronald Gillilan, Sameena Qawi, Audrey J Weymiller, Christina Puchalski
As patients face serious and chronic illness, they are confronted with the realities of dying. Spiritual and existential issues are particularly prominent near the end of life and can result in significant distress. It is critical that healthcare professionals know how to address patients' and families' spiritual concerns, diagnose spiritual distress and attend to the deep suffering of patients in a way that can result in a better quality of life for patients and families. Tools such as the FICA spiritual history tool help clinicians invite patients and families to share their spiritual or existential concerns as well as sources of hope and meaning which can help them cope better with their illness...
July 24, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28736698/impact-of-automated-ica-based-denoising-of-fmri-data-in-acute-stroke-patients
#10
D Carone, R Licenik, S Suri, L Griffanti, N Filippini, J Kennedy
Different strategies have been developed using Independent Component Analysis (ICA) to automatically de-noise fMRI data, either focusing on removing only certain components (e.g. motion-ICA-AROMA, Pruim et al., 2015a) or using more complex classifiers to remove multiple types of noise components (e.g. FIX, Salimi-Khorshidi et al., 2014 Griffanti et al., 2014). However, denoising data obtained in an acute setting might prove challenging: the presence of multiple noise sources may not allow focused strategies to clean the data enough and the heterogeneity in the data may be so great to critically undermine complex approaches...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28736330/impaired-microglia-fractalkine-signaling-affects-stress-reaction-and-coping-style-in-mice
#11
Zsuzsanna Winkler, Dániel Kuti, Szilamér Ferenczi, Krisztina Gulyás, Ágnes Polyák, Krisztina J Kovács
Microglia, resident immune cells of the CNS are sensitive to various perturbations of the environment, such as stress exposure, and may be involved in translating these changes to behavior. Among the pathways mediating stress-related neuronal cues to microglia, the fractalkine-fractalkine receptor (CX3CR1) signaling plays a crucial role. Using mice, in which the CX3CR1 gene was deleted, we explored hormonal and behavioral responses to acute and chronic stress along with changes in hypothalamic microglia. CX3CR1(-/-) animals display active escape in forced swim- and tail suspension tests, exaggerated neuronal activation in the hypothalamic paraventricular nucleus and increased corticosterone release in response to restraint...
July 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28736192/the-presence-of-phb-granules-in-cytoplasm-protects-non-halophilic-bacterial-cells-against-the-harmful-impact-of-hypertonic-environments
#12
Stanislav Obruca, Petr Sedlacek, Filip Mravec, Vladislav Krzyzanek, Jana Nebesarova, Ota Samek, Dan Kucera, Pavla Benesova, Kamila Hrubanova, Miluse Milerova, Ivana Marova
Numerous prokaryotes accumulate polyhydroxybutyrate (PHB) intracellularly as a storage material. It has also been proposed that PHB accumulation improves bacterial stress resistance. Cupriavidus necator and its PHB non-accumulating mutant were employed to investigate the protective role of PHB under hypertonic conditions. The presence of PHB granules enhanced survival of the bacteria after exposure to hypertonic conditions. Surprisingly, when coping with such conditions, the bacteria did not utilize PHB to harvest carbon or energy, suggesting that, in the osmotic upshock of C...
July 20, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28736103/what-impact-do-chaplains-have-a-pilot-study-of-spiritual-aim-for-advanced-cancer-patients-in-outpatient-palliative-care
#13
Allison Kestenbaum, Michele Shields, Jennifer James, Will Hocker, Stefana Morgan, Shweta Karve, Michael W Rabow, Laura B Dunn
CONTEXT: Spiritual care is integral to quality palliative care. Although chaplains are uniquely trained to provide spiritual care, studies evaluating chaplains' work in palliative care are scarce. OBJECTIVES: The goals of this pre-post study, conducted among patients with advanced cancer receiving outpatient palliative care, were to evaluate the feasibility and acceptability of chaplain-delivered spiritual care, utilizing the Spiritual Assessment and Intervention Model ("Spiritual AIM"); and to gather pilot data on Spiritual AIM's effects on spiritual well-being, religious and cancer-specific coping, and physical and psychological symptoms...
July 20, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28735721/-the-first-moments-of-the-carer-the-process-of-becoming-a-caregiver-of-a-dependent-elderly-relative
#14
Lourdes Moral-Fernández, Antonio Frías-Osuna, Sara Moreno-Cámara, Pedro A Palomino-Moral, Rafael Del-Pino-Casado
AIM: Describe the initial process through which people who imminently become caregivers of a dependent elderly relative. DESIGN: Qualitative study, for which its analysis has been directed by Grounded Theory principles. LOCATION: This study was conducted in the Health Districts of Jaén, during 2015 and 2016 at the community level. PARTICIPANTS AND/OR CONTEXTS: The recruitment was carried out by managers of the Health Centres of each Health District, who located the participants who met the inclusion criteria and invited them to participate in the study...
July 20, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/28735699/establishing-clinical-cutoffs-for-response-and-remission-on-the-screen-for-child-anxiety-related-emotional-disorders-scared
#15
Nicole E Caporino, Dara Sakolsky, Douglas M Brodman, Joseph F McGuire, John Piacentini, Tara S Peris, Golda S Ginsburg, John T Walkup, Satish Iyengar, Philip C Kendall, Boris Birmaher
OBJECTIVE: To determine optimal percent reduction and raw score cutoffs on the parent- and child-report Screen for Child Anxiety Related Emotional Disorders (SCARED) for predicting treatment response and remission among youth with anxiety disorders. METHOD: Data were obtained from youth (N = 438; 7-17 years old) who completed treatment in the Child/Adolescent Anxiety Multimodal treatment Study, a multisite, randomized clinical trial that examined the relative efficacy of medication (sertraline), cognitive-behavioral therapy (Coping Cat), their combination, and pill placebo for the treatment of separation anxiety disorder, generalized anxiety disorder, and social phobia...
August 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28735418/gap-junction-communication-between-chromaffin-cells-the-hidden-face-of-adrenal-stimulus-secretion-coupling
#16
REVIEW
Nathalie C Guérineau
From birth to death, catecholamine secretion undergoes continuous adjustments, allowing the organism to adapt to homeostasis changes. To cope with these stressful conditions, the neuroendocrine cells of the adrenal medulla play an immediate and crucial role. Chromaffin cell-driven catecholamine release is chiefly controlled by a neurogenic command that arises from the sympathetic nervous system, which releases acetylcholine at the splanchnic nerve terminal-chromaffin cell synapses. In addition to receiving several synaptic inputs individually, chromaffin cells are coupled by gap junctions...
July 22, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28735404/porous-graphitic-carbon-liquid-chromatography-mass-spectrometry-analysis-of-drought-stress-responsive-raffinose-family-oligosaccharides-in-plant-tissues
#17
Tiago F Jorge, Maria H Florêncio, Carla António
Drought is a major limiting factor in agriculture and responsible for dramatic crop yield losses worldwide. The adjustment of the metabolic status via accumulation of drought stress-responsive osmolytes is one of the many strategies that some plants have developed to cope with water deficit conditions. Osmolytes are highly polar compounds, analysis of whcih is difficult with typical reversed-phase chromatography. Porous graphitic carbon (PGC) has shown to be a suitable alternative to reversed-phase stationary phases for the analysis of highly polar compounds typically found in the plant metabolome...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735161/types-of-strain-among-family-members-of-individuals-with-autism-spectrum-disorder-across-the-lifespan
#18
Carolyn M Shivers, Katarina Krizova, Gloria K Lee
BACKGROUND: Although increased caregiver strain is often found among family caregivers of individuals with autism spectrum disorder, it is still unclear as to how different types of strain relate to amount and types of caregiving across the lifespan. AIMS: The present study examined different types of strain (i.e. subjective internalized strain, subjective externalized strain, and objective strain) and how such strain relates to the amount of caregiving responsibilities...
July 20, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28734864/reasons-for-seeking-clinical-care-for-lower-urinary-tract-symptoms-a-mixed-methods-study
#19
James W Griffith, Emily E Messersmith, Brenda W Gillespie, Jonathan B Wiseman, Kathryn E Flynn, Ziya Kirkali, John W Kusek, Tamara Bavendam, David Cella, Karl J Kreder, Jasmine J Nero, Maria E Corona, Catherine S Bradley, Kimberly S Kenton, Brian T Helfand, Robert M Merion, Kevin P Weinfurt
PURPOSE: The primary objective of this study was to evaluate reasons for seeking care among men and women with lower urinary tract symptoms (LUTS). METHODS: Participants were recruited from urology and urogynecology clinics, and the community. The sample was enriched with persons expected to have abnormal or diminished bladder sensations (e.g., participants with lower back surgery, participants aged 65+). In-person interviews were conducted, beginning with an open-ended assessment of urinary symptoms and associated bother, followed by more directed questions, including reasons for seeking or not seeking treatment...
July 19, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28734802/co-transplantation-of-mesenchymal-and-neural-stem-cells-and-overexpressing-stromal-derived-factor-1-for-treating-spinal-cord-injury
#20
Andrew N Stewart, Griffin Kendziorski, Zachary M Deak, Dara J Brown, Matthew N Fini, Katherine L Copely, Julien Rossignol, Gary L Dunbar
Genetic engineering of mesenchymal stem cells (MSCs) and neuronal stem cells (NSCs) has been used to treat spinal cord injuries (SCI). As a mechanism of therapy, MSCs secrete high amounts of anti-inflammatory cytokines and trophic factors, while NSCs can differentiate into neuronal lineages and aid in tissue replacement. Additionally, the forced overexpression of secreted proteins can enhance the secretome of transplanted cells, which can increase therapeutic efficacy. This study utilized a combinational treatment consisting of MSCs, NSCs, and the forced overexpression of the chemokine stromal-derived factor-1 (SDF-1) from MSCs (SDF-1-MSCs), to treat a rat model of SCI...
July 19, 2017: Brain Research
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