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https://www.readbyqxmd.com/read/29935010/centromere-and-its-associated-proteins-what-we-know-about-them-in-plasmodium-falciparum
#1
REVIEW
Garima Verma, Namita Surolia
The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasite. Chromosomal loci called centromeres and their associated proteins play an essential role in accurate chromosome segregation. Although new information on the centromere-kinetochore proteins has been added to the existing pool of knowledge, a paucity of biomarkers for nuclear division prevents a global view of chromosome segregation mechanism in the malaria parasite...
June 22, 2018: IUBMB Life
https://www.readbyqxmd.com/read/29934901/computational-approaches-in-multitarget-drug-discovery
#2
Luciana Scotti, Hamilton Mitsugu Ishiki, Marcelo Cavalcante Duarte, Tiago Branquinho Oliveira, Marcus T Scotti
Current therapeutic strategies entail identifying and characterizing a single protein receptor whose inhibition is likely to result in the successful treatment of a disease of interest, and testing experimentally large libraries of small molecule compounds "in vitro" and "in vivo" to identify promising inhibitors in model systems and determine if the findings are extensible to humans. This highly complex process is largely based on tests, errors, risk, time, and intensive costs. The virtual computational study of compounds simulates situations predicting possible drug linkages with multiple protein target atomic structures, taking into account the dynamic protein inhibitor, and can help identify inhibitors efficiently, particularly for complex drug-resistant diseases...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29934102/pik-ing-new-malaria-chemotherapy
#3
Matthew R Hassett, Paul D Roepe
Phosphatidylinositol (PI) kinases (PIKs) regulate cell proliferation, survival, membrane trafficking, and other processes. PIK classes are distinguished by substrate preference and their distinct phosphorylated PI products. Recently two Plasmodium falciparum PIKs (PfPIKs) have been recognized as attractive new drug targets. Here we briefly summarize PIK biochemistry and recent progress with PfPIKs.
June 19, 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29933738/-determination-of-imported-malaria-cases-in-hatay-by-the-use-of-molecular-methods
#4
Gülnaz Çulha, Fadile Yıldız Zeyrek, Yusuf Önlen, Nebiye Yentür Doni
Malaria, being among the most important diseases throughout history, is still an important public health problem among parasitic diseases due to increasing population movements with various reasons such as migration, war and travel. According to WHO data each year 300-350 million people get exposed to malaria, each year 1.5-2.7 million people die from malaria and also 40% of the world's population is still at risk for this disease. According to World Health Organisation (WHO) data, imported cases were not reported since 2013 in our country...
April 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29929118/facile-synthesis-of-vanillin-based-novel-bischalcones-identifies-one-that-induces-apoptosis-and-displays-synergy-with-artemisinin-in-killing-chloroquine-resistant-plasmodium-falciparum
#5
Upendra K Sharma, Dinesh Mohanakrishnan, Nandini Sharma, Danish Equbal, Dinkar Sahal, Arun K Sinha
The inherent affinity of natural compounds for biological receptors has been comprehensively exploited with great success for the development of many drugs, including antimalarials. Here the natural flavoring compound vanillin has been used as an economical precursor for the synthesis of a series of novel bischalcones whose in vitro antiplasmodial activities have been evaluated against erythrocytic stages of Plasmodium falciparum. Bischalcones 9, 11 and 13 showed promising antiplasmodial activity {Chloroquine (CQ) sensitive Pf3D7 IC50 (μM): 2...
June 15, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29929007/molecular-evaluation-of-pvdhfr-and-pvmdr-1-mutants-in-plasmodium-vivax-isolates-after-treatment-with-sulfadoxine-pyrimethamine-and-chloroquine-in-iran-during-2001-2016
#6
Mahdi Parsaei, Ahmad Reisi, Adel Spotin, Abbas Shahbazi, Mahmoud Mahami-Oskouei, Teimour Hazratian, Alireza Salimi Khorashad, Jalal Zaman, Ahad Bazmani, Sedighe Sarafraz
The rising use of sulfadoxine/pyrimethamine (SP) in the treatment of chloroquine (CQ)-resistant Plasmodium falciparum has resulted in increased exposure to P. vivax isolates in Iran, where both species are being circulated. In this investigation, the frequency of pvdhfr and pvmdr-1 mutants was assessed in P. vivax strains during 2001-2016 after the introduction of SP/CQ in malarious areas of Iran. The P. vivax isolates (n, 52) were obtained from autochthonous samples in Southeast Iran during 2015-2016. The genomic DNA was extracted and examined using nested polymerase chain reaction-(PCR) and sequencing...
June 18, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29928025/malaria-during-pregnancy-and-newborn-outcome-in-an-unstable-transmission-area-in-brazil-a-population-based-record-linkage-study
#7
Jamille Gregório Dombrowski, Rodrigo Medeiros de Souza, Natércia Regina Mendes Silva, André Barateiro, Sabrina Epiphanio, Lígia Antunes Gonçalves, Claudio Romero Farias Marinho
BACKGROUND: Malaria in pregnancy (MiP) is one of the major causes of mortality and morbidity in tropical regions, causing maternal anemia, intrauterine growth retardation, preterm birth, and low birth weight (LBW). The integration of the information systems on pregnancy and malaria could prove to be a useful method of improved decision making for better maternal-child health. METHODS: A population-based observational study acquired information retrospectively from all live births that occurred between 2006 and 2014 in Cruzeiro do Sul (Acre, Brazil)...
2018: PloS One
https://www.readbyqxmd.com/read/29926974/mapping-potential-anopheles-gambiae-s-l-larval-distribution-using-remotely-sensed-climatic-and-environmental-variables-in-baringo-kenya
#8
J A Amadi, G O Ong'amo, D O Olago, S O Oriaso, I K Nyamongo, B B A Estambale
Anopheles gambiae s.l. (Diptera: Culicidae) is responsible for the transmission of the devastating Plasmodium falciparum (Haemosporida: Plasmodiidae) strain of malaria in Africa. This study investigated the relationship between climate and environmental conditions and An. gambiae s.l. larvae abundance and modelled the larval distribution of this species in Baringo County, Kenya. Mosquito larvae were collected using a 350-mL dipper and a pipette once per month from December 2015 to December 2016. A random forest algorithm was used to generate vegetation cover classes...
June 21, 2018: Medical and Veterinary Entomology
https://www.readbyqxmd.com/read/29925378/a-cross-sectional-study-of-asymptomatic-plasmodium-falciparum-infection-burden-and-risk-factors-in-general-population-children-in-12-villages-in-northern-uganda
#9
Marlena Maziarz, Hadijah Nabalende, Isaac Otim, Ismail D Legason, Tobias Kinyera, Martin D Ogwang, Ambrose O Talisuna, Steven J Reynolds, Patrick Kerchan, Kishor Bhatia, Robert J Biggar, James J Goedert, Ruth M Pfeiffer, Sam M Mbulaiteye
BACKGROUND: Plasmodium falciparum malaria is an important cause of morbidity in northern Uganda. This study was undertaken to assess village-, household-, and individual-level risk factors of asymptomatic falciparum malaria in children in 12 villages in northern Uganda. METHODS: Between 10/2011 and 02/2014, 1006 apparently healthy children under 16 years old were enrolled in 12 villages using a stratified, multi-stage, cluster survey design and assessed for P. falciparum malaria infection using the rapid diagnostic test (RDT) and thick film microscopy (TFM), and structured interviewer-administered questionnaires...
June 20, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29924612/mdn-0185-an-antiplasmodial-polycyclic-xanthone-isolated-from-micromonospora-sp-ca-256353
#10
Frederick Annang, Ignacio Pérez-Victoria, Guiomar Pérez-Moreno, Elizabeth Domingo, Ignacio González, José Rubén Tormo, Jesús Martín, Luis M Ruiz-Pérez, Olga Genilloud, Dolores González-Pacanowska, Francisca Vicente, Fernando Reyes
A potent antiplasmodial polycyclic xanthone, MDN-0185 (1), was isolated from an unidentified species of the genus Micromonospora. The planar structure of 1 was established as a seven-ring polycyclic xanthone with partial structures very similar to two known natural products, namely, xantholipin and Sch 54445. Using ROESY correlations, the relative stereochemistry of the two independent stereoclusters of compound 1 could be determined. Mosher analysis and comparison of the specific rotation of compound 1 with that of xantholipin allowed the determination of its absolute configuration...
June 20, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29924131/synthesis-and-molecular-modelling-studies-of-pyrimidinones-and-pyrrolo-3-4-d-pyrimidinodiones-as-new-antiplasmodial-compounds
#11
Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search for new, effective and safe antimalarial drugs is crucial. Heterocyclic compounds, such as dihydropyrimidinones (DHPM), synthesised via the Biginelli multicomponent reaction, as well as bicyclic compounds synthesised from DHPMs, have emerged as potential antimalarial candidates in the last few years...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29922917/genetic-analysis-of-cerebral-malaria-in-the-mouse-model-infected-with-plasmodium-berghei
#12
REVIEW
Sabrina Torre, David Langlais, Philippe Gros
Malaria is a common and sometimes fatal disease caused by infection with Plasmodium parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium falciparum parasites which features a complex immunopathology that includes a prominent neuroinflammation. The experimental mouse model of cerebral malaria (ECM) induced by infection with Plasmodium berghei ANKA has been used abundantly to study the role of single genes, proteins and pathways in the pathogenesis of CM, including a possible contribution to neuroinflammation...
June 19, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29922617/role-of-rs4986790-polymorphism-of-tlr4-gene-in-susceptibility-towards-malaria-infection-in-the-pakistani-population
#13
Asima Rani, Syed Kashif Nawaz, Muhammad Arshad, Shazia Irfan
Background: Toll-like receptors (TLRs) of the human immune mechanism play important role in the detection of invading pathogens. TLRs specifically recognize the pathogen-associated molecular patterns (PAMPs) from pathogens and start the effective response. Single nucleotide polymorphisms (SNPs) in the TLRs can mediate their functions. Present study evaluated the importance of rs4986790 polymorphism of TLR4 gene in susceptibility towards malaria, clinical outcomes of the disease and responsible species of malaria...
May 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29921926/independent-regulation-of-plasmodium-falciparum-rif-gene-promoters
#14
Rosana Beatriz Duque Araujo, Tatiane Macedo Silva, Charlotte Sophie Kaiser, Gabriela Fernandes Leite, Diego Alonso, Paulo Eduardo Martins Ribolla, Gerhard Wunderlich
All Plasmodium species express variant antigens which may mediate immune escape in the vertebrate host. In Plasmodium falciparum, the rif gene family encodes variant antigens which are partly exposed on the infected red blood cell surface and may function as virulence factors. Not all rif genes are expressed at the same time and it is unclear what controls rif gene expression. In this work, we addressed global rif transcription using plasmid vectors with two drug resistance markers, one controlled by a rif 5' upstream region and the second by a constitutively active promoter...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921492/development-of-multi-epitope-driven-subunit-vaccine-in-secretory-and-membrane-protein-of-plasmodium-falciparum-to-convey-protection-against-malaria-infection
#15
Rajan Kumar Pandey, Mudassar Ali, Rupal Ojha, Tarun Kumar Bhatt, Vijay Kumar Prajapati
Malaria infection is the severe health concern for a long time. As per the WHO reports, the malarial infection causes huge mortality all around the world and is incomparable with any other infectious diseases. The absence of effective treatment options and increasing drug resistance to the available therapeutics like artemisinin and other derivatives demand an efficient alternative to overcome this death burden. Here, we performed the literature survey and sorted the Plasmodium falciparum secretory and membrane proteins to design multi-epitope subunit vaccine using an adjuvant, B-cell- and T-cell epitopes...
June 16, 2018: Vaccine
https://www.readbyqxmd.com/read/29920562/whole-blood-transcriptome-changes-following-controlled-human-malaria-infection-in-malaria-pre-exposed-volunteers-correlate-with-parasite-prepatent-period
#16
Julian Rothen, Carl Murie, Jason Carnes, Atashi Anupama, Salim Abdulla, Mwajuma Chemba, Maxmillian Mpina, Marcel Tanner, B Kim Lee Sim, Stephen L Hoffman, Raphael Gottardo, Claudia Daubenberger, Ken Stuart
Malaria continues to be one of mankind's most devastating diseases despite the many and varied efforts to combat it. Indispensable for malaria elimination and eventual eradication is the development of effective vaccines. Controlled human malaria infection (CHMI) is an invaluable tool for vaccine efficacy assessment and investigation of early immunological and molecular responses against Plasmodium falciparum infection. Here, we investigated gene expression changes following CHMI using RNA-Seq. Peripheral blood samples were collected in Bagamoyo, Tanzania, from ten adults who were injected intradermally (ID) with 2...
2018: PloS One
https://www.readbyqxmd.com/read/29920176/epidemiology-of-malaria-in-yulin-south-china-1999-2016-imported-malaria-threatens-zero-local-case-status
#17
Yan Yang, Yiwei Liu, Zhichun Xie, Shuzhi Wu, Lu Yang, Wen Li, Xinbin Quan
OBJECTIVES: This article describes the epidemiology of malaria in Yulin, 1999-2016. We review also malaria control strategy in Yulin in the posteradication phase. MATERIALS AND METHODS: We examined all malaria case records from Yulin prefecture reported to the Ministry of Health since 1999 and extracted malaria data between 1999 and 2003, the stage of malaria eradication, from the notifiable disease reporting records and case records of Guangxi. Malaria data between 2004 and 2016, the stage of malaria elimination, was obtained from the National Notifiable Disease Reporting System and National Malaria Reporting System...
June 19, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29917147/the-feasibility-and-acceptability-of-mass-drug-administration-for-malaria-in-cambodia-a-mixed-methods-study
#18
Thomas J Peto, Rupam Tripura, Nou Sanann, Bipin Adhikari, James Callery, Mark Droogleever, Chhouen Heng, Phaik Yeong Cheah, Chan Davoeung, Chea Nguon, Lorenz von Seidlein, Arjen M Dondorp, Christopher Pell
Background: Mass drug administrations (MDAs) are part of the World Health Organization's Plasmodium falciparum elimination strategy for the Greater Mekong Subregion (GMS). In Cambodia, a 2015-2017 clinical trial evaluated the effectiveness of MDA. This article explores factors that influence the feasibility and acceptability of MDA, including seasonal timing, financial incentives and the delivery model. Methods: Quantitative data were collected through structured questionnaires from the heads of 163 households...
June 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29916442/insights-into-the-early-liver-stage-biology-of-plasmodium
#19
REVIEW
Lokesh D Kori, Neena Valecha, Anupkumar R Anvikar
Even though malaria is preventable and curable, it has become a serious threat to mankind. In 2016, there were an estimated 216 million cases of malaria across the world. The biology of its causative agent, i.e. Plasmodium parasite is full of complex mechanisms. There are five Plasmodium species responsible for malaria in humans, viz. Plasmodium falciparum, P. vivax, P. malariae, P. ovale and recently identified P. knowlesi that normally infect apes. In humans, malaria is spread by the injection of Plasmodium sporozoites through the bite of infectious Anopheles' female mosquito during their blood meal...
January 2018: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/29916441/epidemiology-drug-resistance-and-pathophysiology-of-plasmodium-vivax-malaria
#20
REVIEW
Kiran K Dayananda, Rajeshwara N Achur, D Channe Gowda
Malaria, caused by the protozoan parasites of the genus Plasmodium, is a major health problem in many countries of the world. Five parasite species namely, Plasmodium falciparum, P. vivax, P. malariae, P. ovale, and P. knowlesi, cause malaria in humans. Of these, P. falciparum and P. vivax are the most prevalent and account for the majority of the global malaria cases. In most areas of Africa, P. vivax infection is essentially absent because of the inherited lack of Duffy antigen receptor for chemokines on the surface of red blood cells that is involved in the parasite invasion of erythrocytes...
January 2018: Journal of Vector Borne Diseases
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