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https://www.readbyqxmd.com/read/29238723/relationship-between-malaria-and-abo-blood-types-in-east-china
#1
Xuan Zhang, Meifang Yang, Hong Zhao, Jianhua Hu, Lanjuan Li
Objectives: This study aims at investigating the relationship between malaria and blood group types in east China. Methods: Between 1 January 2011 and 31 March 2017, 99 malaria patients were enrolled for the study. Laboratory tests were conducted on their infection status and blood types. Clinical data of the participants were retrieved for analysis. Results: There was no mortality during the period of study. Overall, 90 (90.91%) of the patients were positive for Plasmodium falciparum, 8 (8...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29237461/systematic-literature-review-and-meta-analysis-of-the-efficacy-of-artemisinin-based-and-quinine-based-treatments-for-uncomplicated-falciparum-malaria-in-pregnancy-methodological-challenges
#2
Makoto Saito, Mary Ellen Gilder, François Nosten, Rose McGready, Philippe J Guérin
BACKGROUND: There is no agreed standard method to assess the efficacy of anti-malarials for uncomplicated falciparum in pregnancy despite an increased risk of adverse outcomes for the mother and the fetus. The aim of this review is to present the currently available evidence from both observational and interventional cohort studies on anti-malarial efficacy in pregnancy and summarize the variability of assessment and reporting found in the review process. METHODS: Efficacy methodology and assessment of artemisinin-based treatments (ABT) and quinine-based treatments (QBT) were reviewed systematically using seven databases and two clinical trial registries (protocol registration-PROSPERO: CRD42017054808)...
December 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/29237012/clinical-implications-of-plasmodium-resistance-to-atovaquone-proguanil-a-systematic-review-and-meta-analysis
#3
Henry M Staines, Rebekah Burrow, Beatrix Huei-Yi Teo, Irina Chis Ster, Peter G Kremsner, Sanjeev Krishna
Background: Atovaquone/proguanil, registered as Malarone®, is a fixed-dose combination recommended for first-line treatment of uncomplicated Plasmodium falciparum malaria in non-endemic countries and its prevention in travellers. Mutations in the cytochrome bc1 complex are causally associated with atovaquone resistance. Methods: This systematic review assesses the clinical efficacy of atovaquone/proguanil treatment of uncomplicated malaria and examines the extent to which codon 268 mutation in cytochrome b influences treatment failure and recrudescence based on published information...
December 11, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29236492/pimentelamines-a-c-indole-alkaloids-isolated-from-the-leaves-of-the-australian-tree-flindersia-pimenteliana
#4
Luke P Robertson, Sandra Duffy, Yun Wang, Dongdong Wang, Vicky M Avery, Anthony R Carroll
Three members of a new class of ascorbic acid-adduct indole alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC50 values ranging from 0.19 to 3.6 μM.
December 13, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29236299/apicomplexa-specific-%C3%AE-hairpin-of-plasmodium-and-toxoplasma-profilins-a-molecular-dynamics-simulation-study
#5
Priyadarsini Kadirvel, Sharmila Anishetty
Profilin is one of the actin-binding proteins that regulate dynamics of actin polymerization. It plays a key role in cell motility and invasion. It also interacts with several other proteins notably through its poly-L-proline (PLP) binding site. Profilin in apicomplexa is characterized by a unique mini-domain consisting of a large β-hairpin extension and an acidic loop which is relatively longer in Plasmodium species. Profilin is essential for the invasive blood stages of Plasmodium falciparum. In the current study, unbound profilins from Plasmodium falciparum (Pf), Toxoplasma gondii (Tg) and Homo sapiens (Hs) were subjected to molecular dynamics (MD) simulations for a timeframe of 100 ns each to understand the conformational dynamics of these proteins...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29233590/structure-activity-analysis-of-cj-15-801-analogues-that-interact-with-plasmodium-falciparum-pantothenate-kinase-and-inhibit-parasite-proliferation
#6
Christina Spry, Alan L Sewell, Yuliya Hering, Mathew V J Villa, Jonas Weber, Stephen J Hobson, Suzannah J Harnor, Sheraz Gul, Rodolfo Marquez, Kevin J Saliba
Survival of the human malaria parasite Plasmodium falciparum is dependent on pantothenate (vitamin B5), a precursor of the fundamental enzyme cofactor coenzyme A. CJ-15,801, an enamide analogue of pantothenate isolated from the fungus Seimatosporium sp. CL28611, was previously shown to inhibit P. falciparum proliferation in vitro by targeting pantothenate utilization. To inform the design of next generation analogues, we set out to synthesize and test a series of synthetic enamide-bearing pantothenate analogues...
August 25, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29229871/antifolate-drug-resistance-novel-mutations-and-haplotype-distribution-in-dhps-and-dhfr-from-northeast-india
#7
N P Sarmah, K Sarma, D R Bhattacharyya, A A Sultan, D Bansal, N Singh, P K Bharti, R Sehgal, P K Mohapatra, P Parida, J Mahanta
Malaria is a major public health concern in Northeast India with a preponderance of drug-resistant strains. Until recently the partner drug for artemisinin combination therapy (ACT) was sulphadoxine pyrimethamine (SP). Antifolate drug resistance has been associated with the mutations at dihydropteroate synthase (dhps) and dihydrofolatereductase (dhfr) genes. This study investigated antifolate drug resistance at the molecular level. A total of 249 fever cases from Arunachal Pradesh, NE India, were screened for malaria, and of these, 75 were found to be positive for Plasmodium falciparum...
December 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29229635/plasmodium-falciparum-recrudescence-two-years-after-a-first-treated-uncomplicated-infection-without-return-in-a-malaria-endemic-area
#8
Denis Malvy, Marylin Torrentino-Madamet, Coralie L'Ollivier, Marie-Catherine Receveur, Fakhri Jeddi, Laurence Delhaes, Renaud Piarroux, Pascal Millet, Bruno Pradines
We report here evidence, confirmed by the lack of travel activity outside of France and genetic diversity analysis using polymorphic microsatellite markers, that Plasmodium falciparum malaria infection effectively treated with an artemisinin-based combination can remain dormant and relapse during pregnancy at least 2 years after treatment.
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229188/plasmodium-p47-a-key-gene-for-malaria-transmission-by-mosquito-vectors
#9
REVIEW
Alvaro Molina-Cruz, Gaspar E Canepa, Carolina Barillas-Mury
Malaria is caused by infection with Plasmodium parasites that have a complex life cycle. The parasite protein P47 is critical for disease transmission. P47 mediates mosquito immune evasion in both Plasmodium berghei (Pbs47) and Plasmodium falciparum (Pfs47), and has been shown to be important for optimal female gamete fertility in P. berghei. Pfs47 presents strong geographic structure in natural P. falciparum populations, consistent with natural selection of Pfs47 haplotypes by the mosquito immune system as the parasite adapted to new vector species worldwide...
December 8, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29228132/vivax-malaria-chemoprophylaxis-the-role-of-atovaquone-proguanil-compared-to-other-options
#10
Meltzer Eyal, Galia Rahav, Schwartz Eli
Background: Atovaquone-Proguanil is considered causal prophylaxis (inhibition of liver-stage schizonts) for Plasmodium falciparum, however, its causal prophylactic efficacy for P. vivax is not known. Travelers returning to non-endemic areas, provide a unique opportunity to study P. vivax prophylaxis. Methods: A retrospective observational study. For 11 years Israeli rafters who had traveled to the Omo River in Ethiopia, a highly malaria endemic area, were followed for at least one year after their return...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29227011/synthesis-of-novel-benzimidazole-acrylonitriles-for-inhibition-of-plasmodium-falciparum-growth-by-dual-target-inhibition
#11
Kalicharan Sharma, Apeksha Shrivastava, Ram N Mehra, Girdhar S Deora, Mohammad M Alam, Mohammad S Zaman, Mymoona Akhter
Antimalarial drug resistance has emerged as a threat for treating malaria, generating a need to design and develop newer, more efficient antimalarial agents. This research aimed to identify novel leads as antimalarials. Dual receptor mechanism could be a good strategy to combat developing drug resistance. A series of benzimidazole acrylonitriles containing 18 compounds were designed, synthesized and evaluated for cytotoxicity, heme binding, ferriprotoporphyrin IX biomineralisation inhibition, and falcipain-2 enzyme assay...
December 11, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/29225629/synthesis-sar-and-docking-studies-disclose-2-arylfuran-1-4-naphthoquinones-as-in-vitro-antiplasmodial-hits
#12
Tatiane Freitas Borgati, Maria Fernanda Alves do Nascimento, Juma Fortunato Bernardino, Lunamaura Claudia Oliveira Martins, Alex Gutterres Taranto, Alaíde Braga de Oliveira
A total of 28 lapachol-related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine-resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method. Cytotoxicity against Hep G2A16 cell was determined by the MTT assay. All compounds disclosed higher in vitro antiplasmodial activity than lapachol. Ortho- and para-naphthoquinones with a furan ring fused to the quinonoid moiety were more potent than 2-hydroxy-3-(1'-alkenyl)-1,4-naphthoquinones, while ortho-furanonaphthoquinones were more cytotoxic...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29224404/edip-the-epitope-dilution-phenomenon-lessons-learnt-from-a-malaria-vaccine-antigen-and-its-applicability-to-polymorphic-antigens
#13
Kwadwo Asamoah Kusi, Bart W Faber, Gerrit Koopman, Edmond Joseph Remarque
Polymorphism in vaccine antigens poses major challenges to vaccinologists. The Plasmodium falciparum Apical Membrane Antigen 1 (AMA1) poses such a challenge. We found that immunization with a mixture of three variants yielded functional antibody levels to all variants comparable to levels induced by monovalent immunization. The mechanism behind the observed broadening was shown to be an increase in the fraction of cross-reactive antibodies, most likely because strain-specific epitopes are present at lower frequency relative to conserved epitopes...
December 11, 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/29223887/a-minimalistic-approach-to-develop-new-anti-apicomplexa-polyamines-analogs
#14
Esteban A Panozzo-Zénere, Exequiel O J Porta, Gustavo Arrizabalaga, Lucía Fargnoli, Shabana I Khan, Babu L Tekwani, Guillermo R Labadie
The development of new chemical entities against the major diseases caused by parasites is highly desired. A library of thirty diamines analogs following a minimalist approach and supported by chemoinformatics tools have been prepared and evaluated against apicomplexan parasites. Different member of the series of N,N'-disubstituted aliphatic diamines shown in vitro activities at submicromolar concentrations and high levels of selectivity against Toxoplasma gondii and in chloroquine-sensitive and resistant-strains of Plasmodium falciparum...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220497/post-treatment-hrp2-clearance-in-patients-with-uncomplicated-plasmodium-falciparum-malaria
#15
Mateusz M Plucinski, Pedro Rafael Dimbu, Filomeno Fortes, Salim Abdulla, Saumu Ahmed, Julie Gutman, S Patrick Kachur, Aida Badiane, Daouda Ndiaye, Eldin Talundzic, Naomi Lucchi, Michael Aidoo, Venkatachalam Udhayakumar, Eric Halsey, Eric Rogier
Background: Response to antimalarial treatment is assessed using serial microscopy. New techniques for accurate measurement of the Plasmodium falciparum histidine rich protein 2 (HRP2) antigen have made monitoring antigen concentration over time a potential alternative for assessing treatment response. Methods: Post-treatment HRP2 concentration was measured in longitudinal samples from 537 participants with P. falciparum malaria from efficacy trials in Angola, Tanzania, and Senegal...
December 6, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29220419/high-resolution-single-cell-sequencing-of-malaria-parasites
#16
Simon G Trevino, Standwell C Nkhoma, Shalini Nair, Benjamin J Daniel, Karla Moncada, Stanley Khoswe, Rachel L Banda, François Nosten, Ian H Cheeseman
Single-cell genomics is a powerful tool for determining the genetic architecture of complex communities of unicellular organisms. In areas of high transmission, malaria patients are often challenged by the activities of multiple Plasmodium falciparum lineages, which can potentiate pathology, spread drug resistance loci and also complicate most genetic analysis. Single-cell sequencing of P. falciparum would be key to understanding infection complexity, though efforts are hampered by the extreme nucleotide composition of its genome (∼80% AT-rich)...
December 6, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29219249/activities-of-11-azaartemisinin-and-n-sulfonyl-derivatives-against-asexual-and-transmissible-malaria-parasites
#17
Rozanne Harmse, Dina Coertzen, Ho Ning Wong, Frans J Smit, Mariette E van der Watt, Janette Reader, Sindiswe H Nondaba, Lyn-Marie Birkholtz, Richard K Haynes, David D N'Da
Dihydroartemisinin (DHA), either used in its own right or as the active drug generated in vivo from the other artemisinins in current clinical use-artemether and artesunate-induces quiescence in ring-stage parasites of Plasmodium falciparum (Pf). This induction of quiescence is linked to artemisinin resistance. Thus, we have turned to structurally disparate artemisinins that are incapable of providing DHA on metabolism. Accordingly, 11-azaartemisinin 5 and selected N-sulfonyl derivatives were screened against intraerythrocytic asexual stages of drug-sensitive Pf NF54 and drug-resistant K1 and W2 parasites...
December 8, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29217951/five-years-malaria-trend-analysis-in-woreta-health-center-northwest-ethiopia
#18
Awoke Derbie, Megbaru Alemu
Background: An estimated 68% of the Ethiopian population, living in 75% of the landmass, is at risk of contracting malaria at any time making it the leading public health problem. The temporal analysis of malaria data could be important to evaluate the performance of malaria prevention programmes. Thus, the aim of this study was to determine the trend of malaria at Woreta Health Center (WHC) over a period of five years. Methods: We analyzed the records of 8,057 presumptive malaria patients registered in 2012 to 2016...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29217416/identification-of-target-proteins-of-clinical-immunity-to-plasmodium-falciparum-in-a-region-of-low-malaria-transmission
#19
Hirokazu Sakamoto, Satoru Takeo, Eizo Takashima, Kazutoyo Miura, Bernard N Kanoi, Takamasa Kaneko, Eun-Taek Han, Mayumi Tachibana, Kazuhiro Matsuoka, Jetsumon Sattabongkot, Rachanee Udomsangpetch, Tomoko Ishino, Takafumi Tsuboi
The target molecules of antibodies against falciparum malaria remain largely unknown. Recently we have identified multiple proteins as targets of immunity against Plasmodium falciparum using African serum samples. To investigate whether potential targets of clinical immunity differ with transmission intensity, we assessed immune responses in residents of low malaria transmission region in Thailand. Malaria asymptomatic volunteers (Asy: n=19) and symptomatic patients (Sym: n=21) were enrolled into the study...
December 4, 2017: Parasitology International
https://www.readbyqxmd.com/read/29217380/evaluation-of-rapid-pfhrp-2-pldh-based-tests-in-diagnosing-microscopy-confirmed-falciparum-malaria-in-hodeidah-governorate-yemen
#20
Ahmed A Azazy, Ali Jamaly Alhawery, Rashad Abdul-Ghani, R A Alharbi, Shaia S R Almalki
Along with the determination of malaria infection rate among suspected patients attending hospitals in Hodeidah governorate, the present study evaluated the accuracy of Plasmodium falciparum histidine-rich protein-2 (PfHRP-2)/parasite-specific lactate dehydrogenase (pLDH)-based rapid diagnostic test (RDT) for the diagnosis of microscopy-confirmed falciparum malaria. An overall malaria infection rate of 19.3% (57/295) among suspected patients attending hospitals was microscopically confirmed. The sensitivity of thin blood films for the detection of malaria parasites was 79...
December 5, 2017: Acta Tropica
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