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https://www.readbyqxmd.com/read/28327148/drug-resistance-mediating-plasmodium-falciparum-polymorphisms-and-clinical-presentations-of-parasitaemic-children-in-uganda
#1
Stephen Tukwasibwe, Patrick Tumwebaze, Melissa Conrad, Emmanuel Arinaitwe, Moses R Kamya, Grant Dorsey, Samuel L Nsobya, Bryan Greenhouse, Philip J Rosenthal
BACKGROUND: Plasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth the odds of symptomatic malaria compared to those with infections with wild type (WT) sequences. However, results may have been confounded by greater likelihood in those with symptomatic disease of higher density mixed infections and/or recent prior treatment that selected for WT alleles...
March 21, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28322706/malaria-in-children-adopted-from-the-democratic-republic-of-the-congo
#2
Elena Chiappini, Sara Sollai, Maurizio de Martino, Luisa Galli
Data are lacking regarding asymptomatic and symptomatic malaria prevalence in internationally adopted children. Among 20 children from Democratic Republic of the Congo evaluated in Florence, Italy, in April 2016, malaria prevalence was 80%; 50% of infected children had symptomatic malaria. Adopted children from areas of high malaria endemicity should be screened for malaria.
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28322694/plasmodium-malariae-prevalence-and-csp-gene-diversity-kenya-2014-and-2015
#3
Eugenia Lo, Kristie Nguyen, Jennifer Nguyen, Elizabeth Hemming-Schroeder, Jiaobao Xu, Harrisone Etemesi, Andrew Githeko, Guiyun Yan
In Africa, control programs that target primarily Plasmodium falciparum are inadequate for eliminating malaria. To learn more about prevalence and genetic variability of P. malariae in Africa, we examined blood samples from 663 asymptomatic and 245 symptomatic persons from western Kenya during June-August of 2014 and 2015. P. malariae accounted for 5.3% (35/663) of asymptomatic infections and 3.3% (8/245) of clinical cases. Among asymptomatic persons, 71% (32/45) of P. malariae infections detected by PCR were undetected by microscopy...
April 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28320389/age-and-geographic-patterns-of-plasmodium-falciparum-malaria-infection-in-a-representative-sample-of-children-living-in-burkitt-lymphoma-endemic-areas-of-northern-uganda
#4
Marlena Maziarz, Tobias Kinyera, Isaac Otim, Paul Kagwa, Hadijah Nabalende, Ismail D Legason, Martin D Ogwang, Samuel Kirimunda, Benjamin Emmanuel, Steven J Reynolds, Patrick Kerchan, Moses M Joloba, Andrew W Bergen, Kishor Bhatia, Ambrose O Talisuna, Robert J Biggar, James J Goedert, Ruth M Pfeiffer, Sam M Mbulaiteye
BACKGROUND: Falciparum malaria is an important risk factor for African Burkitt lymphoma (BL), but few studies have evaluated malaria patterns in healthy BL-age children in populations where both diseases are endemic. To obtain accurate current data, patterns of asymptomatic malaria were investigated in northern Uganda, where BL is endemic. METHODS: Between 2011 and 2015, 1150 apparently healthy children under 15 years old were sampled from 100 villages in northern Uganda using a stratified, multi-stage, cluster survey design...
March 20, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28303984/silent-killers-transfusion-transmissible-infections-tti-among-asymptomatic-population-of-pakistan
#5
Muhammad Saeed, Shahida Hussain, Farhan Rasheed, Maqsood Ahmad, Mizna Arif, Muhammad Tariq Hamid Rahmani
OBJECTIVE: To analyse transfusion transmissible infections in asymptomatic population. METHODS: This study was conducted at the Allama Iqbal Medical College and Jinnah Hospital, Lahore, Pakistan, from December 2014 to November 2015, and comprised healthy asymptomatic blood donors.Every sample was screened for the presence of antibodies/antigens of hepatitis C virus, human immunodeficiency virus, treponemapallidum, hepatitis B virus and malaria parasite through rapid immunochromatographic technique...
March 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28284964/optimal-control-of-a-malaria-model-with-asymptomatic-class-and-superinfection
#6
Liming Cai, Xuezhi Li, Necibe Tuncer, Maia Martcheva, Abid Ali Lashari
In this paper, we introduce a malaria model with an asymptomatic class in human population and exposed classes in both human and vector populations. The model assumes that asymptomatic individuals can get re-infected and move to the symptomatic class. In the case of an incomplete treatment, symptomatic individuals move to the asymptomatic class. If successfully treated, the symptomatic individuals recover and move to the susceptible class. The basic reproduction number, R0, is computed using the next generation approach...
March 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28268096/impact-of-long-lasting-insecticidal-nets-on-prevalence-of-subclinical-malaria-among-children-in-the-presence-of-pyrethroid-resistance-in-anopheles-culicifacies-in-central-india
#7
Mehul Kumar Chourasia, Raghavendra Kamaraju, Immo Kleinschmidt, Rajendra M Bhatt, Dipak Kumar Swain, Tessa Bellamy Knox, Neena Valecha
BACKGROUND: Subclinical (asymptomatic) cases of malaria could be a major barrier to the success of malaria elimination programs. This study has evaluated the impact of long-lasting insecticidal nets (LLINs) on the prevalence of subclinical malaria in the presence of pyrethroid resistance in the main malaria vector Anopheles culicifacies on malaria transmission among a cohort of children in villages of the Keshkal sub-district in Chhattisgarh state. METHODS: A cohort of 6582 children ages less than 14 years was enrolled from 80 study clusters...
March 6, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28263883/asymptomatic-plasmodium-malariae-infections-in-children-from-suburban-areas-of-yaound%C3%A3-cameroon
#8
Dongang Nana Rodrigue Roman, Ngono Ngane Annie Rosalie, Amit Kumar, Koanga Mogtomo Martin Luther, Vineeta Singh, Mouelle Sone Albert
The gold standard for malaria diagnosis is the microscopic examination of Giemsa stained thick blood smears though microscopy mostly may not detect the presence of Plasmodium species infections in asymptomatic samples. In the reported study, we used two diagnostic methods viz. the conventional microscopic examination and polymerase chain reaction (PCR) assay to analyse the asymptomatic malaria samples. PCR assay amplifying 18S small-subunit ribosomal RNA (SSU rRNA) gene of Plasmodium in 122 samples confirmed 68% of isolates as asymptomatic P...
March 2, 2017: Parasitology International
https://www.readbyqxmd.com/read/28253867/the-shape-of-the-iceberg-quantification-of-submicroscopic-plasmodium-falciparum-and-plasmodium-vivax-parasitaemia-and-gametocytaemia-in-five-low-endemic-settings-in-ethiopia
#9
Fitsum G Tadesse, Lotus van den Hoogen, Kjerstin Lanke, Jodie Schildkraut, Kevin Tetteh, Abraham Aseffa, Hassen Mamo, Robert Sauerwein, Ingrid Felger, Chris Drakeley, Endalamaw Gadissa, Teun Bousema
BACKGROUND: The widespread presence of low-density asymptomatic infections with concurrent gametocytes may be a stumbling block for malaria elimination. This study investigated the asymptomatic reservoir of Plasmodium falciparum and Plasmodium vivax infections in schoolchildren from five settings in northwest Ethiopia. METHODS: Two cross-sectional surveys were conducted in June and November 2015, enrolling 551 students from five schools and 294 students from three schools, respectively...
March 3, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28245264/longitudinal-analysis-of-antibody-responses-in-symptomatic-malaria-cases-do-not-mirror-parasite-transmission-in-peri-urban-area-of-cote-d-ivoire-between-2010-and-2013
#10
David Koffi, Marie-Louise Varela, Cheikh Loucoubar, Sylvain Beourou, Inès Vigan-Womas, Aissatou Touré, Joseph Allico Djaman, André Offianan Touré, Ronald Perraut
BACKGROUND: In the agenda towards malaria eradication, assessment of both malaria exposure and efficacy of anti-vectorial and therapeutic strategies is a key component of management and the follow-up of field interventions. The simultaneous use of several antigens (Ags) as serological markers has the potential for accurate evaluation of malaria exposure. Here we aimed to measure the longitudinal evolution of the background levels of immunity in an urban setting in confirmed clinical cases of malaria...
2017: PloS One
https://www.readbyqxmd.com/read/28237491/homozygosity-for-the-cd1e-02-allele-is-associated-with-a-resistance-to-plasmodium-falciparum-malaria-infection-in-gabonese-school-children
#11
Landry-Erik Mombo, Francine Ntoumi, Cyrille Bisseye, Rajendranath Ramasawmy, Pascal Millet, Ryad Tamouza
OBJECTIVE: To explore the possible association between polymorphisms in CD1 genes and both asymptomatic and mild Plasmodium falciparum infection. METHODS: Two clusters of 85 school children, from the village of Dienga (Gabon) were investigated. The first group was analysed for the prevalence and the multiplicity of asymptomatic P. falciparum infection, whereas the second group was screened for the frequency of malarial attacks. RESULTS: Our findings showed that homozygosity for the CD1E*02 allele was associated with a low frequency of malarial attacks...
February 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28221121/molecular-evidence-of-drug-resistance-in-asymptomatic-malaria-infections-myanmar-2015
#12
Myat Htut Nyunt, Thinzar Shein, Ni Ni Zaw, Soe Soe Han, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Kyaw Zin Thant, Eun-Taek Han, Myat Phone Kyaw
Artemisinin resistance containment in Myanmar was initiated in 2011 after artemisinin-resistant Plasmodium falciparum malaria was reported. Molecular evidence suggests that asymptomatic malaria infections harboring drug resistance genes are present among residents of the Myanmar artemisinin resistance containment zone. This evidence supports efforts to eliminate these hidden infections.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28219989/submicroscopic-falciparum-malaria-in-febrile-individuals-in-urban-and-rural-areas-of-gabon
#13
Denise P Mawili-Mboumba, Rosalie Nikiéma Ndong Ella, Noemi Bahamontes Rosa, Jose Luis Llergo Largo, Aude Lembet-Mikolo, Prycil Nzamba, Christelle Offouga Mbouoronde, Maryvonne Kombila, Marielle K Bouyou Akotet
Characterization of the parasite reservoir is required to improve malaria control. Asymptomatic patients with subpatent parasitemia have been identified in Gabon, but the prevalence of such infections among febrile subjects is unclear. We assessed the prevalence of submicroscopic Plasmodium falciparum infections on an island (Port-Gentil), and in urban (Libreville), semiurban (Melen), and rural (Oyem) settings in Gabon. Blood samples (N = 310) from febrile patients were tested for malaria parasites by quantitative nucleic acid sequence-based amplification (QT-NASBA)...
February 20, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28196536/community-engagement-and-the-social-context-of-targeted-malaria-treatment-a-qualitative-study-in-kayin-karen-state-myanmar
#14
Kate Sahan, Christopher Pell, Frank Smithuis, Aung Kyaw Phyo, Sai Maung Maung, Chanida Indrasuta, Arjen M Dondorp, Nicholas J White, Nicholas P J Day, Lorenz von Seidlein, Phaik Yeong Cheah
BACKGROUND: The spread of artemisinin-resistance in Plasmodium falciparum is a threat to current global malaria control initiatives. Targeted malaria treatment (TMT), which combines mass anti-malarial administration with conventional malaria prevention and control measures, has been proposed as a strategy to tackle this problem. The effectiveness of TMT depends on high levels of population coverage and is influenced by accompanying community engagement activities and the local social context...
February 14, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28177074/the-consequences-of-treating-asymptomatic-malaria-parasitemia
#15
Nicholas J White
No abstract text is available yet for this article.
February 8, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28151955/predicting-ebola-severity-a-clinical-prioritization-score-for-ebola-virus-disease
#16
Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi
BACKGROUND: Despite the notoriety of Ebola virus disease (EVD) as one of the world's most deadly infections, EVD has a wide range of outcomes, where asymptomatic infection may be almost as common as fatality. With increasingly sensitive EVD diagnosis, there is a need for more accurate prognostic tools that objectively stratify clinical severity to better allocate limited resources and identify those most in need of intensive treatment. METHODS/PRINCIPAL FINDINGS: This retrospective cohort study analyses the clinical characteristics of 158 EVD(+) patients at the GOAL-Mathaska Ebola Treatment Centre, Sierra Leone...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28129759/demography-maternal-health-and-the-epidemiology-of-malaria-and-other-major-infectious-diseases-in-the-rural-department-tsamba-magotsi-ngounie-province-in-central-african-gabon
#17
R Zoleko Manego, G Mombo-Ngoma, M Witte, J Held, M Gmeiner, T Gebru, B Tazemda, J Mischlinger, M Groger, B Lell, A A Adegnika, S T Agnandji, P G Kremsner, B Mordmüller, M Ramharter, P B Matsiegui
BACKGROUND: Sub-Saharan Africa is undergoing an epidemiological transition from a predominance of infectious diseases to non-communicable and lifestyle related conditions. However, the pace of this transition and the pattern of disease epidemiology are uneven between affluent urban and rural poor populations. To address this question for a remote rural region located in the central African rainforest region of Gabon, this study was conducted to assess reasons for health care attendance and to characterize the epidemiology of malaria and other major infectious diseases for the department of Tsamba Magotsi...
January 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28122572/artemether-lumefantrine-and-liver-enzyme-abnormalities-in-non-severe-plasmodium-falciparum-malaria-in-returned-travellers-a-retrospective-comparative-study-with-quinine-doxycycline-in-a-portuguese-centre
#18
André Silva-Pinto, Rogério Ruas, Francisco Almeida, Raquel Duro, André Silva, Cândida Abreu, António Sarmento
BACKGROUND: Artemisinin-based therapy is the current standard treatment for non-severe malaria due to Plasmodium falciparum. The potential for asymptomatic liver toxicity of this therapy and its implication in clinical practice is currently unknown. The aim of this study is to assess the hepatic function in patients treated with a standard three-day artemisinin-based regimen and to compare it with the quinine-doxycycline regimen. METHODS: Retrospective and comparative study of returned adult travellers admitted with non-severe P...
January 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28118367/characterizing-antibody-responses-to-plasmodium-vivax-and-plasmodium-falciparum-antigens-in-india-using-genome-scale-protein-microarrays
#19
Swapna Uplekar, Pavitra Nagesh Rao, Lalitha Ramanathapuram, Vikky Awasthi, Kalpana Verma, Patrick Sutton, Syed Zeeshan Ali, Ankita Patel, Sri Lakshmi Priya G, Sangamithra Ravishankaran, Nisha Desai, Nikunj Tandel, Sandhya Choubey, Punam Barla, Deena Kanagaraj, Alex Eapen, Khageswar Pradhan, Ranvir Singh, Aarti Jain, Philip L Felgner, D Huw Davies, Jane M Carlton, Jyoti Das
Understanding naturally acquired immune responses to Plasmodium in India is key to improving malaria surveillance and diagnostic tools. Here we describe serological profiling of immune responses at three sites in India by probing protein microarrays consisting of 515 Plasmodium vivax and 500 Plasmodium falciparum proteins with 353 plasma samples. A total of 236 malaria-positive (symptomatic and asymptomatic) plasma samples and 117 malaria-negative samples were collected at three field sites in Raurkela, Nadiad, and Chennai...
January 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28100237/surveillance-and-response-for-high-risk-populations-what-can-malaria-elimination-programmes-learn-from-the-experience-of-hiv
#20
REVIEW
Jerry O Jacobson, Carmen Cueto, Jennifer L Smith, Jimee Hwang, Roly Gosling, Adam Bennett
To eliminate malaria, malaria programmes need to develop new strategies for surveillance and response appropriate for the changing epidemiology that accompanies transmission decline, in which transmission is increasingly driven by population subgroups whose behaviours place them at increased exposure. Conventional tools of malaria surveillance and response are likely not sufficient in many elimination settings for accessing high-risk population subgroups, such as mobile and migrant populations (MMPs), given their greater likelihood of asymptomatic infections, illegal risk behaviours, limited access to public health facilities, and high mobility including extended periods travelling away from home...
January 18, 2017: Malaria Journal
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