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https://www.readbyqxmd.com/read/28817634/cross-reactivity-between-apical-membrane-antgen-1-and-rhoptry-neck-protein-2-in-p-vivax-and-p-falciparum-a-structural-and-binding-study
#1
Brigitte Vulliez-Le Normand, Frederick A Saul, Sylviane Hoos, Bart W Faber, Graham A Bentley
Malaria, a disease endemic in many tropical and subtropical regions, is caused by infection of the erythrocyte by the apicomplexan parasite Plasmodium. Host-cell invasion is a complex process but two Plasmodium proteins, Apical Membrane Antigen 1 (AMA1) and the Rhoptry Neck protein complex (RON), play a key role. AMA1, present on the surface of the parasite, binds tightly to the RON2 component of the RON protein complex, which is inserted into the erythrocyte membrane during invasion. Blocking the AMA1-RON2 interaction with antibodies or peptides inhibits invasion, underlining its importance in the Plasmodium life cycle and as a target for therapeutic strategies...
2017: PloS One
https://www.readbyqxmd.com/read/28813452/plasma-metabolomics-reveals-membrane-lipids-aspartate-asparagine-and-nucleotide-metabolism-pathway-differences-associated-with-chloroquine-resistance-in-plasmodium-vivax-malaria
#2
Karan Uppal, Jorge L Salinas, Wuelton M Monteiro, Fernando Val, Regina J Cordy, Ken Liu, Gisely C Melo, Andre M Siqueira, Belisa Magalhaes, Mary R Galinski, Marcus V G Lacerda, Dean P Jones
BACKGROUND: Chloroquine (CQ) is the main anti-schizontocidal drug used in the treatment of uncomplicated malaria caused by Plasmodium vivax. Chloroquine resistant P. vivax (PvCR) malaria in the Western Pacific region, Asia and in the Americas indicates a need for biomarkers of resistance to improve therapy and enhance understanding of the mechanisms associated with PvCR. In this study, we compared plasma metabolic profiles of P. vivax malaria patients with PvCR and chloroquine sensitive parasites before treatment to identify potential molecular markers of chloroquine resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28812552/competition-along-trajectories-governs-adaptation-rates-towards-antimicrobial-resistance
#3
C Brandon Ogbunugafor, Margaret J Eppstein
The increasing availability of genotype-phenotype maps for different combinations of mutations has empowered evolutionary biologists with the tools to interrogate the predictability of adaptive evolution, especially in the context of the evolution of antimicrobial resistance. Large microbial populations are known to generate competing beneficial mutations, but determining how these mutations contribute to the adaptive trajectories that are most likely to be followed remains a challenge. Despite a recognition that there may also be competition between successive alleles on the same trajectory, prior studies have not fully considered how this impacts adaptation rates along, or likelihood of following, individual trajectories...
November 21, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28808240/micro-epidemiology-and-spatial-heterogeneity-of-p-vivax-parasitaemia-in-riverine-communities-of-the-peruvian-amazon-a-multilevel-analysis
#4
Gabriel Carrasco-Escobar, Dionicia Gamboa, Marcia C Castro, Shrikant I Bangdiwala, Hugo Rodriguez, Juan Contreras-Mancilla, Freddy Alava, Niko Speybroeck, Andres G Lescano, Joseph M Vinetz, Angel Rosas-Aguirre, Alejandro Llanos-Cuentas
Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surveys were conducted between May and July 2015 in four riverine communities in Mazan district. Analysis of 2785 samples of 820 individuals nested within 154 households for Plasmodium parasitaemia was carried out using light microscopy and qPCR...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28804661/imported-asymptomatic-bancroftian-filariasis-discovered-from-a-plasmodium-vivax-infected-patient-a-case-report-from-singapore
#5
Jean-Marc Chavatte, Roland Jureen
Human lymphatic filariasis is a vector-borne disease mainly caused by the parasitic nematode Wuchereria bancrofti and transmitted worldwide within the tropical and subtropical regions. Singapore was once endemic for bancroftian filariasis but recent reports are scarce and the disease is nearly forgotten. The case report presented here reports the incidental hospital laboratory finding of an asymptomatic microfilaremia in a relapsing Plasmodium vivax imported case during a malaria treatment follow-up appointment...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28800475/biological-immunological-and-functional-properties-of-two-novel-multi-variant-chimeric-recombinant-proteins-of-csp-antigens-for-vaccine-development-against-plasmodium-vivax-infection
#6
Samaneh H Shabani, Sedigheh Zakeri, Ali H Salmanian, Jafar Amani, Akram A Mehrizi, Georges Snounou, François Nosten, Chiara Andolina, Yousef Mourtazavi, Navid D Djadid
The circumsporozoite protein (CSP) of the malaria parasite Plasmodium vivax is a major pre-erythrocyte vaccine candidate. The protein has a central repeat region that belongs to one of repeat families (VK210, VK247, and the P. vivax-like). In the present study, computer modelling was employed to select chimeric proteins, comprising the conserved regions and different arrangements of the repeat elements (VK210 and VK247), whose structure is similar to that of the native counterparts. DNA encoding the selected chimeras (named CS127 and CS712) were synthetically constructed based on E...
August 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28798400/characterization-of-p-vivax-blood-stage-transcriptomes-from-field-isolates-reveals-similarities-among-infections-and-complex-gene-isoforms
#7
Adam Kim, Jean Popovici, Amélie Vantaux, Reingsey Samreth, Sophalai Bin, Saorin Kim, Camille Roesch, Li Liang, Huw Davies, Philip Felgner, Sócrates Herrera, Myriam Arévalo-Herrera, Didier Ménard, David Serre
Our understanding of the structure and regulation of Plasmodium vivax genes is limited by our inability to grow the parasites in long-term in vitro cultures. Most P. vivax studies must therefore rely on patient samples, which typically display a low proportion of parasites and asynchronous parasites. Here, we present stranded RNA-seq data generated directly from a small volume of blood from three Cambodian vivax malaria patients collected before treatment. Our analyses show surprising similarities of the parasite gene expression patterns across infections, despite extensive variations in parasite stage proportion...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28797255/barriers-to-routine-g6pd-testing-prior-to-treatment-with-primaquine
#8
Benedikt Ley, Kamala Thriemer, Jessica Jaswal, Eugenie Poirot, Mohammad Shafiul Alam, Ching Swe Phru, Wasif Ali Khan, Lek Dysoley, Gao Qi, Chong Chee Kheong, Ummi Kalthom Shamsudin, Ingrid Chen, Jimee Hwang, Roly Gosling, Ric N Price
BACKGROUND: Primaquine is essential for the radical cure of vivax malaria, however its broad application is hindered by the risk of drug-induced haemolysis in individuals with glucose-6-phosphate-dehydrogenase (G6PD) deficiency. Rapid diagnostic tests capable of diagnosing G6PD deficiency are now available, but these are not used widely. METHODS: A series of qualitative interviews were conducted with policy makers and healthcare providers in four vivax-endemic countries...
August 10, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28796475/detection-of-plasmodium-lactate-dehydrogenase-pldh-antigen-in-buffer-using-aptamer-modified-magnetic-microparticles-for-capture-oligonucleotide-modified-quantum-dots-for-detection-and-oligonucleotide-modified-gold-nanoparticles-for-signal-amplification
#9
Chloe Kim, Peter C Searson
To overcome the limitations associated with antibody-based sensors, we describe a proof-of-concept of an aptamer-based sandwich assay for detection of lactate dehydrogenase, an antigen associated with malaria. We show a detection limit of Plasmodium falciparum lactate dehydrogenase and Plasmodium vivax lactate dehydrogenase of 0.5 fmole in buffer, comparable to an antibody-based assay, using a magnetic particle - aptamer construct for capture, and a quantum dot - aptamer construct for detection. We then demonstrate a detection limit of 10 amole (50-fold amplification) using oligonucleotide-functionalized gold nanoparticles to allow conjugation of multiple quantum dots for each target antigen...
August 10, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28794861/platelet-distribution-width-mean-platelet-volume-and-haematological-parameters-in-patients-with-uncomplicated-plasmodium-falciparum-and-p-vivax-malaria
#10
Elrazi A Ali, Tajeldin M Abdalla, Ishag Adam
BACKGROUND:  The association between the haematological profile (including abnormal platelets) and malaria is not completely understood. There are few published data on haematological profiles of malaria patients in areas with unstable malaria transmission. The current study was conducted to investigate if the haematological parameters, including platelet indices, were reliable predictors for microscopically-diagnosed malaria infection. METHODS: A case-control study with a total of 324 participants (162 in each arm) was conducted at the out-patient clinic of New Halfa hospital during the rainy and post rainy season (August 2014 through to January 2015)...
2017: F1000Research
https://www.readbyqxmd.com/read/28793022/kidney-involvement-in-malaria-an-update
#11
Geraldo Bezerra da Silva, José Reginaldo Pinto, Elvino José Guardão Barros, Geysa Maria Nogueira Farias, Elizabeth De Francesco Daher
Malaria is an infectious disease of great importance for Public Health, as it is the most prevalent endemic disease in the world, affecting millions of people living in tropical areas of the globe. Kidney involvement is relatively frequent in infections by P. falciparum and P. malariae, but has also been described in the infection by P. vivax. Kidney complications in malaria mainly occur due to hemodynamic dysfunction and immune response. Liver complications leading to hepatomegaly, jaundice and hepatic dysfunction can also contribute to the occurrence of acute kidney injury...
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28792284/neurological-involvement-associated-with-plasmodium-vivax-malaria-from-pakistan
#12
Yousaf Abdullah Khan, Usman Hameed Mian, Najia Karim Ghanchi, Ali Bin Sarwar Zubairi, Mohammad Asim Beg
Plasmodium vivax is the most common specie causing malaria outside Africa with approximately 13.8 million reported cases worldwide. We report case of P. vivax infection with cerebral involvement. A nine year old boy presented with high grade fever accompanied by projectile vomiting and abnormal behavior later he developed seizures, shock, and unconsciousness. P. vivax monoinfection was diagnosed based on peripheral smears and PCR. After antimalarial therapy, patient made full recovery. Current case highlights increasing trend of cerebral complications caused by P...
January 1, 2017: Tropical Doctor
https://www.readbyqxmd.com/read/28780020/a-continuous-long-term-plasmodium-vivax-in-vitro-blood-stage-culture-what-are-we-missing
#13
Richard Thomson-Luque, Katy Shaw Saliba, Clemens H M Kocken, Erica M Pasini
The recent research efforts to establish a Plasmodium vivax continuous, long-term blood-stage culture have focused on the ideal host cell type. However, this is only part of the story, as the P. vivax intraerythrocytic life cycle is complex. A successful, long-term, robust culture system will depend on a multifaceted approach combining the ideal cell type and parasite isolates, and the culture conditions.
August 2, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28777043/diagnostic-potential-of-monoclonal-antibodies-developed-against-c-terminal-polypeptide-of-p-falciparum-histidine-rich-protein2-pfhrp2-in-malaria-infected-patients-from-india
#14
Reena Verma, Sara Chandy, N S Jayaprakash, Anand Manoharan, M A Vijayalakshmi, Krishnan Venkataraman
Malaria, caused by Plasmodium falciparum has become a major health burden in most tropical and developing countries. P. falciparum Histidine Rich Protein2 (PfHRP2), which exhibits polymorphism, is being widely used as a diagnostic marker. Recently, we reported the development of monoclonal antibodies against conserved C-terminal 105 amino acids of PfHRP2 for malaria diagnosis. Now, in this study, the diagnostic performance of two anti-C-terminal PfHRP2 mAbs (b10c1 and Aa3c10) were evaluated with 100 blood samples from clinically identified malaria patients from seven different geographical centers in India...
August 4, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28770814/malaria
#15
REVIEW
Margaret A Phillips, Jeremy N Burrows, Christine Manyando, Rob Hooft van Huijsduijnen, Wesley C Van Voorhis, Timothy N C Wells
Malaria is caused in humans by five species of single-celled eukaryotic Plasmodium parasites (mainly Plasmodium falciparum and Plasmodium vivax) that are transmitted by the bite of Anopheles spp. mosquitoes. Malaria remains one of the most serious infectious diseases; it threatens nearly half of the world's population and led to hundreds of thousands of deaths in 2015, predominantly among children in Africa. Malaria is managed through a combination of vector control approaches (such as insecticide spraying and the use of insecticide-treated bed nets) and drugs for both treatment and prevention...
August 3, 2017: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/28764710/host-attraction-and-biting-behaviour-of-anopheles-mosquitoes-in-south-halmahera-indonesia
#16
Brandyce St Laurent, Timothy A Burton, Siti Zubaidah, Helen C Miller, Puji B Asih, Amirullah Baharuddin, Sully Kosasih, Shinta, Saya Firman, William A Hawley, Thomas R Burkot, Din Syafruddin, Supratman Sukowati, Frank H Collins, Neil F Lobo
BACKGROUND: Indonesia is home to a variety of malaria vectors whose specific bionomic traits remain largely uncharacterized. Species-specific behaviours, such as host feeding preferences, impact the dynamics of malaria transmission and the effectiveness of vector control interventions. METHODS: To examine species-specific host attraction and feeding behaviours, a Latin square design was used to compare Anopheles mosquitoes attracted to human, cow, and goat-baited tents...
August 2, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28761494/underdiagnosed-complicated-plasmodium-vivax-malaria-in-a-child-need-to-think
#17
Sonu Agrawal
Malaria is major cause of morbidity and mortality worldwide. The highest incidence of malaria in the world is South East Asia. India is most affected country followed by Indonesia and Myanmar. The prevalence of malaria varies according to geographical region. Diagnosis of malaria infection has been underestimated. Here, we report a case of under-diagnosed complicated vivax malaria in one-yr-old child in 2016. Early diagnosis and prompt treatment can reduce both morbidity and mortality in complicated malaria infection...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761465/absence-of-asymptomatic-malaria-infection-in-a-cross-sectional-study-in-iranshahr-district-iran-under-elimination-programmes
#18
Sakineh Pirahmadi, Sedigheh Zakeri, Ahmad Raeisi
BACKGROUND: Asymptomatic malaria infection provides a reservoir of parasites, causing the persistence of malaria transmission. It accounts an important challenge for successful management of the control, elimination, and eradication programmes in any malaria-endemic region. This investigation was designed to assess the presence and the prevalence of asymptomatic carriers in Iranshahr district of Sistan and Baluchistan Province (2013-2014), with a considerable population movement, during the malaria elimination phase in Iran...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28759593/proteogenomic-analysis-of-the-total-and-surface-exposed-proteomes-of-plasmodium-vivax-salivary-gland-sporozoites
#19
Kristian E Swearingen, Scott E Lindner, Erika L Flannery, Ashley M Vaughan, Robert D Morrison, Rapatbhorn Patrapuvich, Cristian Koepfli, Ivo Muller, Aaron Jex, Robert L Moritz, Stefan H I Kappe, Jetsumon Sattabongkot, Sebastian A Mikolajczak
Plasmodium falciparum and Plasmodium vivax cause the majority of human malaria cases. Research efforts predominantly focus on P. falciparum because of the clinical severity of infection and associated mortality rates. However, P. vivax malaria affects more people in a wider global range. Furthermore, unlike P. falciparum, P. vivax can persist in the liver as dormant hypnozoites that can be activated weeks to years after primary infection, causing relapse of symptomatic blood stages. This feature makes P. vivax unique and difficult to eliminate with the standard tools of vector control and treatment of symptomatic blood stage infection with antimalarial drugs...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28759591/genome-wide-diversity-and-differentiation-in-new-world-populations-of-the-human-malaria-parasite-plasmodium-vivax
#20
Thais C de Oliveira, Priscila T Rodrigues, Maria José Menezes, Raquel M Gonçalves-Lopes, Melissa S Bastos, Nathália F Lima, Susana Barbosa, Alexandra L Gerber, Guilherme Loss de Morais, Luisa Berná, Jody Phelan, Carlos Robello, Ana Tereza R de Vasconcelos, João Marcelo P Alves, Marcelo U Ferreira
BACKGROUND: The Americas were the last continent colonized by humans carrying malaria parasites. Plasmodium falciparum from the New World shows very little genetic diversity and greater linkage disequilibrium, compared with its African counterparts, and is clearly subdivided into local, highly divergent populations. However, limited available data have revealed extensive genetic diversity in American populations of another major human malaria parasite, P. vivax. METHODS: We used an improved sample preparation strategy and next-generation sequencing to characterize 9 high-quality P...
July 2017: PLoS Neglected Tropical Diseases
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