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https://www.readbyqxmd.com/read/29345221/therapeutic-response-to-dihydroartemisinin-piperaquine-for-p-falciparum-and-p-vivax-nine-years-after-its-introduction-in-southern-papua-indonesia
#1
Jeanne Rini Poespoprodjo, Enny Kenangalem, Johny Wafom, Freis Chandrawati, Agatha M Puspitasari, Benedikt Ley, Leily Trianti, Zoé Korten, Asik Surya, Din Syafruddin, Nicholas M Anstey, Jutta Marfurt, Rintis Noviyanti, Ric N Price
Dihydroartemisinin-piperaquine (DHP) has been the first-line treatment of uncomplicated malaria due to both Plasmodium falciparum and Plasmodium vivax infections in Papua, Indonesia, since March 2006. The efficacy of DHP was reassessed to determine whether there had been any decline following almost a decade of its extensive use. An open-label drug efficacy study of DHP for uncomplicated P. falciparum and P. vivax malaria was carried out between March 2015 and April 2016 in Timika, Papua, Indonesia. Patients with uncomplicated malaria were administered supervised DHP tablets once daily for 3 days...
January 15, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29345110/remarkable-similarity-in-plasmodium-falciparum-and-plasmodium-vivax-geranylgeranyl-diphosphate-synthase-ggpps-dynamics-and-its-implication-for-anti-malarial-drug-design
#2
Aishwarya Venkatramani, Clarisse G Ricci, Eric Oldfield, J Andrew McCammon
Malaria, mainly caused by Plasmodium falciparum and Plasmodium vivax, has been a growing cause of morbidity and mortality. P. falciparum is more lethal than is P. vivax, but there is a vital need for effective drugs against both species. Geranylgeranyl diphosphate synthase (GGPPS) is an enzyme involved in the biosynthesis of quinones and in protein prenylation, and has been proposed to be a malaria drug target. However, the structure of P. falciparum GGPPS (PfGGPPS) has not been determined, due to difficulties in crystallization...
January 18, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29338786/a-systematic-review-of-transfusion-transmitted-malaria-in-non-endemic-areas
#3
Federica Verra, Andrea Angheben, Elisa Martello, Giovanni Giorli, Francesca Perandin, Zeno Bisoffi
BACKGROUND: Transfusion-transmitted malaria (TTM) is an accidental Plasmodium infection caused by whole blood or a blood component transfusion from a malaria infected donor to a recipient. Infected blood transfusions directly release malaria parasites in the recipient's bloodstream triggering the development of high risk complications, and potentially leading to a fatal outcome especially in individuals with no previous exposure to malaria or in immuno-compromised patients. A systematic review was conducted on TTM case reports in non-endemic areas to describe the epidemiological characteristics of blood donors and recipients...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29334956/identification-and-characterization-of-areas-of-high-and-low-risk-for-asymptomatic-malaria-infections-at-sub-village-level-in-ratanakiri-cambodia
#4
Lies Durnez, Myrthe Pareyn, Vanna Mean, Saorin Kim, Nimol Khim, Didier Menard, Marc Coosemans, Tho Sochantha, Vincent Sluydts
BACKGROUND: Malaria elimination needs a concentration of activities towards identification of residual transmission foci and intensification of efforts to eliminate the last few infections, located in so-called 'malaria hotspots'. Previous work on characterizing malaria transmission hotspots has mainly focused on falciparum malaria and especially on symptomatic cases, while the malaria reservoir is expected to be mainly concentrated in the asymptomatic human population when transmission is low...
January 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29334944/changes-in-malaria-epidemiology-in-germany-2001-2016-a-time-series-analysis
#5
Sabine Vygen-Bonnet, Klaus Stark
BACKGROUND: German surveillance data showed a sharp rise of malaria cases in 2014 and 2015 due to the increased arrival of refugees from malaria endemic countries. A time series analysis of data from 2001 to 2016 was performed in order to describe the epidemiology of imported malaria in Germany in general and of the recent increase in particular. RESULTS: In total, 11,678 malaria cases were notified between 2001 and 2016 (range 526-1063 cases/year). Newly arriving refugees averaged 10 cases/year (1...
January 15, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29330980/comparison-of-efficacy-of-chloroquine-and-artemether-lumafantrine-in-treating-vivax-malaria-in-thall-and-surrounding-area
#6
Syed Mohammad Abrar, Syed Sajid Ali Shah, Raja Jibran Akbar, Sheema Rahim, Faizan Malik, Fakhar Uzzaman Khan
BACKGROUND: Fever is the main complaint in patients reporting to our hospital and the most common cause of fever in our set up is malaria. The aim of this study was to know about the clinical response, efficacy and resistance of vivax malaria to chloroquine in patients reporting to Thall Scouts Hospital. METHODS: All the adult male patients reporting to Thall Scouts Hospital with fever and other symptoms of malaria having slide positive vivax malaria were included in the study...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29325573/genetic-diversity-of-three-surface-protein-genes-in-plasmodium-malariae-from-three-asian-countries
#7
Suttipat Srisutham, Naowarat Saralamba, Kanlaya Sriprawat, Mayfong Mayxay, Frank Smithuis, Francois Nosten, Sasithon Pukrittayakamee, Nicholas P J Day, Arjen M Dondorp, Mallika Imwong
BACKGROUND: Genetic diversity of the three important antigenic proteins, namely thrombospondin-related anonymous protein (TRAP), apical membrane antigen 1 (AMA1), and 6-cysteine protein (P48/45), all of which are found in various developmental stages of Plasmodium parasites is crucial for targeted vaccine development. While studies related to the genetic diversity of these proteins are available for Plasmodium falciparum and Plasmodium vivax, barely enough information exists regarding Plasmodium malariae...
January 11, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29322086/engineered-livers-for-infectious-diseases
#8
REVIEW
Nil Gural, Liliana Mancio-Silva, Jiang He, Sangeeta N Bhatia
Engineered liver systems come in a variety of platform models, from 2-dimensional cocultures of primary human hepatocytes and stem cell-derived progeny, to 3-dimensional organoids and humanized mice. Because of the species-specificity of many human hepatropic pathogens, these engineered systems have been essential tools for biologic discovery and therapeutic agent development in the context of liver-dependent infectious diseases. Although improvement of existing models is always beneficial, and the addition of a robust immune component is a particular need, at present, considerable progress has been made using this combination of research platforms...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29320817/development-of-monoclonal-antibodies-for-diagnosis-of-plasmodium-vivax
#9
Nguyen Thi Phuong Linh, Hyun Park, Jinyoung Lee, Dong-Xu Liu, Ga-Eun Seo, Hae-Jin Sohn, Jin-Hee Han, Eun-Taek Han, Ho-Joon Shin, Seon-Ju Yeo
Plasmodium lactate dehydrogenase (pLDH) is a strong target antigen for the determination of infection with Plasmodium species specifically. However, a more effective antibody is needed because of the low sensitivity of the current antibody in many immunological diagnostic assays. In this study, recombinant Plasmodium vivax LDH (PvLDH) was experimentally constructed and expressed as a native antigen to develop an effective P. vivax-specific monoclonal antibody (mAb). Two mAbs (2CF5 and 1G10) were tested using ELISA and immunofluorescence assays (IFA), as both demonstrated reactivity against pLDH antigen...
December 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29317838/primaquine-double-dose-for-7-days-is-inferior-to-single-dose-treatment-for-14-days-in-preventing-plasmodium-vivax-recurrent-episodes-in-suriname
#10
M Sigrid Mac Donald-Ottevanger, Malti R Adhin, Jeetendra Kumar Jitan, Gustavo Bretas, Stephen Gs Vreden
Background: Recurrent episodes of Plasmodium vivax are caused by dormant liver stages of the parasite, which are not eradicated by choloroquine. Therefore, effective treatment also includes the use of primaquine (PQ). However, this secondary preventive therapy is often not effective, mostly due to poor adherence to the relatively long treatment course, justifying a comparative study of the efficacy of different durations of PQ treatment. Materials and methods: We included patients presenting with an acute and documented P...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29316918/in-silico-epitope-mapping-and-experimental-evaluation-of-the-merozoite-adhesive-erythrocytic-binding-protein-maebl-as-a-malaria-vaccine-candidate
#11
Pedro Cravo, Renato B Machado, Juliana A Leite, Taizy Leda, Rossarin Suwanarusk, Najara Bittencourt, Letusa Albrecht, Carla Judice, Stefanie C P Lopes, Marcus V G Lacerda, Marcelo U Ferreira, Irene S Soares, Yun Shan Goh, Daniel Y Bargieri, François Nosten, Bruce Russell, Laurent Rénia, Fabio T M Costa
BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping of MAEBL through immunoinformatics identified several MHCI, MHCII and B cell epitopes throughout the peptide, with several of these lying in the M2 domain and being conserved between P...
January 10, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29314720/correlation-of-april-with-production-of-inflammatory-cytokines-during-acute-malaria-in-the-brazilian-amazon
#12
Raquel A Pinna, Adriana C Dos Santos, Daiana S Perce-da-Silva, Luciene A da Silva, Rodrigo N R da Silva, Marcelo R Alves, Fátima Santos, Joseli de Oliveira Ferreira, Josué C Lima-Junior, Déa M Villa-Verde, Paula M De Luca, Carla E Carvalho-Pinto, Dalma M Banic
INTRODUCTION: A proliferation-inducing ligand (APRIL) and B cell activation factor (BAFF) are known to play a significant role in the pathogenesis of several diseases, including BAFF in malaria. The aim of this study was to investigate whether APRIL and BAFF plasma concentrations could be part of inflammatory responses associated with P. vivax and P. falciparum malaria in patients from the Brazilian Amazon. METHODS: Blood samples were obtained from P. vivax and P...
January 3, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29313805/nationwide-genetic-surveillance-of-plasmodium-vivax-in-papua-new-guinea-reveals-heterogeneous-transmission-dynamics-and-routes-of-migration-amongst-subdivided-populations
#13
Abebe A Fola, Elma Nate, G L Abby Harrison, Céline Barnadas, Manuel W Hetzel, Jonah Iga, Peter Siba, Ivo Mueller, Alyssa E Barry
The Asia Pacific Leaders in Malaria Alliance (APLMA) have committed to eliminate malaria from the region by 2030. Papua New Guinea (PNG) has the highest malaria burden in the Asia-Pacific region but with the intensification of control efforts since 2005, transmission has been dramatically reduced and Plasmodium vivax is now the dominant malaria infection in some parts of the country. To gain a better understanding of the transmission dynamics and migration patterns of P. vivax in PNG, here we investigate population structure in eight geographically and ecologically distinct regions of the country...
December 4, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29313573/p-vivax-malaria-presenting-as-thrombotic-microangiopathy
#14
Dharmendra Bhadauria, Harsh Vardhan, Anupma Kaul, Raj Kumar Sharma, Amit Gupta, Narayan Prasad, Manoj Jain
Introduction: Acute kidney injury (AKI) is reported to occur in patients with falciparum malaria but not uncommon with vivax malaria. AKI, anemia, thrombocytopenia and jaundice is a recurrent finding in severe malaria and can mimic as thrombotic microangiopathy (TMA). Relationship of malaria with TMA is unclear till date however evidences suggest their association. Methods & Material: We reviewed our electronic database to evaluate relationship of malaria with TMA, of cases of malaria, jaundice and AKI...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29313481/case-report-severe-plasmodium-vivax-malaria-mimicking-sepsis-in-a-neonate
#15
Suryadi N N Tatura, Elizabeth Clarissa Wowor, Jose M Mandei, Rocky Wilar, Sarah M Warouw, Johnny Rompis, Priscilla Kalensang, Joseph Tuda
Severe congenital malaria associated with Plasmodium vivax is uncommon. In Indonesia, most congenital malaria cases are due to Plasmodium falciparum infections. Most cases of congenital or neonatal malaria in endemic areas are diagnosed from peripheral smear as part of routine sepsis workup. Differentiating congenital and acquired neonatal malaria is very difficult. The case presented in this study describes severe P. vivax malaria with cholestatic jaundice and sepsis-like signs and symptoms in neonates. The mother was asymptomatic and the neonate was successfully treated with intravenous artesunate...
January 8, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29311638/an-assay-for-the-identification-of-plasmodium-simium-infection-for-diagnosis-of-zoonotic-malaria-in-the-brazilian-atlantic-forest
#16
Denise Anete Madureira de Alvarenga, Richard Culleton, Anielle de Pina-Costa, Danielle Fonseca Rodrigues, Cesare Bianco, Sidnei Silva, Ana Júlia Dutra Nunes, Julio César de Souza, Zelinda Maria Braga Hirano, Sílvia Bahadian Moreira, Alcides Pissinatti, Filipe Vieira Santos de Abreu, André Luiz Lisboa Areas, Ricardo Lourenço-de-Oliveira, Mariano Gustavo Zalis, Maria de Fátima Ferreira-da-Cruz, Patricia Brasil, Cláudio Tadeu Daniel-Ribeiro, Cristiana Ferreira Alves de Brito
Zoonotic malaria poses a unique problem for malaria control. Autochthonous cases of human malaria in the Atlantic Forest have recently been attributed to Plasmodium simium, a parasite that commonly infects non-human primates in this Brazilian biome. However, due to its close similarity at both the morphological and molecular level to Plasmodium vivax, the diagnosis of P. simium in this region remains problematic. Therefore, a diagnostic assay able to accurately identify P. simium is important for malaria surveillance...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29304809/estimation-on-local-transmission-of-malaria-by-serological-approach-under-low-transmission-setting-in-myanmar
#17
Myat Htut Nyunt, Than Naing Soe, Thinzar Shein, Ni Ni Zaw, Soe Soe Han, Fauzi Muh, Seong-Kyun Lee, Jin-Hee Han, Ji-Hoon Park, Kwon-Soo Ha, Won Sun Park, Seok-Ho Hong, Myat Phone Kyaw, Eun-Taek Han
BACKGROUND: As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be established in this setting. METHODS: One-year cohort study was conducted and sera samples were collected in every 3 months with active and passive case detection for clinical malaria episodes by RDT, microscopy and molecular method...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304258/the-relative-contribution-of-symptomatic-and-asymptomatic-plasmodium-vivax-and-plasmodium-falciparum-infections-to-the-infectious-reservoir-in-a-low-endemic-setting-in-ethiopia
#18
Fitsum G Tadesse, Hannah C Slater, Wakweya Chali, Karina Teelen, Kjerstin Lanke, Mulualem Belachew, Temesgen Menberu, Girma Shumie, Getasew Shitaye, Lucy C Okell, Wouter Graumans, Geert-Jan van Gemert, Soriya Kedir, Addisu Tesfaye, Feleke Belachew, Wake Abebe, Hassen Mamo, Robert Sauerwein, Taye Balcha, Abraham Aseffa, Delenasaw Yewhalaw, Endalamaw Gadisa, Chris Drakeley, Teun Bousema
Background: The majority of P. vivax and P. falciparum infections in low-endemic settings are asymptomatic. The relative contribution to the infectious reservoir of these infections, often of low-parasite-density, compared to clinical malaria cases, is currently unknown but important for malaria elimination strategies. Methods: We assessed infectivity of passively-recruited symptomatic malaria patients (n=41) and community-recruited asymptomatic individuals with microscopy- (n=41) and PCR-detected infections (n=82) using membrane feeding assays with Anopheles arabiensis mosquitoes in Adama, Ethiopia...
January 3, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29302006/transferrin-receptor-1-is-a-reticulocyte-specific-receptor-for-plasmodium-vivax
#19
Jakub Gruszczyk, Usheer Kanjee, Li-Jin Chan, Sébastien Menant, Benoit Malleret, Nicholas T Y Lim, Christoph Q Schmidt, Yee-Foong Mok, Kai-Min Lin, Richard D Pearson, Gabriel Rangel, Brian J Smith, Melissa J Call, Michael P Weekes, Michael D W Griffin, James M Murphy, Jonathan Abraham, Kanlaya Sriprawat, Maria J Menezes, Marcelo U Ferreira, Bruce Russell, Laurent Renia, Manoj T Duraisingh, Wai-Hong Tham
Plasmodium vivax shows a strict host tropism for reticulocytes. We identified transferrin receptor 1 (TfR1) as the receptor for P. vivax reticulocyte-binding protein 2b (PvRBP2b). We determined the structure of the N-terminal domain of PvRBP2b involved in red blood cell binding, elucidating the molecular basis for TfR1 recognition. We validated TfR1 as the biological target of PvRBP2b engagement by means of TfR1 expression knockdown analysis. TfR1 mutant cells deficient in PvRBP2b binding were refractory to invasion of P...
January 5, 2018: Science
https://www.readbyqxmd.com/read/29301534/submicroscopic-malaria-cases-play-role-in-local-transmission-in-trenggalek-district-east-java-province-indonesia
#20
Heny Arwati, Subagyo Yotopranoto, Etik Ainun Rohmah, Din Syafruddin
BACKGROUND: Trenggalek district is a hypoendemic malaria area with mainly imported cases brought by migrant workers from islands outside Java. During malaria surveillance in 2015, no malaria cases were found microscopically, but some cases were positive by PCR. Therefore, a study was conducted to prove that local malaria transmission still occur. METHODS: The adult villagers were invited to the house of the head of this village to be screened for malaria using aseptic venipuncture of 1 mL blood upon informed consent...
January 5, 2018: Malaria Journal
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