Erkang Yi, Weitao Cao, Jiahuan Zhang, Biting Lin, Zihui Wang, Xiaoyu Wang, Ge Bai, Xinyue Mei, ChengShu Xie, Jing Jin, Xinyuan Liu, Haiqing Li, Fan Wu, Zhiwei Lin, Ruiting Sun, Bing Li, Yumin Zhou, Pixin Ran
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous syndrome. Airway inflammation and remodeling are the two key processes involved in COPD pathogenesis. However, the key pathogenic genes driving COPD development have not been revealed. This study aims to identify and validate hub gene(s) underlying COPD development through bioinformatics analysis and experimental validation. METHODS: Three lung tissue sequencing datasets of the COPD (including GSE38974, GSE103174, and GSE106986) were analyzed...
November 25, 2022: Life Sciences