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interneurons auditory cortex psychosis

Tony W Wilson, Olivia O Hernandez, Ryan M Asherin, Peter D Teale, Martin L Reite, Donald C Rojas
Neurobiological theories of schizophrenia and related psychoses have increasingly emphasized impaired neuronal coordination (i.e., dysfunctional connectivity) as central to the pathophysiology. Although neuroimaging evidence has mostly corroborated these accounts, the basic mechanism(s) of reduced functional connectivity remains elusive. In this study, we examine the developmental trajectory and underlying mechanism(s) of dysfunctional connectivity by using gamma oscillatory power as an index of local and long-range circuit integrity...
February 2008: Cerebral Cortex
Susan M Cochran, Matthew Kennedy, Clare E McKerchar, Lucinda J Steward, Judith A Pratt, Brian J Morris
Numerous human imaging studies have revealed an absolute or relative metabolic hypofunction within the prefrontal cortex, thalamus and temporal lobes of schizophrenic patients. The former deficit correlates with cognitive deficits and negative symptoms, whereas the latter correlates with positive symptomologies. There is also general consensus that schizophrenia is associated with decreased parvalbumin expression in the prefrontal cortex. Since the drug phencyclidine can induce a psychosis resembling schizophrenia in humans, we have examined whether repeated phencyclidine (PCP) treatment to rats could produce similar metabolic and neurochemical deficits to those occurring in schizophrenia and whether these deficits could be modulated by antipsychotic drugs...
February 2003: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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