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Auditory cortex schizophrenia

Marion Psomiades, Marine Mondino, Clara Fonteneau, Remy Bation, Frederic Haesebaert, Marie-Françoise Suaud-Chagny, Jerome Brunelin
Auditory verbal hallucinations (AVH) in patients with schizophrenia are linked to abnormalities within a large cerebral network including frontal and temporal regions. Whilst abnormalities of frontal speech production and temporal speech perception regions have been extensively studied, alterations of the dorsolateral prefrontal cortex (DLPFC), a region critically involved in the pathophysiology of schizophrenia, have rarely been studied in relation to AVH. Using 1.5 T proton magnetic resonance spectroscopy, this study examined the relationship between right and left DLPFCs N-AcetylAspartate (NAA) levels and the severity of AVH in patients with schizophrenia...
March 7, 2018: Scientific Reports
Chi C Chan, Philip R Szeszko, Edmund Wong, Cheuk Y Tang, Caitlin Kelliher, Justin D Penner, M Mercedes Perez-Rodriguez, Daniel R Rosell, Margaret McClure, Panos Roussos, Antonia S New, Larry J Siever, Erin A Hazlett
Abnormalities in temporal and frontal cortical volume, white matter tract integrity, and hemispheric asymmetry have been implicated in schizophrenia-spectrum disorders. Schizotypal personality disorder can provide insight into vulnerability and protective factors in these disorders without the confounds associated with chronic psychosis. However, multimodal imaging and asymmetry studies in SPD are sparse. Thirty-seven individuals with SPD and 29 healthy controls (HC) received clinical interviews and 3T magnetic resonance T1-weighted and diffusion tensor imaging scans...
February 14, 2018: Schizophrenia Research
Lynn Mørch-Johnsen, Stener Nerland, Kjetil N Jørgensen, Kåre Osnes, Cecilie B Hartberg, Ole A Andreassen, Ingrid Melle, Ragnar Nesvåg, Ingrid Agartz
OBJECTIVES: We aimed to investigate morphometric correlates of auditory hallucinations in bipolar disorder (BD) by comparing cortical thickness and cortical surface area in bipolar disorder patients with (BD+) and without (BD-) a lifetime history of auditory hallucinations. Based on previous findings in schizophrenia patients, we hypothesized that the cortex would be thinner in the auditory cortex in BD+ compared to BD-. METHODS: Bipolar disorder spectrum (n = 157) patients and healthy controls (n = 279) underwent 1...
February 13, 2018: Bipolar Disorders
Sibin Li, Lanlan Ma, Yuchen Wang, Xuejiao Wang, Yingzhuo Li, Ling Qin
Auditory steady-state responses (ASSRs) represent the electrophysiological activity of the auditory nervous system in response to a periodic acoustic stimulus. Spectrogram analysis can reveal the frequency and phase information entrained in ASSRs. Clinically, the ASSR is used to detect abnormalities in electroencephalographs obtained from schizophrenia patients, who show reduced power and phase locking of ASSRs. The neonatal ventral hippocampal lesion (NVHL) rat is a widely used model to investigate the neurodevelopmental mechanisms of schizophrenia...
2018: PloS One
Shogo Hirano, Alexander Nakhnikian, Yoji Hirano, Naoya Oribe, Shigenobu Kanba, Toshiaki Onitsuka, Margaret Levin, Kevin M Spencer
BACKGROUND: Cross-frequency interactions may coordinate neural circuits operating at different frequencies. While neural oscillations associated with particular circuits in schizophrenia (SZ) are impaired, few studies have examined cross-frequency interactions. Here we examined phase-amplitude coupling (PAC) in the electroencephalograms of individuals with SZ and healthy control subjects (HCs). We computed PAC during the baseline period of 40-Hz auditory steady-state stimulation and rest...
January 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Kit Melissa Larsen, Morten Mørup, Michelle Rosgaard Birknow, Elvira Fischer, Oliver Hulme, Anders Vangkilde, Henriette Schmock, William Frans Christiaan Baaré, Michael Didriksen, Line Olsen, Thomas Werge, Hartwig R Siebner, Marta I Garrido
22q11.2 deletion syndrome (22q11.2DS) is one of the most common copy number variants and confers a markedly increased risk for schizophrenia. As such, 22q11.2DS is a homogeneous genetic liability model which enables studies to delineate functional abnormalities that may precede disease onset. Mismatch negativity (MMN), a brain marker of change detection, is reduced in people with schizophrenia compared to healthy controls. Using dynamic causal modelling (DCM), previous studies showed that top-down effective connectivity linking the frontal and temporal cortex is reduced in schizophrenia relative to healthy controls in MMN tasks...
January 30, 2018: Schizophrenia Research
Katharina M Kubera, Philipp A Thomann, Dusan Hirjak, Anja Barth, Fabio Sambataro, Nenad Vasic, Nadine D Wolf, Karel Frasch, R Christian Wolf
In schizophrenia temporal cortical volume loss differs between patients presenting with persistent auditory verbal hallucinations (pAVH) in contrast to those without hallucinatory symptoms (nAVH). However, it is unknown whether this deficit reflects a neural signature of neurodevelopmental origin or if abnormal temporal cortical volume is reflective of factors which may be relevant at later stages of the disorder. Here, we tested the hypothesis that local gyrification index (LGI) in regions of the temporal cortex differs between patients with pAVH (n=10) and healthy controls (n=14), and that abnormal temporal LGI discriminates between pAVH and nAVH (n=10)...
January 2, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
William B Holliday, Kate Gurnsey, Robert A Sweet, Tobias Teichert
BACKGROUND: The amplitude of the auditory evoked N1 component that can be derived from noninvasive electroencephalographic recordings increases as a function of time between subsequent tones. N1 amplitudes in individuals with schizophrenia saturate at a lower asymptote, thus giving rise to a reduced dynamic range. Reduced N1 dynamic range is a putative electrophysiological biomarker of altered sensory memory function in individuals with the disease. To date, it is not clear what determines N1 dynamic range and what causes reduced N1 dynamic range in individuals with schizophrenia...
December 13, 2017: Journal of Psychiatry & Neuroscience: JPN
Christian Plewnia, Bettina Brendel, Tobias Schwippel, Peter Martus, Joachim Cordes, Alkomiet Hasan, Andreas J Fallgatter
Auditory verbal hallucinations (AH) are core symptoms of schizophrenia. They are often severely distressing and refractory to therapy. Their perception is associated with increased activity in temporoparietal areas of the brain. Repetitive transcranial magnetic stimulation (rTMS) can reduce focal brain hyperactivity and has been shown to ameliorate AH. However, controlled multicenter clinical trials are still missing, effect sizes are moderate, and the treatment with rTMS is time consuming. Continuous theta burst stimulation (cTBS) is a quicker and potentially more effective technique to reduce cortical hyperactivity...
December 9, 2017: European Archives of Psychiatry and Clinical Neuroscience
Yuhui Du, Susanna L Fryer, Dongdong Lin, Jing Sui, Qingbao Yu, Jiayu Chen, Barbara Stuart, Rachel L Loewy, Vince D Calhoun, Daniel H Mathalon
Although individuals at clinical high risk (CHR) for psychosis exhibit a psychosis-risk syndrome involving attenuated forms of the positive symptoms typical of schizophrenia (SZ), it remains unclear whether their resting-state brain intrinsic functional networks (INs) show attenuated or qualitatively distinct patterns of functional dysconnectivity relative to SZ patients. Based on resting-state functional magnetic imaging data from 70 healthy controls (HCs), 53 CHR individuals (among which 41 subjects were antipsychotic medication-naive), and 58 early illness SZ (ESZ) patients (among which 53 patients took antipsychotic medication) within five years of illness onset, we estimated subject-specific INs using a novel group information guided independent component analysis (GIG-ICA) and investigated group differences in INs...
2018: NeuroImage: Clinical
Christopher Timmermann, Meg J Spriggs, Mendel Kaelen, Robert Leech, David J Nutt, Rosalyn J Moran, Robin L Carhart-Harris, Suresh D Muthukumaraswamy
Under the predictive coding framework, perceptual learning and inference are dependent on the interaction between top-down predictions and bottom-up sensory signals both between and within regions in a network. However, how such feedback and feedforward connections are modulated in the state induced by lysergic acid diethylamide (LSD) is poorly understood. In this study, an auditory oddball paradigm was presented to healthy participants (16 males, 4 female) under LSD and placebo, and brain activity was recorded using magnetoencephalography (MEG)...
October 31, 2017: Neuropharmacology
A Aleman, J Brummelman, J J Dlabac-de Lange, S Koops, H Knegtering, S F W Neggers, I E Sommer
New approaches are needed in the treatment of characteristic symptoms of schizophrenia such as hallucinations and negative symptoms. Non-invasive brain stimulation can make a useful contribution.<br/> AIM: To discuss the published evidence regarding efficacy and safety of repetitive transcranial magnetic stimulation (rtms) and transcranial direct current stimulation (tdcs) when used in the treatment of auditory verbal hallucinations and negative symptoms.<br/> METHOD: We review and discuss recent meta-analyses and we analyse relevant factors...
2017: Tijdschrift Voor Psychiatrie
Brian A Coffman, Sarah M Haigh, Timothy K Murphy, Justin Leiter-Mcbeth, Dean F Salisbury
Auditory scene analysis (ASA) dysfunction is likely an important component of the symptomatology of schizophrenia. Auditory object segmentation, the grouping of sequential acoustic elements into temporally-distinct auditory objects, can be assessed with electroencephalography through measurement of the auditory segmentation potential (ASP). Further, N2 responses to the initial and final elements of auditory objects are enhanced relative to medial elements, which may indicate auditory object edge detection (initiation and termination)...
October 22, 2017: Schizophrenia Research
Ashley M Schnakenberg Martin, Brian F OʼDonnell, James B Millward, Jenifer L Vohs, Emma Leishman, Amanda R Bolbecker, Olga Rass, Sandra L Morzorati
BACKGROUND/AIMS: The onset response to a single tone as measured by electroencephalography (EEG) is diminished in power and synchrony in schizophrenia. Because neural synchrony, particularly at gamma frequencies (30-80 Hz), is hypothesized to be supported by the N-methyl-D-aspartate receptor (NMDAr) system, we tested whether phencyclidine (PCP), an NMDAr antagonist, produced similar deficits to tone stimuli in rats. METHODS: Experiment 1 tested the effect of a PCP dose (1...
October 24, 2017: Neuropsychobiology
Jung Hoon Lee
The pathophysiology of auditory hallucination, a common symptom of schizophrenia, has yet been understood, but during auditory hallucination, primary auditory cortex (A1) shows paradoxical responses. When auditory stimuli are absent, A1 becomes hyperactive, while A1 responses to auditory stimuli are reduced. Such activation pattern of A1 responses during auditory hallucination is consistent with aberrant gamma rhythms in schizophrenia observed during auditory tasks, raising the possibility that the pathology underlying abnormal gamma rhythms can account for auditory hallucination...
December 2017: Journal of Computational Neuroscience
Tasnim Rahman, Katerina Zavitsanou, Tertia Purves-Tyson, Lauren R Harms, Crystal Meehan, Ulrich Schall, Juanita Todd, Deborah M Hodgson, Patricia T Michie, Cyndi Shannon Weickert
BACKGROUND: Glutamatergic receptor [N-methyl-d-aspartate receptor (NMDAR)] alterations within cortex, hippocampus, and striatum are linked to schizophrenia pathology. Maternal immune activation (MIA) is an environmental risk factor for the development of schizophrenia in offspring. In rodents, gestational timing of MIA may result in distinct behavioral outcomes in adulthood, but how timing of MIA may impact the nature and extent of NMDAR-related changes in brain is not known. We hypothesize that NMDAR-related molecular changes in rat cortex, striatum, and hippocampus are induced by MIA and are dependent on the timing of gestational inflammation and sex of the offspring...
2017: Frontiers in Psychiatry
Anushree Bose, Venkataram Shivakumar, Sri Mahavir Agarwal, Sunil V Kalmady, Sonia Shenoy, Vanteemar S Sreeraj, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Persistent auditory verbal hallucinations (AVH) that are refractory to antipsychotic medications are reported in about 20-30% of schizophrenia patients. Transcranial Direct Current Stimulation (tDCS), a non-invasive and safe neuromodulatory technique, has attracted significant interest as an add-on treatment for refractory AVH in schizophrenia. Studies examining the efficacy of tDCS for refractory AVH in schizophrenia have reported inconsistent findings. In this study, using a randomized, double-blind, sham-controlled design (RCT), we sought to examine the effect of add-on tDCS [anode corresponding to left dorsolateral prefrontal cortex and cathode to left temporo-parietal junction; 2-mA, twice-daily sessions for 5-days] to treat refractory AVH in schizophrenia patients (N=25); following this RCT phase, patients that had <30% reduction in AVH severity were offered an open-label extension (OLE) active stimulation to evaluate the effect of cross-over to verum tDCS...
August 30, 2017: Schizophrenia Research
Migyung Lee, Pejman Sehatpour, Elisa C Dias, Gail S Silipo, Joshua T Kantrowitz, Antigona M Martinez, Daniel C Javitt
Deficits in mismatch negativity (MMN) generation are among the best replicated neurophysiological deficits in schizophrenia, with reduced amplitude reflecting impaired information processing at the level of supratemporal auditory cortex. Differential patterns of MMN dysfunction according to deviant types have been reported across studies, with some research groups showing impairment in duration MMN but not frequency MMN, and other research groups reporting both findings. We evaluate the hypothesis that recruitment setting, reflecting current functional status, might be an important determinant of the pattern of MMN dysfunction...
August 2, 2017: Schizophrenia Research
Walter Dunn, Yuri Rassovsky, Jonathan Wynn, Allan D Wu, Marco Iacoboni, Gerhard Hellemann, Michael F Green
Transcranial direct current stimulation (tDCS) was applied bilaterally over the auditory cortex in 12 schizophrenia patients to modulate early auditory processing. Performance on a tone discrimination task (tone-matching task-TMT) and auditory mismatch negativity were assessed after counterbalanced anodal, cathodal, and sham tDCS. Cathodal stimulation improved TMT performance (p < 0.03) compared to sham condition. Post-hoc analyses revealed a stimulation condition by negative symptom interaction in which greater negative symptoms were associated with a better TMT performance after anodal tDCS...
July 7, 2017: Journal of Neural Transmission
Daniel C Javitt, Migyung Lee, Joshua T Kantrowitz, Antigona Martinez
Mismatch negativity (MMN) is among the best established biomarkers of cortical dysfunction in schizophrenia. MMN generators are localized primarily to primary and secondary auditory regions, and are known to reflect activity mediated by cortical N-methyl-d-aspartate-type glutamate receptors (NMDAR). Nevertheless, mechanisms underlying MMN generation at the local circuit level remain incompletely understood. This review synthesizes recent advances in circuit-level conceptualization of MMN based upon neuro-oscillatory findings...
June 27, 2017: Schizophrenia Research
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