Masataka Ichikawa, Nobuhiro Nakamoto, Sharon Kredo-Russo, Eyal Weinstock, Iddo Nadav Weiner, Efrat Khabra, Noa Ben-Ishai, Dana Inbar, Noga Kowalsman, Ron Mordoch, Julian Nicenboim, Myriam Golembo, Naomi Zak, Jagoda Jablonska, Hila Sberro-Livnat, Sharon Navok, Nufar Buchshtab, Takahiro Suzuki, Kentaro Miyamoto, Toshiaki Teratani, Sota Fujimori, Yoshimasa Aoto, Mikiko Konda, Naoki Hayashi, Po-Sung Chu, Nobuhito Taniki, Rei Morikawa, Ryosuke Kasuga, Takaya Tabuchi, Shinya Sugimoto, Yohei Mikami, Atsushi Shiota, Merav Bassan, Takanori Kanai
Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation and fibrosis. Although gut commensals are associated with PSC, their causative roles and therapeutic strategies remain elusive. Here we detect abundant Klebsiella pneumoniae (Kp) and Enterococcus gallinarum in fecal samples from 45 PSC patients, regardless of intestinal complications. Carriers of both pathogens exhibit high disease activity and poor clinical outcomes. Colonization of PSC-derived Kp in specific pathogen-free (SPF) hepatobiliary injury-prone mice enhances hepatic Th17 cell responses and exacerbates liver injury through bacterial translocation to mesenteric lymph nodes...
June 5, 2023: Nature Communications