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https://www.readbyqxmd.com/read/28227494/localised-impedance-monitoring-device-for-the-remote-clinical-assessment-of-home-based-dialysis-patients
#1
A Montalibet, W Arkouche, P Bogonez Franco, S Bonnet, A Clarion, G Delhomme, C Gehin, S Gharbi, R Guillemaud, P Jallon, B Massot, P Pham, E Ribbe-Cornet, E McAdams, A Montalibet, W Arkouche, P Bogonez Franco, S Bonnet, A Clarion, G Delhomme, C Gehin, S Gharbi, R Guillemaud, P Jallon, B Massot, P Pham, E Ribbe-Cornet, E McAdams, B Massot, P Pham, A Montalibet, P Jallon, E Ribbe-Cornet, P Bogonez Franco, G Delhomme, S Bonnet, R Guillemaud, W Arkouche, A Clarion, C Gehin, S Gharbi, E McAdams
BioImpedance Spectroscopy (BIS) has been clinically used to determine the hydrational status of patients undergoing haemodialysis (HD). In the present project we are developing a calf-localised, integrated impedimetric device to periodically and conveniently measure and transmit information on the hydrational status of home-based patients to a remote clinic. Surprisingly, we have found that simple postural changes before or during measurement lead to significant fluid shifts in the lower leg that are as important and as long lasting as the effects of haemodialysis...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227459/leg-fluid-accumulation-during-prolonged-sitting
#2
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi, Daniel Vena, Azadeh Yadollahi, Jonathan Rubianto, Milos Popovic
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28220806/on-the-long-term-stability-of-clines-in-some-metabolic-genes-in-drosophila-melanogaster
#3
Rodrigo Cogni, Kate Kuczynski, Spencer Koury, Erik Lavington, Emily L Behrman, Katherine R O'Brien, Paul S Schmidt, Walter F Eanes
Very little information exists for long-term changes in genetic variation in natural populations. Here we take the unique opportunity to compare a set of data for SNPs in 15 metabolic genes from eastern US collections of Drosophila melanogaster that span a large latitudinal range and represent two collections separated by 12 to 13 years. We also expand this to a 22-year interval for the Adh gene and approximately 30 years for the G6pd and Pgd genes. During these intervals, five genes showed a statistically significant change in average SNP allele frequency corrected for latitude...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28217595/impact-of-pre-hospital-care-on-the-outcome-of-children-arriving-with-agonal-breathing-to-a-pediatric-emergency-service-in-south-india
#4
Debasis Das Adhikari, Krishna Mahathi, Urmi Ghosh, Indira Agarwal, Anila Chacko, Ebor Jacob, Kala Ebenezer
BACKGROUND: Data on the prehospital interventions received by critically ill children at arrival to Paediatric Emergency Services (PES) is limited in developing countries. This study aims to describe the pre-hospital care scenario, transport and their impact on outcome in non-traumatic, acutely ill children presenting in PES with agonal breathing. METHODS: Prospective observational study done on children aged below 15 years arriving in PES with agonal breathing due to non-trauma related causes...
July 2016: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/28216455/proximal-tubal-patency-demonstrated-through-air-infusion-during-flexible-office-hysteroscopy-is-predictive-of-whole-tubal-patency
#5
J Preston Parry, Daniel Riche, Justin Aldred, John Isaacs, Elizabeth Lutz, Vicki Butler, James Shwayder
OBJECTIVE: To determine whether air bubbles infused in to saline during flexible office hysteroscopy can accurately predict tubal patency. DESIGN: Diagnostic accuracy study (Canadian Task Force classification II-1); SETTING: Academic hospital PATIENTS: Women undergoing office hysteroscopy and ultrasound INTERVENTION: Air infusion into saline during office hysteroscopy MEASUREMENTS AND MAIN RESULTS: The primary outcome measures were whether air bubbles traverse the ostia at hysteroscopy, whether there is patency at abdominal surgery, and the rate of cul de sac (CDS) fluid accumulation from office hysteroscopy...
February 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28214605/the-effect-of-sitting-and-calf-activity-on-leg-fluid-and-snoring
#6
Bhajan Singh, Azadeh Yadollahi, Owen Lyons, Hisham Alshaer, TDouglas Bradley
Prolonged sitting may promote leg fluid retention that redistributes to the neck during sleep and contributes to snoring. This could be attenuated by calf activity while sitting. In 16 healthy non-obese subjects we measured leg fluid volume (LFV) below the knees using bioelectrical impedance while sitting for 4hours, snoring using a portable BresoDx™ device, and Mallampati grade. Using a double cross-over study design, subjects were randomized to one of two arms and crossed-over one week later: control arm - no calf exercise while sitting; intervention arm - calf contraction against a pedal resistance while sitting...
February 15, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28211128/staged-intraperitoneal-brachytherapy-and-hyperthermic-intraperitoneal-chemotherapy-in-an-adolescent-novel-anesthetic-challenges-for-pediatric-anesthetists
#7
Andrew D Weatherall, Tristan R Bennett, Mark Lovell, Winnie Fung, Jonathan de Lima
Newer techniques that have found a place in cancer management in adults are offered far less commonly in pediatric patients. We present a case of a patient with recurrent Wilms' tumor managed with a novel combination of cytoreductive surgery, intraperitoneal brachytherapy, and subsequent hyperthermic intraperitoneal chemotherapy. Each stage presents challenges that the pediatric anesthetist is unlikely to have faced before. Such cases require flexibility and thorough planning to manage the combination of major surgery, remote anesthesia with brachytherapy and hyperthermic chemotherapy with its potential for metabolic derangement, significant fluid shifts, analgesic care, and potential exposure of staff to cytotoxic agents...
February 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28209267/assessment-of-volume-status-and-appropriate-fluid-replenishment-in-the-setting-of-nephrotic-syndrome
#8
Pierluigi Marzuillo, Stefano Guarino, Andrea Apicella, Rosaria Marotta, Vincenzo Tipo, Laura Perrone, Angela La Manna, Giovanni Montini
BACKGROUND: When the permeability of the glomerular filtration barrier increases, leading to proteinuria, nephrotic syndrome (NS) occurs. First episodes or relapses of NS can be concurrent with acute gastroenteritis (AGE) infections. This condition can cause further deterioration of the hypovolemic state, as intravascular water is lost through both AGE-related vomiting/diarrhea and NS-related fluid shifting into the interstitium. In this case report, we wish to raise the issues about the difficult management of children presenting with both NS and AGE...
February 10, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28209177/is-posture-related-craniospinal-compliance-shift-caused-by-jugular-vein-collapse-a-theoretical-analysis
#9
Manuel Gehlen, Vartan Kurtcuoglu, Marianne Schmid Daners
BACKGROUND: Postural changes are related to changes in cerebrospinal fluid (CSF) dynamics. While sitting up leads to a decrease in cranial CSF pressure, it also causes shifts in the craniospinal CSF volume and compliance distribution. We hypothesized that jugular vein collapse in upright posture is a major contributor to these shifts in CSF volume and compliance. METHODS: To test this hypothesis, we implemented a mathematical lumped-parameter model of the CSF system and the relevant parts of the cardiovascular system...
February 16, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28208313/diffusion-of-a-rouse-chain-in-porous-media-a-mode-coupling-theory-study
#10
Huai Ding, Huijun Jiang, Nanrong Zhao, Zhonghuai Hou
We use a kinetic mode-coupling theory (MCT) combining with generalized Langevin equation (GLE) to study the diffusion and conformational dynamics of a bead-spring Rouse chain (RC) dissolved in porous media. The media contains fluid particles and immobile matrix ones wherein the latter leads to the lack of translational invariance. The friction kernel ζ(t) used in the GLE can be obtained directly by adopting a simple density-functional approach in which the density correlators calculated by MCT equations of porous media serve as inputs...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28202437/oscillation-patterns-are-enhanced-and-firing-threshold-is-lowered-in-medullary-respiratory-neuron-discharges-by-threshold-doses-of-a-%C3%AE-opioid-receptor-agonist
#11
Peter M Lalley, Steve W Mifflin
μ-Opioid receptors are distributed widely in the brainstem respiratory network, and opioids with selectivity for μ-type receptors slow in-vivo respiratory rhythm in lowest effective doses. Several studies have reported μ-opioid receptor effects on the three-phase rhythm of respiratory neurons, but there are until now no reports of opioid effects on oscillatory activity within respiratory discharges. In this study, effects of the μ-opioid receptor agonist fentanyl on spike train discharge properties of several different types of rhythm-modulating medullary respiratory neuron discharges were analyzed...
February 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28195345/in-vivo-measurements-of-human-neck-skin-elasticity-using-mri-and-finite-element-modeling
#12
Yunqiang An, Changjin Ji, Yong Li, Jianxia Wang, Xinyue Zhang, Yaqi Huang
PURPOSE: The assessment of mechanical properties of the human skin is very important in investigating the mechanism of obstructive sleep apnea, a common disorder characterized by repetitive collapse and obstruction of the upper airway during sleep. In this study, a unique method, combining magnetic resonance imaging (MRI) and finite element modeling (FEM), was developed to obtain the value of the in vivo elastic modulus of the neck skin. MEHTHOD: A total of 22 subjects, 16 males and 6 females, were recruited to participate in the MRI studies...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28193020/viscoelastic-separation-of-particles-by-size-in-straight-rectangular-microchannels-a-parametric-study-for-a-refined-understanding
#13
Di Li, Xinyu Lu, Xiangchun Xuan
Microfluidic separation of particles has been implemented using a variety of force fields. We demonstrate in this work a continuous sheath-free separation of both a binary and a ternary particle mixture in viscoelastic polymer solutions through straight rectangular microchannels. This label-free separation arises from the flow-induced lift force that directs particles toward size-sensitive focusing positions in a high width/height channel. It is found to be a strong function of multiple experimental parameters, which is systematically investigated in terms of dimensionless numbers...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28191384/delayed-temporal-lobe-hemorrhage-after-initiation-of-acyclovir-in-an-immunocompetent-patient-with-herpes-simplex-virus-2-encephalitis-a-case-report
#14
Kyle Mueller, Joshua E Ryan, Alex Tai, Rocco A Armonda
Herpes simplex virus (HSV) is the most common cause of non-epidemic, sporadic, acute focal encephalitis in the United States. Inflammation of the vasculature makes them friable and susceptible to hemorrhage. Massive hemorrhage, though rare, can present in a delayed fashion after initiation of acyclovir and often requires surgical intervention. We report a unique case of delayed temporal lobe hemorrhage after initiation of acyclovir in an immunocompetent patient, specifically for its presentation, virology, and surgical management...
January 15, 2017: Curēus
https://www.readbyqxmd.com/read/28190559/use-of-renal-near-infrared-spectroscopy-measurements-in-congenital-diaphragmatic-hernia-patients-on-ecmo
#15
Patricio E Lau, Stephanie Cruz, Joseph Garcia-Prats, Milenka Cuevas, Christopher Rhee, Darrell L Cass, Sarah E Horne, Timothy C Lee, Stephen E Welty, Oluyinka O Olutoye
INTRODUCTION: This study tests the hypothesis that renal tissue oxygen saturation as measured by Near Infrared Spectroscopy (NIRS) would correlate with urine output in neonates with congenital diaphragmatic hernia (CDH) on extracorporeal membrane oxygenation (ECMO). METHODS: Between 2012 and 2015, neonates with CDH were enrolled as part of a comprehensive study that provided renal/cerebral/abdominal NIRS monitoring for the duration of ECMO support. Continuous NIRS measurements, mean arterial pressure, and urine output were recorded...
January 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28190443/neurologic-manifestations-of-major-electrolyte-abnormalities
#16
M Diringer
The brain operates in an extraordinarily intricate environment which demands precise regulation of electrolytes. Tight control over their concentrations and gradients across cellular compartments is essential and when these relationships are disturbed neurologic manifestations may develop. Perturbations of sodium are the electrolyte disturbances that most often lead to neurologic manifestations. Alterations in extracellular fluid sodium concentrations produce water shifts that lead to brain swelling or shrinkage...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28182581/application-of-single-and-dual-energy-ct-brain-tissue-segmentation-to-pet-monitoring-of-proton-therapy
#17
Bianca Berndt, Guillaume Landry, Florian Schwarz, Thomas Tessonnier, Florian Kamp, Georgios Dedes, Christian Thieke, Matthias Wuerl, Christopher Kurz, Ute Ganswindt, Frank Verhaegen, Juergen Debus, Claus Belka, Wieland Sommer, Maximilian Reiser, Julia Bauer, Katia Parodi
The purpose of this work was to evaluate the ability of single and dual energy computed tomography (SECT, DECT) to estimate tissue composition and density for usage in Monte Carlo (MC) simulations of irradiation induced β<sup>+</sup> activity distributions. This was done to assess the impact on positron emission tomography (PET) range verification in proton therapy. A DECT-based brain tissue segmentation method was developed for white matter (WM), grey matter (GM) and cerebrospinal fluid (CSF)...
February 9, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28181795/water-responsive-shape-recovery-induced-buckling-in-biodegradable-photo-cross-linked-poly-ethylene-glycol-peg-hydrogel
#18
Abhijit Vijay Salvekar, Wei Min Huang, Rui Xiao, Yee Shan Wong, Subbu S Venkatraman, Kiang Hiong Tay, Ze Xiang Shen
The phenomenon of recovering the permanent shape from a severely deformed temporary shape, but only in the presence of the right stimulus, is known as the shape memory effect (SME). Materials with such an interesting effect are known as shape memory materials (SMMs). Typical stimuli to trigger shape recovery include temperature (heating or cooling), chemical (including water/moisture and pH value), and light. As a SMM is able not only to maintain the temporary shape but also to respond to the right stimulus when it is applied, via shape-shifting, a seamless integration of sensing and actuation functions is achieved within one single piece of material...
February 9, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28176941/bioglass-implant-coating-interactions-in-synthetic-physiological-fluids-with-varying-degrees-of-biomimicry
#19
A C Popa, G E Stan, M A Husanu, I Mercioniu, L F Santos, H R Fernandes, Jmf Ferreira
Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid-implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials' structure-dissolution behavior...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28167076/brain-network-alterations-in-the-inflammatory-soup-animal-model-of-migraine
#20
Lino Becerra, James Bishop, Gabi Barmettler, Vanessa Kainz, Rami Burstein, David Borsook
Advances in our understanding of the human pain experience have shifted much of the focus of pain research from the periphery to the brain. Current hypotheses suggest that the progression of migraine depends on abnormal functioning of neurons in multiple brain regions. Accordingly, we sought to capture functional brain changes induced by the application of an inflammatory cocktail known as inflammatory soup (IS), to the dura mater across multiple brain networks. Specifically, we aimed to determine whether IS alters additional neural networks indirectly related to the primary nociceptive pathways via the spinal cord to the thalamus and cortex...
February 3, 2017: Brain Research
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