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Fluid shift*

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https://www.readbyqxmd.com/read/29211803/hypoxia-and-inactivity-related-physiological-changes-precede-or-take-place-in-absence-of-significant-rearrangements-in-bacterial-community-structure-the-planhab-randomized-trial-pilot-study
#1
Robert Šket, Nicole Treichel, Susanne Kublik, Tadej Debevec, Ola Eiken, Igor Mekjavić, Michael Schloter, Marius Vital, Jenna Chandler, James M Tiedje, Boštjan Murovec, Zala Prevoršek, Matevž Likar, Blaž Stres
We explored the assembly of intestinal microbiota in healthy male participants during the randomized crossover design of run-in (5 day) and experimental phases (21-day normoxic bed rest (NBR), hypoxic bed rest (HBR) and hypoxic ambulation (HAmb) in a strictly controlled laboratory environment, with balanced fluid and dietary intakes, controlled circadian rhythm, microbial ambiental burden and 24/7 medical surveillance. The fraction of inspired O2 (FiO2) and partial pressure of inspired O2 (PiO2) were 0.209 and 133...
2017: PloS One
https://www.readbyqxmd.com/read/29208025/change-in-cardiac-output-during-trendelenburg-maneuver-is-a-reliable-predictor-of-fluid-responsiveness-in-patients-with-acute-respiratory-distress-syndrome%C3%A2-in-the-prone-position-under-protective-ventilation
#2
Hodane Yonis, Laurent Bitker, Mylène Aublanc, Sophie Perinel Ragey, Zakaria Riad, Floriane Lissonde, Aurore Louf-Durier, Sophie Debord, Florent Gobert, Romain Tapponnier, Claude Guérin, Jean-Christophe Richard
BACKGROUND: Predicting fluid responsiveness may help to avoid unnecessary fluid administration during acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate the diagnostic performance of the following methods to predict fluid responsiveness in ARDS patients under protective ventilation in the prone position: cardiac index variation during a Trendelenburg maneuver, cardiac index variation during an end-expiratory occlusion test, and both pulse pressure variation and change in pulse pressure variation from baseline during a tidal volume challenge by increasing tidal volume (VT) to 8 ml...
December 5, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29202496/primary-aldosteronism-and-obstructive-sleep-apnea-is-this-a-bidirectional-relationship
#3
Aleksander Prejbisz, Sylwia Kołodziejczyk-Kruk, Jacques W M Lenders, Andrzej Januszewicz
It has been suggested that the high prevalence of obstructive sleep apnea (OSA) in resistant hypertension (RHT) may be related to the high prevalence of primary aldosteronism (PA) in patients with RHT. It has been also hypothesized that the relationship between aldosterone and OSA might be bidirectional. In patients with RHT, it has been shown that aldosterone levels correlate with severity of OSA and that blockade of aldosterone reduces the severity of OSA. It has been postulated that aldosterone worsens OSA by promoting accumulation of fluid, which shifted in the supine position to the neck, contributes to increased upper airway resistance...
December 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29198070/sugar-detection-threshold-after-laparoscopic-sleeve-gastrectomy-in-adolescents
#4
Ghalia N Abdeen, Alexander D Miras, Aayed R Alqhatani, Carel W le Roux
INTRODUCTION: Obesity in young people is one of the most serious public health problems worldwide. Moreover, the mechanisms preventing obese adolescents from losing and maintaining weight loss have been elusive. Laparoscopic sleeve gastrectomy (LSG) is successful at achieving long-term weight loss in patients across all age groups, including children and adolescents. Anecdotal clinical observation as well as evidence in rodents suggests that LSG induces a shift in preference of sugary foods...
December 2, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29193856/physical-forces-modulate-cell-differentiation-and-proliferation-processes
#5
REVIEW
Laurent Schwartz, Jorgelindo da Veiga Moreira, Mario Jolicoeur
Currently, the predominant hypothesis explains cellular differentiation and behaviour as an essentially genetically driven intracellular process, suggesting a gene-centrism paradigm. However, although many living species genetic has now been described, there is still a large gap between the genetic information interpretation and cell behaviour prediction. Indeed, the physical mechanisms underlying the cell differentiation and proliferation, which are now known or suspected to guide such as the flow of energy through cells and tissues, have been often overlooked...
November 30, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29189158/cancer-targeted-therapy-strategy-the-pathologist-s-perspectives
#6
Lara Alessandrini, Tiziana Perin, Shahin Kadare, Lino Del Pup, Lorenzo Memeo, Agostino Steffan, Lorenzo Colarossi, Massimiliano Berretta, Paolo De Paoli, Vincenzo Canzonieri
The effectiveness of new personalized treatment procedures in oncology is based on the fact that a certain tumor exhibits specific molecular features. More in detail, neoplastic tissues of patients should display a specific biomarker, most often a specific genetic alteration and/or under/overexpression of a definite protein, that could be the target of its respective drug. Immunohistochemical and molecular analyses, which usuallyinclude examination of nucleic acids from either tissues or fluids, are common tests to define the status of a tumor...
November 29, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29187679/cardiac-driven-pulsatile-motion-of-intracranial-cerebrospinal-fluid-visualized-based-on-a-correlation-mapping-technique
#7
Satoshi Yatsushiro, Saeko Sunohara, Naokazu Hayashi, Akihiro Hirayama, Mitsunori Matsumae, Hideki Atsumi, Kagayaki Kuroda
PURPOSE: A correlation mapping technique delineating delay time and maximum correlation for characterizing pulsatile cerebrospinal fluid (CSF) propagation was proposed. After proofing its technical concept, this technique was applied to healthy volunteers and idiopathic normal pressure hydrocephalus (iNPH) patients. METHODS: A time-resolved three dimensional-phase contrast (3D-PC) sampled the cardiac-driven CSF velocity at 32 temporal points per cardiac period at each spatial location using retrospective cardiac gating...
November 29, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29186767/a-microwave-microfluidic-sensor-based-on-a-dual-mode-resonator-for-dual-sensing-applications
#8
(no author information available yet)
In this paper, we propose a novel microwave microfluidic sensor with dual-sensing capability. The sensor is based on a dual-mode resonator that consists of a folded microstrip line loaded with interdigital lines and a stub at the plane of symmetry. Due to the specific configuration, the resonator exhibits two entirely independent resonant modes, which allows simultaneous sensing of two fluids using a resonance shift method. The sensor is designed in a multilayer configuration with the proposed resonator and two separated microfluidic channels-one intertwined with the interdigital lines and the other positioned below the stub...
November 24, 2017: Sensors
https://www.readbyqxmd.com/read/29178963/chloral-hydrate-enteral-infusion-for-sedation-in-ventilated-children-the-chosen-pilot-study
#9
Ari R Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P Duff, Gonzalo Garcia Guerra
BACKGROUND: We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. METHODS: Children < 12 years old, within 72 hours of admission, who were ventilated, receiving enteral tube-feeds, with intermittent CH ordered were enrolled after signed consent. Patients received a CH loading-dose of 10 mg/kg enterally, then a syringe-pump enteral infusion at 5 mg/kg/hour, increasing to a maximum of 9 mg/kg/hour...
November 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29178525/flow-dynamics-of-cerebrospinal-fluid-between-the-intracranial-cavity-and-the-subarachnoid-space-of-the-optic-nerve-measured-with-a-diffusion-magnetic-resonance-imaging-sequence-in-patients-with-normal-tension-glaucoma
#10
Dirk Boy, Margherita Montali, Neil R Miller, Achmed Pircher, Philipp Gruber, Hans-Peter E Killer, Luca Remonda, Jatta Berberat
IMPORTANCE: This study offers a new approach for the quantification of CSF-dynamics. BACKGROUND: Non-invasive method to quantify the CSF-dynamics in the subarachnoid-space of the optic nerve is highly desirable. The aim of the study was to measure slow-flow CSF-velocities in healthy controls and normal-tension glaucoma patients between the intracranial cavity and the subarachnoid-space of the optic nerve. DESIGN: Prospective observational study...
November 25, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29174145/using-video-microscopy-to-improve-quantitative-estimates-of-protozoal-motility-and-cell-volume
#11
B A Wenner, B K Wagner, J L Firkins
The objective of this study was to apply digital imaging to improve quantification of rumen protozoal biomass and distinguish treatment differences in cell motility and volume among ruminal protozoa. Observations of protozoa in rumen fluid treated with essential oils (CinnaGar, CIN; Provimi North America, Brookville, OH) or an ionophore (monensin, MON) indicated possible cell shrinkage. We hypothesized that MON would decrease protozoal motility and interact with CIN on cell volume. In addition, we hypothesized that analysis of still frames from video of swimming protozoa would improve volume prediction accuracy...
November 22, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29166045/controlling-relative-polymorph-stability-in-soft-porous-crystals-with-a-barostat
#12
Nathan A Mahynski, Vincent K Shen
We use Monte Carlo simulations to investigate the thermodynamic behavior of soft porous crystal (SPC) adsorbents under the influence of an external barostat. We consider SPCs that naturally exhibit polymorphism between crystal forms of two distinct pore sizes. In the absence of barostatting, these crystals may be naturally divided into two categories depending on their response to stress applied by the adsorbate fluid: those which macroscopically deform and change the volume of their unit cell ("breathing") and those which instead undergo internal rearrangements that change the adsorbate-accessible volume without modifying the unit cell volume ("gate-opening")...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29163444/progressive-colonization-of-bacteria-and-degradation-of-rice-straw-in-the-rumen-by-illumina-sequencing
#13
Yanfen Cheng, Ying Wang, Yuanfei Li, Yipeng Zhang, Tianyi Liu, Yu Wang, Thomas J Sharpton, Weiyun Zhu
The aim of this study was to improve the utilization of rice straw as forage in ruminants by investigating the degradation pattern of rice straw in the dairy cow rumen. Ground up rice straw was incubated in situ in the rumens of three Holstein cows over a period of 72 h. The rumen fluid at 0 h and the rice straw at 0.5, 1, 2, 4, 6, 12, 24, 48, and 72 h were collected for analysis of the bacterial community and the degradation of the rice straw. The bacterial community and the carbohydrate-active enzymes in the rumen fluid were analyzed by metagenomics...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163138/perspective-insights-into-disease-progression-diagnostics-and-therapeutic-approaches-in-alzheimer-s-disease-a-judicious-update
#14
REVIEW
Arif Tasleem Jan, Mudsser Azam, Safikur Rahman, Angham M S Almigeiti, Duk Hwan Choi, Eun Ju Lee, Qazi Mohd Rizwanul Haq, Inho Choi
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive accumulation of β-amyloid fibrils and abnormal tau proteins in and outside of neurons. Representing a common form of dementia, aggravation of AD with age increases the morbidity rate among the elderly. Although, mutations in the ApoE4 act as potent risk factors for sporadic AD, familial AD arises through malfunctioning of APP, PSEN-1, and-2 genes. AD progresses through accumulation of amyloid plaques (Aβ) and neurofibrillary tangles (NFTs) in brain, which interfere with neuronal communication...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29162796/deconvoluting-interrelationships-between-concentrations-and-chemical-shifts-in-urine-provides-a-powerful-analysis-tool
#15
Panteleimon G Takis, Hartmut Schäfer, Manfred Spraul, Claudio Luchinat
The NMR chemical shifts of a substance in a complex mixture strongly depend on the composition of the mixture itself, as many weak interactions occur that are hardly predictable. Chemical shift variability is the major obstacle to automatically assigning, and subsequently quantitating, metabolite signals in body fluids, particularly urine. Here we demonstrate that the chemical shifts of signals in urine are actually predictable. This is achieved by constructing ca. 4000 artificial mixtures where the concentrations of 52 most abundant urine metabolites-including 11 inorganic ions-are varied, to sparsely but efficiently populate an N-dimensional concentration matrix...
November 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/29158999/recurrent-primary-suprahepatic-abscess-due-to-providencia-stuartii-a-rare-phenomenon
#16
Kyawzaw Lin, Aung Naing Lin, Sandar Linn, Madhavi Reddy, Anjali Bakshi
Gram-negative urease-producing bacilli, Providencia stuartii (P. stuartii), is reported in urinary tract infections, gastroenteritis, and bacteremia in humans but they rarely present with a hepatic abscess. We present a rare case of a recurrent suprahepatic cyst due to P. stuartii in a 45-year-old female, intravenous ( IV) heroin abuser with chronic hepatitis B and C. A 45-year-old female with 10 days status post right suprahepatic abscess drainage presented with recurrent, right, upper quadrant abdominal pain for one day...
September 16, 2017: Curēus
https://www.readbyqxmd.com/read/29158529/accurate-thermal-conductivities-from-optimally-short-molecular-dynamics-simulations
#17
Loris Ercole, Aris Marcolongo, Stefano Baroni
The evaluation of transport coefficients in extended systems, such as thermal conductivity or shear viscosity, is known to require impractically long simulations, thus calling for a paradigm shift that would allow to deploy state-of-the-art quantum simulation methods. We introduce a new method to compute these coefficients from optimally short molecular dynamics simulations, based on the Green-Kubo theory of linear response and the cepstral analysis of time series. Information from the full sample power spectrum of the relevant current for a single and relatively short trajectory is leveraged to evaluate and optimally reduce the noise affecting its zero-frequency value, whose expectation is proportional to the corresponding conductivity...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29156640/clinical-beneficial-effects-of-using-crystalloid-only-in-recipients-of-living-donor-liver-transplantation
#18
Chia-Jung Huang, Kwok-Wai Cheng, Chao-Long Chen, Shao-Chun Wu, Tsung-Hsiao Shih, Sheng-Chun Yang, Sin-Ei Juang, Ying-En Lee, Chiu-En Huang, Bruno Jawan, Chih-Hsien Wang
OBJECTIVE: Liver transplantation (LT) is a major surgery associated with intraoperative massive fluid shift, which is usually replaced by crystalloid, 5% albumin (colloid) and blood products. We studied 15 patients from 477 consecutive recipients of adult living donor liver transplantation. Each patient received crystalloid only during LT. Whether LT provides any clinical benefit is not clear and must be determined. METHODS AND PATIENTS: The anesthesia records of 477 adult LDLT were reviewed retrospectively...
November 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29156107/hemodynamic-force-triggers-rapid-netosis-within-sterile-thrombotic-occlusions
#19
X Yu, J Tan, S L Diamond
BACKGROUND: Neutrophil extracellular traps (NETs) are released when neutrophils encounter infectious pathogens, especially during sepsis. Additionally, NETosis occurs during venous and arterial thrombosis, disseminated intravascular coagulation, and trauma. OBJECTIVE: We tested if hemodynamic forces trigger NETosis during sterile thrombosis. METHODS: NETs were imaged with Sytox-green during microfluidic perfusion of Factor XIIa-inhibited or thrombin-inhibited human whole blood over fibrillar collagen (± tissue factor)...
November 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29154926/site-specific-effects-of-apolipoprotein-e-expression-on-diet-induced-obesity-and-white-adipose-tissue-metabolic-activation
#20
Aikaterini Hatziri, Christina Kalogeropoulou, Eva Xepapadaki, Eleni Birli, Eleni A Karavia, Eugenia Papakosta, Serafoula Filou, Caterina Constantinou, Kyriakos E Kypreos
Apolipoprotein E (APOE) has been strongly implicated in the development of diet induced obesity. In the present study, we investigated the contribution of brain and peripherally expressed human apolipoprotein E3 (APOE3), the most common human isoform, to diet induced obesity. In our studies APOE3 knock-in (Apoe3(knock-in)), Apoe-deficient (apoe(-/-)) and brain-specific expressing APOE3 (Apoe3(brain)) mice were fed western-type diet for 12week and biochemical analyses were performed. Moreover, AAV-mediated gene transfer of APOE3 to apoe(-/-) mice was employed, as a means to achieve APOE3 expression selectively in periphery, since peripherally expressed APOE does not cross blood brain barrier (BBB) or blood-cerebrospinal fluid barrier (BCSFB)...
November 20, 2017: Biochimica et Biophysica Acta
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