Shuguang Han, Qingtong Zheng, Zixuan Zheng, Jie Su, Xiaohua Liu, Changzhou Shi, Bo Li, Xuanxuan Zhang, Minghao Zhang, Qian Yu, Ziwei Hou, Ting Li, Bin Zhang, Yong Lin, Ge Wen, Yanjia Deng, Kai Liu, Kai Xu
Previous large-sample postmortem study revealed that the expression of miR-1202 in brain tissues from Brodmann area 44 (BA44) was dysregulated in patients with major depressive disorder (MDDs). However, the specific in vivo neuropathological mechanism of miR-1202 as well as its interplay with BA44 circuits in the depressed brain are still unclear. Here, we performed a case-control study with imaging-genetic approach based on resting-state functional magnetic resonance imaging (MRI) data and miR-1202 quantification from 110 medication-free MDDs and 102 healthy controls...
April 10, 2024: Journal of Affective Disorders