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antiphospholipid guidelines

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https://www.readbyqxmd.com/read/27676644/novel-enzyme-immunoassay-system-for-simultaneous-detection-of-six-subclasses-of-antiphospholipid-antibodies-for-differential-diagnosis-of-antiphospholipid-syndrome
#1
Junzo Nojima, Yukari Motoki, Kazusa Hara, Toshiyuki Sakata, Kiyoshi Ichihara
Antiphospholipid syndrome, which often complicates systemic lupus erythematosus (SLE), features high occurrence of arterial and/or venous thrombosis and recurrent fetal loss. However, which antibody subclass contributes to which clinical event remains uncertain. We newly developed an up-to-date enzyme immunoassay system using the AcuStar automated analyzer (Instrumentation Laboratory, Bedford, Massachusetts, USA) for parallel detection of six subclasses of antiphospholipid antibodies (aPLs): anticardiolipin antibodies (aCL) of IgG, IgM, and IgA and anti-β2-glycoprotein I antibodies (aβ2GPI) of IgG, IgM, and IgA...
September 24, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/27658514/-non-criteria-neurologic-manifestations-of-antiphospholipid-syndrome-a-hidden-kingdom-to-be-discovered
#2
Md Asiful Islam, Fahmida Alam, Mohammad Amjad Kamal, Kah Keng Wong, Teguh Haryo Sasongko, Siew Hua Gan
Neurological manifestations or disorders associated with central nervous system (CNS) are one of the most common as well as important clinical characteristics of antiphospholipid syndrome (APS). Although in the last updated (2006) classification criteria of APS its neurological manifestations encompassed only transient ischemic attack (TIA) and stroke, diverse 'non-criteria' neurological disorders or manifestations (headache, migraine, bipolar disorder, transverse myelitis, dementia, chorea, epileptic seizures, multiple sclerosis, psychosis, cognitive impairment, Tourette's syndrome, parkinsonism, dystonia, transient global amnesia, obsessive compulsive disorder and leukoencephalopathy) have been observed in APS patients...
September 20, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27510601/association-between-antiphospholipid-antibodies-and-arterial-thrombosis-in-patients-with-rheumatoid-arthritis
#3
K-J Kim, I-W Baek, K-S Park, W-U Kim, C-S Cho
OBJECTIVES: Antiphospholipid antibodies (aPL) are present in a proportion of patients with rheumatoid arthritis but their clinical significance remains unclear. We investigated the association between aPL and thrombotic events in rheumatoid arthritis patients. METHODS: In this cross-sectional study, aPL profiles were evaluated in 376 rheumatoid arthritis patients in accordance with the standard guidelines. Clinical and radiographic data were retrospectively collected...
August 9, 2016: Lupus
https://www.readbyqxmd.com/read/27486689/aps-diagnostics-and-challenges-for-the-future
#4
V Pengo, E Bison, G Zoppellaro, S Padayattil Jose, G Denas, A Hoxha, A Ruffatti, A Banzato
Diagnosis of antiphospholipid syndrome (APS) is essentially based on the detection of circulating antiphospholipid (aPL) antibodies. Progress have been made on the standardization of tests exploring the presence of aPL as guidelines on coagulation and immunological tests were recently published in the literature. Clinical relevance of aPL profile has come from prospective cohort studies in populations with a homogeneous antibody profile supporting the view that triple positivity is a high risk pattern in patients and carriers...
July 31, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27342460/additional-treatments-for-high-risk-obstetric-antiphospholipid-syndrome-a-comprehensive-review
#5
Amelia Ruffatti, Ariela Hoxha, Maria Favaro, Marta Tonello, Anna Colpo, Umberto Cucchini, Alessandra Banzato, Vittorio Pengo
Most investigators currently advocate prophylactic-dose heparin plus low-dose aspirin as the preferred treatment of otherwise healthy women with obstetric antiphospholipid syndrome, whilst women with a history of vascular thrombosis alone or associated with pregnancy morbidity are usually treated with therapeutic heparin doses in association with low-dose aspirin in an attempt to prevent both thrombosis and pregnancy morbidity. However, the protocols outlined above fail in about 20 % of pregnant women with antiphospholipid syndrome...
June 25, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27321859/recommendations-for-the-evaluation-and-management-of-patients-with-rheumatic-autoimmune-and-inflammatory-diseases-during-the-reproductive-age-pregnancy-postpartum-and-breastfeeding
#6
Juan Antonio Martínez López, M Luz García Vivar, Rafael Cáliz, Mercedes Freire, María Galindo, Maria Victoria Hernández, Francisco Javier López Longo, Víctor Martínez Taboada, Jose María Pego Reigosa, Esteban Rubio, Elisa Trujillo, Paloma Vela-Casasempere
OBJECTIVE: To develop recommendations on the evaluation and management of patients with rheumatic autoimmune and inflammatory diseases during the reproductive age, pregnancy, post-partum and breastfeeding based on the best evidence and experience. METHODS: Recommendations were generated using nominal group and Delphi techniques. An expert panel of 12 rheumatologists was established. A systematic literature review and a narrative review (websites, clinical guidelines and other relevant documentation) were performed and presented to the panel in its 1(st) meeting to be discussed and to help define recommendations...
June 16, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27279342/igg-igm-antiphospholipid-antibodies-present-in-the-classification-criteria-for-the-antiphospholipid-syndrome-a-critical-review-of-their-association-with-thrombosis
#7
H Kelchtermans, L Pelkmans, B de Laat, K M Devreese
UNLABELLED: Essentials The clinical value of IgM antibodies in thrombotic antiphospholipid syndrome (APS) is debated. By review of literature, we reconsidered the clinical value of IgM antibodies in thrombotic APS. More significant correlations with thrombosis were found for the IgG compared to IgM isotype. Unavailability of paired IgG/IgM results hampers evaluating the added value of IgM positivity. Click to hear Dr de Groot's perspective on antiphospholipid syndrome SUMMARY: Background Despite the update of the classification criteria for the antiphospholipid syndrome (APS), difficulties persist in the identification of patients at risk for thrombosis...
August 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27274510/thrombophilia-in-korean-patients-with-arterial-or-venous-thromboembolisms
#8
Sungbae Kim, Incheol Song, Hyung-Kee Kim, Seung Huh
PURPOSE: To determine the prevalence of thrombophilia in Korean patients with an arterial thromboembolism (ATE) or a venous thromboembolism (VTE), and to evaluate the characteristic of VTE in patients with thrombophilia. METHODS: Hospital records of 294 patients (228 with VTE, 66 with ATE) including two foreign ones (mean age, 51.4 years) who underwent thrombophilia testing between August 2006 and March 2015 were reviewed retrospectively. In general, such screening was performed according to the guidelines of the international consensus statement for VTE...
June 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27096232/thrombophilia-testing-results-in-patients-with-a-first-venous-thromboembolic-event-should-the-selection-criteria-for-testing-be-revisited
#9
Jana Hirmerova, Jitka Seidlerova, Ivan Subrt, Jitka Slechtova
BACKGROUND: After the first episode of venous thromboembolism (VTE), the guidelines recommend selective thrombophilia testing and suggest not to test the patients older than 40 years with a provoked event and all patients above 60. METHODS: We compared thrombophilia workup results in 544 patients, meeting or not meeting the selection criteria. Homozygous factor V Leiden or prothrombin gene mutation, natural anticoagulant deficiencies, antiphospholipid syndrome or combination of ≥2 disorders were considered a strong thrombophilia...
April 14, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27039249/pregnancy-loss-french-clinical-practice-guidelines
#10
EDITORIAL
C Huchon, X Deffieux, G Beucher, P Capmas, X Carcopino, N Costedoat-Chalumeau, A Delabaere, V Gallot, E Iraola, V Lavoue, G Legendre, V Lejeune-Saada, J Leveque, S Nedellec, J Nizard, T Quibel, D Subtil, F Vialard, D Lemery
In intrauterine pregnancies of uncertain viability with a gestational sac without a yolk sac (with a mean of three orthogonal transvaginal ultrasound measurements <25mm), the suspected pregnancy loss should only be confirmed after a follow-up scan at least 14 days later shows no embryo with cardiac activity (Grade C). In intrauterine pregnancies of uncertain viability with an embryo <7mm on transvaginal ultrasound, the suspected pregnancy loss should only be confirmed after a follow-up scan at least 7 days later (Grade C)...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26972733/the-wound-burn-guidelines-4-guidelines-for-the-management-of-skin-ulcers-associated-with-connective-tissue-disease-vasculitis
#11
Manabu Fujimoto, Yoshihide Asano, Takayuki Ishii, Fumihide Ogawa, Tamihiro Kawakami, Masanari Kodera, Masatoshi Abe, Taiki Isei, Takaaki Ito, Yuji Inoue, Shinichi Imafuku, Ryokichi Irisawa, Masaki Ohtsuka, Mikio Ohtsuka, Takafumi Kadono, Masakazu Kawaguchi, Ryuichi Kukino, Takeshi Kono, Keisuke Sakai, Masakazu Takahara, Miki Tanioka, Takeshi Nakanishi, Yasuhiro Nakamura, Akira Hashimoto, Minoru Hasegawa, Masahiro Hayashi, Hiroshi Fujiwara, Takeo Maekawa, Koma Matsuo, Naoki Madokoro, Osamu Yamasaki, Yuichiro Yoshino, Andres Le Pavoux, Takao Tachibana, Hironobu Ihn
The Japanese Dermatological Association prepared guidelines focused on the treatment of skin ulcers associated with connective tissue disease/vasculitis practical in clinical settings of dermatological care. Skin ulcers associated with connective tissue diseases or vasculitis occur on the background of a wide variety of diseases including, typically, systemic sclerosis but also systemic lupus erythematosus (SLE), dermatomyositis, rheumatoid arthritis (RA), various vasculitides and antiphospholipid antibody syndrome (APS)...
July 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/26927441/treatment-of-catastrophic-antiphospholipid-syndrome
#12
Nayef M Kazzaz, W Joseph McCune, Jason S Knight
PURPOSE OF REVIEW: Catastrophic antiphospholipid syndrome (CAPS) is a severe manifestation of antiphospholipid syndrome (APS). Although affecting only 1% of patients with APS, the condition is frequently fatal if not recognized and treated early. Here, we will review the current approach to diagnosis and treatment of CAPS. RECENT FINDINGS: Data from the international 'CAPS registry', spearheaded by the European Forum on Antiphospholipid Antibodies, have improved our understanding of at-risk patients, typical clinical features, and precipitating diagnoses...
May 2016: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/26899776/-prevention-of-infections-in-adults-and-adolescents-with-systemic-lupus-erythematosus-guidelines-for-the-clinical-practice-based-on-the-literature-and-expert-opinion
#13
A Mathian, L Arnaud, D Adoue, C Agard, B Bader-Meunier, V Baudouin, C Belizna, B Bonnotte, F Boumedine, A Chaib, M Chauchard, L Chiche, E Daugas, A Ghali, P Gobert, G Gondran, G Guettrot-Imbert, E Hachulla, M Hamidou, J Haroche, B Hervier, A Hummel, N Jourde-Chiche, A-S Korganow, T Kwon, V Le Guern, A Le Quellec, N Limal, N Magy-Bertrand, P Marianetti-Guingel, T Martin, N Martin Silva, O Meyer, M Miyara, S Morell-Dubois, J Ninet, J-L Pennaforte, K Polomat, J Pourrat, V Queyrel, I Raymond, P Remy, K Sacre, J Sibilia, J-F Viallard, A Viau Brabant, T Hanslik, Z Amoura
PURPOSE: To develop French recommendations about the management of vaccinations, the screening of cervical cancer and the prevention of pneumocystis pneumonia in systemic lupus erythematosus (SLE). METHODS: Thirty-seven experts qualified in internal medicine, rheumatology, dermatology, nephrology and pediatrics have selected recommendations from a list of proposition based on available data from the literature. For each recommendation, the level of evidence and the level of agreement among the experts were specified...
May 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/26868300/emergency-situations-in-rheumatology-with-a-focus-on-systemic-autoimmune-diseases
#14
Jiri Vymetal, Martina Skacelova, Andrea Smrzova, Anna Klicova, Marketa Schubertova, Pavel Horak, Josef Zadrazil
BACKGROUND AND AIM: Rheumatic diseases are commonly considered chronic conditions. However, acute manifestations can be very severe and represent a diagnostic problem. Examples are systemic lupus erythematosus with acute flare, glomerulonephritis, CNS disorders and catastrophic antiphospholipid syndrome, scleroderma with interstitial lung disease, pulmonary hypertension and renal crisis and polyangiitis with alveolar haemorhage and acute respiratory failure. This aim of this paper is to overview emergency situations which can be encountered in the care of patients with autoimmune systemic diseases and vasculitides...
March 2016: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/26847159/analytical-and-clinical-comparison-of-different-immunoassay-systems-for-the-detection-of-antiphospholipid-antibodies
#15
B Montaruli, E De Luna, L Erroi, C Marchese, G Mengozzi, P Napoli, C Nicolo', A Romito, M T Bertero, P Sivera, M Migliardi
INTRODUCTION: We evaluated analytical and clinical performances of IgG and IgM anticardiolipin (aCL) antibodies and anti-β2-glycoprotein I (a-β2GpI) antibodies and upper limit reference ranges (99th percentiles) in comparison with manufacturer's cutoff values with different commercial methods. METHODS: We assayed aCL and a-β2GpI in serum samples from 30 healthy individuals, 77 patients with antiphospholipid syndrome (APS) diagnosed according to the Sydney criteria, 51 patients with autoimmune diseases, eight patients with previous thrombotic events, six patients with other diseases, and 18 patients with infectious diseases, using ELISA Inova Diagnostics; EliA Phadia Laboratory Systems; CliA Zenit-RA; and CliA Bio-Flash...
April 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/26568591/optimal-monitoring-for-coronary-heart-disease-risk-in-patients-with-systemic-lupus-erythematosus-a-systematic-review
#16
REVIEW
Konstantinos Tselios, Barry J Sheane, Dafna D Gladman, Murray B Urowitz
OBJECTIVE: Premature coronary heart disease (CHD) significantly affects morbidity and mortality in systemic lupus erythematosus (SLE). Several studies have detected factors influencing the atherosclerotic process, as well as methods to quantify the atherosclerotic burden in subclinical stages. The aim of this systematic review was to identify the minimum investigations to optimally monitor CHD risk in SLE. METHODS: English-restricted literature review was performed using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines through Ovid Medline, Embase, and Cochrane Central databases, from inception until May 2014 (Medline until October 2014)...
January 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/26559249/antithrombotic-treatment-for-recurrent-miscarriage-bayesian-network-meta-analysis-and-systematic-review
#17
REVIEW
Tianyi Zhang, Xiaofei Ye, Tiantian Zhu, Xiang Xiao, Yuzhou Liu, Xin Wei, Yu Liu, Cheng Wu, Rui Guan, Xiao Li, Xiaojing Guo, Huili Hu, Jia He
Combined use of heparin and aspirin is frequently prescribed for treatment of recurrent miscarriage (RM) in patients with antiphospholipid syndrome (APS), or in those without apparent cause of RM other than thrombophilia; however, this strategy is largely based on expert opinion and has not been well studied. The option for the use of different antithrombotic therapies to improve live birth remains unclear. In this network meta-analysis, we incorporated direct and indirect evidence to evaluate effects of different antithrombotic treatments on prevention of pregnancy losses...
November 2015: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26527025/-postnatal-visit-routine-and-particularity-after-complicated-pregnancy-guidelines-for-clinical-practice
#18
REVIEW
M Doret
OBJECTIVES: To propose guidelines for clinical practice for routine postnatal visit and after pathological pregnancies. MATERIALS AND METHODS: Bibliographic searches were performed with PubMed and Cochrane databases, and within international guidelines references. RESULTS: Postpartum visit should be planned 6 to 8 weeks after delivery and can be performed by an obstetrician, a gynecologist, a general practitioner or a midwife, when after normal pregnancy and delivery (Professional consensus)...
December 2015: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
https://www.readbyqxmd.com/read/26343213/lipoprotein-a-its-relevance-to-the-pediatric-population
#19
REVIEW
Catherine J McNeal
Lipoprotein(a) (Lp(a)) is a highly atherogenic and heterogeneous lipoprotein that is inherited in an autosomal codominant trait. A unique aspect of this lipoprotein is that it is fully expressed by the first or second year of life in children, a pattern that is distinctly different from other lipoproteins, which typically only reach adult levels after adolescence. Despite decades of research, Lp(a) metabolism is still poorly understood but what is abundantly clear is that it is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD)...
September 2015: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26307097/diagnosis-and-therapy-of-antiphospholipid-syndrome
#20
Vittorio Pengo, Gentian Denas, Seena J Padayattil, Giacomo Zoppellaro, Elisa Bison, Alessandra Banzato, Ariela Hoxha, Amelia Ruffatti
Antiphospholipid syndrome (APS) is a clinical condition that has not been well defined yet. Although the clinical component is well established, the laboratory part is a mood issue. According to current guidelines, 3 tests (lupus anticoagulant, anticardiolipin, and anti β2-glycoprotein I antibodies) are officially recommended to assess the presence of antiphospholipid antibodies. According to test positivity, patients are classified into categories in clinical studies. However, it is now clear that classification categories have a different impact on the clinical course of APS...
2015: Polskie Archiwum Medycyny Wewnętrznej
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