Megumi Sasatani, Yang Xi, Kazuhiro Daino, Atsuko Ishikawa, Yuji Masuda, Junko Kajimura, Jinlian Piao, Elena Karamfilova Zaharieva, Hiroaki Honda, Guanyu Zhou, Kanya Hamasaki, Yoichiro Kusunoki, Tsutomu Shimura, Shizuko Kakinuma, Yoshiya Shimada, Kazutaka Doi, Tomoko Ishikawa-Fujiwara, Yusuke Sotomaru, Kenji Kamiya
Rev1 has two important functions in the translesion synthesis pathway, including dCMP transferase activity, and acts as a scaffolding protein for other polymerases involved in translesion synthesis. However, the role of Rev1 in mutagenesis and tumorigenesis in vivo remains unclear. We previously generated Rev1-overexpressing (Rev1-Tg) mice and reported that they exhibited a significantly increased incidence of intestinal adenoma and thymic lymphoma (TL) after N-methyl-N-nitrosourea (MNU) treatment. In this study, we investigated mutagenesis of MNU-induced TL tumorigenesis in wild-type (WT) and Rev1-Tg mice using diverse approaches, including whole-exome sequencing (WES)...
April 4, 2024: Cancer Science