William R Parry Smith, Argyro Papadopoulou, Eleanor Thomas, Aurelio Tobias, Malcolm J Price, Shireen Meher, Zarko Alfirevic, Andrew D Weeks, G Justus Hofmeyr, Ahmet Metin Gülmezoglu, Mariana Widmer, Olufemi T Oladapo, Joshua P Vogel, Fernando Althabe, Arri Coomarasamy, Ioannis D Gallos
BACKGROUND: Postpartum haemorrhage (PPH), defined as a blood loss of 500 mL or more after birth, is the leading cause of maternal death worldwide. The World Health Organization (WHO) recommends that all women giving birth should receive a prophylactic uterotonic agent. Despite the routine administration of a uterotonic agent for prevention, PPH remains a common complication causing one-quarter of all maternal deaths globally. When prevention fails and PPH occurs, further administration of uterotonic agents as 'first-line' treatment is recommended...
November 24, 2020: Cochrane Database of Systematic Reviews