keyword
https://read.qxmd.com/read/38474178/sindbis-virus-vaccine-platform-a-promising-oncolytic-virus-mediated-approach-for-ovarian-cancer-treatment
#21
REVIEW
Christine Pampeno, Silvana Opp, Alicia Hurtado, Daniel Meruelo
This review article provides a comprehensive overview of a novel Sindbis virus vaccine platform as potential immunotherapy for ovarian cancer patients. Ovarian cancer is the most lethal of all gynecological malignancies. The majority of high-grade serous ovarian cancer (HGSOC) patients are diagnosed with advanced disease. Current treatment options are very aggressive and limited, resulting in tumor recurrences and 50-60% patient mortality within 5 years. The unique properties of armed oncolytic Sindbis virus vectors (SV) in vivo have garnered significant interest in recent years to potently target and treat ovarian cancer...
March 2, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473208/molecular-metabolic-and-subcellular-mapping-of-the-tumor-immune-microenvironment-via-3d-targeted-and-non-targeted-multiplex-multi-omics-analyses
#22
JOURNAL ARTICLE
Sammy Ferri-Borgogno, Jared K Burks, Erin H Seeley, Trevor D McKee, Danielle L Stolley, Akshay V Basi, Javier A Gomez, Basant T Gamal, Shamini Ayyadhury, Barrett C Lawson, Melinda S Yates, Michael J Birrer, Karen H Lu, Samuel C Mok
Most platforms used for the molecular reconstruction of the tumor-immune microenvironment (TIME) of a solid tumor fail to explore the spatial context of the three-dimensional (3D) space of the tumor at a single-cell resolution, and thus lack information about cell-cell or cell-extracellular matrix (ECM) interactions. To address this issue, a pipeline which integrated multiplex spatially resolved multi-omics platforms was developed to identify crosstalk signaling networks among various cell types and the ECM in the 3D TIME of two FFPE (formalin-fixed paraffin embedded) gynecologic tumor samples...
February 20, 2024: Cancers
https://read.qxmd.com/read/38473019/optimizing-palliative-pelvic-radiotherapy-in-gynecological-cancers-a-systematic-review-and-analysis
#23
REVIEW
Beatrice Anghel, Mihai-Teodor Georgescu, Crenguta Sorina Serboiu, Andreea Nicoleta Marinescu, Cătălin Aliuș, Dragoș-Eugen Georgescu, Bogdan Mocanu, Sabina Sucuri, Anca Daniela Stanescu
BACKGROUND: Palliative radiotherapy plays a crucial role in managing symptomatic gynecological cancers (GCs). This article aims to systematically review literature studies on palliative pelvic radiotherapy in cervical, endometrial, ovarian, vaginal, and vulvar cancers. The primary focus is centered around evaluating symptom relief, quality of life (QOL), and toxicity in order to ascertain optimal radiotherapy regimens. METHODOLOGY: For this thorough review, we mainly relied on Medline to gather papers published until November 2023...
March 5, 2024: Diagnostics
https://read.qxmd.com/read/38472736/comprehensive-young-age-breast-cancer-registry-from-clinical-genomics-and-patient-reported-outcomes-measured-with-15%C3%A2-years-follow-up-the-charm-cohort-profile
#24
JOURNAL ARTICLE
Danbee Kang, Seri Park, Hyo Jung Kim, Jiseon Lee, Jiyoon Han, Seok Won Kim, Jeong Eon Lee, Jonghan Yu, Se Kyung Lee, Ji-Yeon Kim, Seok Jin Nam, Juhee Cho, Yeon Hee Park
BACKGROUND: In recognition of the distinct clinical challenges and research gaps in young breast cancer (YBC) patients, we established the Comprehensive Young Age Breast Cancer (CHARM) registry to collect prospective data. METHODS: This prospective cohort included patients who were newly diagnosed with histologically confirmed breast cancer without prior treatment at the Samsung Medical Center (SMC) in April 2013. We included patients who were either 40 years old or younger at the time of diagnosis, pregnant at breast cancer diagnosis or diagnosed with breast cancer within 1 year of delivery...
March 12, 2024: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/38472567/circulating-tumor-dna-ctdna-and-its-role-in-gynecologic-malignancies
#25
REVIEW
Tali Pomerantz, Rebecca Brooks
Circulating tumor DNA (ctDNA) refers to small fragments of DNA released into the bloodstream by cancer cells. It is obtained through "liquid biopsy;" which most commonly refers to plasma or blood samples, but can be obtained from a number of bodily fluids including ascitic fluid, saliva, and even urine and stool. ctDNA is detected via polymerase chain reaction (PCR) or next-generation sequencing (NGS). The DNA from these samples is analyzed for the detection of point mutations, copy-number alterations, gene fusion, and DNA methylation...
March 12, 2024: Current Treatment Options in Oncology
https://read.qxmd.com/read/38471676/intraepithelial-tumor-infiltrating-lymphocytes-shape-loco-regional-pet-ct-spread-of-locally-advanced-cervical-cancer
#26
JOURNAL ARTICLE
Mathilde Del, Claire Illac, Mathilde Morisseau, Martina Aida Angeles, Anne Ducassou, Sarah Betrian, Guillaume Bataillon, Gwenael Ferron, Elodie Chantalat, Erwan Gabiache, Alejandra Martinez
BACKGROUND: Data suggest an association between positron emission tomography/CT (PET/CT) metabolic metrics and tumor microenvironment in several malignancies, and a potential role of PET/CT to monitor response to immunotherapy. OBJECTIVE: To evaluate the correlation between tumor loco-regional extension and tumor-infiltrating lymphocyte infiltration in locally advanced cervical cancer prior to concurrent chemo-radiotherapy.The secondary objective was to assess the association between tumor-infiltrating lymphocytes and PET/CT metabolic metrics...
March 12, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38471508/phase-1b-study-of-intraperitoneal-ipilimumab-and-nivolumab-in-patients-with-recurrent-gynecologic-malignancies-with-peritoneal-carcinomatosis
#27
JOURNAL ARTICLE
Anne Knisely, Emily Hinchcliff, Bryan Fellman, Ann Mosley, Kathryn Lito, Sara Hull, Shannon N Westin, Anil K Sood, Kathleen M Schmeler, Jolyn S Taylor, Steven Y Huang, Rahul A Sheth, Karen H Lu, Amir A Jazaeri
BACKGROUND: Intravenous immune checkpoint blockade (ICB) has shown poor response rates in recurrent gynecologic malignancies. Intraperitoneal (i.p.) ICB may result in enhanced T cell activation and anti-tumor immunity. METHODS: In this phase 1b study, registered at Clinical. TRIALS: gov (NCT03508570), initial cohorts received i.p. nivolumab monotherapy, and subsequent cohorts received combination i.p. nivolumab every 2 weeks and i...
March 7, 2024: Med
https://read.qxmd.com/read/38471464/can-endometrial-cytology-identify-patients-who-would-benefit-from-immunotherapy
#28
JOURNAL ARTICLE
Shintaro Yanazume, Yukari Kirita, Yusuke Kobayashi, Ikumi Kitazono, Toshiaki Akahane, Mika Mizuno, Shinichi Togami, Akihide Tanimoto, Hiroaki Kobayashi
INTRODUCTION: Patients with POLE (polymerase epsilon) mutation (POLEmut)-subtype, MMR-deficient (MMR-d)-subtype as classified by the Cancer Genome Atlas (TCGA), and a high tumor mutation burden (TMB-high) potentially benefit from immunotherapy. However, characteristics of the cytological morphology within these populations remain unknown. METHODS: DNA extracted from formalin fixed paraffin embedded tissues was subjected to next-generation sequencing analysis. Genomic mutations related to gynecological cancers, TMB, and microsatellite instability (MSI) were analyzed and were placed in four TCGA classification types...
March 12, 2024: Acta Cytologica
https://read.qxmd.com/read/38469132/successful-fertility-preservation-in-stage-ii-endometrial-carcinoma-with-long-term-progestin-therapy-a-case-report
#29
Yuki Kashihara, Kentaro Sekiyama, Akiko Abe, Akitoshi Yamamura, Yuki Kozono, Akiko Okuda, Yumiko Yoshioka, Toshihiro Higuchi
Progestin therapy is a fertility-sparing treatment option for well-differentiated stage IA endometrioid carcinomas without myometrial invasion. Here, we present a case of successful pregnancy and live birth following long-term progestin therapy in a patient with stage II well-differentiated endometrioid carcinoma. A 30-year-old nulliparous woman with an unremarkable medical history presented with abnormal uterine bleeding. A 45 mm mass was identified in the lower uterine segment. An endometrial biopsy revealed grade 1 endometrioid carcinoma, leading to a diagnosis of stage II uterine corpus cancer based on hysteroscopic findings...
April 2024: Gynecologic Oncology Reports
https://read.qxmd.com/read/38461424/investigating-the-mechanisms-of-drug-resistance-and-prognosis-in-ovarian-cancer-using-single-cell-rna-sequencing-and-bulk-rna-sequencing
#30
JOURNAL ARTICLE
Pengfei Liu, Jinbao Liu, Jinxing Liu, Xiao Yu
Ovarian cancer stands as a prevalent malignancy within the realm of gynecology, and the emergence of resistance to chemotherapeutic agents remains a pivotal impediment to both prognosis and treatment. Through a single-cell level investigation, we scrutinize the drug resistance and mitotic activity of the core tumor cells in ovarian cancer. Our study revisits the interrelationships and temporal trajectories of distinct epithelial cells (EPCs) subpopulations, while identifying genes associated with ovarian cancer prognosis...
March 8, 2024: Aging
https://read.qxmd.com/read/38460968/outcomes-of-patients-with-early-stage-mucinous-ovarian-carcinoma-a-dutch-population-based-cohort-study-comparing-expansile-and-infiltrative-subtypes
#31
JOURNAL ARTICLE
Marc Daniël Algera, Koen K Van de Vijver, Willemien J van Driel, Brigitte F M Slangen, Fabienne C Lof, Maaike van der Aa, R F P M Kruitwagen, Christianne A R Lok
OBJECTIVE: This study aimed to assess the outcomes of patients with early stage mucinous ovarian carcinoma based on subtype (expansile vs infiltrative). METHODS: We retrospectively analyzed all surgically treated patients with mucinous ovarian carcinoma in the Netherlands (2015-2020), using data from national registries. Subtypes were determined, with any ambiguities resolved by a dedicated gynecologic pathologist. Patients with International Federation of Gynecology and Obstetrics (FIGO) stage I were categorized into full staging, fertility-sparing, or partial stagings...
March 9, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38459419/quality-of-life-after-extended-pelvic-surgery-with-neurovascular-or-bony-resections-in-gynecological-oncology-a-systematic-review
#32
JOURNAL ARTICLE
Andreas Denys, Sofie Thielemans, Rawand Salihi, Philippe Tummers, Gabrielle H van Ramshorst
BACKGROUND: Extended pelvic surgery with neurovascular or bony resections in gynecological oncology has significant impact on quality of life (QoL) and high morbidity. The objective of this systematic review was to provide an overview of QoL, morbidity and mortality following these procedures. METHODS: The registered PROSPERO protocol included database-specific search strategies. Studies from 1966 onwards reporting on QoL after extended pelvic surgery with neurovascular or bony resections for gynecological cancer were considered eligible...
March 8, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38459390/transcriptome-analysis-reveals-the-clinical-significance-of-cxcl13-in-pan-gyn-tumors
#33
JOURNAL ARTICLE
Yue Ding, Quan Zhou, Bo Ding, Yang Zhang, Yang Shen
BACKGROUND: Gynecologic and breast tumors (Pan-Gyn) exhibit similar characteristics, and the role of CXCL13 in anti-tumor immunity and it's potential as a biomarker for immune checkpoint blockade (ICB) therapy have been gradually revealed. However, the precise role of CXCL13 in Pan-Gyn remains unclear, lacking a systematic analysis. METHODS: We analyzed 2497 Pan-Gyn samples from the TCGA database, categorizing them into high and low CXCL13 expression groups. Validation was conducted using tumor expression datasets sourced from the GEO database...
March 9, 2024: Journal of Cancer Research and Clinical Oncology
https://read.qxmd.com/read/38458026/circ_0001495-influences-the-development-of-endometriosis-through-the-mirna-34c-5p-e2f3-axis
#34
JOURNAL ARTICLE
Yan Yue, Bin Lu, Guantai Ni
Endometriosis is a chronic gynecological condition characterized by the presence of endometrial glands and stroma outside the uterine cavity., accounting for 7% of all female malignant tumors and 20%- 30% of malignant tumors of the female reproductive system. Multiple studies have shown that circular RNA (circRNA) has the potential to become a targeted target and marker for EM. However, the roles of circ_0001495 in EM are still unclear. Our research aims to reveal the molecular mechanism of circ_0001495 in EM...
March 7, 2024: Reproductive Biology
https://read.qxmd.com/read/38457565/association-between-the-quantitative-characteristics-of-dual-energy-spectral-ct-and-cytoreduction-surgery-outcome-in-patients-with-advanced-epithelial-ovarian-cancers-a-prospective-observational-study
#35
JOURNAL ARTICLE
Xiaojuan Xu, Yan Chen, Xinxin Zhang, Yilin Wang
This study aimed to explore the association between the quantitative characteristics of dual-energy spectral CT and cytoreduction surgery outcome in patients with advanced epithelial ovarian carcinoma (EOC). In this prospective observational study, patients with advanced EOC (federation of gynecology and obstetrics stage III-IV) treated in the Department of Gynecological Oncology at our Hospital between June 2021 and March 2022 were enrolled. All participants underwent dual-energy spectral computed tomography (DECT) scanning 2 weeks before cytoreductive surgery...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456660/phase-1-2-study-of-combined-bcl-xl-and-mek-inhibition-with-navitoclax-and-trametinib-in-kras-or-nras-mutant-advanced-solid-tumors
#36
JOURNAL ARTICLE
Ryan B Corcoran, Khanh T Do, Jeong E Kim, James M Cleary, Aparna R Parikh, Oladapo O Yeku, Niya Xiong, Colin D Weekes, Jennifer Veneris, Leanne G Ahronian, Gianluca Mauri, Jun Tian, Bryanna L Norden, Alexa G Michel, Emily E Van Seventer, Giulia Siravegna, Kyle Camphausen, Gary Chi, Isobel J Fetter, Joan S Brugge, Helen X Chen, Naoko Takebe, Richard T Penson, Dejan Juric, Keith T Flaherty, Ryan J Sullivan, Jeffrey W Clark, Rebecca S Heist, Ursula A Matulonis, Joyce F Liu, Geoffrey I Shapiro
PURPOSE: MEK inhibitors (MEKi) lack monotherapy efficacy in most RAS-mutant cancers. BCL-xL is an anti-apoptotic protein identified by a synthetic lethal shRNA screen as a key suppressor of apoptotic response to MEKi. PATIENTS AND METHODS: We conducted a dose escalation study (NCT02079740) of the BCL-xL inhibitor navitoclax and MEKi trametinib in patients with RAS-mutant tumors with expansion cohorts for: pancreatic, gynecologic (GYN), non-small cell lung cancer (NSCLC), and other cancers harboring KRAS/NRAS mutations...
March 8, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38456590/cdk1-promotes-the-phosphorylation-of-kifc1-to-regulate-the-tumorgenicity-of-endometrial-carcinoma
#37
JOURNAL ARTICLE
Xi Lin, Yingying He, Yiming Liu, Huihao Zhou, Xiaomin Xu, Jingui Xu, Kening Zhou
OBJECTIVE: This study aims to clarify the mechanical action of cyclin-dependent protein kinase 1 (CDK1) in the development of endometrial carcinoma (EMCA), which may be associated with the phosphorylation of kinesin family member C1 (KIFC1) and further activate the PI3K/AKT pathway. METHODS: The protein and gene expression of CDK1 in EMCA tissues and tumor cell lines were evaluated by western blot, quantitative polymerase chain reaction, and immunohistochemistry staining...
February 26, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38456588/tet3-mediated-dna-demethylation-modification-activates-shp2-expression-to-promote-endometrial-cancer-progression-through-the-egfr-erk-pathway
#38
JOURNAL ARTICLE
Fen Xue, Lifen Liu, Xueqiang Tao, Weipei Zhu
OBJECTIVE: Src homology phosphotyrosin phosphatase 2 (SHP2) has been implicated in the progression of several cancer types. However, its function in endometrial cancer (EC) remains unclear. Here, we report that the ten-eleven translocation 3 (TET3)-mediated DNA demethylation modification is responsible for the oncogenic role of SHP2 in EC and explore the detailed mechanism. METHODS: The transcriptomic differences between EC tissues and control tissues were analyzed using bioinformatics tools, followed by protein-protein interaction network establishment...
February 29, 2024: Journal of Gynecologic Oncology
https://read.qxmd.com/read/38455819/utility-of-ct-scan-in-detecting-bladder-involvement-among-patients-with-cervical-carcinoma
#39
JOURNAL ARTICLE
Rajni Agrawal, Ritika Agarwal
Background Cervical cancer is a widespread health issue in India, particularly affecting women as the second most common cancer. The burden of cervical cancer in the country necessitates accurate staging for treatment optimization. The revised International Federation of Gynecology and Obstetrics (FIGO) staging system is vital for this purpose, emphasizing the extent of parametrial and pelvic sidewall involvement. Cervical cancer's propensity to infiltrate neighboring pelvic organs, including the bladder, necessitates precise staging...
February 2024: Curēus
https://read.qxmd.com/read/38455810/unraveling-the-enigma-a-case-report-on-unilateral-ovarian-dermoid-cyst
#40
H S Deeksha, Sandhya Pajai, Dharmesh J Patel, Vinayak U Navalihiremath, Garapati Jyotsna
Mature teratomas, also known as ovarian dermoid cysts, are benign embryonal tumors that develop slowly. One of the following imaging techniques is commonly employed to evaluate these cysts: transvaginal ultrasound, pelvic ultrasonography, magnetic resonance imaging, or computed tomography. The two surgical methods most frequently used for removing persistent or very large cysts are laparoscopy and laparotomy. A 42-year-old female, who is P3L1D2 with a history of previous cesarean section, presented with an abdominal mass that had been gradually increasing in size over the past five months...
February 2024: Curēus
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