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Anita Bhansali, Michael Musacchio, Noam Stadlan
Cervical disc arthroplasty (CDA) has emerged as a popular alternative to anterior cervical discectomy and fusion (ACDF) for the surgical treatment of cervical degenerative disc disease. CDA has been well studied, with efficacy reported to be equivalent to or better than that seen with ACDF, and it is associated with a consistently low incidence of adverse events. The development or progression of myelopathy after CDA is a particularly rare occurrence. In this report, the authors describe the first known case of recurrence of myelopathy at the index level of surgery after CDA implantation due the continuation of the spondylitic process after placement of the artificial disc...
May 2018: Journal of Neurosurgery. Spine
M K Ahsan, N Sakeb
Out of wide range of surgical techniques direct repair techniques are emphasized to avoid fusion related complications in pars defects. To assess the clinical, functional and radiological outcome of direct operative repair of pars defects by intra-laminar screws and bone graft, this retrospective study was done in Bangabandhu Sheikh Mujib Medical University and in our private settings, within the period of July 2005 to December 2012. Records of 12 patients (age range, 21-35 years) with symptomatic pars defect, 07 men and 05 women (mean 28 years) who underwent direct pars repair with intralaminar screws and bone graft were reviewed...
July 2015: Mymensingh Medical Journal: MMJ
Alexander I Evins, Matei A Banu, Innocent Njoku, Eric H Elowitz, Roger Härtl, Antonio Bernado, Christoph P Hofstetter
Foraminal stenosis frequently causes radiculopathy in lumbar degenerative spondylosis. Endoscopic transforaminal techniques allow for foraminal access with minimal tissue disruption. However, the effectiveness of foraminal decompression by endoscopic techniques has yet to be studied. We evaluate radiographic outcome of endoscopic transforaminal foraminotomies performed at L3-L4, L4-L5, and L5-S1 on cadaveric specimens. Before and after the procedures, three dimensional CT scans were obtained to measure foraminal height and area...
April 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Kaveh Khajavi, Alessandria Shen
INTRODUCTION: Many options for interbody spacer and graft biologic exist for multilevel anterior cervical discectomy and fusion (ACDF). The objective of this study is to evaluate the safety and efficacy of a bioabsorbable cervical spacer (BCS) (Cornerstone HSR, Medtronic Sofamor Danek) filled with low-dose rhBMP-2 (INFUSE, Medtronic Sofamor Danek) in multilevel ACDF. METHODS: 72 consecutive patients treated with a multi-level ACDF using BCS and rhBMP-2 (dosage between 0...
2014: International Journal of Spine Surgery
Henry Aitchison, Petrus Poolman, Marilette Coetzer, Caron Griffiths, Johan Jacobs, Mignon Meyer, Shahn Bisschop
Infections in broilers and broiler breeders by Enterococcus cecorum, causing clinical disease, have increasingly been described in various countries in the Northern Hemisphere over the past decade. This case report describes an outbreak of enterococcal-associated vertebral osteoarthritis (EVOA) in male broiler breeders in several flocks in South Africa. Male birds aged 4 and 9 weeks displayed the common presentation of lameness, paresis or complete paralysis. Autopsies of culled birds revealed masses on caudal thoracic vertebrae T5-T7, with vertebral osteomyelitis and spondylitis...
2014: Journal of the South African Veterinary Association
Rao Kommu, B P Sahu, A K Purohit
OBJECTIVE: Ossification of the posterior longitudinal ligament (OPLL) is a complex multi-factorial disease process having both metabolic and biomechanical factors. The role of surgical intervention as well as the choice of approach weather anterior or posterior is ambiguous. The objective of this study was to assess the surgical out come and post operative functional improvement in patients with cervical OPLL at a tertiary care centre. PATIENTS AND METHODS: This prospective study included 63 patients of cervical OPLL who underwent either anterior and/or posterior surgeries in Department of Neurosurgery, Nizam's Institute of Medical Sciences, Hyderabad between June 2009 to May 2011...
October 2014: Asian Journal of Neurosurgery
A Keat
The aetiology of ankylosing spondylitis involves some genetic predisposition: the disease occurs mainly in males, and many spondylitics have the HLA-827 antigen. However, the correlation with known genetic factors is not absolute. For example, not all identical twin siblings of spondylitics develop the disease. In this review Andrew Keat discusses the genetic and environmental factors which may contribute to the development of spondylitis.
May 1986: Immunology Today
Tom Edward Ngo Lo, Mary Lareine V Que, Michael L Tee
Psoriatic arthritis is a seronegative arthropathy occurring in the presence of psoriasis. In majority of cases, typical psoriatic skin lesions precede joint disease, making diagnosis of psoriatic arthritis without typical skin lesions, a diagnostic challenge. Nail lesions are commonly seen in patients affected by this condition, making it a useful clue in the diagnosis of psoriatic arthritis. This is a case of a 58-year-old Filipino woman presenting with sudden acute urinary retention and weakness of both lower extremities accompanied with active polyarthritis...
April 30, 2014: BMJ Case Reports
Rubén Queiro, Patricia Tejón, Sara Alonso, Pablo Coto, Carlos López-Larrea, Jesús Martínez-Borra, Segundo González
With the aim of clarifying the role of several polymorphisms around the HLA-C locus in the clinical expression of PsA, the distribution of several polymorphic markers and genes located around the HLA-C locus was analyzed in a well-established cohort of 110 patients with PsA, 50 patients with psoriasis alone, and 110 healthy controls. The frequency of these genes was also analyzed by PsA articular models, based on three main subgroups: oligoarthritis, polyarthritis, and spondylitis. Distal interphalangeal joint (DIP) involvement was associated with the presence of MICB-CA20 (OR 6...
2014: ISRN Dermatology
Michael T Koltz, Christopher M Maulucci, Charles A Sansur, D Kojo Hamilton
BACKGROUND: The authors present a case to illustrate the necessity and technical feasibility of C7 laminar screw placement for treatment of sub-axial cervical spondylitic myelopathy. The indications for C7 lateral mass screw placement was required internal fixation, with small lateral masses (8 mm) and pedicles (4 mm). CASE DESCRIPTION: A 67-year-old female with compressive myelopathy after a fall from standing is presented. Magnetic resonance (MR) imaging of the cervical spine showed severe C3-6 spondylosis with canal and foraminal compromise...
2014: Surgical Neurology International
P Kyebambe, R Kasyaba, S Nkakyekorera
No abstract text is available yet for this article.
September 2012: African Health Sciences
John C Kelly, Patrick J Groarke, Joseph S Butler, Ashley R Poynton, John M O'Byrne
Cervical spondylosis is a broad term which describes the age related chronic disc degeneration, which can also affect the cervical vertebrae, the facet and other joints and their associated soft tissue supports. Evidence of spondylitic change is frequently found in many asymptomatic adults. Radiculopathy is a result of intervertebral foramina narrowing. Narrowing of the spinal canal can result in spinal cord compression, ultimately resulting in cervical spondylosis myelopathy. This review article examines the current literature in relation to the cervical spondylosis and describes the three clinical syndromes of axial neck pain, cervical radiculopathy and cervical myelopathy...
2012: Advances in Orthopedics
Steven W Forbush, Terry Cox, Eric Wilson
STUDY DESIGN: Retrospective clinical case series. OBJECTIVE: To describe the management of 10 patients with advanced cervical spondyloarthrosis with radiculopathy, using manual therapy, intermittent mechanical cervical traction, and home exercises. BACKGROUND: Predictors and short-term outcomes of cervical radiculopathy have been published. These predictors have not been developed for, or applied to, geriatric patients with spondylitic radiculopathy...
October 2011: Journal of Orthopaedic and Sports Physical Therapy
J Gratacós
Extra-articular manifestations can be defined as all symptoms and signs etiopathogenically related, at least in part, to ankylosing spondylitis (AS) that arise in the various organs and tissues of the locomotor apparatus. Thus, ocular, intestinal and cardiac manifestations, which are common to all spondylarthritides through their association with HLA-B27, are grouped under this heading. Complications include clinical manifestations that result from persistent spondylitic activity and/or treatment. Table 1 provides a list and the main characteristics of these manifestations...
June 2005: Reumatología Clinica
Elaine C Campbell, Franziska Fettke, Smita Bhat, Kenneth D Morley, Simon J Powis
The human leucocyte antigen HLA-B27 is strongly associated with ankylosing spondylitis, a form of seronegative inflammatory arthritis. In this study aspects related to several hypothesized mechanisms of disease pathogenesis have been investigated. Blood monocyte-derived dendritic cells (DC) from a small patient cohort of 29 patients with ankylosing spondylitis and one with reactive arthritis, were compared with DC from 34 healthy control subjects, of whom four were found to be HLA-B27 positive. The ability of HLA-B27 to form heavy-chain dimers reactive with monoclonal antibody HC10 was tested, along with the induction of endoplasmic reticulum (ER) stress, assessed by splicing xbp1 mRNA and immunoblotting of Immunoglobulin Binding Protein (BiP)...
July 2011: Immunology
Patrick A Sugrue, Jamal McClendon, Ryan J Halpin, John C Liu, Tyler R Koski, Aruna Ganju
OBJECT: Ossification of the posterior longitudinal ligament (OPLL) is a complex multifactorial disease process combining both metabolic and biomechanical factors. The role for surgical intervention and choice of anterior or posterior approach is controversial. The object of this study was to review the literature and present a single-institution experience with surgical intervention for OPLL. METHODS: The authors performed a retrospective review of their institutional experience with surgical intervention for cervical OPLL...
March 2011: Neurosurgical Focus
Yan Zeng, Zhong-qiang Chen, Zhao-qing Guo, Qiang Qi, Chui-guo Sun, Wei-shi Li
OBJECTIVE: To evaluate the clinical outcomes of posterior surgical corrective methods for ankylosing spondylitic kyphosis. METHODS: From June 2003 to June 2008, 21 cases of ankylosing spondylitic kyphosis received posterior surgical correction. There were 17 male and 4 female, and the average age was 39.5 years (range, 20 to 57 years). The total spine X-ray and CT were used to evaluate sagittal balance and thoracolumbar spine kyphosis angle, and chin brow-vertical angle was obtained from clinical lateral photograph...
August 15, 2010: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Gülsüm Emel Pamuk, Omer Nuri Pamuk, Hüseyin Orüm, Ozer Arican, Burhan Turgut, Muzaffer Demir
We evaluated platelet and endothelial activation parameters in psoriatic arthritis (PsA), a disease reported to be associated with the development of endothelial dysfunction and increased atherosclerotic complications. Twenty patients with PsA, eight psoriasis and 20 healthy controls were included into the study. The patients' clinical features and acute phase parameters were assessed. In all patients and controls, platelet-monocyte complexes (PMC), platelet-neutrophil complexes (PNC), and basal and ADP-stimulated P-selectin expression were determined with flow cytometry; soluble E-selectin (sE-selectin) and soluble CD40L (sCD40L) were determined with ELISA...
November 2009: Platelets
Andrew Keat
No abstract text is available yet for this article.
November 2009: Rheumatology
N Dhingra, J Morgan, A D Dick
PURPOSE: To observe whether switching between biological agents helps to gain or maintain uveitis remission in cases with sight-threatening refractory uveitis. METHODS: We reviewed the case notes of seven patients with refractory uveitis, who had switched between biological agents. The switch between biological agents (infliximab or adalimumab) was for gaining control of systemic symptoms, uveitis, or for the ease of administration. RESULTS: There were three adults (one each with sarcoidosis, ankylosing spondylites, and sero-negative polyarthropathy) and four children with juvenile idiopathic arthritis...
September 2009: Eye
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