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https://www.readbyqxmd.com/read/29898828/spinal-dural-arteriovenous-fistula-delay-to-radiological-diagnosis-and-sources-of-radiological-error
#1
R Hunt, R M Roberts, A M Mortimer
AIM: To highlight the magnetic resonance imaging (MRI) signs associated with spinal dural arteriovenous fistula (SDAVF) through categorisation of sources of radiological error and investigation of the delay to radiological diagnosis. MATERIAL AND METHODS: This was a retrospective, observational study of cases referred to a neuroscience centre over 11 years. All patients who underwent spinal digital subtraction angiography (DSA) with a subsequent diagnosis of SDAVF were identified...
June 10, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29880637/quantifying-syringeal-dynamics-in-vitro-using-electroglottography
#2
Jeppe H Rasmussen, Christian T Herbst, Coen P H Elemans
The complex and elaborate vocalizations uttered by many of the 10,000 extant bird species are considered a major driver in their evolutionary success, warranting study of the underlying mechanisms of vocal production. Additionally, birdsong has developed into a highly productive model system for vocal imitation learning and motor control, where, in contrast to humans, we have experimental access to the entire neuromechanical control loop. In human voice production, complex laryngeal geometry, vocal fold tissue properties, airflow and laryngeal musculature all interact to ultimately control vocal fold kinematics...
June 7, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29795089/-treatment-of-patients-with-ossifying-arachnoiditis-and-progressive-syringomyelia-analysis-of-three-cases-and-a-literature-review
#3
A A Zuev, D S Epifanov
To date, only 12 cases of ossifying arachnoiditis with concomitant syringomyelia have been reported in the world literature. In this article, we presented our experience of treating three patients with syringomyelia associated with ossifying arachnoiditis. OBJECTIVE: based on the literature data and our own experience, we tried to define the most optimal treatment approach for this disease. MATERIAL AND METHODS: We analyzed the data of 15 patients (12 cases reported in the literature and 3 our own cases)...
2018: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
https://www.readbyqxmd.com/read/29784434/cell-therapy-with-autologous-mesenchymal-stromal-cells-in-post-traumatic-syringomyelia
#4
Jesús Vaquero, Mercedes Zurita, Miguel A Rico, Concepcion Aguayo, Cecilia Fernandez, Gregorio Rodriguez-Boto, Esperanza Marin, Noemi Tapiador, Marta Sevilla, Joaquin Carballido, David Vazquez, Damian Garcia-Olmo, Hector Guadalajara, Miguel Leon, Ignacio Valverde
BACKGROUND AIMS: Recently, clinical studies show that cell therapy with mesenchymal stromal cells (MSCs) improves the sequelae chronically established in paraplegic patients, being necessary to know which of them can obtain better benefit. METHODS: We present here a phase 2 clinical trial that includes six paraplegic patients with post-traumatic syringomyelia who received 300 million MSCs inside the syrinx and who were followed up for 6 months. Clinical scales, urodynamic, neurophysiological, magnetic resonance (MR) and studies of ano-rectal manometry were performed to assess possible improvements...
May 18, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29734193/spontaneous-resolution-of-chiari-1-associated-syringomyelia-a-report-of-two-cases
#5
R Ramnarayan, C V Shankar Ganesh, Ramesh Kumar
BACKGROUND: Traditional teaching is that Chiari 1 malformations with syrinx should be operated as soon as possible. We present 2 cases of a radiologically proven Chiari 1 malformation with syrinx which were treated nonoperatively and improved radiologically. METHODS: Two children with an MRI-proven Chiari 1 malformations were followed up nonoperatively for 7 years (2010-2017). One was a boy aged 8 years and the other a girl aged 9 years at first presentation. Their parents were not interested in a surgical option and so it was decided to adopt a wait-and-watch policy...
May 7, 2018: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29721352/dorsal-hemangioblastoma-manifesting-as-holocord-syringomyelia
#6
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind K Srivastava, Anita Jagetia, Atul Agrawal
Background: Intramedullary spinal hemangioblastomas are known to be accompanied by syringomyelia. Case Description: Here, we report a patient who presented with symptoms of a Chiari malformation but was found to have a D4 intramedullary hemangioblastoma with a holocord syrinx. Conclusions: Although rare, neurosurgeons should keep in mind the possibility of an intramedullary hemangioblastoma in patients presenting with symptoms of a Chiari malformation...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29688076/case-report-development-of-syringomyelia-after-anatomically-successful-craniovertebral-decompression-for-chiari-i-malformation-without-syrinx
#7
Joshua Pepper, Graham Flint
An 18 year old female with headaches and radiologically confirmed Chiari I malformation, without syringomyelia, underwent an anatomically and clinically successful craniovertebral decompression. Five years later she returned with extensive syringomyelia. This was treated successfully by division of an arachnoid web at the foramen of Magendie.
April 24, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29679614/the-regulation-of-birdsong-by-testosterone-multiple-time-scales-and-multiple-sites-of-action
#8
REVIEW
Beau A Alward, Charlotte A Cornil, Jacques Balthazart, Gregory F Ball
Sex steroid hormones act during early development to shape the circuitry upon which these same hormones act in adulthood to control behavioral responses to various stimuli. The "organizational" vs. "activational" distinction was proposed to explain this temporal difference in hormone action. In both of these cases steroids were thought to act genomically over a time-scale of days to weeks. However, sex steroids can affect behavior over short (e.g., seconds or minutes) time-scales. Here, we discuss how testosterone controls birdsong via actions at different sites and over different time-scales, with an emphasis on this process in canaries (Serinus canaria)...
April 23, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29675990/intracranial-administration-of-the-g-protein-coupled-estrogen-receptor-1-antagonist-g-15-selectively-affects-dimorphic-characteristics-of-the-song-system-in-zebra-finches-taeniopygia-guttata
#9
Mahtab Attarhaie Tehrani, Sean L Veney
In zebra finches (Taeniopygia guttata), estradiol contributes to sexual differentiation of the song system but the receptor(s) underlying its action are not exactly known. Whereas mRNA and/or protein for nuclear estrogen receptors ERα and ERβ are minimally expressed, G-protein coupled estrogen receptor 1 (GPER1) has a much greater distribution within neural song regions and the syrinx. At present, however, it is unclear if this receptor contributes to dimorphic development of the song system. To test this, the specific GPER1 antagonist, G-15, was intracranially administered to zebra finches for 25 days beginning on the day of hatching...
April 20, 2018: Developmental Neurobiology
https://www.readbyqxmd.com/read/29675087/chari-1-malformation-with-scoliosis-and-holocord-syringomyelia-a-rare-association
#10
Raja K Kutty, B S SunilKumar, Anilkumar Peethambaran
Syringomyelia and scoliosis are not uncommon phenomena in the spectrum of Chiari malformations. However, the presence of holocord syrinx in association with Chiari 1 malformation is quite rare.
October 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29652242/chiari-decompression-outcomes-using-ligamentum-nuchae-harvest-and-duraplasty-in-pediatric-patients-with-chiari-malformation-type-i
#11
Michael J Cools, Carolyn S Quinsey, Scott W Elton
OBJECTIVE The choice of graft material for duraplasty in decompressions of Chiari malformations remains a matter of debate. The authors present a detailed technique for harvesting ligamenta nuchae, as well as the clinical and radiographic outcomes of this technique, in a case series. METHODS The authors conducted a retrospective study evaluating the outcomes of Chiari malformation type I decompression and duraplasty in children aged 0-18 years at a single institution from 2013 to 2016. They collected both intraoperative and postoperative variables and compared them qualitatively to published data...
April 13, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29618081/origin-of-syrinx-fluid-in-syringomyelia-a-physiological-study
#12
John D Heiss, Katie Jarvis, René K Smith, Eric Eskioglu, Mortimer Gierthmuehlen, Nicholas J Patronas, John A Butman, Davis P Argersinger, Russell R Lonser, Edward H Oldfield
BACKGROUND: The origin of syrinx fluid is controversial. OBJECTIVE: To elucidate the mechanisms of syringomyelia associated with cerebrospinal fluid pathway obstruction and with intramedullary tumors, contrast transport from the spinal subarachnoid space (SAS) to syrinx was evaluated in syringomyelia patients. METHODS: We prospectively studied patients with syringomyelia: 22 with Chiari I malformation and 16 with SAS obstruction-related syringomyelia before and 1 wk after surgery, and 9 with tumor-related syringomyelia before surgery only...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29610967/early-analysis-of-operative-management-of-chiari-i-malformation-in-pediatric-cystic-fibrosis-patients
#13
Derek C Samples, Dewey J Thoms, Izabela Tarasiewicz
INTRODUCTION: Chiari I malformation, defined as herniation of the cerebellar tonsils at least 5 mm below the foramen magnum, can result from congenital or acquired pathology. While the mechanism is not well understood, an association between Chiari I and cystic fibrosis has been described in the literature. The lifelong respiratory status management necessitated by cystic fibrosis creates a greater risk of Chiari symptomatology as well as post-operative CSF-related complications in the setting of duraplasty secondary to recurrent transient increases in intracranial pressure...
April 2, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29605278/rare-case-of-diffuse-spinal-arachnoiditis-following-a-complicated-vertebral-artery-dissection
#14
Elias Atallah, Sophia Dang, Sage Rahm, James Feghali, Chalouhi Nohra, Stavropoula Tjoumakaris, Robert H Rosenwasser, Hekmat Zarzour, Nabeel Herial, Michael Reid Gooch, Pascal Jabbour
Spinal arachnoiditis (SA) is an extremely rare and delayed complication of subarachnoid hemorrhage (SAH). Little is known about its underlying pathogenesis and subsequent clinical course. A middle-aged patient presented with the worst headache of her life and a grade 3 SAH of the basal-cisterns and posterior fossa was identified on Computed Tomography scans (CT). Angiography revealed a ruptured dissecting aneurysm of the left vertebral artery (VA-V4), as well as an unruptured left Anterior Cerebral Artery (ACA-A1) aneurysm...
June 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29588484/neurosurgical-untethering-with-or-without-syrinx-drainage-results-in-high-patient-satisfaction-and-favorable-clinical-outcome-in-post-traumatic-myelopathy-patients
#15
Ulrika Holmström, Parmenion P Tsitsopoulos, Hjalmar Flygt, Anders Holtz, Niklas Marklund
STUDY DESIGN: Retrospective data collection and patient-reported outcome measures. OBJECTIVES: To investigate surgical outcome, complications, and patient satisfaction in patients with chronic SCI and symptomatic post-traumatic progressive myelopathy (PPM) who underwent neurosurgical untethering and/or spinal cord cyst drainage with the aim of preventing further neurological deterioration. SETTING: Single-center study at an academic neurosurgery department...
March 27, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29566674/a-genome-wide-association-study-identifies-candidate-loci-associated-to-syringomyelia-secondary-to-chiari-like-malformation-in-cavalier-king-charles-spaniels
#16
Frédéric Ancot, Philippe Lemay, Susan P Knowler, Karen Kennedy, Sandra Griffiths, Giunio Bruto Cherubini, Jane Sykes, Paul J J Mandigers, Guy A Rouleau, Clare Rusbridge, Zoha Kibar
BACKGROUND: Syringomyelia (SM) is a common condition affecting brachycephalic toy breed dogs and is characterized by the development of fluid-filled cavities within the spinal cord. It is often concurrent with a complex developmental malformation of the skull and craniocervical vertebrae called Chiari-like malformation (CM) characterized by a conformational change and overcrowding of the brain and cervical spinal cord particularly at the craniocervical junction. CM and SM have a polygenic mode of inheritance with variable penetrance...
March 22, 2018: BMC Genetics
https://www.readbyqxmd.com/read/29550415/rhythmic-neck-muscle-spasms-and-upper-limb-muscle-myoclonic-jerks-as-an-unusual-initial-presentation-of-posttraumatic-cervicothoracic-syringomyelia-a-case-report
#17
Hsin-Chin Lin, Yu-Lin Tsai, Wen-Chung Tsai
No abstract text is available yet for this article.
March 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29532167/dandy-walker-malformation-and-syringomyelia-a-rare-association
#18
Valentina Baro, Renzo Manara, Luca Denaro, Domenico d'Avella
PURPOSE: Dandy-Walker malformation is a rare condition due to imperforation of the Blake's pouch during intrauterine brain development, usually leading to early severe hydrocephalus. The association with holocord syringomyelia is rare, and from the Gardner's first report in 1957, only 23 cases have been described, mostly from autopsy series and pre-MRI period. Besides a worsening of clinical picture, its occurrence generates some concern about the best surgical treatment that varies widely among the literature reports...
March 12, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29532166/international-survey-on-the-management-of-chiari-1-malformation-and-syringomyelia-evolving-worldwide-opinions
#19
Ash Singhal, Alexander Cheong, Paul Steinbok
INTRODUCTION: In 2003, pediatric neurosurgeons were surveyed under the auspices of the education committee of the International Society for Pediatric Neurosurgery (ISPN) to determine prevailing opinions regarding the management of Chiari I malformation (C1M) with and without associated syringomyelia. In the ensuing years, there has been further information from multiple C1M studies, with regards to indications, success rates of different surgical interventions, and complications. The purpose of this study was to re-evaluate current opinions and practices in pediatric C1M...
March 12, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29523203/computer-simulation-of-syringomyelia-in-dogs
#20
Srdjan Cirovic, Robert Lloyd, Jelena Jovanovik, Holger A Volk, Clare Rusbridge
BACKGROUND: Syringomyelia is a pathological condition in which fluid-filled cavities (syringes) form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the craniocervical junction and a Chiari malformation, which is similar in both humans and animals. Some brachycephalic toy breed dogs such as Cavalier King Charles Spaniels (CKCS) are particularly predisposed. The exact mechanism of the formation of syringomyelia is undetermined and consequently with the lack of clinical explanation, engineers and mathematicians have resorted to computer models to identify possible physical mechanisms that can lead to syringes...
March 9, 2018: BMC Veterinary Research
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