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https://www.readbyqxmd.com/read/29472893/late-onset-puberty-induction-by-transdermal-estrogen-in-turner-syndrome-girls-a-longitudinal-study
#1
Aneta Monika Gawlik, Magdalena Hankus, Kamila Szeliga, Aleksandra Antosz, Tomasz Gawlik, Kamil Soltysik, Agnieszka Drosdzol-Cop, Krzysztof Wilk, Grzegorz Kudela, Tomasz Koszutski, Ewa Malecka-Tendera
Objective: Estrogen replacement therapy (ERT) for Turner syndrome (TS) is a widely discussed topic; however, the optimal model of ERT for patients with delayed diagnosis and/or initiation of therapy is still unclear, mainly due to insufficient data. We present the results of a prospective observational single-center study in which the efficacy of late-onset puberty induction by one-regimen transdermal ERT in TS girls was evaluated. Methods: The analysis encompassed 49 TS girls (63...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29472355/use-of-thrombin-generation-assay-to-personalize-treatment-of-breakthrough-bleeds-in-a-patient-with-hemophilia-and-inhibitors-receiving-prophylaxis-with-emicizumab
#2
Yesim Dargaud, Anne Lienhart, Maissaa Janbain, Sandra LeQuellec, Nathalie Enjolras, Claude Negrier
Emicizumab is a recombinant, humanized, bispecific, monoclonal antibody that bridges activated factor IX and factor X to restore the function of deficient factor VIII. Treatment of bleeding in patients with hemophilia and inhibitors involves the use of bypassing agents (BPA).These molecules are also used for the management of breakthrough bleeds in patients on prophylaxis with emicizumab, with increased concerns about the risks of combining two procoagulant drugs. Using thrombin generation assay, we tailored the dosage of activated prothrombin complex concentrate (APCC) and successfully treated an acute spontaneous arterial bleeding in a patient on prophylaxis with emicizumab 1...
February 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29471676/results-and-challenges-of-immune-checkpoint-inhibitors-in-colorectal-cancer
#3
Sheik Emambux, Gaelle Tachon, Audelaure Junca, David Tougeron
Introduction Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and clinical outcome has improved substantially during the last two decades with targeted therapies. The immune system has a major role in cancers, especially the CD8+ T cells specific to tumor antigens. However, tumors can escape immune response by different mechanisms including upregulation of inhibitory immune checkpoint receptors, such as well-known Programmed cell Death protein-1 (PD-1)/Programmed cell Death Ligand 1 (PD-L1) interaction, leading CD8+ T cells to a state of anergy...
February 22, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29471633/benchmarks-and-breakthroughs
#4
Michael J Sailor
No abstract text is available yet for this article.
February 23, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29471432/effectiveness-of-seven-and-thirteen-valent-pneumococcal-conjugate-vaccines-in-a-schedule-without-a-booster-dose-a-ten-year-observational-study
#5
Sanjay Jayasinghe, Clayton Chiu, Helen Quinn, Rob Menzies, Robin Gilmour, Peter McIntyre
Background: Uniquely among high income countries, Australia uses a 3+0 schedule (3 primary doses; no booster) for infant pneumococcal conjugate vaccine since January 2005, initially 7-valent (PCV7) then 13-valent (PCV13) from July 2011. We measured vaccine effectiveness (VE) of both PCVs against invasive pneumococcal disease (IPD) by two methods. Method: Cases were IPD notifications to national surveillance system in children eligible for respective PCVs. For the case-control method, up to ten age-matched controls were derived from Australian Childhood Immunisation Register...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29471037/butyrophilins-and-%C3%AE-%C3%AE-t-cell-recognition
#6
REVIEW
Siyi Gu, Marta Borowska, Christopher T Boughter, Erin J Adams
Despite playing critical roles in the immune response and having significant potential in immunotherapy, γδ T cells have garnered little of the limelight. One major reason for this paradox is that their antigen recognition mechanisms are largely unknown, limiting our understanding of their biology and our potential to modulate their activity. One of the best-studied γδ subsets is the human Vγ9Vδ2 T cell population, which predominates in peripheral blood and can combat both microbial infections and cancers...
February 19, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29470801/episodic-breathlessness-in-patients-with-advanced-cancer-characteristics-and-management
#7
REVIEW
Sebastiano Mercadante
The aim of this review is to present the way in which episodic breathlessness (EB) has been recognized over the years, with regard to definition, characteristics, and management of these acute episodes that have serious consequences for patients. EB is characterized by a sudden increase in intensity of dyspnea over a short duration of time, leading to high levels of anxiety. A significant aggravation of dyspnea may occur in patients with a background of dyspnea or intermittently even without basal breathlessness...
February 22, 2018: Drugs
https://www.readbyqxmd.com/read/29470756/study-on-transport-and-transformation-of-contaminant-through-layered-soil-with-large-deformation
#8
Chuang Yu, Junfeng Liu, Jianjun Ma, Xiaoniu Yu
Based on large-deformation consolidation theory and the advection-dispersion equation of contaminant in saturated porous media, a one-dimensional theoretical model for coupled large-deformation and solute transport through layered finite soil is presented. This model comprehensively takes the effect of soil weight, sorption, and biodegradation into account. Model validation and applications are achieved through case studies of double-layered finite soil, with the transport and transformation process of contaminant being reproduced numerically...
February 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29470639/arabinogalactan-proteins-and-their-sugar-chains-functions-in-plant-reproduction-research-methods-and-biosynthesis
#9
REVIEW
Shihao Su, Tetsuya Higashiyama
The arabinogalactan protein (AGP) family is one of the most complex protein families and is ubiquitous in the plant kingdom. Moreover, it has been demonstrated to play various roles during plant reproduction. A typical AGP contains a hydroxyproline-rich core protein with high heterogeneity and varying numbers of polysaccharide side chains. However, the functions of the polysaccharide components (i.e. AG sugar chains) remain largely unknown due to the general difficulties associated with studying sugar chains in glycobiology...
February 22, 2018: Plant Reproduction
https://www.readbyqxmd.com/read/29470193/breakthrough-reactions-to-gadobenate-dimeglumine
#10
Zeeshaan S Bhatti, Benjamin M Mervak, Jonathan R Dillman, Matthew S Davenport
PURPOSE: The aim of this study was to determine the severity of breakthrough reactions to gadobenate dimeglumine in patients premedicated with a 13-hour premedication regimen. METHODS: Institutional review board approval was obtained and informed consent waived for this Health Insurance Portability and Accountability Act-compliant retrospective cohort study. All acute allergic-like reactions to gadobenate dimeglumine from 11/1/2008 to 1/31/2016 were identified. Of these, 19 allergic-like reactions followed 13-hour premedication: 150 mg prednisone and 50 mg diphenhydramine (ie, "breakthrough reactions")...
February 21, 2018: Investigative Radiology
https://www.readbyqxmd.com/read/29467605/challenges-for-alzheimer-s-disease-therapy-insights-from-novel-mechanisms-beyond-memory-defects
#11
REVIEW
Rudimar L Frozza, Mychael V Lourenco, Fernanda G De Felice
Alzheimer's disease (AD), the most common form of dementia in late life, will become even more prevalent by midcentury, constituting a major global health concern with huge implications for individuals and society. Despite scientific breakthroughs during the past decades that have expanded our knowledge on the cellular and molecular bases of AD, therapies that effectively halt disease progression are still lacking, and focused efforts are needed to address this public health challenge. Because AD is classically recognized as a disease of memory, studies have mainly focused on investigating memory-associated brain defects...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29465253/-nanocrystal-a-novel-approach-to-overcome-skin-barriers-for-improved-topical-drug-delivery
#12
Viral Patel, Om Prakash Sharma, Tejal Mehta
Skin is an important route of drug delivery for the treatment of various dermatological conditions. The advent of nanotechnology is paving the roadmaps for topical drug delivery by providing sustained release as well as maintaining a localized effect, outweighing the toxicity concern. Area Covered: This review highlighted the morphology of skin, its barrier nature as well as drug penetration pathways after topical application of formulations. The existing methods to improve topical drug delivery, by infringing or permeating the skin barriers, are discussed...
February 21, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29464590/methods-for-the-effective-study-of-collective-behavior-in-a-radial-arm-maze
#13
Johann Delcourt, Noam Y Miller, Iain D Couzin, Simon Garnier
Collective behaviors are observed throughout nature, from bacterial colonies to human societies. Important theoretical breakthroughs have recently been made in understanding why animals produce group behaviors and how they coordinate their activities, build collective structures, and make decisions. However, standardized experimental methods to test these findings have been lacking. Notably, easily and unambiguously determining the membership of a group and the responses of an individual within that group is still a challenge...
February 20, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29464397/mining-protein-evolution-for-insights-into-mechanisms-of-voltage-dependent-sodium-channel-auxiliary-subunits
#14
Steven Molinarolo, Daniele Granata, Vincenzo Carnevale, Christopher A Ahern
Voltage-gated sodium channel (VGSC) beta (β) subunits have been called the "overachieving" auxiliary ion channel subunit. Indeed, these subunits regulate the trafficking of the sodium channel complex at the plasma membrane and simultaneously tune the voltage-dependent properties of the pore-forming alpha-subunit. It is now known that VGSC β-subunits are capable of similar modulation of multiple isoforms of related voltage-gated potassium channels, suggesting that their abilities extend into the broader voltage-gated channels...
February 21, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29463914/oxidation-stable-amine-containing-adsorbents-for-carbon-dioxide-capture
#15
Kyungmin Min, Woosung Choi, Chaehoon Kim, Minkee Choi
Amine-containing solids have been investigated as promising adsorbents for CO2 capture, but the low oxidative stability of amines has been the biggest hurdle for their practical applications. Here, we developed an extra-stable adsorbent by combining two strategies. First, poly(ethyleneimine) (PEI) was functionalized with 1,2-epoxybutane, which generates tethered 2-hydroxybutyl groups. Second, chelators were pre-supported onto a silica support to poison p.p.m.-level metal impurities (Fe and Cu) that catalyse amine oxidation...
February 20, 2018: Nature Communications
https://www.readbyqxmd.com/read/29461039/dark-classics-in-chemical-neuroscience-lysergic-acid-diethylamide-lsd
#16
David E Nichols
LSD is one of the most potent psychoactive agents known, producing dramatic alterations of consciousness after submilligram (≥20 g) oral doses. Following the accidental discovery of its potent psychoactive effects in 1943, it was supplied by Sandoz Laboratories as an experimental drug that might be useful as an adjunct for psychotherapy, or to give psychiatrists insight into the mental processes in their patients. The finding of serotonin in the mammalian brain in 1953, and its structural resemblance to LSD, quickly led to ideas that serotonin in the brain might be involved in mental illness, initiating rapid research interest in the neurochemistry of serotonin...
February 20, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29459471/gender-sex-as-a-social-determinant-of-cardiovascular-risk
#17
REVIEW
Adrienne O'Neil, Anna J Scovelle, Allison J Milner, Anne Kavanagh
The social gradient for cardiovascular disease (CVD) onset and outcomes is well established. The American Heart Association's Social Determinants of Risk and Outcomes of Cardiovascular Disease Scientific Statement advocates looking beyond breakthroughs in biological science toward a social determinants approach that focuses on socioeconomic position, race and ethnicity, social support, culture and access to medical care, and residential environments to curb the burden of CVD going forward. Indeed, the benefits of this approach are likely to be far reaching, enhancing the positive effects of advances in CVD related to prevention and treatment while reducing health inequities that contribute to CVD onset and outcomes...
February 20, 2018: Circulation
https://www.readbyqxmd.com/read/29458960/challenging-standard-of-care-paradigms-in-the-precision-oncology-era
#18
REVIEW
Vivek Subbiah, Razelle Kurzrock
The pace of genomic and immunological breakthroughs in oncology is accelerating, making it likely that large randomized trials will increasingly become outdated before their completion. Traditional clinical research/practice paradigms must adapt to the reality unveiled by genomics, especially the need for customized drug combinations, rather than one-size-fits-all monotherapy. The raison-d'être of precision oncology is to offer 'the right drug for the right patient at the right time', a process enabled by transformative tissue and blood-based genomic technologies...
February 2018: Trends in Cancer
https://www.readbyqxmd.com/read/29458790/non-pharmacological-interventions-and-non-fentanyl-pharmacological-treatments-for-breakthrough-cancer-pain-a-systematic-and-critical-review
#19
REVIEW
Sebastiano Mercadante
BACKGROUND: Oral opioids or other pharmacological or non-pharmacological interventions are often suggested in the management of breakthrough cancer pain (BTcP). The aim of this systematic and critical review was to analyse and critically comment the evidence of any non-fentanyl therapies proposed for BTcP. METHODS: A systematic literature search was carried out to find studies providing clinical data on any treatment excluding fentanyl products. RESULTS: No data exist about the use of oral opioids...
February 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29458758/determining-the-rad51-dna-nucleoprotein-filament-structure-and-function-by-cryo-electron-microscopy
#20
Lingyun Zhao, Jingfei Xu, Weixing Zhao, Patrick Sung, Hong-Wei Wang
Homologous recombination is a universal tool for DNA double-strand break and replication fork repair, and it is catalyzed by a highly conserved family of recombinases. In eukaryotes, Rad51 is the recombinase that catalyzes the pairing of homologous DNA molecules and the exchange of strands between the paired molecules. Rad51 assembles on single-stranded DNA (ssDNA) stemming from lesion processing to form a right-handed helical polymer that engages then samples double-stranded DNA (dsDNA) for homology. Upon matching with a homologous sequence, the Rad51-bound ssDNA invades the dsDNA, leading to the formation of a DNA joint with concomitant displacement of the strand of like polarity...
2018: Methods in Enzymology
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