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https://www.readbyqxmd.com/read/29227986/bcl-2-on-the-brink-of-breakthroughs-in-cancer-treatment
#1
EDITORIAL
John C Reed
No abstract text is available yet for this article.
January 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29226594/selective-surface-enhanced-raman-scattering-for-quantitative-detection-of-lung-cancer-biomarkers-in-superparticle-mof-structure
#2
Xuezhi Qiao, Bensheng Su, Cong Liu, Qian Song, Dan Luo, Guang Mo, Tie Wang
Surface enhanced Raman scattering (SERS) is a trace detection technique that extends even to single molecule detection. Its potential application to the noninvasive recognition of lung malignancies by detecting volatile organic compounds (VOCs) that serve as biomarkers would be a breakthrough in early cancer diagnostics. This application, however, is currently limited by two main factors: (1) most VOC biomarkers exhibit only weak Raman scattering; and (2) the high mobility of gaseous molecules results in a low adsorptivity on solid substrates...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29226554/controllable-solid-electrolyte-interphase-in-nickel-rich-cathodes-by-an-electrochemical-rearrangement-for-stable-lithium-ion-batteries
#3
Junhyeok Kim, Jieun Lee, Hyunsoo Ma, Hu Young Jeong, Hyungyeon Cha, Hyomyung Lee, Youngshin Yoo, Minjoon Park, Jaephil Cho
The layered nickel-rich materials have attracted extensive attention as a promising cathode candidate for high-energy density lithium-ion batteries (LIBs). However, they have been suffering from inherent structural and electrochemical degradation including severe capacity loss at high electrode loading density (>3.0 g cm-3 ) and high temperature cycling (>60 °C). In this study, an effective and viable way of creating an artificial solid-electrolyte interphase (SEI) layer on the cathode surface by a simple, one-step approach is reported...
December 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29226545/nitrous-oxide-oxygen-mixture-for-analgesia-in-adult-cancer-patients-with-breakthrough-pain-a-randomized-double-blind-controlled-trial
#4
Q Liu, L-L Gao, Y-L Dai, Y-X Li, Y Wang, C-F Bai, G-X Mu, X-M Chai, W-J Han, L-J Zhou, Y-J Zhang, L Tang, J Liu, J-Q Yu
BACKGROUND: The aim of this study was to assess the efficacy of a fixed nitrous oxide/oxygen mixture for the management of breakthrough cancer pain. METHODS/DESIGN: A double-blind, placebo-controlled, randomized clinical trial was undertaken in the Medical ward of Tumor Hospital of General Hospital of Ningxia Medical University. 240 cancer patients with breakthrough pain were recruited and randomly received a standard pain treatment (morphine sulphate immediate release) plus a pre-prepared nitrous oxide/oxygen mixture, or the standard pain treatment plus oxygen...
December 11, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29226313/model-based-assessments-of-cyp-mediated-drug-drug-interaction-risk-of-alectinib-physiologically-based-pharmacokinetic-modeling-supported-clinical-development
#5
Yumi Cleary, Michael Gertz, Peter N Morcos, Li Yu, Kuresh Youdim, Alex Phipps, Stephen Fowler, Neil Parrott
Alectinib is a selective anaplastic lymphoma kinase (ALK) inhibitor approved for the treatment of ALK-positive non-small cell lung cancer. Alectinib and its major active metabolite M4 exhibited drug-drug interaction (DDI) potential through cytochrome P450 (CYP) enzymes CYP3A4 and CYP2C8 in vitro. Clinical relevance of the DDI risk was investigated as part of a rapid development program to fulfil the breakthrough therapy designation. Therefore, a strategy with a combination of physiologically based pharmacokinetic (PBPK) modeling and limited clinical trials focused on generating informative data for modeling was taken to ensure extrapolation ability of DDI risk...
December 11, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29225707/how-to-evaluate-the-immune-status-of-lung-cancer-patients-before-immunotherapy
#6
Joanna Domagala-Kulawik, Agata Raniszewska
Nowadays, cancer immunotherapy is a promising strategy in solid tumour treatment. It has become a breakthrough in achieving long-term survival in many advanced cases. The essence of modern immunotherapy is to improve the host antitumour immune defence. Currently, it is critically important to determine the biomarkers that could be helpful in planning this type of individual therapy. It has turned out that an important prognostic factor is the evaluation of inflammatory infiltration of the tumour mass, including the characteristics of populations of lymphocytes and macrophages, and the expression of suppressive and regulatory molecules...
December 2017: Breathe
https://www.readbyqxmd.com/read/29225557/toward-the-development-of-a-flexible-mesoscale-mri-compatible-neurosurgical-continuum-robot
#7
Yeongjin Kim, Shing Shin Cheng, Mahamadou Diakite, Rao P Gullapalli, J Marc Simard, Jaydev P Desai
Brain tumor, be it primary or metastatic, is usually life threatening for a person of any age. Primary surgical resection which is one of the most effective ways of treating brain tumors can have tremendously increased success rate if the appropriate imaging modality is used for complete tumor resection. Magnetic resonance imaging (MRI) is the imaging modality of choice for brain tumor imaging because of its excellent soft-tissue contrast. MRI combined with continuum soft robotics has immense potential to be the next major technological breakthrough in the field of brain cancer diagnosis and therapy...
December 2017: IEEE Transactions on Robotics: a Publication of the IEEE Robotics and Automation Society
https://www.readbyqxmd.com/read/29224962/incidence-of-invasive-pneumococcal-disease-before-and-during-an-era-of-use-of-three-different-pneumococcal-conjugate-vaccines-in-quebec
#8
Philippe De Wals, Brigitte Lefebvre, Geneviève Deceuninck, Jean Longtin
BACKGROUND: In Quebec, 7-valent (PCV7), 10-valent (PCV10) and 13-valent (PCV13) pneumococcal conjugate vaccines were successively used for the immunization of children according to a 2+1 doses schedule. OBJECTIVE: Our aim was to assess the impact of this program on the epidemiology of invasive pneumococcal disease (IPD) in children and adults. METHODS: Notification and laboratory surveillance data were analyzed and the immunization status of IPD cases in children was checked...
December 7, 2017: Vaccine
https://www.readbyqxmd.com/read/29224930/transport-of-dissolved-organic-matter-in-boom-clay-size-effects
#9
D Durce, M Aertsens, D Jacques, N Maes, M Van Gompel
A coupled experimental-modelling approach was developed to evaluate the effects of molecular weight (MW) of dissolved organic matter (DOM) on its transport through intact Boom Clay (BC) samples. Natural DOM was sampled in-situ in the BC layer. Transport was investigated with percolation experiments on 1.5cm BC samples by measuring the outflow MW distribution (MWD) by size exclusion chromatography (SEC). A one-dimensional reactive transport model was developed to account for retardation, diffusion and entrapment (attachment and/or straining) of DOM...
December 5, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29224698/sarcopenia
#10
REVIEW
Nicholas Fuggle, Sarah Shaw, Elaine Dennison, Cyrus Cooper
Sarcopenia is a condition that is characterized by loss of muscle mass, muscle strength and muscle functional impairment with ageing. The definition of sarcopenia has been through various permutations; however, an enormous recent breakthrough is the inclusion of the condition in the ICD-10 classification of diseases. This chapter covers the background issues regarding definition before describing the epidemiology of the disease according to human and environmental factors. It then provides a practical guide for the assessment of sarcopenia in a clinical setting and finishes with advice on present treatment and the exciting frontiers of future therapies...
April 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29223847/funding-breakthrough-therapies-a-systematic-review-and-recommendation
#11
REVIEW
E Hanna, M Toumi, C Dussart, B Borissov, O Dabbous, K Badora, P Auquier
BACKGROUND: Advanced therapy medicinal products (ATMPs) are innovative therapies likely associated with high prices. Payers need guidance to create a balance between ensuring patient access to breakthrough therapies and maintaining the financial sustainability of the healthcare system. OBJECTIVE: The aims of this study were to identify, define, classify and compare the approaches to funding high-cost medicines proposed in the literature, to analyze their appropriateness for ATMP funding and to suggest an optimal funding model for ATMPs...
December 2, 2017: Health Policy
https://www.readbyqxmd.com/read/29223589/breakthroughs-in-neuroactive-steroid-drug-discovery
#12
REVIEW
Maria-Jesus Blanco, Daniel La, Quinn Coughlin, Caitlin A Newman, Andrew M Griffin, Boyd L Harrison, Francesco G Salituro
Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABAA) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS), and there is growing evidence suggesting that dysregulation of neurosteroid production plays a role in numerous neurological disorders. The significant unmet medical need for treatment of CNS disorders has increased the interest for these types of compounds...
December 2, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29223368/transport-of-polymer-stabilized-nano-scale-zero-valent-iron-in-porous-media
#13
Pulin K Mondal, Paul D Furbacher, Ziteng Cui, Magdalena M Krol, Brent E Sleep
This study presents a set of laboratory-scale transport experiments and numerical simulations evaluating carboxymethyl cellulose (CMC) polymer stabilized nano-scale zero-valent iron (nZVI) transport. The experiments, performed in a glass-walled two-dimensional (2D) porous medium system, were conducted to identify the effects of water specific discharge and CMC concentration on nZVI transport and to produce data for model validation. The transport and movement of a tracer lissamine green B® (LGB) dye, CMC, and CMC-nZVI were evaluated through analysis of the breakthrough curves (BTCs) at the outlets, the time-lapsed images of the plume, and retained nZVI in the sandbox...
November 21, 2017: Journal of Contaminant Hydrology
https://www.readbyqxmd.com/read/29223010/pelvic-abscess-complicating-sigmoid-colon-perforation-by-migrating-intrauterine-device-a-case-report-and-review-of-the-literature
#14
Omar Toumi, Houssem Ammar, Abdessalem Ghdira, Amine Chhaidar, Wided Trimech, Rahul Gupta, Randa Salem, Jamel Saad, Ibtissem Korbi, Mohamed Nasr, Faouzi Noomen, Mondher Golli, Khadija Zouari
INTRODUCTION: Intrauterine devices (IUDs) are commonly used as a contraceptive method. However, they may cause rare but potentially serious complications such as migration through the uterine wall and gastrointestinal perforation. PRESENTATION OF CASE: We report a case of a 26-year woman, carrying an IUD for 2 years, who presented to the emergency with pelvic pain with breakthrough bleeding. Abdominal imaging revealed the presence of two devices the first of which was located in the uterine cavity and the other in the wall of the sigmoid colon associated with a 5-centimeter pelvic collection...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29220819/fluoride-removal-from-water-using-a-magnesia-pullulan-composite-in-a-continuous-fixed-bed-column
#15
Yuanyao Ye, Jing Yang, Wei Jiang, Jianxiong Kang, Ying Hu, Huu Hao Ngo, Wenshan Guo, Yiwen Liu
A magnesia-pullulan composite (MgOP) was previously shown to effectively remove fluoride from water. In the present study, a continuous fixed-bed column was used to examine the application of the composite at an industrial scale. The influencing parameters included bed mass (4.0, 6.0 and 8.0 g), influent flow rate (8, 16 and 32 mL/min), inlet fluoride concentration (5, 10 and 20 mg/L), reaction temperature (20, 30 and 40 °C), influent pH (4, 7 and 10) and other existing anions (HCO3-, SO42-, Cl- and NO3-), through which the breakthrough curves could be depicted for the experimental data analysis...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29220771/estimation-of-refueling-emissions-based-on-theoretical-model-and-effects-of-e10-fuel-on-refueling-and-evaporative-emissions-from-gasoline-cars
#16
Hiroyuki Yamada, Satoshi Inomata, Hiroshi Tanimoto, Hiroo Hata, Kenichi Tonokura
The effects of Reid vapor pressure (RVP) on refueling emissions and the effects of ethanol 10% (E10) fuel on refueling and evaporative emissions were observed using six cars and seven fuels. The results indicated that refueling emissions can be reproduced by a simple theoretical model in which fuel vapor in the empty space in the tank is pushed out by the refueling process. In this model, the vapor pressures of fuels can be estimated by the Clausius-Clapeyron equation as a function of temperature. We also evaluated E10 fuel in terms of refueling and evaporative emissions, excluding the effect of contamination of ethanol in the canister...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220126/can-the-retina-be-used-to-diagnose-and-plot-the-progression-of-alzheimer-s-disease
#17
REVIEW
Deepti Mahajan, Marcela Votruba
Alzheimer's disease (AD) is a neurodegenerative disease and the most common cause of senile dementia. It impairs the quality of life of a person and their family, posing a serious economic and social threat in developed countries. The fact that the diagnosis can only be definitively made post-mortem, or when the disease is fairly advanced, presents a serious problem if novel therapeutic interventions are to be devised and used early in the course of the disease. There is therefore a pressing need for more sensitive and specific diagnostic tests with which we can detect AD in the preclinical stage...
December 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29220110/non-responsiveness-and-susceptibility-of-opioids-side-effects-related-to-cancer-patients-clinical-characteristics-a-post-hoc-analysis
#18
Oscar Corli, Anna Roberto, Michael I Bennett, Francesca Galli, Nicole Corsi, Eliana Rulli, Raffaella Antonione
BACKGROUND: Response to opioids is not always positive in cancer patients. A considerable proportion of patients do not respond (non-responders, NRs) or experience severe toxicity. The aim of this analysis was to assess the role of demographic characteristics, pain features, comorbidities and ongoing therapy on the lack of efficacy and on the occurrence of severe adverse drug reactions (ADRs). METHODS: This is a post-hoc analysis of a randomized controlled trial that involved 520 patients and was aimed to evaluate the efficacy and safety of four strong opioids...
December 8, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29218560/a-successful-combination-coupling-se-hplc-with-saxs
#19
Javier Pérez, Patrice Vachette
A monodispersed and ideal solution is a central (unique?) requirement of SAXS to allow one to extract structural information from the recorded pattern. On-line Size Exclusion Chromatography (SEC) marked a major breakthrough, separating particles present in solution according to their size. Identical frames under an elution peak can be averaged and further processed free from contamination. However, this is not always straightforward, separation is often incomplete and software have been developed to deconvolve the contributions from the different species (molecules or oligomeric forms) within the sample...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29218389/primary-prophylaxis-of-invasive-fungal-infections-in-patients-with-haematological-malignancies-2017-update-of-the-recommendations-of-the-infectious-diseases-working-party-agiho-of-the-german-society-for-haematology-and-medical-oncology-dgho
#20
REVIEW
Sibylle C Mellinghoff, Jens Panse, Nael Alakel, Gerhard Behre, Dieter Buchheidt, Maximilian Christopeit, Justin Hasenkamp, Michael Kiehl, Michael Koldehoff, Stefan W Krause, Nicola Lehners, Marie von Lilienfeld-Toal, Annika Y Löhnert, Georg Maschmeyer, Daniel Teschner, Andrew J Ullmann, Olaf Penack, Markus Ruhnke, Karin Mayer, Helmut Ostermann, Hans-H Wolf, Oliver A Cornely
Immunocompromised patients are at high risk of invasive fungal infections (IFI), in particular those with haematological malignancies undergoing remission-induction chemotherapy for acute myeloid leukaemia (AML) or myelodysplastic syndrome (MDS) and recipients of allogeneic haematopoietic stem cell transplants (HSCT). Despite the development of new treatment options in the past decades, IFI remains a concern due to substantial morbidity and mortality in these patient populations. In addition, the increasing use of new immune modulating drugs in cancer therapy has opened an entirely new spectrum of at risk periods...
December 7, 2017: Annals of Hematology
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