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Radon gas lung cancer

J Elío, Q Crowley, R Scanlon, J Hodgson, L Zgaga
Radon is a naturally occurring gas, classified as a Class 1 human carcinogen, being the second most significant cause of lung cancer after tobacco smoking. A robust spatial definition of radon distribution in the built environment is therefore essential for understanding the relationship between radon exposure and its adverse health effects on the general population. Using Ireland as a case study, we present a methodology to estimate an average indoor radon concentration and calculate the expected radon-related lung cancer incidence...
February 24, 2018: Environment International
Ludwik Dobrzynski, Krzysztof W Fornalski, Joanna Reszczynska
A re-analysis has been carried out of thirty-two case-control and two ecological studies concerning the influence of radon, a radioactive gas, on the risk of lung cancer. Three mathematically simplest dose-response relationships (models) were tested: constant (zero health effect), linear, and parabolic (linear-quadratic). Health effect end-points reported in the analysed studies are odds ratios or relative risk ratios, related either to morbidity or mortality. In our preliminary analysis, we show that the results of dose-response fitting are qualitatively (within uncertainties, given as error bars) the same, whichever of these health effect end-points are applied...
November 23, 2017: Journal of Radiation Research
F Kabrt, A Baumgartner, M Stietka, F J Maringer
The radioactive noble gas radon is identified as the highest risk factor for lung cancer after smoking. The exhalation of radon from building materials can contribute to the radon indoor activity concentration. Therefore, the emanation of radon might be a crucial factor. It is defined as the release of radon from the solid soil matter into the pore space of the material. This article describes a new on-site measurement method for the emanation of radon from building materials at industrial sites. Therefore, a closed vessel with sample material and a passive radon detector inside is used to measure the integrated build-up-curve of the activity concentration...
November 1, 2017: Radiation Protection Dosimetry
Patricia Blanco-Rodríguez, Luis Alfonso Fernández-Serantes, Alberto Otero-Pazos, José Luis Calvo-Rolle, Francisco Javier de Cos Juez
Radon gas is the second leading cause of lung cancer, causing thousands of deaths annually. It can be a problem for people or animals in houses, workplaces, schools or any building. Therefore, its mitigation has become essential to avoid health problems and to prevent radon from interfering in radioactive measurements. This study describes the implementation of radon mitigation systems at a radioactivity laboratory in order to reduce interferences in the different works carried out. A large set of radon concentration samples is obtained from measurements at the laboratory...
May 11, 2017: Sensors
Fintan K T Stanley, Siavash Zarezadeh, Colin D Dumais, Karin Dumais, Renata MacQueen, Fiona Clement, Aaron A Goodarzi
BACKGROUND: The inhalation of naturally occurring radon (222Rn) gas from indoor air exposes lung tissue to α-particle bombardment, a highly mutagenic form of ionizing radiation that damages DNA and increases the lifetime risk of lung cancer. We analyzed household radon concentrations and risk factors in southern Alberta, including Calgary, the third-largest Canadian metropolis. METHODS: A total of 2382 residential homes (2018 in Calgary and 364 in surrounding townships) from an area encompassing 82% of the southern Alberta population were tested for radon, per Health Canada guidelines, for at least 90 days (median 103 d) between 2013 and 2016...
January 2017: CMAJ Open
C Meenakshi, K Sivasubramanian, B Venkatraman
Radon is a naturally occurring radionuclide in the environment, during decay it emits high linear energy transfer (LET) alpha particles. When radon exposure is accompanied by smoking it has been reported that lung cancer risk is higher. Blood samples were collected after prior consent, 25 smokers and 25 non smokers (only males) exposed in vitro to radon gas with doses ranging between 0.3-12.6mGy Ionizing radiation is a strong clastogenic agent and a potent inducer of MN. Cytokinesis-Blocked Micro Nucleus (CBMN) assay has proven to be a reliable, thoroughly validated and standardised technique in the field of radiation biology...
February 2017: Mutation Research
Amela Kasić, Amira Kasumović, Feriz Adrović, Muhamed Hodžić
Investigations of natural radioactivity in water, air, and soil are conducted frequently and routinely. Exposure to high concentrations of natural radioactive radon gas can cause irradiation of respiratory organs, which can lead to lung cancer. This paper presents measurements of radon activity concentrations in dug wells and natural springs of the Tuzla area (Bosnia and Herzegovina), which ranged from 214 to 3702 mBq L-1. Our results have shown that the radon activity concentration did not exceed the EU reference level for radon in drinking water (100 Bq L-1)...
December 1, 2016: Arhiv za Higijenu Rada i Toksikologiju
Gavin Gillmore, David Wertheim, Simon Crust
Solid State Nuclear Track Detectors (SSNTDs) are used extensively for monitoring alpha particle radiation, neutron flux and cosmic ray radiation. Radon gas inhalation is regarded as being a significant contributory factor to lung cancer deaths in the UK each year. Gas concentrations are often monitored using CR39 based SSNTDs as the natural decay of radon results in alpha particles which form tracks in these detectors. Such tracks are normally etched for about 4h to enable microscopic analysis. This study examined the effect of etching time on the appearance of alpha tracks in SSNTDs by collecting 2D and 3D image datasets using laser confocal microscope imaging techniques...
January 1, 2017: Science of the Total Environment
Maryam Yarahmadi, Abbas Shahsavani, Mohammad Hassan Mahmoudian, Narges Shamsedini, Noushin Rastkari, Majid Kermani
INTRODUCTION: Radon is the second most important cause of lung cancer after smoking. Thus, the determination of indoor radon concentrations in dwellings and workplaces is an important public health concern. The purpose of this research was to measure the concentration of radon gas in residential homes and public places in the city of Shiraz and its relationship with the type and age of the buildings as well as the type of materials used to construct the building (brick, block). We also determined the radon dosages that occupants of the building would receive...
June 2016: Electronic Physician
A R Denman, R G M Crockett, C J Groves-Kirkby, P S Phillips
Radon gas is naturally occurring, and can concentrate in the built environment. It is radioactive and high concentration levels within buildings, including homes, have been shown to increase the risk of lung cancer in the occupants. As a result, several methods have been developed to measure radon. The long-term average radon level determines the risk to occupants, but there is always pressure to complete measurements more quickly, particularly when buying and selling the home. For many years, the three-month exposure using etched-track detectors has been the de facto standard, but a decade ago, Phillips et al...
October 2016: Journal of Environmental Radioactivity
R Smyth, S Long, E Wiseman, D Sharpe, D Breen, A O'Regan
BACKGROUND: Radon is a naturally occurring radioactive gas and a level 1 carcinogen. It acts synergistically with cigarette smoke to cause lung cancer. In Ireland, radon is estimated to be associated with 13 % of all lung cancers. Rapid access lung cancer clinics (RALC's) were established in the UK and Ireland to improve lung cancer management outcomes. There has been no attempt to date to provide advice on household radon exposure assessments in this setting. AIMS: We performed a prospective feasibility study of radon assessment in our RALC to test the hypothesis that patients would avail of this service and that it would provide an opportunity for secondary prevention in at risk persons...
May 2017: Irish Journal of Medical Science
Allison A Bain, Anne L Abbott, Laura L Miller
BACKGROUND: Radon gas has recently become more prominent in discussions of lung cancer prevention nationally and in Iowa. A review in 2013 of cancer plans in the National Comprehensive Cancer Control Program found that 42% of cancer plans, including Iowa's, had terminology on radon. Plans included awareness activities, home testing, remediation, policy, and policy evaluation. COMMUNITY CONTEXT: Iowa has the highest average radon concentrations in the United States; 70% of homes have radon concentrations above the Environmental Protection Agency's action levels...
April 14, 2016: Preventing Chronic Disease
Ji Young Yoon, Jung-Dong Lee, So Won Joo, Dae Ryong Kang
Lung cancer has high mortality and incidence rates. The leading causes of lung cancer are smoking and radon exposure. Indeed, the World Health Organization (WHO) has categorized radon as a carcinogenic substance causing lung cancer. Radon is a natural, radioactive substance; it is an inert gas that mainly exists in soil or rock. The gas decays into radioactive particles called radon progeny that can enter the human body through breathing. Upon entering the body, these radioactive elements release α-rays that affect lung tissue, causing lung cancer upon long-term exposure thereto...
2016: Annals of Occupational and Environmental Medicine
Jung Ran Choi, Seong Yong Park, O Kyu Noh, Young Wha Koh, Dae Ryong Kang
Although the incidence and mortality for most cancers such as lung and colon are decreasing in several countries, they are increasing in several developed countries because of an unhealthy western lifestyles including smoking, physical inactivity and consumption of calorie-dense food. The incidences for lung and colon cancers in a few of these countries have already exceeded those in the United States and other western countries. Among them, lung cancer is the main cause of cancer death in worldwide. The cumulative survival rate at five years differs between 13 and 21 % in several countries...
2016: Annals of Occupational and Environmental Medicine
Seungsoo Sheen, Keu Sung Lee, Wou Young Chung, Saeil Nam, Dae Ryong Kang
Lung cancer is a leading cause of cancer-related death in the world. Smoking is definitely the most important risk factor for lung cancer. Radon ((222)Rn) is a natural gas produced from radium ((226)Ra) in the decay series of uranium ((238)U). Radon exposure is the second most common cause of lung cancer and the first risk factor for lung cancer in never-smokers. Case-control studies have provided epidemiological evidence of the causative relationship between indoor radon exposure and lung cancer. Twenty-four case-control study papers were found by our search strategy from the PubMed database...
2016: Annals of Occupational and Environmental Medicine
Si-Heon Kim, Won Ju Hwang, Jeong-Sook Cho, Dae Ryong Kang
Exposure to radon gas is the second most common cause of lung cancer after smoking. A large number of studies have reported that exposure to indoor radon, even at low concentrations, is associated with lung cancer in the general population. This paper reviewed studies from several countries to assess the attributable risk (AR) of lung cancer death due to indoor radon exposure and the effect of radon mitigation thereon. Worldwide, 3-20 % of all lung cancer deaths are likely caused by indoor radon exposure. These values tend to be higher in countries reporting high radon concentrations, which can depend on the estimation method...
2016: Annals of Occupational and Environmental Medicine
Austin L Mitchell, W Michael Griffin, Elizabeth A Casman
The amount of radon in natural gas varies with its source. Little has been published about the radon from shale gas to date, making estimates of its impact on radon-induced lung cancer speculative. We measured radon in natural gas pipelines carrying gas from the Marcellus Shale in Pennsylvania and West Virginia. Radon concentrations ranged from 1,520 to 2,750 Bq/m(3) (41-74 pCi/L), and the throughput-weighted average was 1,983 Bq/m(3) (54 pCi/L). Potential radon exposure due to the use of Marcellus Shale gas for cooking and space heating using vent-free heaters or gas ranges in northeastern U...
November 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
Shuguang Leng, Cynthia L Thomas, Amanda M Snider, Maria A Picchi, Wenshu Chen, Derall G Willis, Teara G Carr, Jacek Krzeminski, Dhimant Desai, Amin Shantu, Yong Lin, Marty R Jacobson, Steven A Belinsky
BACKGROUND: High radon exposure is a risk factor for squamous cell carcinoma, a major lung cancer histology observed in former uranium miners. Radon exposure can cause oxidative stress, leading to pulmonary inflammation. Interleukin-6 (IL-6) is a pro-carcinogenic inflammatory cytokine that plays a pivotal role in lung cancer development. OBJECTIVES: We assessed whether single nucleotide polymorphisms (SNPs) in the IL6 promoter are associated with lung cancer in former uranium miners with high occupational exposure to radon gas...
April 2016: Environmental Health Perspectives
Hassan Lemjabbar-Alaoui, Omer Ui Hassan, Yi-Wei Yang, Petra Buchanan
Lung cancer remains the leading cause of cancer mortality in men and women in the U.S. and worldwide. About 90% of lung cancer cases are caused by smoking and the use of tobacco products. However, other factors such as radon gas, asbestos, air pollution exposures, and chronic infections can contribute to lung carcinogenesis. In addition, multiple inherited and acquired mechanisms of susceptibility to lung cancer have been proposed. Lung cancer is divided into two broad histologic classes, which grow and spread differently: small-cell lung carcinomas (SCLCs) and non-small cell lung carcinomas (NSCLCs)...
December 2015: Biochimica et Biophysica Acta
Natalia Sumption, Dudley T Goodhead, Rhona M Anderson
Human exposure to high-linear energy transfer α-particles includes environmental (e.g. radon gas and its decay progeny), medical (e.g. radiopharmaceuticals) and occupational (nuclear industry) sources. The associated health risks of α-particle exposure for lung cancer are well documented however the risk estimates for leukaemia remain uncertain. To further our understanding of α-particle effects in target cells for leukaemogenesis and also to seek general markers of individual exposure to α-particles, this study assessed the transmission of chromosomal damage initially-induced in human haemopoietic stem and progenitor cells after exposure to high-LET α-particles...
2015: PloS One
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