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https://www.readbyqxmd.com/read/28732401/can-brook-trout-survive-climate-change-in-large-rivers-if-it-rains
#1
Eric R Merriam, Rodrigo Fernandez, J Todd Petty, Nicolas Zegre
We provide an assessment of thermal characteristics and climate change vulnerability for brook trout (Salvelinus fontinalis) habitats in the upper Shavers Fork sub-watershed, West Virginia. Spatial and temporal (2001-2015) variability in observed summer (6/1-8/31) stream temperatures was quantified in 23 (9 tributary, 14 main-stem) reaches. We developed a mixed effects model to predict site-specific mean daily stream temperature from air temperature and discharge and coupled this model with a hydrologic model to predict future (2016-2100) changes in stream temperature under low (RCP 4...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28714376/retrospective-comparison-of-low-molecular-weight-heparin-vs-warfarin-vs-oral-xa-inhibitors-for-the-prevention-of-recurrent-venous-thromboembolism-in-oncology-patients-the-re-clot-study
#2
Saeed K Alzghari, Susan E Seago, Jessica E Garza, Yasmeen F Hashimie, Kimberly A Baty, Martha F Evans, Courtney Shaver, Jon D Herrington
Background There is increasing evidence indicating oral factor Xa inhibitors can be used for secondary prevention of venous thromboembolism. Studies are needed to compare oral factor Xa inhibitors, low molecular weight heparins, and warfarin in the oncology population. The purpose of this study is to evaluate the recurrent venous thromboembolism incidence in oncology patients utilizing oral Xa inhibitors, low molecular weight heparins, or warfarin. Methods Using retrospectively collected data, we compared the recurrent venous thromboembolism incidence in oncology patients taking rivaroxaban/apixaban, enoxaparin, or warfarin with at least three months of follow-up...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28656505/videoexoscopic-real-time-intraoperative-navigation-for-spinal-neurosurgery-a-novel-co-adaptation-of-two-existing-technology-platforms-technical-note
#3
Meng Huang, Sean Michael Barber, William James Steele, Zain Boghani, Viren Rajendrakumar Desai, Gavin Wayne Britz, George Alexander West, Todd Wilson Trask, Paul Joseph Holman
Image-guided approaches to spinal instrumentation and interbody fusion have been widely popularized in the last decade [1-5]. Navigated pedicle screws are significantly less likely to breach [2, 3, 5, 6]. Navigation otherwise remains a point reference tool because the projection is off-axis to the surgeon's inline loupe or microscope view. The Synaptive robotic brightmatter drive videoexoscope monitor system represents a new paradigm for off-axis high-definition (HD) surgical visualization. It has many advantages over the traditional microscope and loupes, which have already been demonstrated in a cadaveric study [7]...
June 27, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28652942/time-to-cash-in-on-positive-interactions-for-coral-restoration
#4
Elizabeth C Shaver, Brian R Silliman
Coral reefs are among the most biodiverse and productive ecosystems on Earth, and provide critical ecosystem services such as protein provisioning, coastal protection, and tourism revenue. Despite these benefits, coral reefs have been declining precipitously across the globe due to human impacts and climate change. Recent efforts to combat these declines are increasingly turning to restoration to help reseed corals and speed-up recovery processes. Coastal restoration theory and practice has historically favored transplanting designs that reduce potentially harmful negative species interactions, such as competition between transplants...
2017: PeerJ
https://www.readbyqxmd.com/read/28651982/design-and-optimization-of-highly-selective-broad-spectrum-fungal-cyp51-inhibitors
#5
Christopher M Yates, Edward P Garvey, Sammy R Shaver, Robert J Schotzinger, William J Hoekstra
While the orally-active azoles such as fluconazole and posaconazole are effective antifungal agents, they potently inhibit a broad range of off-target human cytochrome P450 enzymes (CYPs) leading to various safety issues (e.g., drug-drug interactions, liver, and reproductive toxicities). Recently we described the rationally-designed, antifungal agent VT-1161 that is more selective for fungal CYP51 than related human CYP enzymes such as CYP3A4. Herein, we describe the use of a homology model of Aspergillus fumigatus to design and optimize a novel series of highly selective, broad spectrum fungal CYP51 inhibitors...
August 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28637556/pretrauma-functional-independence-measure-score-predicts-survival-in-geriatric-trauma
#6
Brian Fletcher, Eric Bradburn, Christopher Baker, Bryan Collier, Mark Hamill, Katherine Shaver
The Functional Independence Measure (FIM) is used by rehabilitation professionals to access disability. The FIM score combines both motor and cognitive parameters to assess a patient's level of required assistance in performing activities of daily living (ADL). The geriatric trauma patient is becoming an increasingly important cohort for trauma services. FIM has been shown to predict discharge outcomes and those at high risk for falls. We hypothesized pretrauma FIM scores may predict survival in the geriatric trauma population...
June 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28608150/-arthroscopy-of-the-proximal-interphalangeal-joint
#7
N Borisch
OBJECTIVE: Pain reduction in the affected proximal interphalangeal joint (PIP joint) by synovectomy, loose body extraction, dorsal arthrolysis. INDICATIONS: Therapy-resistant synovitis in rheumatoid arthritis (RA), early stage primary and secondary degenerative arthritis, loose bodies, capsular contracture. CONTRAINDICATIONS: Established biomechanic changes in RA (boutonniere and swanneck deformity). Large dorsal synovial cysts. Advanced radiologic changes in degenerative arthritis...
June 12, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28596129/sync-to-link-endorphin-mediated-synchrony-effects-on-cooperation
#8
Martin Lang, Vladimír Bahna, John H Shaver, Paul Reddish, Dimitris Xygalatas
Behavioural synchronization has been shown to facilitate social bonding and cooperation but the mechanisms through which such effects are attained are poorly understood. In the current study, participants interacted with a pre-recorded confederate who exhibited different rates of synchrony, and we investigated three mechanisms for the effects of synchrony on likeability and trusting behaviour: self-other overlap, perceived cooperation, and opioid system activation measured via pain threshold. We show that engaging in highly synchronous behaviour activates all three mechanisms, and that these mechanisms mediate the effects of synchrony on liking and investment in a Trust Game...
June 6, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28588575/gut-associated-lymphoid-tissue-a-key-tissue-inside-the-mucosal-immune-system-of-hens-immunized-with-escherichia-coli-f4
#9
Maria F Peralta, Alejandra Magnoli, Fabrisio Alustiza, Armando Nilson, Raúl Miazzo, Adriana Vivas
Immunoglobulin Y (IgY) is the predominant antibody found in hen's (Gallus domesticus) egg yolk. This antibody, developed against several microorganisms in hen egg yolk, has been successfully used as an alternative to immunoglobulins from mammals for use in immunodiagnostics and immunotherapy. Enteropathogenic Escherichia coli (E.coli) F4 is the main etiological agent associated with swine neonatal diarrhea, and it causes notable economic losses in swine production. The aim of the present study was to evaluate the relationship between humoral immune response and the activation of gut-associated lymphoid tissue (GALT) in laying hens intramuscularly immunized with E...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28575154/effects-of-propylene-glycol-or-elevated-lh-during-follicle-development-on-ovulation-fertilization-and-early-embryo-development
#10
Katherine S Hackbart, Robb W Bender, Paulo D Carvalho, Lais M Vieira, Ana R Dresch, Jerry N Guenther, Hidir Gencoglu, Anibal B Nascimento, Randy D Shaver, Milo C Wiltbank
Seventeen non-lactating Holstein cows were superovulated in a Latin-square designed experiment to determine effects of increased propylene glycol (PROP) and LH during antral follicle development on ovarian function, fertilization, and early embryo quality. PROP was orally drenched every 4 h for 7d to induce hyperinsulinemia and associated metabolic changes. LH concentrations were altered by increasing LH (3-fold) during last 2 d of superovulation. Treatment groups were: 1) Control-oral drenching with water plus low-LH preparation; 2) HLH-water plus high-LH preparation; 3) PROP-drenching with PROP plus low-LH; 4) PROP/HLH-PROP plus high-LH...
May 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28557482/assessing-hyperactivation-and-deactivation-strategies-of-the-caregiving-behavioral-system-psychometric-studies-of-the-portuguese-version-of-the-caregiving-system-scale
#11
Helena Moreira, Ana Fonseca, Phillip R Shaver, Mario Mikulincer, Maria Cristina Canavarro
According to attachment theory, the main goal of the caregiving behavioral system is to relieve others' distress and promote their health and welfare. This is accomplished through a set of caregiving behaviors that are the primary strategy of this system. However, some individuals develop nonoptimal or secondary strategies (hyperactivation or deactivation). The Caregiving System Scale (CSS) is a self-report measure that assesses these nonoptimal caregiving strategies. This study examined the factor structure of the Portuguese version of the CSS using a bifactor model and a 2-factor correlated model; it also examined validity evidence for CSS scores in relation to other relevant variables...
May 29, 2017: Psychological Assessment
https://www.readbyqxmd.com/read/28555510/perioperative-blood-glucose-concentrations-in-kittens-following-overnight-fasting-and-gonadectomy
#12
Danielle N Semick, Stephanie L Shaver, Heather N Cornell, Nancy C Bradley, Rachael E Kreisler
Objectives The objective of this study was to determine if hypoglycemia is an effect of overnight fasting and gonadectomy in kittens, as well as to determine predictors of baseline and postoperative blood glucose. Methods This was a prospective observational study. Seventy-five kittens between the age of 8 and 16 weeks undergoing routine castration or ovariohysterectomy at an animal shelter were included. Two blood glucose measurements were analyzed per kitten after an overnight fast: a baseline reading prior to preoperative examination, and a reading immediately postoperatively...
May 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28545548/circulating-microparticle-levels-are-reduced-in-patients-with-ards
#13
Ciara M Shaver, Justin Woods, Jennifer K Clune, Brandon S Grove, Nancy E Wickersham, J Brennan McNeil, Gregory Shemancik, Lorraine B Ware, Julie A Bastarache
BACKGROUND: It is unclear how to identify which patients at risk for acute respiratory distress syndrome (ARDS) will develop this condition during critical illness. Elevated microparticle (MP) concentrations in the airspace during ARDS are associated with activation of coagulation and in vitro studies have demonstrated that MPs contribute to acute lung injury, but the significance of MPs in the circulation during ARDS has not been well studied. The goal of the present study was to test the hypothesis that elevated levels of circulating MPs could prospectively identify critically ill patients who will develop ARDS and that elevated circulating MPs are associated with poor clinical outcomes...
May 25, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28521665/handbook-of-attachment-third-edition-theory-research-and-clinical-applicationsedited-by-jude-cassidy-and-phillip-r-shaver-new-york-ny-guilford-press-2016-1068-pages-125-00-hardcover-87-29-kindle
#14
https://www.readbyqxmd.com/read/28508238/surgical-excision-for-recurrent-herpes-simplex-virus-2-hsv-2-anogenital-infection-in-a-patient-with-human-immunodeficiency-virus-hiv
#15
Folasade Arinze, Aaron Shaver, Stephen Raffanti
Recurrent anogenital herpes simplex virus infections are common in patients with human immunodeficiency virus (HIV), of whom approximately 5% develop resistance to acyclovir. We present a case of a 49-year-old man with HIV who had an 8-year history of recurrent left inguinal herpes simplex virus type 2 ulcerations. He initially responded to oral acyclovir, but developed resistance to acyclovir and eventually foscarnet. The lesion progressed to a large hypertrophic mass that required surgical excision, which led to resolution without recurrences...
May 15, 2017: Infection
https://www.readbyqxmd.com/read/28483662/the-management-of-polyps-in-female-reproductive-organs
#16
REVIEW
Vasilios Tanos, Kelsey Elizabeth Berry, Jaana Seikkula, Elissa Abi Raad, Andreas Stavroulis, Zaki Sleiman, Rudi Campo, Stephan Gordts
Polyps of the lower reproductive tract are found in 7.8-50% of women. It has been hypothesized that cytogenetic modifications on chromosomes 6, 7 and 12 as well as epigenetic factors involving enzyme and metabolic activities may cause polyps to develop. Cervical polyps found in 2-5% of cases are of low clinical significance and can cause, although rarely, post coital bleedings. Cervical polyps grow during pregnancy and mucorrhoea. Trans vaginal ultrasound (TVU) provides an excellent diagnostic technique to diagnose the size and the anatomic location of endometrial polyps (EPs)...
May 5, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28475275/a-qa-program-for-mrd-testing-demonstrates-that-systematic-education-can-reduce-discordance-among-experienced-interpreters
#17
Michael Keeney, Brent L Wood, Benjamin D Hedley, Joseph A DiGiuseppe, Maryalice Stetler-Stevenson, Elisabeth Paietta, Gerard Lozanski, Adam C Seegmiller, Bruce W Greig, Aaron C Shaver, Lata Mukundan, Howard R Higley, Caroline C Sigman, Gary Kelloff, J Milburn Jessup, Michael J Borowitz
BACKGROUND: Minimal residual disease (MRD) in B lymphoblastic leukemia (B-ALL) by flow cytometry is an established prognostic factor used to adjust treatment in most pediatric therapeutic protocols. MRD in B-ALL has been standardized by the Children's Oncology Group (COG) in North America, but not routine clinical labs. The Foundation for National Institutes of Health sought to harmonize MRD measurement among COG, oncology groups, academic, community and government, laboratories. METHODS: Listmode data from post-induction marrows were distributed from a reference lab to seven different clinical FCM labs with variable experience in B-ALL MRD...
May 5, 2017: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/28467300/tcf7l1-promotes-skin-tumorigenesis-independently-of-%C3%AE-catenin-through-induction-of-lcn2
#18
Amy T Ku, Timothy M Shaver, Ajay S Rao, Jeffrey M Howard, Christine N Rodriguez, Qi Miao, Gloria Garcia, Diep Le, Diane Yang, Malgorzata Borowiak, Daniel N Cohen, Vida Chitsazzadeh, Abdul H Diwan, Kenneth Y Tsai, Hoang Nguyen
The transcription factor TCF7L1 is an embryonic stem cell signature gene that is upregulated in multiple aggressive cancer types, but its role in skin tumorigenesis has not yet been defined. Here we document TCF7L1 upregulation in skin squamous cell carcinoma (SCC) and demonstrate that TCF7L1 overexpression increases tumor incidence, tumor multiplicity, and malignant progression in the chemically induced mouse model of skin SCC. Additionally, we show that downregulation of TCF7L1 and its paralogue TCF7L2 reduces tumor growth in a xenograft model of human skin SCC...
May 3, 2017: ELife
https://www.readbyqxmd.com/read/28452837/factors-related-to-self-rated-health-in-older-adults-a-clinical-approach-using-the-international-classification-of-functioning-disability-and-health-icf-model
#19
Chad W Tiernan, Hali A Fleishman, Meghann A Hiscox, Sarah N Shaver, Caitlyn M Stauffer, Patrick A W Thibodeau
BACKGROUND AND PURPOSE: A growing population of older adults will require health care professionals to become increasingly knowledgeable in geriatric care. Patient ratings, functional measures, and emphasis on health and wellness should be part of geriatric physical therapy practice. The purpose of the current study was to examine relationships between self-rated health (SRH) and movement-related variables in older adults using the International Classification of Functioning, Disability, and Health (ICF) as a research framework...
April 27, 2017: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/28425314/effect-of-transmucosal-corn-syrup-application-on-postoperative-blood-glucose-concentrations-in-kittens
#20
Heather N Cornell, Stephanie L Shaver, Danielle N Semick, Nancy C Bradley, Rachael E Kreisler
Objectives The aim of the study was to determine the effect of a common clinical practice, the transmucosal (TM) application of corn syrup, on postoperative blood glucose concentrations in kittens. Methods This study was designed as a randomized controlled trial. Seventy-five kittens between the age of 8 and 16 weeks scheduled for surgical sterilization by gonadectomy at an animal shelter were enrolled. Kittens were randomly assigned to either a routine treatment group that received the shelter's typical postoperative application of corn syrup immediately following gonadectomy or to a control group that did not receive typical treatment...
April 1, 2017: Journal of Feline Medicine and Surgery
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