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Adam C Seegmiller, Annette S Kim, Claudio A Mosse, Aaron C Shaver, Mary Ann Thompson, Shaoying Li, David R Head, Mary M Zutter
OBJECTIVES: To determine the effect of iterative refinement of standard ordering protocols on test utilization and results for bone marrow biopsy specimens. METHODS: Eighteen months of test utilization and result data were used to revise the protocols that determine cytogenetic and molecular test selection on bone marrow specimens and then compared with data obtained following protocol revision. RESULTS: Revision of protocols resulted in reduction in total tests and associated charges, due to a decrease in tests both concordant and discordant with the protocols...
October 20, 2016: American Journal of Clinical Pathology
Liang Luo, Ciara M Shaver, Zhiguo Zhao, Tatsuki Koyama, Carolyn S Calfee, Julie A Bastarache, Lorraine B Ware
BACKGROUND: Direct (pulmonary) and indirect (extrapulmonary) ARDS are distinct syndromes with important pathophysiologic differences. The goal of this study was to determine whether clinical characteristics and predictors of mortality differ between direct or indirect ARDS. METHODS: A retrospective observational cohort study of 417 ARDS patients. Each patient was classified as having direct (pneumonia or aspiration, n=250) or indirect ARDS (non-pulmonary sepsis or pancreatitis, n=167)...
September 20, 2016: Chest
Peter Gajšek, Paolo Ravazzani, James Grellier, Theodoros Samaras, József Bakos, György Thuróczy
We aimed to review the findings of exposure assessment studies done in European countries on the exposure of the general public to low frequency electric and magnetic fields (EMFs) of various frequencies. The study shows that outdoor average extremely low frequency magnetic fields (ELF-MF) in public areas in urban environments range between 0.05 and 0.2 µT in terms of flux densities, but stronger values (of the order of a few µT) may occur directly beneath high-voltage power lines, at the walls of transformer buildings, and at the boundary fences of substations...
2016: International Journal of Environmental Research and Public Health
Laura Gough, Neil D Bettez, Karie A Slavik, William B Bowden, Anne E Giblin, George W Kling, James A Laundre, Gaius R Shaver
Primary producers form the base of food webs but also affect other ecosystem characteristics, such as habitat structure, light availability, and microclimate. Here, we examine changes caused by 5-30+ years of nutrient addition and resulting increases in net primary productivity (NPP) in tundra, streams, and lakes in northern Alaska. The Arctic provides an important opportunity to examine how ecosystems characterized by low diversity and low productivity respond to release from nutrient limitation. We review how responses of algae and plants affect light availability, perennial biotic structures available for consumers, oxygen levels, and temperature...
November 2016: Oecologia
Laura M River, Jessica L Borelli, S Katherine Nelson-Coffey
Evidence has suggested that parental romantic attachment style and depressive and anxiety symptoms are related to experiences of caregiving (Creswell, Apetroaia, Murray, & Cooper, 2013; Jones, Cassidy, & Shaver, 2014; Lovejoy, Graczyk, O'Hare, & Neuman, 2000), but more research is necessary to clarify the nature of these relations, particularly in the context of attachment-salient events such as reunions. In a cross-sectional study of 150 parents of children ages 1 to 3 years, we assessed participants' attachment styles (self-reported anxiety and avoidance) and depressive and anxiety symptoms...
September 2016: Infant Mental Health Journal
Cathryn T Ryan, Jessica M Kramer, Ellen S Cohn
The purpose of this study was to examine the role of the self-disclosure process in regard to connection development and relationship quality in peer mentoring relationships between transition-age youth (ages 15-20) and young adults (ages 18-36) with intellectual and/or developmental disabilities. Self-disclosure is defined as "the disclosure of inner feelings and experiences to another person" that "fosters liking, caring, and trust, thereby facilitating the deepening of close relationships" ( Reis & Shaver, 1988 , p...
August 2016: Intellectual and Developmental Disabilities
Jan Krátký, Martin Lang, John H Shaver, Danijela Jerotijević, Dimitris Xygalatas
Despite the wide occurrence of ritual behavior in humans and animals, much of its causal underpinnings, as well as evolutionary functions, remain unknown. A prominent line of research focuses on ritualization as a response to anxiogenic stimuli. By manipulating anxiety levels, and subsequently assessing their motor behavior dynamics, our recent study investigated this causal link in a controlled way. As an extension to our original argument, we here discuss 2 theoretical explanations of rituals-ritualized behavior and automated behavior-and their link to anxiety...
May 2016: Communicative & Integrative Biology
Zhengming Xiong, Elisabet Ampudia-Mesias, Rob Shaver, Craig M Horbinski, Christopher L Moertel, Michael R Olin
There are over 400 ongoing clinical trials using tumor-derived vaccines. This approach is especially attractive for many types of brain tumors, including glioblastoma, yet so far the clinical response is highly variable. One contributor to poor response is CD200, which acts as a checkpoint blockade, inducing immune tolerance. We demonstrate that, in response to vaccination, glioma-derived CD200 suppresses the anti-tumor immune response. In contrast, a CD200 peptide inhibitor that activates antigen-presenting cells overcomes immune tolerance...
September 2016: Immunotherapy
Julie A Neumann, Sandeep Mannava, Christopher E Gross, Benjamin M Wooster, Michael T Busch
Symptomatic subfibular and/or lateral talocalcaneal impingement in pediatric patients may result from an accessory anterolateral talar facet (AALTF). This impingement may cause pain and disability and may limit athletic performance in high-level athletes. We report the case of a 12-year-old female competitive gymnast who had refractory, lateral-sided right ankle pain for 4 months and underwent right ankle arthroscopic resection of the AALTF causing impingement. Standard medial and anterolateral portals with the addition of an accessory anterolateral-distal portal were used in conjunction with a 30° 2...
April 2016: Arthroscopy Techniques
William W Schairer, Benedict U Nwachukwu, David M Dare, Mark C Drakos
Standalone open reduction-internal fixation (ORIF) of unstable ankle fractures is the current standard of care. Intraoperative stress radiographs are useful for assessing the extent of ligamentous disruption, but arthroscopic visualization has been shown to be more accurate. Concomitant arthroscopy at the time of ankle fracture ORIF is useful for accurately diagnosing and managing syndesmotic and deltoid ligament injuries. The arthroscopic ankle drive-through sign is characterized by the ability to pass a 2...
April 2016: Arthroscopy Techniques
F M W Rodijk, G Zanelli, M Geerligs, P E J van Erp, M Peppelman
BACKGROUND: The impact of personal care devices on skin is mainly assessed using subjective tools. However, new objective, accurate non-invasive in vivo imaging techniques have been developed. The aim of this study was to evaluate the ability of reflectance confocal microscopy (RCM) in quantifying morphological impact of shavers on skin. Furthermore, tape stripping (TS) as method to study morphological impact of shavers was evaluated. METHODS: In 12 healthy male subjects, for two consecutive days, a split-face test was performed in the neck; on one side a shaver was applied, while the other side was exposed to TS...
August 2016: Skin Research and Technology
Lennart Viezens, Marc Dreimann, Roland Gessler, Martin Stangenberg, Sven Oliver Eicker
BACKGROUND: The lumbar neural foraminal stenosis still is a challenging condition in minimally invasive spine surgery. Due to the anatomic situation a complete decompression of the nerve root often leads to a sub total facetectomy associated with potential instability and the need for additional instrumentation of the decompressed segment. The iO-Flex system was introduced to address this problem by using a minimally-invasive wire-guided microblade shaver to increase the neuroforaminal space by reducing the stenosis from intraforaminal while sparing bigger parts of the facet joint...
July 1, 2016: World Neurosurgery
Lauren Shaver, Eric E Hall, Eric K O'Neal, Svetlana Nepocatych
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Svetlana Nepocatych, Lauren Shaver, Eric E Hall
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
David R Janz, Matthew W Semler, Robert J Lentz, Daniel T Matthews, Tufik R Assad, Brett C Norman, Raj D Keriwala, Benjamin A Ferrell, Michael J Noto, Ciara M Shaver, Bradley W Richmond, Jeannette Zinggeler Berg, Todd W Rice
OBJECTIVE: To evaluate the effect of video laryngoscopy on the rate of endotracheal intubation on first laryngoscopy attempt among critically ill adults. DESIGN: A randomized, parallel-group, pragmatic trial of video compared with direct laryngoscopy for 150 adults undergoing endotracheal intubation by Pulmonary and Critical Care Medicine fellows. SETTING: Medical ICU in a tertiary, academic medical center. PATIENTS: Critically ill patients 18 years old or older...
November 2016: Critical Care Medicine
Christopher E Gross, Julie A Neumann, Jonathan A Godin, James K DeOrio
Rates of medial and/or lateral gutter impingement after total ankle replacement are not insignificant. If impingement should occur, it typically arises an average of 17 months after total ankle replacement. Our patient underwent treatment for right ankle medial gutter bony impingement with arthroscopic debridement 5 years after her initial total ankle replacement. Standard anteromedial and anterolateral portals and a 30° 2.7-mm-diameter arthroscope were used. An aggressive soft-tissue and bony resection was performed using a combination of curettes, a 3...
April 2016: Arthroscopy Techniques
Brock M Huntsman, J Todd Petty, Shikha Sharma, Eric R Merriam
Coldwater fishes in streams, such as brook trout (Salvelinus fontinalis), typically are headwater specialists that occasionally expand distributions downstream to larger water bodies. It is unclear, however, whether larger streams function simply as dispersal corridors connecting headwater subpopulations, or as critical foraging habitat needed to sustain large mobile brook trout. Stable isotopes (δ(13)C and δ(15)N) and a hierarchical Bayesian mixing model analysis was used to identify brook trout that foraged in main stem versus headwater streams of the Shavers Fork watershed, West Virginia...
October 2016: Oecologia
Andrew W Holt, Danielle N Martin, Patti R Shaver, Shaquria P Adderley, Joshua D Stone, Chintamani N Joshi, Jake T Francisco, Robert M Lust, Douglas A Weidner, Brian M Shewchuk, David A Tulis
Coronary artery disease (CAD) accounts for over half of all cardiovascular disease-related deaths. Uncontrolled arterial smooth muscle (ASM) cell migration is a major component of CAD pathogenesis and efforts aimed at attenuating its progression are clinically essential. Cyclic nucleotide signaling has long been studied for its growth-mitigating properties in the setting of CAD and other vascular disorders. Heme-containing soluble guanylyl cyclase (sGC) synthesizes cyclic guanosine monophosphate (cGMP) and maintains vascular homeostasis predominantly through cGMP-dependent protein kinase (PKG) signaling...
September 2016: Cellular Signalling
Nevenka Cakić, Tanja Savić, Janice Stricker-Shaver, Vincent Truffault, Carlos Platas-Iglesias, Christian Mirkes, Rolf Pohmann, Klaus Scheffler, Goran Angelovski
The preparation of a paramagnetic chelator that serves as a platform for multicontrast MRI, and can be utilized either as a T1-weighted, paraCEST or (19)F MRI contrast agent is reported. Its europium(iii) complex exhibits an extremely slow water exchange rate which is optimal for the use in CEST MRI. The potential of this platform was demonstrated through a series of MRI studies on tube phantoms and animals.
July 28, 2016: Chemical Communications: Chem Comm
Hiroki Funasaki, Hiroteru Hayashi, Kanako Sakamoto, Rei Tsuruga, Keishi Marumo
Stenosing tenosynovitis of the flexor hallucis longus (FHL) tendon is known as a major overuse lesion in female dancers. We describe arthroscopic surgical techniques in relation to the dynamic pathology of the disease. Crepitus and pain on moving the great toe with the ankle in plantar flexion on preoperative examination confirm the diagnosis of FHL stenosing tenosynovitis even if the os trigonum is not evident. The ankle is approached through standard posterolateral and posteromedial portals. A 4.0-mm-diameter 30° arthroscope is used...
December 2015: Arthroscopy Techniques
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