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Jose Victor Scarpa-Carniello, Momin T Siddiqui
BACKGROUND: The advances of minimally invasive endoscopy-guided procedures that usually yield limited diagnostic material changed pancreaticobiliary cytopathology into one of the most challenging areas of Cytopathology given the abundance of differential diagnoses to be considered when dealing with limited specimens. SUMMARY: We describes a few challenging, examples of potential pitfalls in pancreatobiliary cytopathology evaluation collected from a busy academic hospital (tertiary) center...
April 17, 2024: Acta Cytologica
#2
JOURNAL ARTICLE
Shuang Liang, Xiaoliang Chen
We report the findings of 68Ga-DOTATATE PET/CT in a 56-year-old woman with solitary pulmonary perivascular epithelioid cell tumor. 68Ga-DOTATATE PET/CT showed a lesion with intense uptake in the region of pancreatic head and a solitary nodule with moderate uptake in the left lung. Pancreatic neuroendocrine tumor with pulmonary metastasis was considered. The postoperative pathological results showed a benign perivascular epithelioid cell tumor of the lung. This case emphasizes the need to increase awareness of benign perivascular epithelioid cell tumors in the differential diagnosis of solitary pulmonary nodule with moderate DOTATATE activity...
April 17, 2024: Clinical Nuclear Medicine
#3
JOURNAL ARTICLE
Wei Diao, Zhenyan Ye, Ying Kou, Zhuzhong Cheng
We presented a case involving a 56-year-old man who had been experiencing shoulder and back pain for over a year, with extensive bone metastases revealed by a bone scan. To identify the primary source of these issues, the patients underwent a fluorine-18-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) scan, which indicated moderate uptake in the right renal soft mass and low uptake in multiple osteolytic lesions. Pathological examination and immunohistochemical staining of the renal mass supported the diagnosis of neuroendocrine tumors...
April 18, 2024: Hellenic Journal of Nuclear Medicine
#4
REVIEW
Dilara Aylar, Ayse Karatug Kacar
The pancreas is made of two compartments: the exocrine pancreas, a source of digestive enzymes, and the endocrine islets which produce vital hormones. Distinct diseases could arise in the pancreas such as diabetes, neuroendocrine tumors, pancreatitis, and pancreatic cancers. Various treatment methods are being researched against these diseases. Treatment with recombinant proteins, therapeutic antibodies, vaccination, gene therapy, tissue engineering, and stem cell treatment are treatment methods. Furthermore, biomarkers are important for both treatment and diagnosis...
April 16, 2024: Molecular Biotechnology
#5
JOURNAL ARTICLE
Luigi Asmundo, Valentina Ambrosini, Mark A Anderson, Stefano Fanti, William R Bradley, Davide Campana, Amirkasra Mojtahed, Ryan Chung, Shaunagh Mcdermott, Subba Digumarthy, Stephan Ursprung, Konstantin Nikolau, Florian J Fintelmann, Michael Blake, Carlos Fernandez-Del Castillo, Motaz Qadan, Ankur Pandey, Jeffrey W Clark, Onofrio A Catalano
Neuroendocrine neoplasms (NENs) are rare neoplasms originating from neuroendocrine cells, with increasing incidence due to enhanced detection methods. These tumors display considerable heterogeneity, necessitating diverse management strategies based on factors like organ of origin and tumor size. This article provides a comprehensive overview of therapeutic approaches for NENs, emphasizing the role of imaging in treatment decisions. It categorizes tumors based on their locations: gastric, duodenal, pancreatic, small bowel, colonic, rectal, appendiceal, gallbladder, prostate, lung, gynecological, and others...
April 15, 2024: Journal of Computer Assisted Tomography
#6
REVIEW
Somdatta Giri, Jayaprakash Sahoo
This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-peutic strategies...
March 28, 2024: World Journal of Gastroenterology: WJG
#7
JOURNAL ARTICLE
Lorenzo Gervaso, Alice Laffi, Aurora Gaeta, Sara Gandini, Laura Boldrini, Monica Isabel Meneses-Medina, Manila Rubino, Lavinia Benini, Michele Borghesani, Laura Algeri, Giuseppe Curigliano, Francesca Spada, Chiara Alessandra Cella, Nicola Fazio
No abstract text is available yet for this article.
March 2024: Research and Practice in Thrombosis and Haemostasis
#8
Yanlei Wang, Zhaoxiang Liu, Wenhui Zhao, Chenxiang Cao, Luqi Xiao, Jianzhong Xiao
BACKGROUND: Von Hippel-Lindau (VHL) syndrome is characterized by tumorous lesions affecting multiple organs. Pancreatic involvement in VHL syndrome can present as endocrine tumors and pancreatic cysts, which can interfere with both exocrine and endocrine functions of the pancreas. Diabetes is an uncommon complication of VHL syndrome. PURPOSE: This study aims to summarize the various mechanisms of diabetes in VHL syndrome by reporting two cases and conducting a literature review...
2024: Diabetes, Metabolic Syndrome and Obesity
#9
JOURNAL ARTICLE
Susumu Hijioka, Daiki Yamashige, Minoru Esaki, Goro Honda, Ryota Higuchi, Toshihiko Masui, Yasuhiro Shimizu, Masayuki Ohtsuka, Yusuke Kumamoto, Akio Katanuma, Naoto Gotohda, Hirofumi Akita, Michiaki Unno, Itaru Endo, Yukihiro Yokoyama, Suguru Yamada, Ippei Matsumoto, Takao Ohtsuka, Satoshi Hirano, Hiroaki Yasuda, Manabu Kawai, Taku Aoki, Masafumi Nakamura, Daisuke Hashimoto, Toshiki Rikiyama, Akihiko Horiguchi, Tsutomu Fujii, Shugo Mizuno, Keiji Hanada, Masaji Tani, Takashi Hatori, Tetsuhide Ito, Masataka Okuno, Shingo Kagawa, Hiroshi Tajima, Tatsuya Ishii, Motokazu Sugimoto, Shunsuke Onoe, Hideki Takami, Ryoji Takada, Takayuki Miura, Yusuke Kurita, Keiko Kamei, Yuko Mataki, Kazuichi Okazaki, Yoshifumi Takeyama, Hiroki Yamaue, Sohei Satoi
BACKGROUND & AIMS: Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases nonfunctioning small pNENs (NF-spNENs) in a large Japanese cohort to elucidate an optimal treatment strategy for NF-spNENs. METHODS: In this Japanese multicenter study, data were retrospectively collected from patients who underwent pancreatectomy between January 1996 and December 2019, were pathologically diagnosed with pNEN, and were treated according to the WHO 2019 classification...
April 12, 2024: Clinical Gastroenterology and Hepatology
#10
JOURNAL ARTICLE
Zhikai Chi, Jing Xu, Dipti M Karamchandani, Lan Peng
INTRODUCTION: Differentiating pancreatic serous cystadenoma (SCA) from well-differentiated neuroendocrine tumors (WDNETs) based on histomorphology is critical yet challenging, particularly in small biopsy samples. Our study aimed to examine the expression profile of INSM1 in cytologic and surgical resection specimens from pancreatic SCA to evaluate its potential as a discriminative marker against pancreatic WDNET. METHODS: We characterized INSM1 immunohistochemistry in 34 patients with pancreatic SCA, comprising 23 surgical resections and 11 cytology specimens...
April 9, 2024: Annals of Diagnostic Pathology
#11
JOURNAL ARTICLE
Maria Ingenerf, Christoph Auernhammer, Roberto Lorbeer, Michael Winkelmann, Shiwa Mansournia, Nabeel Mansour, Nina Hesse, Kathrin Heinrich, Jens Ricke, Frank Berger, Christine Schmid-Tannwald
BACKGROUND: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET). PATIENTS AND METHODS: This retrospective study (n = 44) assessed CAPTEM therapy response in neuroendocrine liver metastases (NELM) patients. Among 33 monitored patients, as a subgroup of the overall study cohort, pretherapeutic and follow-up MRI data (size, apparent diffusion coefficient [ADC] values, and signal intensities), along with clinical parameters (chromogranin A [CgA] and Ki-67%), were analyzed...
April 14, 2024: Radiology and Oncology
#12
EDITORIAL
Philippe Soyer
No abstract text is available yet for this article.
April 12, 2024: Canadian Association of Radiologists Journal
#13
JOURNAL ARTICLE
Francesco Panzuto, Elisa Andrini, Giuseppe Lamberti, Sara Pusceddu, Maria Rinzivillo, Fabio Gelsomino, Alessandra Raimondi, Alberto Bongiovanni, Maria Vittoria Davì, Mauro Cives, Maria Pia Brizzi, Irene Persano, Maria Chiara Zatelli, Ivana Puliafito, Salvatore Tafuto, Davide Campana
Background: The optimal treatment sequencing for advanced, well-differentiated pancreatic neuroendocrine tumors (pNETs) is unknown. We performed a multicenter, retrospective study to evaluate the best treatment sequence in terms of progression-free survival to first-line (PFS1) and to second-line (PFS2), and overall survival among patients with advanced, well-differentiated pNETs. Methods : This multicenter study retrospectively analyzed the prospectively collected data of patients with sporadic well-differentiated pNETs who received at least two consecutive therapeutic lines, with evidence of radiological disease progression before change of treatment lines...
April 3, 2024: Journal of Clinical Medicine
#14
REVIEW
Ibrahim O Sawaid, Abraham O Samson
Background: Proton pump inhibitors (PPIs) are commonly prescribed long-acting drugs used to treat acid reflux, gastroesophageal reflux disease (GERD), and peptic ulcers. Recently, concerns have been raised about their safety, particularly due to the association between long-term PPI use and cancer development. Multiple comprehensive studies have consistently suggested a noteworthy link between prolonged PPI usage and an increased risk of developing gastric, esophageal, colorectal, and pancreatic cancers, yet the precise underlying mechanism remains elusive...
March 28, 2024: Journal of Clinical Medicine
#15
JOURNAL ARTICLE
Mary Esmeralda Fuentes, Xiaoyin Lu, Natasha M Flores, Simone Hausmann, Pawel K Mazur
Pancreatic neuroendocrine tumors (PanNETs) are a heterogeneous group of tumors that exhibit an unpredictable and broad spectrum of clinical presentations and biological aggressiveness. Surgical resection is still the only curative therapeutic option for localized PanNET, but the majority of patients are diagnosed at an advanced and metastatic stage with limited therapeutic options. Key factors limiting the development of new therapeutics are the extensive heterogeneity of PanNETs and the lack of appropriate clinically relevant models...
April 12, 2024: Scientific Reports
#16
JOURNAL ARTICLE
Svenja Sliwinski, Mary Katherine Sammons, Faruk Koca, Hanan El Youzouri, Thomas Vogl, Wolf Bechstein
Bronchobiliary fistulas are defined as an abnormal communication between the biliary system and the bronchial tree. They are extremely rare complications of radiofrequency or microwave ablation. A 39-year-old woman with a history of neuroendocrine pancreatic carcinoma suffering from liver metastasis was treated with microwave ablation (MWA). In this case report, we present a case of intractable biliptysis from a bronchobiliary fistula secondary to an MWA. The patient was diagnosed by endoscopic retrograde cholangiopancreatograph and hepatobiliary scintigraphy...
April 11, 2024: Zeitschrift Für Gastroenterologie
#17
JOURNAL ARTICLE
Priya Kumari Gorai, Simran Rastogi, Prahalad Singh Bharti, Shipra Agarwal, Sujoy Pal, Mehar Chand Sharma, Rakesh Kumar, Fredrik Nikolajeff, Saroj Kumar, Neerja Rani
The survival rate over a five-year period for rare pancreatic neuroendocrine tumors (PanNET) is notably lower compared to other neuroendocrine tumors due to late-stage detection, which is a consequence of the absence of suitable diagnostic markers; therefore, there exists a critical need for an early-stage biomarker-specific to PanNETs. This study introduces a novel approach, investigating the impact of small extracellular vesicles (sEV) in PanNET growth and metastasis. As proof of concept, this study shows a correlation between sEV concentration in controls and PanNET...
April 15, 2024: Heliyon
#18
XueMei Fan, Shuai Wang, Tianwen Chen, Wei Hu, Hui Yang
BACKGROUND: Von-Hipple Lindau syndrome is an uncommon autosomal dominant disorder. 17 years ago we diagnosed a young woman with VHL syndrome validated by Sanger sequencing, her family members were genetically tested as well, and 187 healthy people were randomly selected for VHL genetic testing as controls. We analyze the clinical and genetic characteristics of VHL syndrome in a Chinese lineage and with 17-year follow-up. CASE PRESENTATION: A woman was finally diagnosed with VHL syndrome due to the detection of a missense mutation c...
2024: Frontiers in Oncology
#19
REVIEW
Maria Wedin, Eva Tiensuu Janson, Göran Wallin, Anders Sundin, Kosmas Daskalakis
Metastases outside the liver and abdominal/retroperitoneal lymph nodes are nowadays detected frequently in patients with neuroendocrine tumours (NETs), owing to the high sensitivity of positron emission tomography (PET) with Gallium-68-DOTA-somatostatin analogues (68 Ga-SSA) and concomitant diagnostic computed tomography (CT). Our aim was to determine the prevalence of extra-abdominal metastases on 68 Ga-DOTATOC-PET/CT in a cohort of patients with small intestinal (Si-NET) and pancreatic NET (Pan-NET), as well as that of pancreatic metastasis in patients with Si-NET...
April 9, 2024: Journal of Neuroendocrinology
#20
JOURNAL ARTICLE
Okjoo Lee, So Kyung Yoon, So Jeong Yoon, Hongbeom Kim, In Woong Han, Jin Seok Heo, Sang Hyun Shin
PURPOSE: When performing laparoscopic spleen-preserving distal pancreatectomy (LSPDP), sometimes, anatomically challenging patients are encountered, where the pancreatic tail is deep in the splenic hilum. The purpose of this study was to discuss the experience with the surgical technique of leaving the deep pancreatic tail of the splenic hilum in these patients. METHODS: Eleven patients who underwent LSPDP with remnant pancreatic tails between November 2019 and August 2021 at Samsung Medical Center in Seoul, Korea were included in the study...
April 2024: Annals of Surgical Treatment and Research
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