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https://www.readbyqxmd.com/read/29326189/period-prevalence-risk-factors-and-consequent-injuries-of-falling-among-the-saudi-elderly-living-in-riyadh-saudi-arabia-a-cross-sectional-study
#1
Faisal Yousef Almegbel, Ibrahim Muthyib Alotaibi, Faisal Ahmed Alhusain, Emad M Masuadi, Salma Lafyan Al Sulami, Amairah Fahad Aloushan, Bashayer Ibrahim Almuqbil
OBJECTIVES: Approximately 28% to 35% of people aged 65 and over fall each year. The consequent injuries of falls are considered a major public health problem. Falls account for more than half of injury-related hospitalisations among old people. The aim of this study was to measure a 1-year period prevalence of falling among old people in Riyadh, Saudi Arabia. In addition, this study described the most common risk factors and consequent injuries of falls. SETTING AND PARTICIPANTS: A cross-sectional survey was carried out in Riyadh, using a convenient sampling...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29286954/selective-%C3%A3-1-blockers-are-not-associated-with-new-onset-diabetes-mellitus-in-hypertensive-patients
#2
Yoonjee Park, Byoung Geol Choi, Seung-Woon Rha, Man Jong Baek, Yang Gi Ryu, Se Yeon Choi, Jae Kyeong Byun, Min Suk Shim, Ahmed Mashaly, Hu Li, Won Young Jang, Woohyeun Kim, Jun Hyuk Kang, Jah Yeon Choi, Eun Jin Park, Sung Hun Park, Sunki Lee, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
BACKGROUND: Although ß-blockers are known to increase new-onset diabetes mellitus (DM), previous evidence have been controversial. It has been suggested that newer vasodilatory ß-blockers yield better glycemic control than older nonselective agents. The aim of this study was to evaluate the diabetogenicity of currently used newer ß-blockers based on ß1 receptor selectivity in a series of Asian population. METHODS: We investigated a total of 65,686 hypertensive patients without DM from 2004 to 2014...
January 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29249501/predictors-of-survival-in-octogenarians-after-mitral-valve-surgery-for-degenerative-disease-the-mitral-surgery-in-octogenarians-study
#3
Pierpaolo Chivasso, Vito D Bruno, Shakil Farid, Pietro Giorgio Malvindi, Amit Modi, Umberto Benedetto, Franco Ciulli, Yasir Abu-Omar, Massimo Caputo, Gianni D Angelini, Steve Livesey, Hunaid A Vohra
OBJECTIVES: An increasing number of octogenarians are referred to undergo mitral valve surgery for degenerative disease, and percutaneous approaches are being increasingly used in this subgroup of patients. We sought to determine the survival and its predictors after Mitral valve Surgery in Octogenarians (MiSO) in a multicenter UK study of high-volume specialized centers. METHODS: Pooled data from 3 centers were collected retrospectively. To identify the predictors of short-term composite outcome of 30 days mortality, acute kidney injury, and cerebrovascular accident, a multivariable logistic regression model was developed...
November 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29225000/-validity-of-the-abdominal-ecography-in-primary-care-for-detection-of-aorta-abdominal-aneurism-in-male-between-65-and-75-years
#4
Laura Bravo-Merino, Noelia González-Lozano, Ruth Maroto-Salmón, Gloria Meijide-Santos, Patricio Suárez-Gil, Ana Fañanás-Mastral
OBJECTIVE: To determine the usefulness of ultrasound examination in Primary Care (PC) for the detection of abdominal aortic aneurysm (AAA) in male patients from 65-75 years old, as well as the consistency between observers on the diagnosis between general practitioners and the reference specialty in this area, Vascular Surgery. To estimate the prevalence of AAA in that population and its association with risk factors. DESIGN: Cross-sectional descriptive study. LOCATION: Healthcare Centres of Coto and Calzada II (Gijón, Spain)...
December 7, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29222530/seizure-rates-in-enzalutamide-treated-men-with-metastatic-castration-resistant-prostate-cancer-and-risk-of-seizure-the-upward-study
#5
Susan Slovin, William Clark, Joan Carles, Andrew Krivoshik, Jung Wook Park, Fong Wang, Daniel George
Importance: The androgen receptor inhibitor enzalutamide prolongs survival in men with metastatic castration-resistant prostate cancer (mCRPC). In controlled clinical studies, 0.5% (10 of 2051) of patients experienced seizure, but patients with a history of or risk factors for seizure were excluded. Men with mCRPC and seizure risk factors have an estimated seizure rate of 2.8 per 100 patient-years without enzalutamide exposure. Objective: To assess seizure incidence in patients with seizure risk factors who were receiving enzalutamide for mCRPC...
December 7, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29217251/effectiveness-and-safety-of-aprotinin-use-in-thoracic-aortic-surgery
#6
Pierpaolo Chivasso, Vito D Bruno, Roberto Marsico, Anilkumar Sankanahalli Annaiah, Alexander Curtis, Carlo Zebele, Gianni D Angelini, Alan J Bryan, Cha Rajakaruna
OBJECTIVE: To determine the effectiveness and safety of aprotinin use in adult patients undergoing thoracic aortic surgery. DESIGN: Single-center, retrospective study. SETTING: All cases performed at a single university hospital. PARTICIPANTS: Between January 2004 and December 2014, 846 adult patients underwent thoracic aortic surgery. Due to missing or duplicated data on primary outcomes, 314 patients were excluded...
June 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29190171/associations-with-retinal-vascular-occlusions-in-a-diverse-urban-population
#7
Eric J Schwaber, Nia Fogelman, Ethan K Sobol, Devi Mehrotra, Jonathan A Powell, Umar Mian, David C Gritz
PURPOSE: Retinal vascular occlusions can lead to sudden and permanent visual impairment or blindness. Few epidemiological studies on retinal vascular occlusions have been conducted, especially on diverse populations. METHODS: This is a retrospective case-control study of all incident retinal vascular occlusions occurring during a three and one-half year study period at Montefiore Medical Center, capturing all potential cases by diagnosis codes. Patients with retinal venous occlusions (RVO) and retinal arterial occlusions (RAO) were analyzed separately and compared to age-matched control groups...
November 30, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29132199/non-fasting-triglyceride-levels-in-the-korean-population-with-and-without-ischemic-heart-disease-and-cerebrovascular-disease
#8
Seo Young Lee, Bo Kyung Koo, Min Kyong Moon
Background/Aims: Associations between non-fasting triglyceride (TG) levels and a risk of ischemic heart disease (IHD) and cerebrovascular accident (CVA) have been suggested in Caucasians. We aimed to investigate whether non-fasting TG levels reflect the risk of IHD/CVA in Koreans. Methods: We conducted an analysis of patients aged ≥ 30 years from the nationwide survey database. Fasting TG was defined as a measurement taken ≥ 12 hours since the last meal. Non-fasting TG was categorized by fasting duration of 0 to 3, 4 to 7, and 8 to 11 hours...
November 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29098973/-changes-in-cause-of-death-statistics-as-a-consequence-of-automated-coding
#9
P P M Harteloh
In 2013, Statistics Netherlands (CBS) has switched to an automated system for coding causes of death (IRIS). This change of method breaks with the tradition of manual coding of death certificates by medical coders that has lasted for over one hundred years. This article covers the major changes in the frequency of causes of death. It describes an increase of dementia (23%), CVA (11%), infectious diseases (43%) and risk factors (48%) as the underlying cause of death. Researchers, policy makers and medical doctors should take into account the differences between manual and automated coding when interpreting trends or comparing countries...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29097159/the-epidemiology-and-clinical-associations-of-stroke-in-patients-with-acute-myeloid-leukemia-a-review-of-10-972-admissions-from-the-2012-national-inpatient-sample
#10
Christopher Del Prete, Taeha Kim, Frederick Lansigan, Joseph Shatzel, Harley Friedman
BACKGROUND: Acute leukemia is known to confer an elevated risk of both hemorrhagic and thrombotic complications, but the development of stroke in this population is poorly characterized. This study assesses clinical and epidemiologic factors in a population of inpatients with acute myeloid leukemia (AML) and stroke. METHODS: Using the 2012 National Inpatient Sample, demographic and clinical data including age, gender, race, length of stay, in-hospital procedures, discharge diagnosis, disposition, and mortality incidence were extracted...
September 20, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/29056853/evaluation-of-risk-minimization-activities-for-cyproterone-acetate-2%C3%A2-mg-ethinylestradiol-35%C3%A2-%C3%A2%C2%B5g-a-cross-sectional-physician-survey
#11
Kimberly H Davis, Alex Asiimwe, Laurie J Zografos, David J McSorley, Elizabeth B Andrews
BACKGROUND: Cyproterone acetate 2 mg/ethinylestradiol 35 µg, an estrogen/progestogen treatment with anti-androgenic properties, shares a thromboembolism risk with combined hormonal contraceptives. Educational materials (i.e., direct healthcare professional communication, patient information card, prescriber checklist) were distributed to physicians to increase risk awareness. OBJECTIVE: The objective of this study was to measure physician knowledge of thromboembolism risk of cyproterone acetate 2 mg/ethinylestradiol 35 µg and ascertain whether physicians received the educational materials...
2017: Pharmaceutical Medicine
https://www.readbyqxmd.com/read/29027610/risk-factors-for-and-incidence-of-seizures-in-metastatic-castration-resistant-prostate-cancer-a-real-world-retrospective-cohort-study
#12
Charles Dharmani, Machaon Bonafede, Andrew Krivoshik
BACKGROUND AND OBJECTIVE: This real-world study assessed the prevalence, risk factors for, and incidence of seizures in patients with metastatic castration-resistant prostate cancer (mCRPC). METHODS: Patients with mCRPC were selected from MarketScan Commercial and Medicare Supplemental Databases between 1 January 2009 and 31 July 2012. Prevalence of seizure risk factors were described separately and in combination with other risk factors. Seizure incidence was calculated overall and for each risk factor group...
December 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28983399/carotenoids-as-potential-antioxidant-agents-in-stroke-prevention-a-systematic-review
#13
REVIEW
Ahmad Bahonar, Mohammad Saadatnia, Fariborz Khorvash, Mohammadreza Maracy, Alireza Khosravi
Stroke and other cerebrovascular diseases are among the most common causes of death worldwide. Prevention of modifiable risk factors is a cost-effective approach to decrease the risk of stroke. Oxidative stress is regarded as the major flexible operative agent in ischemic brain damage. This review presents recent scientific advances in understanding the role of carotenoids as antioxidants in lowering stroke risk based on observational studies. We searched Medline using the following terms: (Carotenoids [MeSH] OR Carotenes [tiab] OR Carotene [tiab] OR "lycopene [Supplementary Concept]" [MeSH] OR lycopene [tiab] OR beta-Carotene [tiab]) AND (stroke [MeSH] OR stroke [tiab] OR "Cerebrovascular Accident" [tiab] OR "Cerebrovascular Apoplexy" [tiab] OR "Brain Vascular Accident" [tiab] OR "Cerebrovascular Stroke" [tiab]) AND ("oxidative stress" [MeSH] OR "oxidative stress"[tiab])...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28977886/combined-renin-angiotensin-aldosterone-system-blockade-and-statin-therapy-effectively-reduces-the-risk-of-cerebrovascular-accident-in-autosomal-dominant-polycystic-kidney-disease-a-nationwide-population-based-cohort-study
#14
Pei-Hsun Sung, Hsin-Ju Chiang, Mel S Lee, John Y Chiang, Hon-Kan Yip, Yao-Hsu Yang
Fairly limited data reported the incidence and risk of cerebrovascular accident (CVA) in autosomal dominant polycystic kidney disease (ADPKD). Additionally, little is known regarding the therapeutic impact of renin-angiotensin-aldosterone system (RAAS) blockade and statin on reducing the occurrence of CVA in ADPKD. We utilized the data from Taiwan National Health Insurance Research Database (NHIRD) to perform a population-based cohort study (1997-2013). A total of 2,647 patients with ADPKD were selected from 1,000,000 general population after excluding patients with age<18, renal replacement therapy and concomitant diagnosis of CVA...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28852642/cardiovascular-risk-assessment-by-frs-and-score-in-iranian-adult-population
#15
Alipasha Meysamie, Fereshteh Salarvand, MirHojjat Khorasanizadeh, Reza Ghalehtaki, Mahsa Eskian, Saeed Ghodsi, Shirin Ghalehtaki, Mehrshad Abbasi, Koroush Etemad, Fereshteh Asgari, Alireza Esteghamati
BACKGROUND: Handling the growing epidemic of coronary heart disease in developing nations hinges on primary prevention, which logistically requires directing preventive interventions to those at the highest risk. Therefore, implementing cardiovascular risk assessment profiles is crucial to distinguish high risk groups who truly need extensive preventive measures. We aimed to draw a picture of the cardiovascular risk profiles in the Iranian adult population for the first time. METHODS: Demographic, anthropometric, and laboratory data as well as blood pressure and smoking status of 3944 subjects participating in the 2011 national surveillance of risk factors for non-communicable diseases were used to calculate the mean estimated risk of coronary artery disease and the relative frequency of low-, medium- and high-risk subjects based on FRS and SCORE indices in general population as well as different age, sex, and residence subgroups...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28838088/management-and-outcomes-of-patients-with-atrial-fibrillation-and-a-history-of-cancer-the-orbit-af-registry
#16
Chiara Melloni, Peter Shrader, Joseph Carver, Jonathan P Piccini, Laine Thomas, Gregg C Fonarow, Jack Ansell, Bernard Gersh, Alan S Go, Elaine Hylek, Irving M Herling, Kenneth W Mahaffey, Anthony F Yu, Eric D Peterson, Peter R Kowey
Aims: The presence of cancer can complicate treatment choices for patients with atrial fibrillation (AF) increasing both the risk of thrombotic and bleeding events. Methods and results: Using data from Outcomes Registry for Better Informed Treatment of Atrial Fibrillation, we aimed to characterize AF patients with cancer, to describe their management and to assess the association between cancer and cardiovascular (CV) outcomes. Among 9749 patients, 23.8% had history of cancer (57% solid malignancy, 1...
July 1, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/28791563/differences-in-quality-of-life-between-jewish-and-arab-patients-on-hemodialysis
#17
Orly Romano-Zelekha, Eliezer Golan, Anneke Ifrah, Talia Weinstein, Tamy Shohat
PURPOSE: Higher health-related quality of life (HRQOL) in dialysis patients has been associated with fewer hospitalizations and lower mortality. Since Arab patients on dialysis have better survival rates than Jewish patients, we hypothesized that they would have higher HRQOL. We also studied the impact of several risk factors on HRQOL in each population. METHODS: Based on a national dialysis registry, patients from 64 hemodialysis units were recruited to participate...
December 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28777392/long-term-follow-up-of-continuous-flow-left-ventricular-assist-devices-complications-and-predisposing-risk-factors
#18
Tolulope A Adesiyun, Rhondalyn C McLean, Ryan J Tedford, Glenn J R Whitman, Chris M Sciortino, John V Conte, Ashish S Shah, Stuart D Russell
PURPOSE: To assess LVAD complications and their overall effect on mortality and determine factors associated with development of early and long-term complications. METHODS: A retrospective cohort study of patients who underwent continuous flow LVAD placement between January 1, 2000 and November 30, 2013 was performed. The incidence of complications (sepsis or bacteremia, driveline infections, gastrointestinal bleeding, pump thrombosis, cerebrovascular accidents and anemia requiring transfusion) was collected and logistic regression and Cox proportional hazards analyses were performed...
August 2, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28742104/serum-neutrophil-gelatinase-associated-lipocalin-the-estimation-of-hospital-prognosis-in-patients-with-st-elevated-myocardial-infarction
#19
Victoria Karetnikova, Anastasia Osokina, Olga Gruzdeva, Evgenya Uchasova, Michael Zykov, Victoria Kalaeva, Vasiliy Kashtalap, Kristina Shafranskaya, Olga Barbarash
We aimed to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (sNGAL) for predicting in-hospital outcomes in patients with ST-elevated myocardial infarction (STEMI). Patients admitted within 24 hours of developing STEMI clinical symptoms were evaluated for sNGAL on hospitalization days 1 and 12. Recurrent myocardial infarction, early post-infarction angina, acute cerebrovascular accident, and death were assessed as adverse outcomes during hospitalization. The actors associated with adverse outcome were evaluated using univariate and multivariate regression analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28716041/potentially-inappropriate-home-medications-among-older-patients-with-cardiovascular-disease-admitted-to-a-cardiology-service-in-usa
#20
Marwan Sheikh-Taha, Hani Dimassi
BACKGROUND: The use of potentially inappropriate medications (PIMs) may pose more risks than benefits to patients and is a major factor contributing to the likelihood of serious adverse drug reactions and negative health outcomes among older patients. METHODS: A retrospective chart review was conducted in a tertiary care center in USA where home medications of the older patients were reviewed and analyzed upon hospital admission over three months, from March till May 2016...
July 17, 2017: BMC Cardiovascular Disorders
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