Martin Kuric, Susanne Beck, Doris Schneider, Wyonna Rindt, Marietheres Evers, Jutta Meissner-Weigl, Sabine Zeck, Melanie Krug, Marietta Herrmann, Tanja Nicole Hartmann, Ellen Leich, Maximilian Rudert, Denitsa Docheva, Anja Seckinger, Dirk Hose, Franziska Jundt, Regina Ebert
Multiple myeloma involves early dissemination of malignant plasma cells across the bone marrow; however, the initial steps of dissemination remain unclear. Human bone marrow-derived mesenchymal stromal cells (hMSCs) stimulate myeloma cell expansion (e.g., IL-6) and simultaneously retain myeloma cells via chemokines (e.g., CXCL12) and adhesion factors. Hence, we hypothesized that the imbalance between cell division and retention drives dissemination. We present an in vitro model using primary hMSCs co-cultured with INA-6 myeloma cells...
April 10, 2024: Cancer Res Commun