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https://www.readbyqxmd.com/read/28919040/heme-binding-biguanides-target-cytochrome-p450-dependent-cancer-cell-mitochondria
#1
Zhijun Guo, Irina F Sevrioukova, Ilia G Denisov, Xia Zhang, Ting-Lan Chiu, Dafydd G Thomas, Eric A Hanse, Rebecca A D Cuellar, Yelena V Grinkova, Vanessa Wankhede Langenfeld, Daniel S Swedien, Justin D Stamschror, Juan Alvarez, Fernando Luna, Adela Galván, Young Kyung Bae, Julia D Wulfkuhle, Rosa I Gallagher, Emanuel F Petricoin, Beverly Norris, Craig M Flory, Robert J Schumacher, M Gerard O'Sullivan, Qing Cao, Haitao Chu, John D Lipscomb, William M Atkins, Kalpna Gupta, Ameeta Kelekar, Ian A Blair, Jorge H Capdevila, John R Falck, Stephen G Sligar, Thomas L Poulos, Gunda I Georg, Elizabeth Ambrose, David A Potter
The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids (EETs), which promoted the electron transport chain/respiration and inhibited AMPKα. CYP3A4 knockdown activated AMPKα, promoted autophagy, and prevented mammary tumor formation. The diabetes drug metformin inhibited CYP3A4-mediated EET biosynthesis and depleted cancer cell-intrinsic EETs...
August 29, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28917269/triplet-folfoxiri-versus-doublet-folfox-or-folfiri-backbone-chemotherapy-as-first-line-treatment-of-metastatic-colorectal-cancer-a-systematic-review-and-meta-analysis
#2
REVIEW
Rui Pedro Marques, Gonçalo S Duarte, Carmelo Sterrantino, Helena Luna Pais, António Quintela, Ana Paula Martins, João Costa
Uncertainty exists regarding the comparative effectiveness of triplet chemotherapy (FOLFOXIRI) as backbone first-line chemotherapy for metastatic colorectal cancer (mCRC). We conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs) comparing triplet versus doublet chemotherapy (FOLFOX or FOLFIRI) as first-line therapy in mCRC. Methods and reporting followed PRISMA and SAMPL guidelines. Eight RCTs were included, comprising 1732 patients. In pooled analysis, FOLFOXIRI was associated with improvements in efficacy outcomes, notably with a 25% survival increase (95%CI: 10-37%)...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28865744/selective-ru-ii-lawsone-complexes-inhibiting-tumor-cell-growth-by-apoptosis
#3
Katia M Oliveira, Luna-Dulcey Liany, Rodrigo S Corrêa, Victor M Deflon, Marcia R Cominetti, Alzir A Batista
New Ru(II) complexes with lawsone (law) characterized as trans-[Ru(law)(PPh3)2(N-N)]PF6, where PPh3 means triphenylphosphine and N-N is 2,2'-bipyridine (1), 4,4'-dimethyl-2,2'-bipyridine (2), 4,4'-dimethoxy-2,2'-bipyridine (3), 1,10-phenanthroline (4) or 4,7-diphenyl-1,10-phenanthroline (5), induce apoptosis in tumor cells. Cytotoxicity of the complexes against the tumor cell lines DU-145 (prostate cancer cells), MCF-7 (breast cancer cells), A549 (lung cancer cells) and lung non-tumor cell line MRC-5 demonstrated promising IC50 values, lower than those found for the cisplatin, a drug used as a reference...
August 26, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28789930/commentary-on-an-integrated-metabolic-atlas-of-clear-cell-renal-cell-carcinoma-hakimi-aa-reznik-e-lee-ch-creighton-cj-brannon-ar-luna-a-aksoy-ba-liu-em-shen-r-lee-w-chen-y-stirdivant-sm-russo-p-chen-yb-tickoo-sk-reuter-ve-cheng-eh-sander-c-hsieh-jj-cancer-cell
#4
Byron H Lee
Dysregulated metabolism is a hallmark of cancer, manifested through alterations in metabolites. We performed metabolomic profiling on 138 matched clear cell renal cell carcinoma (ccRCC)/normal tissue pairs and found that ccRCC is characterized by broad shifts in central carbon metabolism, one-carbon metabolism, and antioxidant response. Tumor progression and metastasis were associated with metabolite increases in glutathione and cysteine/methionine metabolism pathways. We develop an analytic pipeline and visualization tool (metabolograms) to bridge the gap between TCGA transcriptomic profiling and our metabolomic data, which enables us to assemble an integrated pathway-level metabolic atlas and to demonstrate discordance between transcriptome and metabolome...
August 5, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28777701/a-pet-mr-imaging-approach-for-the-integrated-assessment-of-chemotherapy-induced-brain-heart-and-bone-injuries-in-pediatric-cancer-survivors-a-pilot-study
#5
Ashok J Theruvath, Anat Ilivitzki, Anne Muehe, Johanna Theruvath, Praveen Gulaka, Christine Kim, Sandra Luna-Fineman, Kathleen M Sakamoto, Kristen W Yeom, Phillip Yang, Michael Moseley, Frandics Chan, Heike E Daldrup-Link
Purpose To develop a positron emission tomography (PET)/magnetic resonance (MR) imaging protocol for evaluation of the brain, heart, and joints of pediatric cancer survivors for chemotherapy-induced injuries in one session. Materials and Methods Three teams of experts in neuroimaging, cardiac imaging, and bone imaging were tasked to develop a 20-30-minute PET/MR imaging protocol for detection of chemotherapy-induced tissue injuries of the brain, heart, and bone. In an institutional review board-approved, HIPAA-compliant, prospective study from April to July 2016, 10 pediatric cancer survivors who completed chemotherapy underwent imaging of the brain, heart, and bone with a 3-T PET/MR imager...
August 4, 2017: Radiology
https://www.readbyqxmd.com/read/28753591/mucinous-carcinoma-of-the-breast-a-case-report-and-review-of-the-literature
#6
Jorge Luna-Abanto, Grivette Mendoza Tisoc
Mucinous carcinoma of the breast is a rare histological type, which represents between 1 and 4% of breast cancers. Treatment does not differ from other histological types, and it occurs more frequently in older adult women. Prognosis is good. We report the case of a 72-year-old patient with a 1-year disease course characterized by the appearance of a slow-growing tumor in the left upper quadrant of the left breast, in which the core biopsy showed mucinous breast carcinoma of a low nuclear grade. The patient underwent quadrantectomy plus a sentinel node biopsy, which confirmed the initial diagnosis...
July 27, 2017: Medwave
https://www.readbyqxmd.com/read/28743122/utility-of-transbronchial-lung-cryobiopsy-in-non-interstitial-diseases
#7
Olivia Sánchez-Cabral, Dina Martínez-Mendoza, Sebastián Fernandez-Bussy, Berenice López-González, Carolina Perea-Talamantes, Rosa María Rivera-Rosales, César Luna-Rivero, José Arturo Martínez-Orozco, Luis Felipe Flores-Suárez, Patricio Santillán-Doherty, Gustavo Reyes-Terán
BACKGROUND: Transbronchial lung cryobiopsy (TLCB), performed with a flexible cryoprobe, is an interventional pulmonology procedure that has proved its diagnostic value for interstitial pulmonary disease. However, it has not been explored extensively as a diagnostic tool for patients with non-interstitial lung pathology, including infectious and malignant diseases. OBJECTIVE: To evaluate the diagnostic yield and safety of an interventional pulmonology approach that integrates TLCB and bronchoalveolar lavage (BAL) for the diagnosis of non-interstitial pulmonary disease...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28735896/argonaute-clip-defines-a-deregulated-mir-122-bound-transcriptome-that-correlates-with-patient-survival-in-human-liver-cancer
#8
Joseph M Luna, Juan M Barajas, Kun-Yu Teng, Hui-Lung Sun, Michael J Moore, Charles M Rice, Robert B Darnell, Kalpana Ghoshal
MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and functions as a tumor suppressor, yet systematic and direct biochemical elucidation of the miR-122 target network remains incomplete. To this end, we performed Argonaute crosslinking immunoprecipitation (Argonaute [Ago]-CLIP) sequencing in miR-122 knockout and control mouse livers, as well as in matched human hepatocellular carcinoma (HCC) and benign liver tissue to identify miRNA target sites transcriptome-wide in two species...
August 3, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28731993/-colorectal-cancer-in-young-adults-clinical-and-epidemiological-features-in-the-peruvian-population
#9
Jorge Luna-Abanto, Eliana Rafael-Horna, Fradis Gil-Olivares
OBJECTIVES: To determine the clinical epidemiological characteristics of young adult patients with colorectal cancer. MATERIALS AND METHODS: Information collected by the Direccion General de Epidemiologia by the surveillance strategy in non-communicable diseases for the period 2006-2014 was requested. The rate of age-adjusted incidence and a descriptive statistical analysis of the variables studied were calculated. RESULTS: 1261 CRC cases were reported in patients between 20-49 years of age...
April 2017: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28721605/how-to-provide-gadolinium-free-pet-mr-cancer-staging-of-children-and-young-adults-in-less-than-1%C3%A2-h-the-stanford-approach
#10
Anne M Muehe, Ashok J Theruvath, Lillian Lai, Maryam Aghighi, Andrew Quon, Samantha J Holdsworth, Jia Wang, Sandra Luna-Fineman, Neyssa Marina, Ranjana Advani, Jarrett Rosenberg, Heike E Daldrup-Link
PURPOSE: To provide clinically useful gadolinium-free whole-body cancer staging of children and young adults with integrated positron emission tomography/magnetic resonance (PET/MR) imaging in less than 1 h. PROCEDURES: In this prospective clinical trial, 20 children and young adults (11-30 years old, 6 male, 14 female) with solid tumors underwent 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) PET/MR on a 3T PET/MR scanner after intravenous injection of ferumoxytol (5 mg Fe/kg) and [(18)F]FDG (2-3 MBq/kg)...
July 18, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28663564/no-cancer-predisposition-or-increased-spontaneous-mutation-frequencies-in-neil-dna-glycosylases-deficient-mice
#11
Veslemøy Rolseth, Luisa Luna, Ann Karin Olsen, Rajikala Suganthan, Katja Scheffler, Christine G Neurauter, Ying Esbensen, Anna Kuśnierczyk, Gunn A Hildrestrand, Anne Graupner, Jill M Andersen, Geir Slupphaug, Arne Klungland, Hilde Nilsen, Magnar Bjørås
Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of a number of these enzymes with overlapping substrate specificities has been thought to be the reason why single knock-out models of individual DNA glycosylases are not cancer prone. In this work we have characterized DNA glycosylases NEIL1 and NEIL2 (Neil1 (-/-) /Neil2 (-/-)) double and NEIL1, NEIL2 and NEIL3 (Neil1 (-/-) /Neil2 (-/-) /Neil3 (-/-)) triple knock-out mouse models...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28663073/a-study-of-the-suitability-of-autoencoders-for-preprocessing-data-in-breast-cancer-experimentation
#12
Laura Macías-García, José María Luna-Romera, Jorge García-Gutiérrez, María Del Mar Martínez-Ballesteros, José C Riquelme-Santos, Ricardo González-Cámpora
Breast cancer is the most common cause of cancer death in women. Today, post-transcriptional protein products of the genes involved in breast cancer can be identified by immunohistochemistry. However, this method has problems arising from the intra-observer and inter-observer variability in the assessment of pathologic variables, which may result in misleading conclusions. Using an optimal selection of preprocessing techniques may help to reduce observer variability. Deep learning has emerged as a powerful technique for any tasks related to machine learning such as classification and regression...
June 26, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28654384/fluorescent-plasmonic-and-radiotherapeutic-properties-of-the-177-lu-dendrimer-aunp-folate-bombesin-nanoprobe-located-inside-cancer-cells
#13
Héctor Mendoza-Nava, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Keila Isaac-Olivé
The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of (177)Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ((177)Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP-folate-bombesin for optical imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28638729/cellular-immunotherapies-for-cancer
#14
REVIEW
Pedro Berraondo, Sara Labiano, Luna Minute, Iñaki Etxeberria, Marcos Vasquez, Alvaro Sanchez-Arraez, Alvaro Teijeira, Ignacio Melero
Lessons learned over decades on the use of gene and cell therapies have found clinical applicability in the field of cancer immunotherapy. On December 16(th), 2016 a symposium was held in Pamplona (Spain) to analyze and discuss the critical points for the clinical success of adoptive cell transfer strategies in cancer immunotherapy. Cellular immunotherapy is being currently exploited for the development of new cancer vaccines using ex vivo manipulated dendritic cells or to enhance the number of effector cells, transferring reinvigorated NK cells or T cells...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28602400/novel-protein-interactions-with-an-actin-homolog-mreb-of-helicobacter-pylori-determined-by-bacterial-two-hybrid-system
#15
Reyna Cristina Zepeda Gurrola, Yajuan Fu, Isabel Cristina Rodríguez Luna, Claudia Guadalupe Benítez Cardoza, María de Jesús López López, Yolanda López Vidal, Germán Rubén Aguilar Gutíerrez, Mario A Rodríguez Pérez, Xianwu Guo
The bacterium Helicobacter pylori infects more than 50% of the world population and causes several gastroduodenal diseases, including gastric cancer. Nevertheless, we still need to explore some protein interactions that may be involved in pathogenesis. MreB, an actin homolog, showed some special characteristics in previous studies, indicating that it could have different functions. Protein functions could be realized via protein-protein interactions. In the present study, the MreB protein from H. pylori 26695 fused with two tags 10×His and GST in tandem was overexpressed and purified from Escherchia coli...
August 2017: Microbiological Research
https://www.readbyqxmd.com/read/28574670/performance-of-aptima-and-cobas-hpv-testing-platforms-in-detecting-high-grade-cervical-dysplasia-and-cancer
#16
Yimin Ge, Paul Christensen, Eric Luna, Donna Armylagos, Mary R Schwartz, Dina R Mody
BACKGROUND: Human papillomavirus (HPV) tests and genotyping have been used in clinical risk assessment. The purpose of this study was to analyze the performance of 2 common HPV testing platforms in detecting high-grade cervical lesions (high-grade squamous intraepithelial lesion [HSIL] or worse [≥HSIL]). METHODS: Between January 1 and December 31, 2015, 2041 Papanicolaou (Pap) tests with biopsy confirmation were analyzed along with HPV tests performed on Cobas or Aptima platforms...
August 2017: Cancer
https://www.readbyqxmd.com/read/28535975/novel-poly-diol-sebacate-s-as-additives-to-modify-paclitaxel-release-from-poly-lactic-co-glycolic-acid-thin-films
#17
Lucila Navarro, Diana-Elena Mogosanu, Natalia Ceaglio, Julio Luna, Peter Dubruel, Ignacio Rintoul
Paclitaxel (PTX) incorporation in poly(lactic-co-glycolic acid) (PLGA) matrices produce films with high tensile rigidity and slow release that fail to deliver the required release rate for most biomedical applications such as in drug eluting stents and cancer treatments. To modify and improve this behavior, a set of poly(diol sebacate)s were synthesized and fully characterized as possible additives. The tensile properties of PLGA blends were evaluated as these materials could be used as coatings in drug eluting stent applications...
August 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28533483/high-il-1r8-expression-in-breast-tumors-promotes-tumor-growth-and-contributes-to-impaired-antitumor-immunity
#18
Luis Felipe Campesato, Ana Paula M Silva, Luna Cordeiro, Bruna R Correa, Fabio C P Navarro, Rafael F Zanin, Marina Marçola, Lilian T Inoue, Mariana L Duarte, Martina Molgora, Fabio Pasqualini, Matteo Massara, Pedro Galante, Romualdo Barroso-Sousa, Nadia Polentarutti, Federica Riva, Erico T Costa, Alberto Mantovani, Cecilia Garlanda, Anamaria A Camargo
Tumors develop numerous strategies to fine-tune inflammation and avoid detection and eradication by the immune system. The identification of mechanisms leading to local immune dysregulation is critical to improve cancer therapy. We here demonstrate that Interleukin-1 receptor 8 (IL-1R8 - previously known as SIGIRR/TIR8), a negative regulator of Toll-Like and Interleukin-1 Receptor family signaling, is up-regulated during breast epithelial cell transformation and in primary breast tumors. IL-1R8 expression in transformed breast epithelial cells reduced IL-1-dependent NF-κB activation and production of pro-inflammatory cytokines, inhibited NK cell activation and favored M2-like macrophage polarization...
July 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28474703/-risk-factors-associated-to-diffuse-gastric-cancer-and-intestinal-histological-patterns-in-an-adult-population-from-western-mexico
#19
Netzahualpilli Delgado-Figueroa, Paloma Casas-Junco, Juan Heriberto Torres-Jasso, Andrea Rebeca Bustos-Carpinteyro, Ernesto Santiago-Luna, María Eugenia Marín-Contreras, Josefina Yoaly Sánchez-López
INTRODUCTION: Gastric cancer (GC) is the third leading cause of cancer death worldwide, and is divided histologically in diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC). Multiple risk factors have been associated with GC in different populations. The objective was to analyze the risk factors associated to DGC and IGC in a population from the western region of Mexico. MATERIAL AND METHODS: The DGC (n = 27) and IGC (n = 26) cases, each matched by age and sex with a control group, were analyzed...
March 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28469386/epithelial-ovarian-cancer-diagnosis-of-second-harmonic-generation-images-a-semiautomatic-collagen-fibers-quantification-protocol
#20
Angel A Zeitoune, Johana Sj Luna, Kynthia Sanchez Salas, Luciana Erbes, Carlos L Cesar, Liliana Ala Andrade, Hernades F Carvahlo, Fátima Bottcher-Luiz, Victor H Casco, Javier Adur
A vast number of human pathologic conditions are directly or indirectly related to tissular collagen structure remodeling. The nonlinear optical microscopy second-harmonic generation has become a powerful tool for imaging biological tissues with anisotropic hyperpolarized structures, such as collagen. During the past years, several quantification methods to analyze and evaluate these images have been developed. However, automated or semiautomated solutions are necessary to ensure objectivity and reproducibility of such analysis...
2017: Cancer Informatics
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