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Medial prefrontal cortex

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https://www.readbyqxmd.com/read/29666360/signaling-pathways-responsible-for-the-rapid-antidepressant-like-effects-of-a-glun2a-preferring-nmda-receptor-antagonist
#1
Marta Gordillo-Salas, Fuencisla Pilar-Cuéllar, Yves P Auberson, Albert Adell
In a previous study we found that the preferring GluN2A receptor antagonist, NVP-AAM077, elicited rapid antidepressant-like effects in the forced swim test that was related to the release of glutamate and serotonin in the medial prefrontal cortex. In the present work we sought to examine the duration of this behavioral effect as well as the molecular readouts involved. Our results showed that NVP-AAM077 reduced the immobility in the forced swim test 30 min and 24 h after its administration. However, this effect waned 7 days later...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29665419/widespread-associations-between-trait-conscientiousness-and-thickness-of-brain-cortical-regions
#2
Gary J Lewis, David Alexander Dickie, Simon R Cox, Sherif Karama, Alan C Evans, John M Starr, Mark E Bastin, Joanna M Wardlaw, Ian J Deary
The neural correlates of human personality have been of longstanding interest; however, most studies in the field have relied on modest sample sizes and few replicable results have been reported to date. We investigated relationships between personality and brain gray matter in a sample of generally healthy, older (mean age 73 years) adults from Scotland drawn from the Lothian Birth Cohort 1936. Participants (N = 578) completed a brain MRI scan and self-reported Big Five personality trait measures. Conscientiousness trait scores were positively related to brain cortical thickness in a range of regions, including bilateral parahippocampal gyrus, bilateral fusiform gyrus, left cingulate gyrus, right medial orbitofrontal cortex, and left dorsomedial prefrontal cortex...
April 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29664924/evidence-supporting-a-role-for-astrocytes-in-the-regulation-of-cognitive-flexibility-and-neuronal-oscillations-through-the-ca2-binding-protein-s100%C3%AE
#3
Adam T Brockett, Gary A Kane, Patrick K Monari, Brandy A Briones, Pierre-Antoine Vigneron, Gabriela A Barber, Andres Bermudez, Uma Dieffenbach, Alexander D Kloth, Timothy J Buschman, Elizabeth Gould
The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch between two task-relevant dimensions. Changes in neuronal oscillations and alterations in the coupling across frequency ranges have been correlated with attention and cognitive flexibility. Here we show that astrocytes in the mPFC of adult male Sprague Dawley rats, participate in cognitive flexibility through the astrocyte-specific Ca2+ binding protein S100β, which improves cognitive flexibility and increases phase amplitude coupling between theta and gamma oscillations...
2018: PloS One
https://www.readbyqxmd.com/read/29662447/neural-mechanisms-underlying-time-perception-and-reward-anticipation
#4
Nihal Apaydın, Sertaç Üstün, Emre H Kale, İpek Çelikağ, Halise D Özgüven, Bora Baskak, Metehan Çiçek
Findings suggest that the physiological mechanisms involved in the reward anticipation and time perception partially overlap. But the systematic investigation of a potential interaction between time and reward systems using neuroimaging is lacking. Eighteen healthy volunteers (all right-handed) participated in an event-related functional magnetic resonance imaging (fMRI) experiment that employs a visual paradigm that consists monetary reward to assess whether the functional neural representations of time perception and reward prospection are shared or distinct...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29661965/neural-activity-in-ventral-medial-prefrontal-cortex-is-modulated-more-before-approach-than-avoidance-during-reinforced-and-extinction-trial-blocks
#5
Ronny N Gentry, Matthew R Roesch
Ventromedial prefrontal cortex (vmPFC) is thought to provide regulatory control over Pavlovian fear responses and has recently been implicated in appetitive approach behavior, but much less is known about its role in contexts where appetitive and aversive outcomes can be obtained and avoided, respectively. To address this issue, we recorded from single neurons in vmPFC while male rats performed our combined approach and avoidance task under reinforced and non-reinforced (extinction) conditions. Surprisingly, we found that cues predicting reward modulated cell firing in vmPFC more often and more robustly than cues preceding avoidable shock; additionally, firing of vmPFC neurons was both response (press or no-press) and outcome (reinforced or extinction) selective...
April 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29660081/data-driven-analysis-of-functional-connectivity-reveals-a-potential-auditory-verbal-hallucination-network
#6
Dustin Scheinost, Fuyuze Tokoglu, Michelle Hampson, Ralph Hoffman, R Todd Constable
Schizophrenia is a severe global health problem, with over half of such patients experiencing auditory verbal hallucinations (AVHs). A better understanding of the neural correlates differentiating patients experiencing AVHs from patients not experiencing AVHs and healthy controls may identify targets that lead to better treatment strategies for AVHs. Employing 2 data-driven, voxel-based measure of functional connectivity, we studied 46 patients with schizophrenia or schizoaffective disorder (28 experiencing AVHs and 18 not experiencing AVHs)...
April 5, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29656872/the-medial-prefrontal-cortex-shapes-dopamine-reward-prediction-errors-under-state-uncertainty
#7
Clara Kwon Starkweather, Samuel J Gershman, Naoshige Uchida
Animals make predictions based on currently available information. In natural settings, sensory cues may not reveal complete information, requiring the animal to infer the "hidden state" of the environment. The brain structures important in hidden state inference remain unknown. A previous study showed that midbrain dopamine neurons exhibit distinct response patterns depending on whether reward is delivered in 100% (task 1) or 90% of trials (task 2) in a classical conditioning task. Here we found that inactivation of the medial prefrontal cortex (mPFC) affected dopaminergic signaling in task 2, in which the hidden state must be inferred ("will reward come or not?"), but not in task 1, where the state was known with certainty...
April 9, 2018: Neuron
https://www.readbyqxmd.com/read/29656270/reduced-integrity-of-the-uncinate-fasciculus-and-cingulum-in-depression-a-stem-by-stem-analysis
#8
Kartik D Bhatia, Luke A Henderson, Eugene Hsu, Mark Yim
INTRODUCTION: The subgenual cingulate gyrus (Brodmann's Area 25: BA25) is hypermetabolic in depression and has been targeted successfully with deep brain stimulation. Two of the white matter tracts that play a role in treatment response are the uncinate fasciculus (UF) and the cingulum bundle. The UF has three prefrontal stems, the most medial of which extends from BA25 (which deals with mood regulation) and the most lateral of which extends from the dorso-lateral prefrontal cortex (concerned with executive function)...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656266/cortical-and-subcortical-changes-in-patients-with-premenstrual-syndrome
#9
Peng Liu, Ying Wei, Yingying Fan, Hai Liao, Geliang Wang, Ru Li, Gaoxiong Duan, Demao Deng, Wei Qin
BACKGROUND: Premenstrual syndrome (PMS) is characterized by a series of emotional, physical and behavioral symptoms. Although PMS is related to dysfunctions of the central nervous system, the neuropathological mechanism of PMS still has not been clearly established. The aim of this study is to evaluate potential differences in both cortical thickness and subcortical volumes in PMS patients compared to healthy controls (HCs). METHODS: Twenty PMS patients and twenty HCs underwent a structural magnetic resonance imaging scan and clinical assessment...
April 7, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29656259/increased-coherence-based-regional-homogeneity-in-resting-state-patients-with-first-episode-drug-naive-somatization-disorder
#10
Yangpan Ou, Feng Liu, Jindong Chen, Pan Pan, Renrong Wu, Qinji Su, Zhikun Zhang, Jingping Zhao, Wenbin Guo
BACKGROUND: Abnormal neural activity has been observed in patients with somatization disorder (SD), especially in brain regions of the default-mode network (DMN). In this study, a coherence-based regional homogeneity (Cohe-ReHo) approach was used to detect abnormal regional synchronization in patients with SD, which might be used to differentiate the patients from the controls. METHODS: We recruited 25 patients with SD and 28 healthy controls. The imaging data of the participants were analyzed using the Cohe-ReHo approach...
April 6, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29650697/cell-type-specific-contributions-of-medial-prefrontal-neurons-to-flexible-behaviors
#11
Hirofumi Nakayama, Ines Ibañez-Tallon, Nathaniel Heintz
Behavioral flexibility and impulse control are necessary for successful execution of adaptive behavior. They are impaired in patients with damage to the prefrontal cortex (PFC) and in some clinically important conditions such as obsessive-compulsive disorder (OCD). Although the medial prefrontal cortex (mPFC) has been investigated as a critical structure for behavioral flexibility and impulse control, the contribution of the underlying pyramidal neuron cell types in the mPFC remained to be understood. Here we show that interneuron-mediated local inactivation of pyramidal neurons in the mPFC of male and female mice induces both premature responses and choice bias, and establish that these impulsive and compulsive responses are modulated independently...
April 12, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29648487/bdnf-expression-increases-without-changes-in-play-behavior-following-concussion-in-juvenile-rats-rattus-norvegicus-brief-report
#12
Allison C F Dyck, Tammy L Ivanco
PURPOSE: Young children have a high risk of concussion or mild traumatic brain injury (mTBI). Children often appear healthy soon after mTBI, but some have pervasive cognitive and/or motor impairments. Understanding underlying mechanisms recruited after concussion may help for return to play protocols and mitigating what might be lifelong impairments. METHODS: We investigated molecular and behavioral changes in a rat model of childhood concussion. Rats received an injury or sham procedure at an age approximately equivalent to the human period of early childhood...
April 12, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29644109/morphine-alcohol-treatment-impairs-cognitive-functions-and-increases-neuro-inflammatory-responses-in-the-medial-prefrontal-cortex-of-juvenile-male-rats
#13
Adekomi Damilare Adedayo, Adegoke Adebiyi Aderinola, Tijani Ahmad Adekilekun, Olaniyan Olayinka Olaolu, Alabi Mutiyat Olanike, Ijomone Kafilat Olayemi
In the developed and developing world, opioid consumption in combination with alcohol has become one of the substances abused. In this experiment, we examined the effects of alcohol, morphine, and morphine+alcohol combination on cognitive functions and neuroinflammatory responses in the medial prefrontal cortex (mPFC) of juvenile male rats. Alcohol (1.0 ml of 15% v/v ethanol twice daily, subcutaneously, 7 hours apart), morphine (0.5 ml/kg of 0.4 mg/kg morphine chlorate twice daily, subcutaneously, 7 hours apart), morphine+alcohol co-treatment (0...
March 2018: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29629499/reduced-brain-entropy-by-repetitive-transcranial-magnetic-stimulation-on-the-left-dorsolateral-prefrontal-cortex-in-healthy-young-adults
#14
Donghui Song, Da Chang, Jian Zhang, Wei Peng, Yuanqi Shang, Xin Gao, Ze Wang
Entropy indicates system irregularity and the capacity for information processing. Recent research has identified interesting voxel-wise entropy distribution patterns in normal brain and its changes due to aging and brain disorders. A question of great scientific and clinical importance is whether brain entropy (BEN) can be modulated using non-invasive neuromodulations. The purpose of this study was to address this open question using high-frequency repetitive transcranial magnetic stimulation (rTMS). BEN was calculated from resting state fMRI at each voxel acquired before and after applying 20 Hz rTMS or SHAM (control) stimulation...
April 9, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29628334/consolidative-mechanisms-of-emotional-processing-in-rem-sleep-and-ptsd
#15
REVIEW
Anthony L A Murkar, Joseph De Koninck
Research suggests sleep plays a role in the consolidation of recently acquired memories for long-term storage. rapid eye movement (REM) sleep has been shown to play a complex role in emotional-memory processing, and may be involved in subsequent waking-day emotional reactivity and amygdala responsivity. Interaction of the hippocampus and basolateral amygdala with the medial-prefrontal cortex is associated with sleep-dependent learning and emotional memory processing. REM is also implicated in post-traumatic stress disorder (PTSD), which is characterized by sleep disturbance, heightened reactivity to fearful stimuli, and nightmares...
March 15, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29628186/amygdala-functional-and-structural-connectivity-predicts-individual-risk-tolerance
#16
Wi Hoon Jung, Sangil Lee, Caryn Lerman, Joseph W Kable
Risk tolerance, the degree to which an individual is willing to tolerate risk in order to achieve a greater expected return, influences a variety of financial choices and health behaviors. Here we identify intrinsic neural markers for risk tolerance in a large (n = 108) multimodal imaging dataset of healthy young adults, which includes anatomical and resting-state functional MRI and diffusion tensor imaging. Using a data-driven approach, we found that higher risk tolerance was most strongly associated with greater global functional connectivity (node strength) of and greater gray matter volume in bilateral amygdala...
March 28, 2018: Neuron
https://www.readbyqxmd.com/read/29628067/orbital-and-medial-prefrontal-cortex-functional-connectivity-of-major-depression-vulnerability-and-disease
#17
Zoe Samara, Elisabeth A T Evers, Frenk Peeters, Harry B M Uylings, Grazyna Rajkowska, Johannes G Ramaekers, Peter Stiers
BACKGROUND: Pathophysiology models of major depression (MD) center on the dysfunction of various cortical areas within the orbital and medial prefrontal cortex. While independent structural and functional abnormalities in these areas are consistent findings in MD, the complex interactions among them and the rest of the cortex remain largely unexplored. METHODS: We used resting-state functional magnetic resonance imaging connectivity to systematically map alterations in the communication between orbital and medial prefrontal cortex fields and the rest of the brain in MD...
April 2018: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29626167/intracranial-electrophysiology-reveals-reproducible-intrinsic-functional-connectivity-within-human-brain-networks
#18
Aaron Kucyi, Jessica Schrouff, Stephan Bickel, Brett L Foster, James M Shine, Josef Parvizi
Evidence for intrinsic functional connectivity (FC) within the human brain is largely from neuroimaging studies of hemodynamic activity. Data are lacking from anatomically precise electrophysiological recordings in the most widely studied nodes of human brain networks. Here we used a combination of fMRI and electrocorticography (ECoG) in five human neurosurgical patients with electrodes in the canonical "default" (medial prefrontal and posteromedial cortex), "dorsal attention" (frontal eye fields and superior parietal lobule) and "frontoparietal control" (inferior parietal lobule and dorsolateral prefrontal cortex) networks...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29620428/dietary-dopamine-depletion-blunts-reward-network-sensitivity-to-face-trustworthiness
#19
Leslie A Zebrowitz, Jasmine Boshyan, Noreen Ward, Luke Hanlin, Jutta M Wolf, Nouchine Hadjikhani
Research demonstrating responsiveness of the neural reward network to face trustworthiness has not assessed whether the effects are mediated by dopaminergic function. We filled this gap in the literature by investigating whether dietary dopamine depletion would blunt the sensitivity of neural activation to faces varying in trustworthiness across reward regions as well as the sensitivity of behavioral responses to those faces. As prolactin release is negatively regulated by dopamine, peripheral prolactin levels confirmed the efficacy of our manipulation...
March 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29618082/subjective-value-representations-during-effort-probability-and-time-discounting-across-adulthood
#20
Kendra L Seaman, Nickolas Brooks, Teresa M Karrer, Jaime J Castrellon, Scott F Perkins, Linh Dang, Ming Hsu, David H Zald, Gregory R Samanez-Larkin
Every day, humans make countless decisions which require the integration of information about potential benefits (i.e., rewards) with other decision features (i.e., effort required, probability of an outcome, or time delays). Here we examine the overlap and dissociation of behavioral preferences and neural representations of subjective value in the context of three different decision features (physical effort, probability, time delays) in a healthy adult life-span sample. While undergoing functional neuroimaging, participants (N = 75) made incentive-compatible choices between a smaller monetary reward with lower physical effort, higher probability, or a shorter time delay, versus a larger monetary reward with higher physical effort, lower probability, or a longer time delay...
March 28, 2018: Social Cognitive and Affective Neuroscience
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