Shen Lin, Cui-Ying Fan, Hao-Ran Wang, Xiao-Fan Li, Jia-Li Zeng, Pei-Xuan Lan, Hui-Xian Li, Bin Zhang, Chun Hu, Junyu Xu, Jian-Hong Luo
Cognitive and behavioral rigidity are observed in various psychiatric diseases, including in autism spectrum disorder (ASD). However, the underlying mechanism remains to be elucidated. In this study, we found that neuroligin-3 (NL3) R451C knockin mouse model of autism (KI mice) exhibited deficits in behavioral flexibility in choice selection tasks. Single-unit recording of medium spiny neuron (MSN) activity in the nucleus accumbens (NAc) revealed altered encoding of decision-related cue and impaired updating of choice anticipation in KI mice...
March 8, 2024: Molecular Psychiatry