keyword
Keywords 'randomed control trial' and k...

'randomed control trial' and kidney

https://read.qxmd.com/read/38483735/effect-of-exercise-based-rehabilitation-on-functional-capacity-and-renal-function-in-type-2-diabetes-mellitus-with-nephropathy-a-randomized-controlled-trial
#21
JOURNAL ARTICLE
Megha Nataraj, G Arun Maiya, Shankar Prasad Nagaraju, B A Shastry, K N Shivashankara, Sahana Shetty, Shreemathi S Mayya
INTRODUCTION: Diabetic nephropathy is a growing public health challenge with implications on health. Renal function decline impacts the functional ability and overall health and well-being of individuals with diabetic nephropathy due to development of several renal manifestations. The objective of the study was to determine the effect of an exercise-based rehabilitation program on functional capacity and renal function among individuals with type 2 diabetic nephropathy. METHODS: A total of 283 individuals were screened and 60 eligible participants aged 45-70 years with diabetic nephropathy were randomly allocated (n = 30 each) to the intervention group (IG) and control group (CG), respectively...
March 14, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38481963/modifying-tacrolimus-related-toxicity-after-liver-transplantation-comparing-life-cycle-pharma-tacrolimus-versus-extended-released-tacrolimus-a-multicenter-randomized-controlled-trial
#22
JOURNAL ARTICLE
Midas B Mulder, Bart van Hoek, Wojtek G Polak, Ian P J Alwayn, Brenda C M de Winter, Sarwa Darwish Murad, Elke Verhey-Hart, Lara Elshove, Nicole S Erler, Dennis A Hesselink, Caroline M den Hoed, Herold J Metselaar
BACKGROUND: The aim of this open-label, multicenter, randomized controlled study was to investigate whether the life cycle pharma (LCP)-tacrolimus compared with the extended-release (ER)-tacrolimus formulation results in a difference in the prevalence of posttransplant diabetes, hypertension and chronic kidney disease (CKD) at 12 mo after liver transplantation. METHODS: Patients were 1:1 randomized to either of the 2 tacrolimus formulations. The primary endpoint was defined as a composite endpoint of any of 3 events: sustained (>3 mo postrandomization) posttransplant diabetes, new-onset hypertension, and/or CKD, defined as estimated glomerular filtration rate <60 mL/min/1...
April 2024: Transplantation Direct
https://read.qxmd.com/read/38476327/efficacy-and-safety-of-nonsteroidal-mineralocorticoid-receptor-antagonists-for-renal-and-cardiovascular-outcomes-in-patients-with-chronic-kidney-disease-a-meta-analysis-of-randomized-clinical-trials
#23
Qianlan Chen, Guocui Wei, Yanping Wang, Xiuxia Li, Qian Zhao, Ling Zhu, Qing Xiao, Xuan Xiong
Objective: To systematically review the efficacy and safety of nonsteroidal mineralocorticoid receptor antagonists (MRAs) in chronic kidney disease (CKD). Methods: We systematically searched six databases to identify randomized controlled trials (RCTs) about nonsteroidal MRAs for CKD, from inception to 22 August 2023. Two reviewers independently screened the retrieved articles, extracted data, and assessed the risk of bias of included RCTs using the Cochrane risk of bias tool. We then conducted meta-analysis of the data using Stata 17...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38475999/effects-of-silymarin-supplementation-on-liver-and-kidney-functions-a-systematic-review-and-dose-response-meta-analysis
#24
REVIEW
Shooka Mohammadi, Damoon Ashtary-Larky, Omid Asbaghi, Vida Farrokhi, Yasaman Jadidi, Fatemeh Mofidi, Mehrnaz Mohammadian, Reza Afrisham
It is suggested that supplementation with silymarin (SIL) has beneficial impacts on kidney and liver functions. This systematic review and dose-response meta-analysis assessed the impact of SIL administration on certain hepatic, renal, and oxidative stress markers. A systematic search was conducted in various databases to identify relevant trials published until January 2023. Randomized controlled trials (RCTs) that evaluated the effects of SIL on kidney and liver markers were included. A random-effects model was used for the analysis and 41 RCTs were included...
March 12, 2024: Phytotherapy Research: PTR
https://read.qxmd.com/read/38475822/the-scientific-rationale-and-study-protocol-for-the-dpp3-angiotensin-ii-and-renin-kinetics-in-sepsis-dark-sepsis-randomized-controlled-trial-serum-biomarkers-to-predict-response-to-angiotensin-ii-versus-standard-of-care-vasopressor-therapy-in-the-treatment
#25
JOURNAL ARTICLE
J Pedro Teixeira, David Perez Ingles, Jordan B Barton, James T Dean, Pablo Garcia, Susan J Kunkel, Preeyaporn Sarangarm, Natalie K Weiss, Christopher L Schaich, Laurence W Busse, Nathan D Nielsen
BACKGROUND: Data to support the use of specific vasopressors in septic shock are limited. Since angiotensin II (AT2) was approved by the Food and Drug Administration in 2017, multiple mechanistically distinct vasopressors are available to treat septic shock, but minimal data exist regarding which patients are most likely to benefit from each agent. Renin and dipeptidyl peptidase 3 (DPP3) are components of the renin-angiotensin-aldosterone system which have been shown to outperform lactate in predicting sepsis prognosis, and preliminary data suggest they could prove useful as biomarkers to guide AT2 use in septic shock...
March 12, 2024: Trials
https://read.qxmd.com/read/38467001/the-impact-of-health-care-algorithms-on-racial-and-ethnic-disparities-a-systematic-review
#26
REVIEW
Shazia Mehmood Siddique, Kelley Tipton, Brian Leas, Christopher Jepson, Jaya Aysola, Jordana B Cohen, Emilia Flores, Michael O Harhay, Harald Schmidt, Gary E Weissman, Julie Fricke, Jonathan R Treadwell, Nikhil K Mull
BACKGROUND: There is increasing concern for the potential impact of health care algorithms on racial and ethnic disparities. PURPOSE: To examine the evidence on how health care algorithms and associated mitigation strategies affect racial and ethnic disparities. DATA SOURCES: Several databases were searched for relevant studies published from 1 January 2011 to 30 September 2023. STUDY SELECTION: Using predefined criteria and dual review, studies were screened and selected to determine: 1) the effect of algorithms on racial and ethnic disparities in health and health care outcomes and 2) the effect of strategies or approaches to mitigate racial and ethnic bias in the development, validation, dissemination, and implementation of algorithms...
March 12, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38464414/the-effects-of-omega-3-fatty-acids-supplementation-on-hemoglobin-hematocrit-and-platelet-levels-of-patients-with-esrd-condition-undergoing-dialysis
#27
JOURNAL ARTICLE
Zahra Mahmoudi, Zahra Roumi, Seyed Ali Askarpour, Zahra Mousavi, Hanieh Shafaei, Neda Valisoltani, Mahsa Shapouri, Seyed Reza Mirshafaei, Pouya Mirzaee, Khadijeh Abbasi Mobarakeh, Elahe Taghavi Sufiani, Zeinab Motiee Bijarpasi, Zeynab Motiei, Masoud Khosravi, Saeid Doaei, Maryam Gholamalizadeh
BACKGROUND: Concomitant inflammation may boost the cardiovascular complications in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). Omega-3 fatty acids may have certain health benefits in HD patients. The aim of this study was to investigate the effects of omega-3 fatty acids supplementation on hematocrit (HCT), hemoglobin (HB) level and platelet (PLT) counts of HD patients. METHODS: A randomized controlled trial was conducted on HD patients at a private dialysis center in Rasht, Iran...
June 2024: Journal of translational autoimmunity
https://read.qxmd.com/read/38458564/clinical-outcomes-of-renin-angiotensin-aldosterone-blockade-in-patients-with-advanced-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#28
REVIEW
Nicolas Vendeville, Marc-Antoine Lepage, M Carolina Festa, Thomas A Mavrakanas
BACKGROUND: The cardiovascular and renal benefits of renin-angiotensin aldosterone system (RAAS) blockade are not well-established in patients with advanced CKD. We conducted a systematic review and meta-analysis to identify potential risks and benefits from RAAS blockade in patients with CKD stage 4-5. METHODS: A Medline search from inception to November 2022 was conducted to identify randomized controlled trials (RCTs) in patients with CKD stage 4-5 (estimated GFR ≤ 30 mL/min/1...
March 6, 2024: Canadian Journal of Cardiology
https://read.qxmd.com/read/38457574/sodium-citrate-versus-sodium-bicarbonate-for-metabolic-acidosis-in-patients-with-chronic-kidney-disease-a-randomized-controlled-trial
#29
RANDOMIZED CONTROLLED TRIAL
Bogdan Marian Sorohan, Bogdan Obrișcă, Roxana Jurubiță, Gabriela Lupușoru, Camelia Achim, Andreea Andronesi, Georgiana Frățilă, Andreea Berechet, Georgia Micu, Gener Ismail
BACKGROUND: Metabolic acidosis (MA) is frequently associated with chronic kidney disease (CKD) progression. Our aim was to compare the effect of oral sodium citrate (SC) with that of oral sodium bicarbonate (SB) on renal function and serum bicarbonate correction, as well as to evaluate their safety profile in patients with MA of CKD. METHODS: We conducted a prospective, single-center, randomized 1:1, parallel, controlled, unblinded clinical trial of 124 patients with MA and CKD stages 3b and 4...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38456601/sglt2-inhibitors-from-glucose-lowering-to-cardiovascular-benefits
#30
JOURNAL ARTICLE
Alberto Preda, Fabrizio Montecucco, Federico Carbone, Giovanni G Camici, Thomas F Lüscher, Simon Kraler, Luca Liberale
An increasing number of individuals is at high risk of type 2 diabetes (T2D) and its cardiovascular complications, including heart failure (HF), chronic kidney disease (CKD), and premature death. The sodium-glucose cotransporter-2 (SGLT2) protein sits in the proximal tubule of human nephrons to regulate glucose reabsorption, and its inhibition by gliflozins represents the cornerstone of contemporary T2D and HF management. Herein, we aim to provide an updated view on the pleiotropy of gliflozins, provide mechanistic insights and delineate related cardiovascular (CV) benefits...
March 8, 2024: Cardiovascular Research
https://read.qxmd.com/read/38455607/psychotherapies-for-chronic-kidney-disease-patients-with-hemodialysis-a-systematic-review-of-randomized-control-trials-and-quasi-experiments
#31
JOURNAL ARTICLE
Zulfa Zahra, Elmeida Effendy, Marty Mawarpury, Marthoenis, Indra Jaya
Chronic kidney disease (CKD) patients, especially those with hemodialysis, frequently struggle with mental health issues like anxiety and depression. Psychotherapy has been known to treat psychological problems, but its effectiveness in managing CKD patients is still rarely scientifically proven. The aim of this study was to analyze the role of psychological treatments in improving the mental health of CKD patients with hemodialysis. We comprehensively reviewed the related studies published in PubMed, Google Scholar, ScienceDirect, and Clinical Key over the last ten years, up to June 7, 2023...
December 2023: Narra J
https://read.qxmd.com/read/38452293/personalizing-renal-replacement-therapy-initiation-in-the-intensive-care-unit-a-reinforcement-learning-based-strategy-with-external-validation-on-the-akiki-randomized-controlled-trials
#32
JOURNAL ARTICLE
François Grolleau, François Petit, Stéphane Gaudry, Élise Diard, Jean-Pierre Quenot, Didier Dreyfuss, Viet-Thi Tran, Raphaël Porcher
OBJECTIVE: The timely initiation of renal replacement therapy (RRT) for acute kidney injury (AKI) requires sequential decision-making tailored to individuals' evolving characteristics. To learn and validate optimal strategies for RRT initiation, we used reinforcement learning on clinical data from routine care and randomized controlled trials. MATERIALS AND METHODS: We used the MIMIC-III database for development and AKIKI trials for validation. Participants were adult ICU patients with severe AKI receiving mechanical ventilation or catecholamine infusion...
March 7, 2024: Journal of the American Medical Informatics Association: JAMIA
https://read.qxmd.com/read/38448675/potential-use-of-sodium-glucose-co-transporter-2-inhibitors-during-acute-illness-a-systematic-review-based-on-covid-19
#33
JOURNAL ARTICLE
Carmen Tisch, Eleni Xourgia, Aristomenis Exadaktylos, Mairi Ziaka
OBJECTIVE: SGLT-2i are increasingly recognized for their benefits in patients with cardiometabolic risk factors. Additionally, emerging evidence suggests potential applications in acute illnesses, including COVID-19. This systematic review aims to evaluate the effects of SGLT-2i in patients facing acute illness, particularly focusing on SARS-CoV-2 infection. METHODS: Following PRISMA guidelines, a systematic search of PubMed, Scopus, medRxiv, Research Square, and Google Scholar identified 22 studies meeting inclusion criteria, including randomized controlled trials and observational studies...
March 6, 2024: Endocrine
https://read.qxmd.com/read/38437910/the-protocol-of-enhanced-recovery-after-cardiac-surgery-in-adult-patients-a-stepped-wedge-cluster-randomized-trial
#34
JOURNAL ARTICLE
Dou Dou, Su Yuan, Yuan Jia, Yang Wang, Yinan Li, Hongbai Wang, Jie Ding, Xie Wu, Dongyun Bie, Qiao Liu, Ran An, Haoqi Yan, Fuxia Yan
BACKGROUND: The Enhanced Recovery After Cardiac Surgery is a bundle of measurements from preoperative to postoperative phases to improve patients' recovery. METHODS: This study is a multicenter, stepwise design, cluster randomized controlled trial. 3600 patients presenting during control and intervention periods are eligible if they are aged from 18 to 80 years old awaiting elective cardiac surgery with cardiopulmonary bypass (CPB). 5 centers are randomly assigned to staggered start dates for one-way crossover from the control phase to the intervention phase...
March 2, 2024: American Heart Journal
https://read.qxmd.com/read/38435072/a-ckd-clinical-decision-support-system-a-cluster-randomized-clinical-trial-in-primary-care-clinics
#35
JOURNAL ARTICLE
JoAnn Sperl-Hillen, A Lauren Crain, James B Wetmore, Lilian N Chumba, Patrick J O'Connor
RATIONALE & OBJECTIVE: The study aimed to develop, implement, and evaluate a clinical decision support (CDS) system for chronic kidney disease (CKD) in a primary care setting, with the goal of improving CKD care in adults. STUDY DESIGN: This was a cluster randomized trial. SETTING & PARTICIPANTS: A total of 32 Midwestern primary care clinics were randomly assigned to either receive usual care or CKD-CDS intervention. Between April 2019 and March 2020, we enrolled 6,420 patients aged 18-75 years with laboratory-defined glomerular filtration rate categories of CKD Stage G3 and G4, and 1 or more of 6 CKD care gaps: absence of a CKD diagnosis, suboptimal blood pressure or glycated hemoglobin levels, indication for angiotensin-converting enzyme inhibitor or angiotensin receptor blocker but not prescribed, a nonsteroidal anti-inflammatory agent on the active medication list, or indication for a nephrology referral...
March 2024: Kidney medicine
https://read.qxmd.com/read/38434013/ultrasound-guided-erector-spinae-plane-block-for-perioperative-analgesia-in-patients-undergoing-laparoscopic-nephrectomy-surgery-a-randomized-controlled-trial
#36
JOURNAL ARTICLE
Ming Yang, Lei Cao, Tong Lu, Cheng Xiao, Zhuoxi Wu, Xuetao Jiang, Wei Wang, Hong Li
STUDY OBJECTIVE: Kidney neoplasms have a high incidence, and radical nephrectomy or partial nephrectomy are the main treatment options. Our study aims to investigate the use of ultrasound-guided erector spinae plane block for perioperative analgesia in patients undergoing laparoscopic nephrectomy surgery. DESIGN: Prospective, randomized, double-blind. SETTING: University hospital. PATIENTS: Our study included 50 patients (ASA I-III) who underwent laparoscopic nephrectomy at the hospital of Second Affiliated Hospital of Army Medical University...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38432583/mycophenolate-mofetil-hampers-antibody-responses-to-a-broad-range-of-vaccinations-in-kidney-transplant-recipients-results-from-a-randomized-controlled-study
#37
JOURNAL ARTICLE
Z Al Fatly, M G H Betjes, W A Dik, R A M Fouchier, M E J Reinders, A E de Weerd
OBJECTIVES: To study the effect of mycophenolate mofetil (MMF) on various vaccination responses in kidney transplant recipients. METHODS: In a randomized controlled trial (EudraCT nr.: 2014-001372-66), low immunologically risk kidney transplant recipients were randomized to TAC/MMF or TAC-monotherapy (TACmono), six months post-transplantation. One year after transplantation, in a pre-specified sub-study, recipients were vaccinated against pneumococcus, tetanus and influenza...
March 2, 2024: Journal of Infection
https://read.qxmd.com/read/38432338/cardiovascular-outcomes-with-empagliflozin-and-dapagliflozin-in-patients-without-diabetes
#38
JOURNAL ARTICLE
Sahib Singh, Aakash Garg, Udaya S Tantry, Kevin Bliden, Paul A Gurbel, Martha Gulati
While the cardiovascular (CV) benefits with sodium-glucose cotransporter-2 inhibitors (SGLT2i) in patients with diabetes mellitus (DM) are well known, their effects in patients without DM continue to be explored. We provide a meta-analysis of the available evidence. Online databases were searched for randomized controlled trials (RCTs) comparing SGLT2i to placebo/control in patients without DM. The endpoints of interest were composite CV death/hospitalization for heart failure (HF) with individual components, all cause death, major adverse CV events (MACE) and serious adverse events...
March 1, 2024: American Journal of Cardiology
https://read.qxmd.com/read/38430143/the-complications-of-corticosteroid-for-patients-with-community-acquired-pneumonia-a-systematic-review-and-meta-analysis
#39
JOURNAL ARTICLE
Donglan Wang, Yan Zhu
BACKGROUND: Many randomized controlled trials (RCTs) have reported the complications of corticosteroids for patients with community-acquired pneumonia with inconsistent results. An explicit systematic review and meta-analysis were conducted in this study to evaluate the complications of corticosteroids for patients with community-acquired pneumonia. METHODS: Using PubMed, Embase, the Global Index Medicus of the World Health Organization (WHO), the WHO clinical trial registry, and Clinicaltrials...
March 1, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38423000/rilparencel-renal-autologous-cell-therapy-react%C3%A2-for-chronic-kidney-disease-and-type-1-and-2-diabetes-phase-2-trial-design-evaluating-bilateral-kidney-dosing-and-re-dosing-triggers
#40
JOURNAL ARTICLE
Joseph Stavas, Arnold L Silva, Thomas D Wooldridge, Ahmed Aqeel, Theodore Saad, Rachita Prakash, George Bakris
INTRODUCTION: Autologous cell-based therapies (CBT) to treat Chronic Kidney Disease (CKD) with diabetes are novel and can potentially preserve renal function and decelerate disease progression. CBT dosing schedules are in early development and may benefit from individual bilateral organ dosing and kidney-dependent function to improve efficacy and durability. The objective of this open-label, phase 2 randomized controlled trial (RCT) is to evaluate participants' response to rilparencel (Renal Autologous Cell Therapy-REACT®) following bilateral percutaneous kidney injections into the kidney cortex with a prescribed dosing schedule versus re-dosing based on biomarker triggers...
February 29, 2024: American Journal of Nephrology
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