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https://www.readbyqxmd.com/read/29933385/testosterone-treatment-and-the-risk-of-aggressive-prostate-cancer-in-men-with-low-testosterone-levels
#1
Thomas J Walsh, Molly M Shores, Chloe A Krakauer, Christopher W Forsberg, Alexandra E Fox, Kathryn P Moore, Anna Korpak, Susan R Heckbert, Steven B Zeliadt, Chloe E Kinsey, Mary Lou Thompson, Nicholas L Smith, Alvin M Matsumoto
PURPOSE: Testosterone treatment of men with low testosterone is common and, although relatively short-term, has raised concern regarding an increased risk of prostate cancer (CaP). We investigated the association between modest-duration testosterone treatment and incident aggressive CaP. MATERIALS AND METHODS: Retrospective inception cohort study of male Veterans aged 40 to 89 years with a laboratory-defined low testosterone measurement from 2002 to 2011 and recent prostate specific antigen (PSA) testing; excluding those with recent testosterone treatment, prostate or breast cancer, high PSA or prior prostate biopsy...
2018: PloS One
https://www.readbyqxmd.com/read/29933369/meditation-or-exercise-for-preventing-acute-respiratory-infection-mepari-2-a-randomized-controlled-trial
#2
Bruce Barrett, Mary S Hayney, Daniel Muller, David Rakel, Roger Brown, Aleksandra E Zgierska, Shari Barlow, Supriya Hayer, Jodi H Barnet, Elisa R Torres, Christopher L Coe
BACKGROUND: Practice of meditation or exercise may enhance health to protect against acute infectious illness. OBJECTIVE: To assess preventive effects of meditation and exercise on acute respiratory infection (ARI) illness. DESIGN: Randomized controlled prevention trial with three parallel groups. SETTING: Madison, Wisconsin, USA. PARTICIPANTS: Community-recruited adults who did not regularly exercise or meditate...
2018: PloS One
https://www.readbyqxmd.com/read/29933304/development-of-a-prehabilitation-multimodal-supportive-care-interventions-for-men-and-their-partners-before-radical-prostatectomy-for-localized-prostate-cancer
#3
Catherine Paterson, Charlotte Primeau, Irene Pullar, Ghulam Nabi
BACKGROUND: An important question revolves around when the most opportune time is to introduce recovery-optimizing behaviors for men opting for radical prostatectomy (RP) for localized prostate cancer (PCa). An emerging field of research describes the role of preoperative strategies to improve treatment tolerance and overall physical and psychological recovery. OBJECTIVE: The aim of this study was to explore the perceptions of a multimodal prehabilitation intervention for men and their partners before RP for localized PCa...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933269/high-fidelity-simulation-nurse-training-reduces-unplanned-interruption-of-continuous-renal-replacement-therapy-sessions-in-critically-ill-patients-the-simher-randomized-controlled-trial
#4
Pierre Lemarie, Solenne Husser Vidal, Soizic Gergaud, Xavier Verger, Emmanuel Rineau, Jerome Berton, Elsa Parot-Schinkel, Jean-François Hamel, Sigismond Lasocki
BACKGROUND: Although continuous renal replacement therapy (CRRT) is common, unplanned interruptions (UI) often limit its usefulness. In many units, nurses are responsible for CRRT management. We hypothesized that a nurse training program based on high-fidelity simulation would reduce the rate of interrupted sessions. METHODS: We performed a 2-phase (training and evaluation), randomized, single-center, open study: During the training phase, intensive care unit nurses underwent a 6-hour training program and were randomized to receive (intervention) or not (control) an additional high-fidelity simulation training (6 hours)...
June 20, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29933147/i-care-randomized-clinical-trial-integrating-depression-and-acute-coronary-syndrome-care-in-low-resource-hospitals-in-china-design-and-rationale
#5
Shenshen Li, James A Blumenthal, Chuan Shi, Danielle Millican, Xian Li, Xin Du, Anushka Patel, Pei Gao, Elizabeth Delong, Pallab K Maulik, Runlin Gao, Xin Yu, Yangfeng Wu
Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrate depression care into the management of ACS patients to reduce depression and improve ACS outcomes are critically needed. Integrating Depression Care in ACS patients in Low Resource Hospitals in China (I-CARE) is a multicenter, randomized controlled trial to evaluate the efficacy of an 11-month integrated care (IC) intervention compared to usual care (UC) in management of ACS patients...
May 21, 2018: American Heart Journal
https://www.readbyqxmd.com/read/29932861/do-breast-implants-influence-breastfeeding-a-meta-analysis-of-comparative-studies
#6
Fengrui Cheng, Shuiping Dai, Chiyi Wang, Shaoxue Zeng, Junjie Chen, Ying Cen
BACKGROUND: Aesthetic breast implant augmentation surgery is the most popular plastic surgery worldwide. Many women choose to receive breast implants during their reproductive ages, although the long-term effects are still controversial. Research aim: We conducted a meta-analysis to assess the influence of aesthetic breast augmentation on breastfeeding. We also compared the exclusive breastfeeding rates of periareolar versus inframammary incision. METHODS: A systematic search for comparative studies about breast implants and breastfeeding was performed in PubMed, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ScienceDirect, Scopus, and Web of Science through May 2018...
June 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29932814/infant-cortisol-stress-response-is-associated-with-thymic-function-and-vaccine-response
#7
M Nazmul Huda, Shaikh M Ahmad, Md Jahangir Alam, Afsana Khanam, Md Nure Alam Afsar, Yukiko Wagatsuma, Rubhana Raqib, Charles B Stephensen, Kevin D Laugero
Stress can impair T cell-mediated immunity. To determine if infants with high stress responses had deficits in T-cell mediated immunity, we examined the association of pain-induced cortisol responsiveness with thymic function and vaccine responses in infants. This study was performed among 306 (male = 153 and female = 153) participants of a randomized, controlled trial examining the effect of neonatal vitamin A supplementation on immune function in Bangladesh (NCT01583972). Salivary cortisol was measured before and 20 min after a needle stick (vaccination) at 6 weeks of age...
June 22, 2018: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29932784/consolidation-and-prediction-of-long-term-treatment-effect-of-group-and-online-mindfulness-based-cognitive-therapy-for-distressed-cancer-patients
#8
L Cillessen, M P J Schellekens, M O M Van de Ven, A R T Donders, F R Compen, E M Bisseling, M L Van der Lee, A E M Speckens
BACKGROUND: Group face-to-face and individual internet-based mindfulness-based cognitive therapy (MBCT and eMBCT) have been demonstrated to reduce psychological distress for distressed cancer patients in a randomized controlled trial (RCT). This study focused on the long-term effects of this RCT during the nine-month follow-up period, and on possible predictors, moderators and working mechanisms. METHODS: Distressed cancer patients (n = 245) were randomized to MBCT or eMBCT...
June 22, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29932560/a-multiple-behavior-self-monitoring-intervention-for-african-american-veterans-with-type-2-diabetes-a-feasibility-implementation-study
#9
Ngozi D Mbue, Jing Wang, Stanley G Cron, Jane A Anderson
The purpose of this study was to determine the feasibility of implementing a multiple-behavior self-monitoring intervention within a diabetes education program. This study was a 3-month pre- post-design, conducted with African-Americans (N = 20), who attended diabetes education classes at a large Veteran's Affairs (VA) hospital in Southwest Texas. Participants selfmonitored their blood glucose, diet, exercise, and weight on either a smart phone application or paper diaries. Paired t tests showed strong evidence that patient self-monitoring of healthy lifestyle behaviors improved blood glucose (t = -3...
July 2017: Journal of National Black Nurses' Association: JNBNA
https://www.readbyqxmd.com/read/29932460/a-home-based-mentored-vegetable-gardening-intervention-demonstrates-feasibility-and-improvements-in-physical-activity-and-performance-among-breast-cancer-survivors
#10
Jennifer R Bail, Andrew D Frugé, Mallory G Cases, Jennifer F De Los Santos, Julie L Locher, Kerry P Smith, Alan B Cantor, Harvey J Cohen, Wendy Demark-Wahnefried
BACKGROUND: The current study assessed the feasibility of a mentored home-based vegetable gardening intervention and examined changes in health-related outcomes among breast cancer survivors (BCS). METHODS: BCS were randomized to either a year-long vegetable gardening intervention to begin immediately or a wait-list control. Master Gardeners mentored participants in planning, planting, and maintaining 3 seasonal gardens over the course of 1 year. Participant accrual, retention, and satisfaction rates of ≥80% served as feasibility (primary outcome) benchmarks...
June 22, 2018: Cancer
https://www.readbyqxmd.com/read/29932415/platelet-rich-plasma-injection-in-the-treatment-of-frozen-shoulder-a-randomized-controlled-trial-with-6-month-follow-up
#11
Junhong Lin
PURPOSE: Platelet-rich plasma (PRP) has been utilized in the treatment of chronic injuries. The current study aimed to evaluate the efficiency of PRP in the treatment of frozen shoulder compared to procaine. MATERIALS AND METHODS: 60 patients with frozen shoulder were randomly divided into two groups. The PRP group was injected with 2 mL prepared PRP, while in the control group procaine was used. The stretching and formal strengthening exercises were carried out in both groups during the 6-month follow-up...
June 22, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29932379/safety-and-efficacy-of-a-novel-neurosurgical-enhanced-recovery-after-surgery-protocol-for-elective-craniotomy-a-prospective-randomized-controlled-trial
#12
Yuan Wang, Bolin Liu, Tianzhi Zhao, Binfang Zhao, Daihua Yu, Xue Jiang, Lin Ye, Lanfu Zhao, Wenhai Lv, Yufu Zhang, Tao Zheng, Yafei Xue, Lei Chen, Eric Sankey, Long Chen, Yingxi Wu, Mingjuan Li, Lin Ma, Zhengmin Li, Ruigang Li, Juan Li, Jing Yan, Shasha Wang, Hui Zhao, Xude Sun, Guodong Gao, Yan Qu, Shiming He
OBJECTIVE Although enhanced recovery after surgery (ERAS) programs have gained acceptance in various surgical specialties, no established neurosurgical ERAS protocol for patients undergoing elective craniotomy has been reported in the literature. Here, the authors describe the design, implementation, safety, and efficacy of a novel neurosurgical ERAS protocol for elective craniotomy in a tertiary care medical center located in China. METHODS A multidisciplinary neurosurgical ERAS protocol for elective craniotomy was developed based on the best available evidence...
June 22, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29932345/nitric-oxide-decreases-acute-kidney-injury-and-stage-3-chronic-kidney-disease-after-cardiac-surgery
#13
Chong Lei, Lorenzo Berra, Emanuele Rezoagli, Binglan Yu, Hailong Dong, Shiqiang Yu, Lihong Hou, Min Chen, Wensheng Chen, Hongbing Wang, Qijun Zheng, Jie Shen, Zhenxiao Jin, Tao Chen, Rong Zhao, Emily Christie, Venkata S Sabbisetti, Francesco Nordio, Joseph V Bonventre, Lize Xiong, Warren M Zapol
RATIONALE: No medical intervention has been identified that decreases acute kidney injury and improves renal outcome at 1-year after cardiac surgery. OBJECTIVE: To determine whether administration of nitric oxide reduces the incidence of post-operative acute kidney injury and improves long-term kidney outcomes after multiple cardiac valve replacement requiring prolonged cardiopulmonary bypass. METHODS: 244 Patients undergoing elective, multiple valve replacement surgery mostly due to rheumatic fever were randomized to receive either nitric oxide (treatment) or nitrogen (control)...
June 22, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29932311/rationale-and-design-of-a-multicentre-randomized-placebo-controlled-trial-of-mirabegron-a-beta3-adrenergic-receptor-agonist-on-left-ventricular-mass-and-diastolic-function-in-patients-with-structural-heart-disease-beta3-left-ventricular-hypertrophy-beta3-lvh
#14
Anne-Catherine Pouleur, Stefan Anker, Dulce Brito, Oana Brosteanu, Dirk Hasenclever, Barbara Casadei, Frank Edelmann, Gerasimos Filippatos, Damien Gruson, Ignatios Ikonomidis, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Bernhard L Gerber, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Jean-Luc Balligand
AIMS: Progressive left ventricular (LV) remodelling with cardiac myocyte hypertrophy, myocardial fibrosis, and endothelial dysfunction plays a key role in the onset and progression of heart failure with preserved ejection fraction. The Beta3-LVH trial will test the hypothesis that the β3 adrenergic receptor agonist mirabegron will improve LV hypertrophy and diastolic function in patients with hypertensive structural heart disease at high risk for developing heart failure with preserved ejection fraction...
June 22, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29932239/efficacy-of-different-drugs-in-the-treatment-of-minimal-hepatic-encephalopathy-a-network-meta-analysis-involving-826-patients-based-on-10-randomized-controlled-trials
#15
Xiao-Jun Cai, Lei Wang, Chun-Mei Hu
Minimal hepatic encephalopathy (MHE), a complex neuropsychological complication of cirrhosis, is characterized by delayed reaction time and the inhibition of abnormal response. This network meta-analysis (NMA) was adopted to compare the efficacy of five drugs including lactulose, probiotics, rifaximin, acetyl-L-carnitine (ALC), and L-Ornithine L-aspartate (LOLA) in the treatment of MHE. The Cochrane Library, PubMed, and Embase databases were searched for any existing entail on these five drugs from the inception to February 2018, including Randomized controlled trials (RCTs)...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29932230/effects-of-selenium-supplementation-on-expression-of-sepp1-in-mrna-and-protein-levels-in-subjects-with-and-without-metabolic-syndrome-suffering-from-coronary-artery-disease-selenegene-study-a-double-blind-randomized-controlled-trial
#16
Mojgan Gharipour, Khadija Ouguerram, El-Hassane Nazih, Mansour Salehi, Mehrdad Behmanesh, Hamidreza Roohafza, Syed Mohsen Hosseini, Pouya Nezafati, Minoo Dianatkhah, Amin Gharipour, Shaghayegh Haghjoo, Nizal Sarrafzadegan, Masoumeh Sadeghi
Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases. In this clinical trial, 160 patients with angiographically documented stenosis of more than 75% in each vessel were enrolled. Patients received either 200-mg selenium yeast tablets or placebo tablets orally after a meal, once daily for 60 days...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29932047/strategies-for-treating-scoliosis-in-early-childhood
#17
Karsten Ridderbusch, Alexander S Spiro, Philip Kunkel, Benjamin Grolle, Ralf Stücker, Martin Rupprecht
BACKGROUND: Scoliosis in early childhood is defined as abnormal curvature of the spine of any etiology that arises before age 10. The affected children are at high risk of developing restrictive pulmonary dysfunction. The treatment presents major challenges because of the complexity and high morbidity of the disease. METHODS: This article is based on pertinent articles retrieved by a selective literature search, and on the results of a retrospective study by the authors...
June 1, 2018: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29932038/community-acquired-pneumonia-in-children
#18
Alexander Kc Leung, Alex H C Wong, Kam Lun Hon
BACKGROUND: Community-acquired pneumonia is an important cause of morbidity in developed countries and an important cause of morbidity and mortality in developing countries. Prompt diagnosis and appropriate treatment are very important. OBJECTIVE: To provide an update on the evaluation, diagnosis, and treatment of community-acquired pneumonia in children. METHODS: A PubMed search was completed in Clinical Queries using the key term "community-acquired pneumonia"...
June 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29932023/retrograde-pedal-access-cutting-edge-or-comical
#19
Anahita Dua, Venita Chandra
Retrograde pedal access is a technique utilized with increasing frequency by many interventionists to address patients with advanced multilevel peripheral artery disease and significant comorbidities. This approach to revascularization is being used both in patients who fail traditional antegrade access and in some patients thought to be poor candidates for antegrade approach. However, the lack of randomized controlled trial data, or long-term results, coupled with the associated potential risks including dissection, spasm, and thrombosis have rendered retrograde pedal access a controversial topic...
January 1, 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29932011/20-years-of-researching-stroke-through-audit
#20
Anthony G Rudd, Alex Hoffman, Lizz Paley, Benjamin Bray
Over the last 20 years, England, Wales and Northern Ireland have developed an audit programme that now encompasses nearly all patients admitted to hospital with a stroke. This article records and reviews some questions that have been answered using data from the audit: Is the rate of institutional care after rehabilitation a possible measure of outcome? Does stroke unit care in routine practice give the benefits shown in randomized controlled trials? How is the quality of stroke care affected by a patient's age and the time of their stroke? Do patient-reported measures match those obtained from the professionals recording of processes of care? How do the processes of care after stroke affect mortality? Is thrombolysis safe to use in patients over the age of 80? Do staffing levels matter? Does assessing the safety of swallowing really make a difference? Do clinicians make rational decisions about end-of-life care in patients with haemorrhage? Does socioeconomic status influence the risk of stroke, outcome after stroke and the quality of stroke care? How much does stroke really cost in England, Wales and Northern Ireland? The article concludes that this national audit has improved stroke care across the United Kingdom, has given answers to important questions that could not be answered in any other way and has shown that benefits found in research do generalize into real clinical benefits in day-to-day practice...
June 1, 2018: Clinical Rehabilitation
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