Xiaoling Zhong, Yixuan Qiang, Ling Wang, Yaru Zhang, Jieqiong Li, Jianfeng Feng, Wei Cheng, Lan Tan, Jintai Yu
Whether peripheral immunity prospectively influences brain health remains controversial. This study aims to investigate the longitudinal associations between peripheral immunity markers with incident brain disorders. A total of 161,968 eligible participants from the UK Biobank were included. We investigated the linear and non-linear effects of peripheral immunity markers including differential leukocytes counts, their derived ratios and C-reactive protein (CRP) on the risk of dementia, Parkinson's disease (PD), stroke, schizophrenia, bipolar affective disorder (BPAD), major depressive disorder (MDD) and anxiety, using Cox proportional hazard models and restricted cubic spline models...
December 9, 2023: Translational Psychiatry