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https://www.readbyqxmd.com/read/28812872/effect-of-mineral-dissolution-precipitation-and-co2-exsolution-on-co2-transport-in-geological-carbon-storage
#1
Ruina Xu, Rong Li, Jin Ma, Di He, Peixue Jiang
Geological carbon sequestration (GCS) in deep saline aquifers is an effective means for storing carbon dioxide to address global climate change. As the time after injection increases, the safety of storage increases as the CO2 transforms from a separate phase to CO2(aq) and HCO3(-) by dissolution and then to carbonates by mineral dissolution. However, subsequent depressurization could lead to dissolved CO2(aq) escaping from the formation water and creating a new separate phase which may reduce the GCS system safety...
August 16, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28812692/gene-flow-from-domesticated-escapes-alters-the-life-history-of-wild-atlantic-salmon
#2
Geir H Bolstad, Kjetil Hindar, Grethe Robertsen, Bror Jonsson, Harald Sægrov, Ola H Diserud, Peder Fiske, Arne J Jensen, Kurt Urdal, Tor F Næsje, Bjørn T Barlaup, Bjørn Florø-Larsen, Håvard Lo, Eero Niemelä, Sten Karlsson
Interbreeding between domesticated and wild animals occurs in several species. This gene flow has long been anticipated to induce genetic changes in life-history traits of wild populations, thereby influencing population dynamics and viability. Here, we show that individuals with high levels of introgression (domesticated ancestry) have altered age and size at maturation in 62 wild Atlantic salmon Salmo salar populations, including seven ancestral populations to breeding lines of the domesticated salmon. This study documents widespread changes to life-history traits in wild animal populations following gene flow from selectively bred, domesticated conspecifics...
April 10, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811959/t-helper-and-t-regulatory-cells-modulation-in-head-and-neck-squamous-cell-carcinoma
#3
REVIEW
Daniele Maggioni, Lorenzo Pignataro, Werner Garavello
Head and neck squamous cell carcinoma (HNSCC) is one of the most diffused cancer types, characterized by a high reoccurrence rate, mainly due to the inability of current therapeutic approaches to completely eradicate cancer cells. HNSCC patients often have defective immune functions, thus allowing cancer immune escape and cancer spreading. Particularly important in driving immune escape during HNSCC progression are T-helper and T-regulatory cells. New insights into their mechanisms of action might support the development of effective and long-lasting immunotherapy...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811879/growth-and-fecundity-of-fertile-miscanthus%C3%A2-%C3%A3-%C3%A2-giganteus-powercane-compared-to-feral-and-ornamental-miscanthus-sinensis-in-a-common-garden-experiment-implications-for-invasion
#4
Maria N Miriti, Tahir Ibrahim, Destiny Palik, Catherine Bonin, Emily Heaton, Evans Mutegi, Allison A Snow
Perennial grasses are promising candidates for bioenergy crops, but species that can escape cultivation and establish self-sustaining naturalized populations (feral) may have the potential to become invasive. Fertile Miscanthus × giganteus, known as "PowerCane," is a new potential biofuel crop. Its parent species are ornamental, non-native Miscanthus species that establish feral populations and are sometimes invasive in the USA. As a first step toward assessing the potential for "PowerCane" to become invasive, we documented its growth and fecundity relative to one of its parent species (Miscanthus sinensis) in competition with native and invasive grasses in common garden experiments located in Columbus, Ohio and Ames, Iowa, within the targeted range of biofuel cultivation...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811226/characterization-and-expression-analysis-of-six-interleukin-17-receptor-genes-in-grouper-epinephelus-coioides-after-cryptocaryon-irritans-infection
#5
Biao Jiang, Yan-Wei Li, Ya-Zhou Hu, Heng-Li Luo, An-Xing Li
Interleukin-17 receptors (IL17Rs) mediate the activation of several downstream signal pathways to induce inflammatory response and contribute to the pathology of many autoimmune diseases. In this study, six IL17Rs (IL17RA1, RA2, RB, RC, RD and RE) were cloned and characterized from Epinephelus coioides, an orange-spotted grouper. Multiple sequence alignment and structural analysis revealed that all members of IL17Rs were low in sequence identity with each other. But their structures were conservative in grouper, which contain signal peptide, extracellular FNIII domain (IL17RA1/RA2/RB) or IL-17_R_N domain (IL17RC/RD/RE), transmembrane domain and SEFIR domain in their intracellular region...
August 12, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28810980/risk-factors-for-rhabdomyolysis-in-the-u-s-army
#6
Owen T Hill, Dennis E Scofield, Jenna Usedom, Lakmini Bulathsinhala, Craig McKinnon, Paul Kwon, Timothy Haley, Robert Carter
The standardized mortality rate of rhabdomyolysis (RM) in Active Duty U.S. Army Soldiers is considerably higher than in the civilian population. RM occurs when large amounts of intracellular contents from damaged skeletal muscle escape into circulation, leading to serious sequelae (e.g., acute renal failure, hyperkalemia, compartment syndrome). Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810872/-repel-all-biters-an-enhanced-collection-of-endophilic-anopheles-gambiae-and-anopheles-arabiensis-in-cdc-light-traps-from-the-kagera-region-of-tanzania-in-the-presence-of-a-combination-mosquito-net-impregnated-with-piperonyl-butoxide-and-permethrin
#7
Corey LeClair, Judith Cronery, Enock Kessy, Elsa V E Tomás, Yohannes Kulwa, Franklin W Mosha, Mark Rowland, Natacha Protopopoff, J Derek Charlwood
BACKGROUND: Mosquito nets containing synergists designed to overcome metabolic resistance mechanisms in vectors have been developed. These may enhance excitability in the mosquitoes and affect how they respond to CDC light-traps. Investigating the behaviour of vectors of disease in relation to novel mosquito nets is, therefore, essential for the design of sampling and surveillance systems. METHODS: In an initial experiment in Muleba, Tanzania, nine bedrooms from three housing clusters were sampled...
August 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28810789/tunneling-lifetimes-of-electrons-escaping-from-atoms-under-a-static-electric-field
#8
Rundong Zhao, Yanoar Pribadi Sarwono, Rui-Qin Zhang
The tunneling lifetime of an electron escaping from an atom is calculated using a projected Green's function method, combining with the radial potential of the atom which is obtained from density functional theory. Results of the calculated electron tunneling lifetimes in model systems such as a quantum dot are shown to be comparable with other theoretical studies. For the first time, we have obtained the tunneling lifetimes of electrons escaping from a series of atoms (He, Ne, Ar, Kr, H, Li, Na, K) under a static electric field...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810692/resveratrol-protects-from-lipopolysaccharide-induced-inflammation-in-the-uterus-and-prevents-experimental-preterm-birth
#9
María Victoria Bariani, Fernando Correa, Emma Leishman, Ana Paula Domínguez Rubio, Andreína Arias, Aníbal Stern, Heather B Bradshaw, Ana María Franchi
STUDY QUESTION: Is resveratrol able to prevent the lipopolysaccharide (LPS)-induced preterm labor in 15-day pregnant BALB/c mice? SUMMARY ANSWER: Resveratrol prevented the LPS-induced onset of preterm labor in 64% of the cases and showed anti-inflammatory and tocolytic effects by downregulating COX-2 and iNOS expression and NOS activity, and by changing the uterine prostaglandin and endocannabinoid profiling. WHAT IS KNOWN ALREADY: Genital tract infections by Gram-negative bacteria are a common complication in human pregnancy and have been shown to increase risk of preterm delivery...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28809098/interfacially-engineered-pyridinium-pseudo-gemini-surfactants-as-versatile-and-efficient-supramolecular-delivery-systems-for-dna-sirna-and-mrna
#10
Uttam Satyal, Bogdan Draghici, Lisa L Dragic, Qiangnan Zhang, Kyle Norris, Muniswamy Madesh, Eugen Brailoiu, Marc A Ilies
The article presents the synthesis, self-assembling and biological activity as transfection agents for pDNA, siRNA and mRNA of novel pyridinium pseudo-gemini surfactants, interfacially-engineered from the most efficient gemini surfactants and lipids generated in our amphiphile research program. Formulation of novel amphiphiles in water revealed supramolecular properties very similar to gemini surfactants, despite their lipid-like charge/mass ratio. This dual character was found to also enhance endosomal escape and significantly increase the transfection efficiency...
August 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28808831/the-2017-escap-research-academy-workshop-bright-perspectives-for-child-and-adolescent-psychiatry
#11
Alexis Revet, Johannes Hebebrand, Paul Klauser
No abstract text is available yet for this article.
August 14, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28808162/listeria-monocytogenes-and-shigella-flexneri-activate-the-nlrp1b-inflammasome
#12
Jana Neiman-Zenevich, Sarah Stuart, Mena Abdel-Nour, Stephen E Girardin, Jeremy Mogridge
Activation of the innate immune receptor NLRP1B leads to the formation of an inflammasome, which induces autoproteolytic processing of pro-caspase-1, and ultimately to the release of inflammatory cytokines and to the execution of pyroptosis. One of the signals to which NLRP1B responds is metabolic stress that occurs in cells deprived of glucose or treated with metabolic inhibitors. NLRP1B might, therefore, sense microbial infection as intracellular pathogens such as Listeria monocytogenes and Shigella flexneri cause metabolic stress as a result of nutrient scavenging and host cell damage...
August 14, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28807240/role-of-exosomes-in-treatment-of-hepatocellular-carcinoma
#13
REVIEW
Demetrios Moris, Eliza W Beal, Jeffery Chakedis, Richard A Burkhart, Carl Schmidt, Mary Dillhoff, Xufeng Zhang, Stamatios Theocharis, Timothy M Pawlik
Exosomes are nanovesicles that may play a role in intercellular communication by acting as carriers of functional contents such as proteins, lipids, RNA molecules and circulating DNA from donor to recipient cells. In addition, exosomes may play a potential role in immunosurveillance and tumor pathogenesis and progression. Recently, research has increasingly focused on the role of exosomes in hepatocellular carcinoma (HCC), the most common primary liver malignancy. We herein review data on emerging experimental and clinical studies focused on the role of exosomes in the pathogenesis, diagnosis, progression and chemotherapy response of patients with HCC...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28806528/surface-adaptive-gold-nanoparticles-with-effective-adherence-and-enhanced-photothermal-ablation-of-methicillin-resistant-staphylococcus-aureus-biofilm
#14
Dengfeng Hu, Huan Li, Bailiang Wang, Zi Ye, Wenxi Lei, Fan Jia, Qiao Jin, Ke-Feng Ren, Jian Ji
Biofilms which contribute to the persistent bacterial infections pose serious threats to global public health, mainly due to their resistance to antibiotics penetration and escaping innate immune attacks by phagocytes. Here, we report a kind of surface-adaptive gold nanoparticles (AuNPs) exhibiting (1) self-adaptive target to the acidic microenvironment of biofilm, (2) enhanced photothermal ablation of methicillin-resistant Staphylococcus aureus (MRSA) biofilm under near-infrared (NIR) light irradiation and (3) no damage to the healthy tissues around biofilm...
August 14, 2017: ACS Nano
https://www.readbyqxmd.com/read/28806168/mapping-the-mouse-allelome-reveals-tissue-specific-regulation-of-allelic-expression
#15
Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah J Hudson
To determine the dynamics of allelic-specific expression during mouse development, we analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be detected. We demonstrate that allelic expression arising from genetic or epigenetic differences is highly tissue-specific. We find that tissue-specific strain-biased gene expression may be regulated by tissue-specific enhancers or by post-transcriptional differences in stability between the alleles...
August 14, 2017: ELife
https://www.readbyqxmd.com/read/28805880/vacuum-filling-of-complex-microchannels-with-liquid-metal
#16
Yiliang Lin, Olivia Gordon, M Rashed Khan, Neyanel Vasquez, Jan Genzer, Michael D Dickey
This paper describes the utilization of vacuum to fill complex microchannels with liquid metal. Microchannels filled with liquid metal are useful as conductors for soft and stretchable electronics, as well as for microfluidic components such as electrodes, antennas, pumps, or heaters. Liquid metals are often injected manually into the inlet of a microchannel using a syringe. Injection can only occur if displaced air in the channels has a pathway to escape, which is usually accomplished using outlets. The positive pressure (relative to atmosphere) needed to inject fluids can also cause leaks or delamination of the channels during injection...
August 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28805641/culicoides-virus-interactions-infection-barriers-and-possible-factors-underlying-vector-competence
#17
REVIEW
Mary K Mills, Kristin Michel, Robert S Pfannenstiel, Mark G Ruder, Eva Veronesi, Dana Nayduch
In the United States, Culicoides midges vector arboviruses of economic importance such as Bluetongue Virus and Epizootic Hemorrhagic Disease Virus. A limited number of studies have demonstrated the complexities of midge-virus interactions, including dynamic changes in virus titer and prevalence over the infection time course. These dynamics are, in part, dictated by mesenteron infection and escape barriers. This review summarizes the overarching trends in viral titer and prevalence throughout the course of infection...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28803873/neural-circuitry-that-evokes-escape-behavior-upon-activation-of-nociceptive-sensory-neurons-in-drosophila-larvae
#18
Jiro Yoshino, Rei K Morikawa, Eri Hasegawa, Kazuo Emoto
Noxious stimuli trigger a stereotyped escape response in animals. In Drosophila larvae, class IV dendrite arborization (C4 da) sensory neurons in the peripheral nervous system are responsible for perception of multiple nociceptive modalities, including noxious heat and harsh mechanical stimulation, through distinct receptors [1-9]. Silencing or ablation of C4 da neurons largely eliminates larval responses to noxious stimuli [10-12], whereas optogenetic activation of C4 da neurons is sufficient to provoke corkscrew-like rolling behavior similar to what is observed when larvae receive noxious stimuli, such as high temperature or harsh mechanical stimulation [10-12]...
August 4, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28803862/recombinant-lcmv-vectors-induce-protective-immunity-following-homologous-and-heterologous-vaccinations
#19
Jessica Wingerath, Dmitrij Ostroumov, Norman Woller, Michael P Manns, Daniel D Pinschewer, Klaus Orlinger, Ursula Berka, Florian Kühnel, Thomas C Wirth
Successful vaccination against cancer and infectious diseases relies on the induction of adaptive immune responses that induce high-titer antibodies or potent cytoxic T cell responses. In contrast to humoral vaccines, the amplification of cellular immune responses is often hampered by anti-vector immunity that either pre-exists or develops after repeated homologous vaccination. Replication-defective lymphocytic choriomeningitis virus (LCMV) vectors represent a novel generation of vaccination vectors that induce potent immune responses while escaping recognition by neutralizing antibodies...
July 20, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28803798/radiosynthesis-and-preclinical-pet-evaluation-of-89-zr-nivolumab-bms-936558-in-healthy-non-human-primates
#20
Erin L Cole, Joonyoung Kim, David J Donnelly, R Adam Smith, Daniel Cohen, Virginie Lafont, Paul E Morin, Richard Y-C Huang, Patrick L Chow, Wendy Hayes, Samuel Bonacorsi
Cancer immunotherapy, unlike traditional cytotoxic chemotherapeutic treatments, engages the immune system to identify cancer cells and stimulate immune responses. The Programmed Death-1 (PD-1) protein is an immunoinhibitory receptor expressed by activated cytotoxic T-lymphocytes (CTL) that seek out and destroy cancer cells. Multiple cancer types express and upregulate the Programmed Death-Ligand 1 (PD-L1) and 2 (PD-L2) which bind to PD-1 as an immune escape mechanism. Nivolumab is a fully human IgG4 anti-PD-1 monoclonal antibody (mAb) approved for treatment of multiple cancer types...
August 4, 2017: Bioorganic & Medicinal Chemistry
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