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https://www.readbyqxmd.com/read/28938732/prevalence-of-occult-leiomyosarcomas-and-atypical-leiomyomas-after-laparoscopic-morcellation-of-leiomyomas-in-reproductive-age-women
#1
G Pados, D Tsolakidis, V Theodoulidis, A Makedos, T Zaramboukas, B Tarlatzis
STUDY QUESTION: What is the prevalence of leiomyosarcomas and atypical leiomyomas after laparoscopic morcellation of fibroids in reproductive age women? SUMMARY ANSWER: No case of leiomyosarcomas but seven atypical leiomyomas were found in 1216 subjects. WHAT IS KNOWN ALREADY: Although uterine sarcoma is a rare entity affecting usually older peri- or post-menopausal women, the Food and Drug Administration discourages use of laparoscopic power morcellation of uterine fibroids...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28934806/radiation-exposure-during-uterine-fibroid-embolization-ufe-a-confounder-controlled-comparison-between-a-state-of-the-art-angiography-unit-and-a-conventional-angiography-unit
#2
Christof-Matthias Sommer, Wieland Voigt, Michel Klapp Oliger, Christopher L Schlett, Stefan Erpenbach, Katrina Thomas, Andreas Hatopp, Patrick Kurz, Goetz M Richter
Purpose To compare radiation exposure of a state-of-the-art and a conventional angiography unit in patients undergoing uterine fibroid embolization (UFE). Materials and Methods Between January 2009 and December 2016, 286 patients underwent UFE in our Interdisciplinary Fibroid Center. The inclusion criteria for this retrospective analysis were first-time transarterial embolization for symptomatic fibroids, bilateral embolization, procedures applying a state-of-the-art (Group 1) or a conventional angiography unit (Group 2), and bilateral technical success with an adequate embolization endpoint after the injection of microspheres...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28933575/unexpected-uterine-leiomyosarcoma-in-a-woman-with-multiple-myomas-treated-with-ulipristal-acetate-case-report-and-literature-review
#3
Paola Modaffari, Marta D'alonzo, Marta Garbagnati, Silvia Pecchio, Guido Menato, Nicoletta Biglia
Ulipristal acetate (UPA) has been recognized as an alternative strategy to surgery in the management of symptomatic women with uterine fibroids. We present a case report on a woman with hereditary fibrinogen deficiency exclusively treated with UPA for myoma-related menorrhagia and abdominal pain, who subsequently underwent a hysterectomy because of clinical worsening. A FIGO IB uterine leiomyosarcoma was found among multiple myomas. A review of the literature found two other cases of uterine leiomyosarcoma in patients treated with UPA: clinical data are reported...
September 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28930223/successful-pregnancy-after-treatment-with-chinese-herbal-medicine-in-a-43-year-old-woman-with-diminished-ovarian-reserve-and-multiple-uterus-fibrosis-a-case-report
#4
Benqi Teng, Jie Peng, Madeleine Ong, Xianqin Qu
OBJECTIVE: To highlight a natural approach to coexisting oligomenorrhea, subfertility, luteal phase insufficiency and multiple fibroids cohesively when in vitro fertilisation (IVF) has failed. CASE PRESENTATION: A 43-year-old woman with diminished ovarian reserve and multiple uterine fibroids had previously been advised to discontinue IVF treatment. According to Chinese Medicine diagnosis, herbal formulae were prescribed for improving age-related ovarian insufficiency as well as to control the growth of fibroids...
February 9, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930160/human-chorionic-gonadotrophin-as-a-possible-mediator-of-leiomyoma-growth-during-pregnancy-molecular-mechanisms
#5
REVIEW
Veronica Sarais, Greta Chiara Cermisoni, Matteo Schimberni, Alessandra Alteri, Enrico Papaleo, Edgardo Somigliana, Paola Vigano'
Uterine fibroids are the most common gynecologic benign tumors. Studies supporting a strong pregnancy-related growth of leiomyomas generally claimed a crucial role of sex steroid hormones. However, sex steroids are unlikely the unique actors involved as estrogen and progesterone achieve a pick serum concentration in the last trimester while leiomyomas show a typical increase during the first trimester. Given the rapid exponential raise in serum human Chorionic Gonadotrophin (hCG) at the beginning of gestation, we conducted a review to assess the potential role of hCG in the striking growth of leiomyomas during initial pregnancy...
September 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28929861/ulipristal-acetate-and-extracellular-matrix-production-in-human-leiomyomas-in-vivo-a-laboratory-analysis-of-a-randomized-placebo-controlled-trial
#6
Jeris Cox, Minnie Malik, Joy Britten, Terrence Lewis, William H Catherino
In a prior randomized controlled study, patients treated with ulipristal acetate (UPA) or placebo for 3 months had a decrease in leiomyoma size. A total of 10 patients' tissue samples (5 placebo and 5 treated with 10 mg/d UPA) that underwent hysterectomy and tissue preservation were identified from this study. Quantitative real-time reverse transcriptase polymerase chain reaction and Western blotting were used to assess fold gene and protein expression of extracellular membrane (ECM) proteins: collagen 1A (COL1A), fibronectin (FN1), and versican (VCAN) of the samples...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28929111/monitoring-leiomyoma-response-to-uterine-artery-embolization-using-diffusion-and-perfusion-indices-from-diffusion-weighted-imaging
#7
Mengqiu Cao, Lijun Qian, Xuebin Zhang, Xinjun Suo, Qing Lu, Huilin Zhao, Jialin Liu, Jianxun Qu, Yan Zhou, Jianrong Xu, Shiteng Suo
PURPOSE: To investigate the potential of diffusion and perfusion indices (ADC and perfusion fraction f) from DWI at 3.0 T in monitoring treatment response to uterine artery embolization (UAE) at 6-month follow-up. METHODS: Twelve female patients with uterine fibroids who underwent 3.0-T pelvic DWI before and 6 months after UAE were included. ADC and perfusion fraction f were calculated from DWI. The Wilcoxon signed-rank test and Spearman rank correlation test were used for statistics...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28922305/mayer-rokitansky-k%C3%A3-ster-hauser-syndrome-with-bilateral-ovarian-sertoli-cell-tumors-review-of-the-literature-and-report-of-a-rare-case
#8
Alexander L Juusela, Ilana Naghi, Suresh Thani
BACKGROUND: Patients with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome are infertile secondary to hypoplasia or complete agenesis of the uterus, yet they remain at risk of primary neoplasms of the ovaries because embryologically the uterus and ovaries develop via separate mechanisms. CASE: A 72-year-old nulliparous woman with a history of primary amenorrhea underwent an exploratory laparotomy for a suspected uterine fibroid. In addition to the pelvic mass, the patient was found to have findings consistent with MRKH syndrome...
September 15, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28919823/updated-approaches-for-management-of-uterine-fibroids
#9
REVIEW
Aymara Mas, Marta Tarazona, Joana Dasí Carrasco, Gloria Estaca, Ignacio Cristóbal, Javier Monleón
Uterine anatomy and uterine fibroids (UFs) characteristics have been classically considered as almost a unique issue in gynecology and reproductive medicine. Nowadays, the management of UF pathology is undergoing an important evolution, with the patient's quality of life being the most important aspect to consider. Accordingly, surgical techniques and aggressive treatments are reserved for only those cases with heavy symptomatology, while the clinical diagnostic based on size and number of UFs remains in a second plane in these situations...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28919793/burden-of-uterine-fibroids-in-italy-epidemiology-treatment-outcomes-and-consumption-of-health-care-resources-in-more-than-5-000-women
#10
Marco Chiumente, Mauro De Rosa, Andrea Messori, Enrica Maria Proli
BACKGROUND AND PURPOSE: Epidemiological studies on uterine fibroids (UFs) are mostly based on surveys or analyses of small samples of patients. In 50% of women, the quality of life is worsened by disease-related symptoms; furthermore, treatments imply a remarkable health care cost. The aim of this observational study was to analyze a large sample of Italian patients with UFs and to assess the epidemiology, the appropriateness of treatments, and the consumption of disease-related resources...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28904795/cervical-superficial-myofibroblastoma-case-report-and-review-of-the-literature
#11
Mohamed Abdelaziz, Noura Eziba, Suash Sharma, Daniel Kleven, Ayman Al-Hendy
Superficial myofibroblastoma of the lower female genital tract is a rare benign, recently recognized neoplasm that mostly affects the vulvovaginal area. Our report discusses a case of cervical superficial myofibroblastoma of the lower female genital tract in a 45-year-old patient who is presented with menometrorrhagia. On examination, she had multiple uterine fibroids and a circumscribed submucosal mass lesion involving the anterior lip of cervix. At hysterectomy, histopathological examination of the cervical mass revealed a relatively hypocellular tumor consisted of bland spindled and stellate cells...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28900897/ulipristal-acetate-a-review-in-symptomatic-uterine-fibroids
#12
Karly P Garnock-Jones, Sean T Duggan
Oral ulipristal acetate (Esmya(®); Fibristal(®)), a synthetic selective progesterone receptor modulator, is the first selective progesterone modulator to be approved for the treatment of uterine fibroids. It was initially approved for the preoperative treatment of moderate to severe uterine fibroid symptoms in women of reproductive age. Recently, the indication was extended in the EU to include the intermittent treatment of moderate to severe uterine fibroid symptoms. This narrative review summarizes pharmacological, efficacy and tolerability data relevant to the preoperative and intermittent use of ulipristal acetate in patients with symptomatic uterine fibroids...
September 12, 2017: Drugs
https://www.readbyqxmd.com/read/28892210/myoma-and-myomectomy-poor-evidence-concern-in-pregnancy
#13
REVIEW
Giusi Natalia Milazzo, Angelica Catalano, Valentina Badia, Maddalena Mallozzi, Donatella Caserta
AIM: Summarize the results of the many, but often underpowered, studies on pregnancy complicated by myoma or myomectomy. METHODS: Survey of the electronic PubMed database for the last two decades was conducted. We selected reviews, meta-analyses, case series, case reports, clinical studies only with statistical analysis, and guidelines from scientific societies. RESULTS: Delaying childbearing leads to an increased incidence of pregnancy complicated by fibroids or previous myomectomy...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28890674/treating-symptomatic-uterine-fibroids-with-myomectomy-current-practice-and-views-of-uk-consultants
#14
R Fusun Sirkeci, Anna Maria Belli, Isaac T Manyonda
BACKGROUND: The demand for uterus-sparing treatments is increasing as more women postpone childbirth to their 30-40s, when fibroids are more symptomatic. With an increasing choice of treatment options and changing care-provider profiles, now is an opportune time to survey current practices and opinions. Using a 25-stem questionnaire, a web-based survey was used to capture the practices and opinions of UK consultant gynecologists on the treatment of symptomatic fibroids, including the types of procedure most frequently used, methods used to reduce blood loss, and awareness and acceptability of treatment options, and to assess the impact of gender and experience of the treating gynecologist...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28887670/comparison-of-two-endovascular-steerable-robotic-catheters-for-percutaneous-robot-assisted-fibroid-embolization
#15
C Del Giudice, O Pellerin, M Nouri Neville, G Amouyal, I Fitton, C Leré-Déan, M Sapoval
PURPOSE: To compare outcomes of percutaneous robot-assisted uterine fibroid embolization (UFE) using two different endovascular robotic catheters. METHODS: Twenty-one patients with a symptomatic uterine fibroid were prospectively enrolled in a single-center study to be treated with a percutaneous robot-assisted embolization using the Magellan system. Fourteen patients were treated using a first generation steerable robotic catheter, version 1.0 (group 1), and seven were treated using the new version 1...
September 8, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28885274/fertility-preserved-hysteroscopic-approach-for-the-treatment-of-stage-ia-endometrioid-carcinoma
#16
Fangfang Wang, Aijun Yu, Haichao Xu, Xiaojing Zhang, Li Li, Hanmei Lou, Hua Yu, Jun Lin
OBJECTIVE: This study aims to explore the feasibility of a hysteroscopic procedure combined with progestin therapy in young patients with stage Ia endometrioid carcinoma (EC) to avoid sterilization. MATERIALS AND METHODS: Eleven young women with stage Ia EC (International Federation of Gynecology and Obstetrics grade 1) who were treated with a hysteroscopic approach combined with progestin from July 2004 to June 2016 were retrospectively analyzed and followed up to monitor their general recovery and pregnancy outcome...
September 6, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28883708/rarity-among-benign-gastric-tumors-plexiform-fibromyxoma-report-of-two-cases
#17
Kinga Szurian, Holger Till, Eva Amerstorfer, Nicole Hinteregger, Hans-Jörg Mischinger, Bernadette Liegl-Atzwanger, Iva Brcic
Plexiform fibromyxoma is a very rare mesenchymal tumor of the stomach, found almost exclusively in the antrum/pylorus region. The most common presenting symptoms are anemia, hematemesis, nausea and unintentional weight loss, without sex or age predilection. We describe here two cases of plexiform fibromyxoma, involving a 16-year-old female and a 34-year-old male. Both patients underwent complete resection (R0) by distal gastrectomy and retrocolic gastrojejunostomy (according to Billroth 2); for both, the postoperative course was uneventful...
August 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28883630/a-clinical-investigation-treating-different-types-of-fibroids-identified-by-mri-t2wi-imaging-with-ultrasound-guided-high-intensity-focused-ultrasound
#18
Wen-Peng Zhao, Jing Zhang, Zhi-Yu Han, Jin-Peng Yao, Xiang Zhou, Ping Liang
Clinical data from 172 cases of uterine fibroids with different appearances on MRI-T2WI and accepted ultrasound guided high intensity focused ultrasound (USgHIFU) treatment were retrospectively analyzed. This study aimed to evaluate the clinical safety and efficacy of ablating different types of fibroids, classified by T2-weighted magnetic resonance imaging (MRI-T2WI). Based on MRI-T2WI signal intensities, uterine fibroids were classified as three types: hypointensive (52 cases), isointensive (64 cases) and hyperintensive (56 cases)...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28876143/anti-m%C3%A3-llerian-hormone-levels-before-and-after-uterine-artery-embolization
#19
Bruce McLucas, William D Voorhees, Scott A Snyder
OBJECTIVE: To determine the effects of uterine artery embolization (UAE) on ovarian reserve as measured by Anti-Müllerian hormone (AMH) levels. MATERIAL AND METHODS: Non-randomized, observational study of 89 women 23-40 years of age who received UAE. Control hormone levels were measured prior to UAE and the first post-embolization measurement was taken at various times post-procedure (mean = 190 ± 229 days). RESULTS: Historical work verified by our earlier work has shown that AMH levels decline with age...
September 6, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/28875276/epigenetic-and-genetic-landscape-of-uterine-leiomyomas-a-current-view-over-a-common-gynecological-disease
#20
Antonio Simone Laganà, Daniele Vergara, Alessandro Favilli, Valentina Lucia La Rosa, Andrea Tinelli, Sandro Gerli, Marco Noventa, Amerigo Vitagliano, Onofrio Triolo, Agnese Maria Chiara Rapisarda, Salvatore Giovanni Vitale
PURPOSE: Despite the numerous studies on the factors involved in the genesis and growth of uterine leiomyomas, the pathogenesis of these tumors remains unknown. Intrinsic abnormalities of the myometrium, abnormal myometrial receptors for estrogen, and hormonal changes or altered responses to ischemic damage during the menstrual period may be responsible for the initiation of (epi)genetic changes found in these tumors. Considering these elements, we aimed to offer an overview about epigenetic and genetic landscape of uterine leiomyomas...
September 5, 2017: Archives of Gynecology and Obstetrics
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