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X Yao, E A Stewart, S K Laughlin-Tommaso, H C Heien, B J Borah
OBJECTIVES: To report patterns and patient characteristics associated with initiation of and persistence with medical therapies for uterine fibroid-related heavy menstrual bleeding. DESIGN: Retrospective cohort study. SETTING: US commercial insurance claims database. POPULATION: 41 561 women aged 18-54 years with uterine fibroids and heavy menstrual bleeding who initiated medical therapies from January 2000 through December 2013...
October 21, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
Mi Hyang Ohh, Seong Jin Kim, Jong Kwon Han, Sok Cheon Pak, Kew-Mahn Chee
AIM: Uterine leiomyomas are the most common benign uterine neoplasms associated with significant morbidity. Herbal formulas capable of restoring yin-yang balance by dispersing blood stasis may be useful for managing fibroid symptoms. MATERIALS AND METHODS: In this study, the antitumor properties of three herbs viz., Trogopterus xanthipes Milen-Edwards, Paeonia lactiflora Pallas, and Ulmus davidiana Planch were evaluated in nude mice injected intravenously with human malignant myomas...
September 2016: Journal of Intercultural Ethnopharmacology
Giuseppe Loverro, Leonardo Resta, Miriam Dellino, Di Naro Edoardo, Maria Arcangela Cascarano, Matteo Loverro, Salvatore Andrea Mastrolia
OBJECTIVE: Female-to-male transition remains a specific clinical indication for long-term testosterone administration. There is a limited number of studies dealing with the effect of androgen treatment on their female receptive targets (mainly breast and uterus) and the knowledge in this field is scarce and, sometimes, contradictory. MATERIALS AND METHODS: We performed a prospective study including 12 patients aged between 20 years and 32 years, with a diagnosis of gender dysphoria, treated with parenteral testosterone administration before sexual reassignment surgery...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Sheng-Ling Tung, Ting-Ywan Chou, Hung-Shi Tseng, Chi-Ming Lee
OBJECTIVE: To report our experiences with 40 patients who were treated with magnetic resonance-guided focused ultrasound surgery (MRgFUS) for uterine fibroids and their 6-month follow-up status. MATERIALS AND METHODS: A total of 40 patients with uterine fibroids underwent MRgFUS from January 2009 to November 2011. The Uterine Fibroid Symptoms and Quality of Life Questionnaire was used to determine the patients' Symptom Severity Scores (SSS) prior to and 6 months after treatment...
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Kae Hachiya, Hiroki Kato, Shimpei Kawaguchi, Toshihisa Kojima, Yukiko Nishikawa, Sayaka Fujiwara, Masayuki Matsuo
No abstract text is available yet for this article.
October 17, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Samuel J Fogarty, Graeme Hart, Jim Nicklin, Bala Venkatesh, Nicholas Boyne, David C Wong, Jason L Stone, Andrew J Rainbird
Intracardiac leiomyomatosis is a rare complication that occurs when a uterine leiomyoma (fibroid) undergoes vascular invasion and propagates within the inferior vena cava to reach the right atrium. This article describes a case of intracardiac leiomyomatosis in a middle-aged woman, exploring the presentation, diagnosis and surgical management of this condition. In this case the presenting complaints were syncope and atrial fibrillation, illustrating the importance of performing a transthoracic echocardiogram in patients presenting with their first episode of atrial fibrillation...
September 17, 2016: Heart, Lung & Circulation
Michał Ciebiera, Marta Włodarczyk, Aneta Słabuszewska-Jóźwiak, Grażyna Nowicka, Grzegorz Jakiel
OBJECTIVE: To evaluate the influence of 25-hydroxyvitamin D and transforming growth factor β3 (TGF-β3) serum concentrations, weight, and family history on the risk of developing uterine fibroids. DESIGN: Retrospective cohort study. SETTING: University hospital. PATIENT(S): A total of 188 women, including patients admitted for uterine fibroid surgery (n = 105) as the study group and healthy women of similar age (n = 83) as controls...
October 12, 2016: Fertility and Sterility
Jacques Donnez, Olivier Donnez, Marie-Madeleine Dolmans
During the last decade, there has been increased emphasis on the role of progesterone in the promotion of fibroid growth, as well as heightened interest in modulating progesterone pathways by use of selective progesterone receptor modulators (SPRMs). Among them, ulipristal acetate (UPA) has proved its efficacy in the management of symptomatic myomas by controlling bleeding and inducing amenorrhea, and reducing the size of myomas in the majority of cases. Areas covered: In this review, we summarize published scientific studies exploring evidence of the safety of SPRMs and particularly UPA, a drug approved for the management of symptomatic uterine fibroids...
October 14, 2016: Expert Opinion on Drug Safety
A Mas, L Stone, P M O'Connor, Q Yang, D T Kleven, C Simon, C L Walker, A Al-Hendy
Despite the high prevalence and major negative impact of uterine fibroids (UFs) on women's health, their pathogenesis remains largely unknown. While tumor initiating cells (TICs) have been previously isolated from UFs, the cell of origin for these tumors in normal myometrium has not been identified. We isolated cells with Stro1/CD44 surface markers from normal myometrium expressing stem cell markers Oct-4/c-kit/nanog that exhibited the properties of myometrial stem/progenitor-like cells (MSCs). Using a murine model for UFs, we showed that the cervix was a hypoxic "niche" and primary site (96%) for fibroid development in these animals...
October 14, 2016: Stem Cells
Melanie P Caserta, Candice Bolan, M Jennings Clingan
The purpose of this pictorial review is to describe the normal appearance of the endometrium and to provide radiologists with an overview of endometrial pathology utilizing case examples. The normal appearance of the endometrium varies by age, menstrual phase, and hormonal status with differing degrees of acceptable endometrial thickness. Endometrial pathology most often manifests as either focal or diffuse endometrial thickening, and patients frequently present with abnormal vaginal bleeding. Endovaginal ultrasound (US) is the first-line modality for imaging the endometrium...
October 12, 2016: Abdominal Radiology
Outi Uimari, Juha Auvinen, Jari Jokelainen, Katri Puukka, Aimo Ruokonen, Marjo-Riitta Järvelin, Terhi Piltonen, Sirkka Keinänen-Kiukaanniemi, Krina Zondervan, Ilkka Järvelä, Markku Ryynänen, Hannu Martikainen
STUDY QUESTION: Are uterine fibroids associated with increased cardiovascular risk? SUMMARY ANSWER: This study reports an association between increased serum lipids and metabolic syndrome with an increased risk of uterine fibroids. WHAT IS KNOWN ALREADY: Recent studies suggest similarities in biological disease mechanisms and risk factors for fibroids and atherosclerosis: obesity, hypertension and abnormal serum lipids. These findings are awaiting confirmation that a population-based follow-up study could offer with extensive health examination data collection linked with a national hospital discharge register...
October 12, 2016: Human Reproduction
Karin S Coyne, Ahmed M Soliman, Mary Kay Margolis, Christine L Thompson, Kristof Chwalisz
OBJECTIVE: To assess the psychometric performance of the 4-week recall version of the Uterine Fibroid Symptom and Health-related Quality of Life Questionnaire (UFS-QoL), a patient measure of the severity of uterine fibroid (UF) symptoms and their impact on health-related quality of life (HRQL). METHODS: This was a retrospective analysis of Phase 2a data from pre-menopausal women with heavy menstrual bleeding associated with UF. Participants completed the UFS-QoL at Baseline, Treatment Month 3, and Follow-up Month 3 and a daily diary with a Menstrual Bleeding Scale and the UF Daily Symptom Scale throughout the study duration...
October 13, 2016: Current Medical Research and Opinion
Kozue Takeshita, Kazuhiro Kashiwagi, Yuka Ishibashi, Takanori Kanai
No abstract text is available yet for this article.
2016: Internal Medicine
Subrata Pal, Sajeeb Mondal, Palash Kr Mondal, Gargi Raychaudhuri, Rajashree Pradhan, Suparna Banerjee
Calcified broad ligament leiomyoma is a rare benign lesion in postmenopausal age group. It causes diagnostic confusion with solid calcified adnexal mass and large bladder calculi at the pelvic region. Clinical and radiological diagnoses were confirmed by histopathology of the hysterectomy specimen. We hereby present a case of heavily calcified broad ligament fibroid in a postmenopausal woman.
July 2016: Journal of Mid-life Health
Neeru Goel, Shikha Seth
Uterine fibroids are the most common uterine neoplasm of uterus and the female pelvis and the most common indication for hysterectomy worldwide. When the fibroid is large and fills the whole pelvis or is pedunculated, it becomes difficult to differentiate from ovarian mass clinically. Cervical fibroids pose enormous surgical difficulty by virtue of their relative inaccessibility and proximity to the anterior bladder, posterior rectum, and distorting the normal anatomical relationship of pelvic structures. A cervical fibroid especially with degenerative changes mimics an ovarian tumor and poses a clinical dilemma...
July 2016: Journal of Mid-life Health
C F Forasté-Enríquez, R Mata-Hernández, A Hernández-Villaseñor, G Alderete-Vázquez, P Grube-Pagola
No abstract text is available yet for this article.
October 4, 2016: Revista de Gastroenterología de México
Chang-Woon Kim, Haeng Seon Shim, Hong Jang, Yun Gyu Song
OBJECTIVE: To evaluate the effects of UAE for symptomatic uterine fibroids on ovarian reserve based on AMH. STUDY DESIGN: This was a retrospective study conducted between March 2011 and October 2014. All women underwent UAE. At baseline and at the 3-month and 12-month follow-up visits, serum anti-Müllerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) levels were assessed, and ovarian volume and antral follicle count (AFC) were evaluated in each patient...
September 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Helen Kaganov, Alex Ades
BACKGROUND: Uterine leiomyomas, or fibroids, represent a large proportion of gynaecological presentations in both general and specialist gynaecology practice. The diagnosis is relatively simple with current imaging modalities. The management of fibroids, however, is not always straightforward and can present many challenges. OBJECTIVE: This article reviews current approaches to the management of uterine fibroids, including novel techniques, and highlights important patient counselling points...
October 2016: Australian Family Physician
Ju Ah Lee, Sunju Park, Jeeyoun Jung, Ji Hee Jun, Jiae Choi, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), also known as Guizhi Fuling formula, and is widely used for uterine fibroids in East Asian countries. Many clinical trials assessing the efficacy and safety of GBH formula for the treatment of dysmenorrhoea have been reported. This review will assess the clinical evidence for and against the use of GBH formula as a treatment for dysmenorrhoea. It will also discuss the proposed mechanism(s) that could link herbal medicine to improvements in dysmenorrhoea...
2016: BMJ Open
J G Garza-Leal
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
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